Anticancer activities of chalcone flavokawain B from Alpinia pricei Hayata in human lung adenocarcinoma (A549) cells via induction of reactive oxygen species-mediated apoptotic and autophagic cell death.
Identifieur interne : 000070 ( PubMed/Checkpoint ); précédent : 000069; suivant : 000071Anticancer activities of chalcone flavokawain B from Alpinia pricei Hayata in human lung adenocarcinoma (A549) cells via induction of reactive oxygen species-mediated apoptotic and autophagic cell death.
Auteurs : You-Cheng Hseu [Taïwan] ; Yu-Chi Huang [Taïwan] ; Varadharajan Thiyagarajan [Taïwan] ; Dony Chacko Mathew [Taïwan] ; Kai-Yuan Lin [Taïwan] ; Ssu-Ching Chen [Taïwan] ; Jer-Yuh Liu [Taïwan] ; Li-Sung Hsu [Taïwan] ; Mei-Ling Li [Taïwan] ; Hsin-Ling Yang [Taïwan]Source :
- Journal of cellular physiology [ 1097-4652 ] ; 2019.
Abstract
Chalcones found in fruits and vegetables have promising cancer chemopreventive properties. This study attempts to identify the anticancer efficacies of chalcone flavokawain B (FKB) in the rhizomes of Alpinia pricei Hayata by examining key molecular events in non-small-cell lung cancer (A549) cells. Our results indicated that in human A549 cells, FKB (0-15 μg/ml) decreases cell viability and colony formation, dysregulates the Bax:B-cell lymphoma 2 ratio and increases apoptotic DNA fragmentation. Mitochondrial (caspase-9/-3 and poly ADP ribose polymerase [PARP]) signaling was found to be involved in FKB-induced apoptosis. In addition, FKB-induced reactive oxygen species (ROS) generation, and N-acetylcysteine attenuated FKB-induced apoptotic cell death. Moreover, FKB triggered autophagy, as evidenced by the improved acidic vesicular organelle formation, lipidated light chain 3 (microtubule-related light chain 3) accumulation, and ATG7 expression and the decreased mammalian target of rapamycin phosphorylation. Furthermore, FKB suppressed ROS-mediated ATG4B expression. Inhibiting autophagy using 3-methyladenine/chloroquine diminished FKB-induced cell death, indicating that autophagy is triggered as a death mechanism by FKB. In summary, FKB has a crucial role in the execution and propagation of ROS-mediated apoptotic and autophagic cell death of lung adenocarcinoma cells.
DOI: 10.1002/jcp.28375
PubMed: 30847898
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:30847898Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anticancer activities of chalcone flavokawain B from Alpinia pricei Hayata in human lung adenocarcinoma (A549) cells via induction of reactive oxygen species-mediated apoptotic and autophagic cell death.</title>
<author><name sortKey="Hseu, You Cheng" sort="Hseu, You Cheng" uniqKey="Hseu Y" first="You-Cheng" last="Hseu">You-Cheng Hseu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Yu Chi" sort="Huang, Yu Chi" uniqKey="Huang Y" first="Yu-Chi" last="Huang">Yu-Chi Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thiyagarajan, Varadharajan" sort="Thiyagarajan, Varadharajan" uniqKey="Thiyagarajan V" first="Varadharajan" last="Thiyagarajan">Varadharajan Thiyagarajan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mathew, Dony Chacko" sort="Mathew, Dony Chacko" uniqKey="Mathew D" first="Dony Chacko" last="Mathew">Dony Chacko Mathew</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Kai Yuan" sort="Lin, Kai Yuan" uniqKey="Lin K" first="Kai-Yuan" last="Lin">Kai-Yuan Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Research, Chi-Mei Medical Center, Tainan</wicri:regionArea>
<wicri:noRegion>Tainan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Ssu Ching" sort="Chen, Ssu Ching" uniqKey="Chen S" first="Ssu-Ching" last="Chen">Ssu-Ching Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, National Central University, Chung-Li, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Life Sciences, National Central University, Chung-Li</wicri:regionArea>
<wicri:noRegion>Chung-Li</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Jer Yuh" sort="Liu, Jer Yuh" uniqKey="Liu J" first="Jer-Yuh" last="Liu">Jer-Yuh Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Cancer Biology, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsu, Li Sung" sort="Hsu, Li Sung" uniqKey="Hsu L" first="Li-Sung" last="Hsu">Li-Sung Hsu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biomedical Sciences, Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Mei Ling" sort="Li, Mei Ling" uniqKey="Li M" first="Mei-Ling" last="Li">Mei-Ling Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Hsin Ling" sort="Yang, Hsin Ling" uniqKey="Yang H" first="Hsin-Ling" last="Yang">Hsin-Ling Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:30847898</idno>
<idno type="pmid">30847898</idno>
<idno type="doi">10.1002/jcp.28375</idno>
<idno type="wicri:Area/PubMed/Corpus">000061</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000061</idno>
<idno type="wicri:Area/PubMed/Curation">000061</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000061</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000070</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000070</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Anticancer activities of chalcone flavokawain B from Alpinia pricei Hayata in human lung adenocarcinoma (A549) cells via induction of reactive oxygen species-mediated apoptotic and autophagic cell death.</title>
<author><name sortKey="Hseu, You Cheng" sort="Hseu, You Cheng" uniqKey="Hseu Y" first="You-Cheng" last="Hseu">You-Cheng Hseu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Yu Chi" sort="Huang, Yu Chi" uniqKey="Huang Y" first="Yu-Chi" last="Huang">Yu-Chi Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thiyagarajan, Varadharajan" sort="Thiyagarajan, Varadharajan" uniqKey="Thiyagarajan V" first="Varadharajan" last="Thiyagarajan">Varadharajan Thiyagarajan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mathew, Dony Chacko" sort="Mathew, Dony Chacko" uniqKey="Mathew D" first="Dony Chacko" last="Mathew">Dony Chacko Mathew</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Kai Yuan" sort="Lin, Kai Yuan" uniqKey="Lin K" first="Kai-Yuan" last="Lin">Kai-Yuan Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Research, Chi-Mei Medical Center, Tainan</wicri:regionArea>
<wicri:noRegion>Tainan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Ssu Ching" sort="Chen, Ssu Ching" uniqKey="Chen S" first="Ssu-Ching" last="Chen">Ssu-Ching Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, National Central University, Chung-Li, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Life Sciences, National Central University, Chung-Li</wicri:regionArea>
<wicri:noRegion>Chung-Li</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Jer Yuh" sort="Liu, Jer Yuh" uniqKey="Liu J" first="Jer-Yuh" last="Liu">Jer-Yuh Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Cancer Biology, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsu, Li Sung" sort="Hsu, Li Sung" uniqKey="Hsu L" first="Li-Sung" last="Hsu">Li-Sung Hsu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biomedical Sciences, Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Mei Ling" sort="Li, Mei Ling" uniqKey="Li M" first="Mei-Ling" last="Li">Mei-Ling Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Hsin Ling" sort="Yang, Hsin Ling" uniqKey="Yang H" first="Hsin-Ling" last="Yang">Hsin-Ling Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of cellular physiology</title>
<idno type="eISSN">1097-4652</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Chalcones found in fruits and vegetables have promising cancer chemopreventive properties. This study attempts to identify the anticancer efficacies of chalcone flavokawain B (FKB) in the rhizomes of Alpinia pricei Hayata by examining key molecular events in non-small-cell lung cancer (A549) cells. Our results indicated that in human A549 cells, FKB (0-15 μg/ml) decreases cell viability and colony formation, dysregulates the Bax:B-cell lymphoma 2 ratio and increases apoptotic DNA fragmentation. Mitochondrial (caspase-9/-3 and poly ADP ribose polymerase [PARP]) signaling was found to be involved in FKB-induced apoptosis. In addition, FKB-induced reactive oxygen species (ROS) generation, and N-acetylcysteine attenuated FKB-induced apoptotic cell death. Moreover, FKB triggered autophagy, as evidenced by the improved acidic vesicular organelle formation, lipidated light chain 3 (microtubule-related light chain 3) accumulation, and ATG7 expression and the decreased mammalian target of rapamycin phosphorylation. Furthermore, FKB suppressed ROS-mediated ATG4B expression. Inhibiting autophagy using 3-methyladenine/chloroquine diminished FKB-induced cell death, indicating that autophagy is triggered as a death mechanism by FKB. In summary, FKB has a crucial role in the execution and propagation of ROS-mediated apoptotic and autophagic cell death of lung adenocarcinoma cells.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">30847898</PMID>
<DateRevised><Year>2019</Year>
<Month>07</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-4652</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>234</Volume>
<Issue>10</Issue>
<PubDate><Year>2019</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Journal of cellular physiology</Title>
<ISOAbbreviation>J. Cell. Physiol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Anticancer activities of chalcone flavokawain B from Alpinia pricei Hayata in human lung adenocarcinoma (A549) cells via induction of reactive oxygen species-mediated apoptotic and autophagic cell death.</ArticleTitle>
<Pagination><MedlinePgn>17514-17526</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/jcp.28375</ELocationID>
<Abstract><AbstractText>Chalcones found in fruits and vegetables have promising cancer chemopreventive properties. This study attempts to identify the anticancer efficacies of chalcone flavokawain B (FKB) in the rhizomes of Alpinia pricei Hayata by examining key molecular events in non-small-cell lung cancer (A549) cells. Our results indicated that in human A549 cells, FKB (0-15 μg/ml) decreases cell viability and colony formation, dysregulates the Bax:B-cell lymphoma 2 ratio and increases apoptotic DNA fragmentation. Mitochondrial (caspase-9/-3 and poly ADP ribose polymerase [PARP]) signaling was found to be involved in FKB-induced apoptosis. In addition, FKB-induced reactive oxygen species (ROS) generation, and N-acetylcysteine attenuated FKB-induced apoptotic cell death. Moreover, FKB triggered autophagy, as evidenced by the improved acidic vesicular organelle formation, lipidated light chain 3 (microtubule-related light chain 3) accumulation, and ATG7 expression and the decreased mammalian target of rapamycin phosphorylation. Furthermore, FKB suppressed ROS-mediated ATG4B expression. Inhibiting autophagy using 3-methyladenine/chloroquine diminished FKB-induced cell death, indicating that autophagy is triggered as a death mechanism by FKB. In summary, FKB has a crucial role in the execution and propagation of ROS-mediated apoptotic and autophagic cell death of lung adenocarcinoma cells.</AbstractText>
<CopyrightInformation>© 2019 Wiley Periodicals, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hseu</LastName>
<ForeName>You-Cheng</ForeName>
<Initials>YC</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-5307-6162</Identifier>
<AffiliationInfo><Affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Research Center of Chinese Herbal Medicine, China Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Yu-Chi</ForeName>
<Initials>YC</Initials>
<AffiliationInfo><Affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thiyagarajan</LastName>
<ForeName>Varadharajan</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mathew</LastName>
<ForeName>Dony Chacko</ForeName>
<Initials>DC</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-6822-2716</Identifier>
<AffiliationInfo><Affiliation>Department of Cosmeceutics, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Kai-Yuan</ForeName>
<Initials>KY</Initials>
<AffiliationInfo><Affiliation>Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Ssu-Ching</ForeName>
<Initials>SC</Initials>
<AffiliationInfo><Affiliation>Department of Life Sciences, National Central University, Chung-Li, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Jer-Yuh</ForeName>
<Initials>JY</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hsu</LastName>
<ForeName>Li-Sung</ForeName>
<Initials>LS</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Mei-Ling</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Hsin-Ling</ForeName>
<Initials>HL</Initials>
<AffiliationInfo><Affiliation>Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>CMRC-CHM-9</GrantID>
<Agency>Ministry of Education (MOE), Taiwan</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>MOST-106-2320-B-039-054-MY3</GrantID>
<Agency>Ministry of Science and Technology, Taiwan</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>MOST-104-2320-B-039-040-MY</GrantID>
<Agency>Ministry of Science and Technology, Taiwan</Agency>
<Country></Country>
</Grant>
<Grant><Agency>Chinese Medicine Research Center, China Medical University</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>03</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Cell Physiol</MedlineTA>
<NlmUniqueID>0050222</NlmUniqueID>
<ISSNLinking>0021-9541</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alpinia pricei hayata</Keyword>
<Keyword MajorTopicYN="N">ROS</Keyword>
<Keyword MajorTopicYN="N">apoptosis</Keyword>
<Keyword MajorTopicYN="N">autophagy</Keyword>
<Keyword MajorTopicYN="N">chalcone flavokawain B</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>10</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2019</Year>
<Month>01</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>01</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>3</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>3</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>3</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30847898</ArticleId>
<ArticleId IdType="doi">10.1002/jcp.28375</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Hseu, You Cheng" sort="Hseu, You Cheng" uniqKey="Hseu Y" first="You-Cheng" last="Hseu">You-Cheng Hseu</name>
</noRegion>
<name sortKey="Chen, Ssu Ching" sort="Chen, Ssu Ching" uniqKey="Chen S" first="Ssu-Ching" last="Chen">Ssu-Ching Chen</name>
<name sortKey="Hsu, Li Sung" sort="Hsu, Li Sung" uniqKey="Hsu L" first="Li-Sung" last="Hsu">Li-Sung Hsu</name>
<name sortKey="Huang, Yu Chi" sort="Huang, Yu Chi" uniqKey="Huang Y" first="Yu-Chi" last="Huang">Yu-Chi Huang</name>
<name sortKey="Li, Mei Ling" sort="Li, Mei Ling" uniqKey="Li M" first="Mei-Ling" last="Li">Mei-Ling Li</name>
<name sortKey="Lin, Kai Yuan" sort="Lin, Kai Yuan" uniqKey="Lin K" first="Kai-Yuan" last="Lin">Kai-Yuan Lin</name>
<name sortKey="Liu, Jer Yuh" sort="Liu, Jer Yuh" uniqKey="Liu J" first="Jer-Yuh" last="Liu">Jer-Yuh Liu</name>
<name sortKey="Mathew, Dony Chacko" sort="Mathew, Dony Chacko" uniqKey="Mathew D" first="Dony Chacko" last="Mathew">Dony Chacko Mathew</name>
<name sortKey="Thiyagarajan, Varadharajan" sort="Thiyagarajan, Varadharajan" uniqKey="Thiyagarajan V" first="Varadharajan" last="Thiyagarajan">Varadharajan Thiyagarajan</name>
<name sortKey="Yang, Hsin Ling" sort="Yang, Hsin Ling" uniqKey="Yang H" first="Hsin-Ling" last="Yang">Hsin-Ling Yang</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000070 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000070 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:30847898 |texte= Anticancer activities of chalcone flavokawain B from Alpinia pricei Hayata in human lung adenocarcinoma (A549) cells via induction of reactive oxygen species-mediated apoptotic and autophagic cell death. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:30847898" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |