ChloroquineV1, Ncbi, Curation, bibRecord, 001120

Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.

Identifieur interne : 001120 ( Ncbi/Curation ); précédent : 001119; suivant : 001121

Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.

Auteurs : R. Lüllmann-Rauch ; B. Stoermer

Source :

Virchows Archiv. B, Cell pathology including molecular pathology [ 0340-6075 ] ; 1982.

RBID : pubmed:6123182

Descripteurs français

KwdFr :
- Animaux, Chloroquine, Chlorphentermine, Cochons d'Inde, Femelle, Foie (ultrastructure), Glandes surrénales (ultrastructure), Grossesse, Hypophyse (ultrastructure), Hypothalamus (ultrastructure), Lignées consanguines de rats, Lipidoses (), Microscopie électronique, Moelle spinale (ultrastructure), Phentermine (analogues et dérivés), Pipérazines, Poumon (ultrastructure), Rate (ultrastructure), Rats, Rein (ultrastructure), Échange foetomaternel.
MESH :
- analogues et dérivés : Phentermine.
- Animaux, Chloroquine, Chlorphentermine, Cochons d'Inde, Femelle, Foie, Glandes surrénales, Grossesse, Hypophyse, Hypothalamus, Lignées consanguines de rats, Lipidoses, Microscopie électronique, Moelle spinale, Pipérazines, Poumon, Rate, Rats, Rein, Échange foetomaternel.

English descriptors

KwdEn :
- Adrenal Glands (ultrastructure), Animals, Chloroquine, Chlorphentermine, Female, Guinea Pigs, Hypothalamus (ultrastructure), Kidney (ultrastructure), Lipidoses (chemically induced), Liver (ultrastructure), Lung (ultrastructure), Maternal-Fetal Exchange, Microscopy, Electron, Phentermine (analogs & derivatives), Piperazines, Pituitary Gland (ultrastructure), Pregnancy, Rats, Rats, Inbred Strains, Spinal Cord (ultrastructure), Spleen (ultrastructure).
MESH :
- chemical , analogs & derivatives : Phentermine.
- chemical : Chloroquine, Chlorphentermine, Piperazines.
- chemically induced : Lipidoses.
- ultrastructure : Adrenal Glands, Hypothalamus, Kidney, Liver, Lung, Pituitary Gland, Spinal Cord, Spleen.
- Animals, Female, Guinea Pigs, Maternal-Fetal Exchange, Microscopy, Electron, Pregnancy, Rats, Rats, Inbred Strains.

Abstract

Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way; the quantitative differences found may be related to pharmacokinetic and cellular factors.

DOI: 10.1007/bf02892837
PubMed: 6123182

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Le document en format XML

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<author><name sortKey="Lullmann Rauch, R" sort="Lullmann Rauch, R" uniqKey="Lullmann Rauch R" first="R" last="Lüllmann-Rauch">R. Lüllmann-Rauch</name>
</author>
<author><name sortKey="Stoermer, B" sort="Stoermer, B" uniqKey="Stoermer B" first="B" last="Stoermer">B. Stoermer</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.</title>
<author><name sortKey="Lullmann Rauch, R" sort="Lullmann Rauch, R" uniqKey="Lullmann Rauch R" first="R" last="Lüllmann-Rauch">R. Lüllmann-Rauch</name>
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<author><name sortKey="Stoermer, B" sort="Stoermer, B" uniqKey="Stoermer B" first="B" last="Stoermer">B. Stoermer</name>
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<series><title level="j">Virchows Archiv. B, Cell pathology including molecular pathology</title>
<idno type="ISSN">0340-6075</idno>
<imprint><date when="1982" type="published">1982</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Glands (ultrastructure)</term>
<term>Animals</term>
<term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Female</term>
<term>Guinea Pigs</term>
<term>Hypothalamus (ultrastructure)</term>
<term>Kidney (ultrastructure)</term>
<term>Lipidoses (chemically induced)</term>
<term>Liver (ultrastructure)</term>
<term>Lung (ultrastructure)</term>
<term>Maternal-Fetal Exchange</term>
<term>Microscopy, Electron</term>
<term>Phentermine (analogs & derivatives)</term>
<term>Piperazines</term>
<term>Pituitary Gland (ultrastructure)</term>
<term>Pregnancy</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
<term>Spinal Cord (ultrastructure)</term>
<term>Spleen (ultrastructure)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Cochons d'Inde</term>
<term>Femelle</term>
<term>Foie (ultrastructure)</term>
<term>Glandes surrénales (ultrastructure)</term>
<term>Grossesse</term>
<term>Hypophyse (ultrastructure)</term>
<term>Hypothalamus (ultrastructure)</term>
<term>Lignées consanguines de rats</term>
<term>Lipidoses ()</term>
<term>Microscopie électronique</term>
<term>Moelle spinale (ultrastructure)</term>
<term>Phentermine (analogues et dérivés)</term>
<term>Pipérazines</term>
<term>Poumon (ultrastructure)</term>
<term>Rate (ultrastructure)</term>
<term>Rats</term>
<term>Rein (ultrastructure)</term>
<term>Échange foetomaternel</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Phentermine</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Piperazines</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Phentermine</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Lipidoses</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Adrenal Glands</term>
<term>Hypothalamus</term>
<term>Kidney</term>
<term>Liver</term>
<term>Lung</term>
<term>Pituitary Gland</term>
<term>Spinal Cord</term>
<term>Spleen</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Guinea Pigs</term>
<term>Maternal-Fetal Exchange</term>
<term>Microscopy, Electron</term>
<term>Pregnancy</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Cochons d'Inde</term>
<term>Femelle</term>
<term>Foie</term>
<term>Glandes surrénales</term>
<term>Grossesse</term>
<term>Hypophyse</term>
<term>Hypothalamus</term>
<term>Lignées consanguines de rats</term>
<term>Lipidoses</term>
<term>Microscopie électronique</term>
<term>Moelle spinale</term>
<term>Pipérazines</term>
<term>Poumon</term>
<term>Rate</term>
<term>Rats</term>
<term>Rein</term>
<term>Échange foetomaternel</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way; the quantitative differences found may be related to pharmacokinetic and cellular factors.</div>
</front>
</TEI>
</record>

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Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.

Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki