Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.
Identifieur interne : 000606 ( PubMed/Corpus ); précédent : 000605; suivant : 000607Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.
Auteurs : R. Lüllmann-Rauch ; B. StoermerSource :
- Virchows Archiv. B, Cell pathology including molecular pathology [ 0340-6075 ] ; 1982.
English descriptors
- KwdEn :
- Adrenal Glands (ultrastructure), Animals, Chloroquine, Chlorphentermine, Female, Guinea Pigs, Hypothalamus (ultrastructure), Kidney (ultrastructure), Lipidoses (chemically induced), Liver (ultrastructure), Lung (ultrastructure), Maternal-Fetal Exchange, Microscopy, Electron, Phentermine (analogs & derivatives), Piperazines, Pituitary Gland (ultrastructure), Pregnancy, Rats, Rats, Inbred Strains, Spinal Cord (ultrastructure), Spleen (ultrastructure).
- MESH :
- chemical , analogs & derivatives : Phentermine.
- chemical : Chloroquine, Chlorphentermine, Piperazines.
- chemically induced : Lipidoses.
- ultrastructure : Adrenal Glands, Hypothalamus, Kidney, Liver, Lung, Pituitary Gland, Spinal Cord, Spleen.
- Animals, Female, Guinea Pigs, Maternal-Fetal Exchange, Microscopy, Electron, Pregnancy, Rats, Rats, Inbred Strains.
Abstract
Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way; the quantitative differences found may be related to pharmacokinetic and cellular factors.
DOI: 10.1007/bf02892837
PubMed: 6123182
Links to Exploration step
pubmed:6123182Le document en format XML
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Stoermer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1982">1982</date><idno type="RBID">pubmed:6123182</idno><idno type="pmid">6123182</idno><idno type="doi">10.1007/bf02892837</idno><idno type="wicri:Area/PubMed/Corpus">000606</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000606</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.</title><author><name sortKey="Lullmann Rauch, R" sort="Lullmann Rauch, R" uniqKey="Lullmann Rauch R" first="R" last="Lüllmann-Rauch">R. Lüllmann-Rauch</name></author><author><name sortKey="Stoermer, B" sort="Stoermer, B" uniqKey="Stoermer B" first="B" last="Stoermer">B. Stoermer</name></author></analytic><series><title level="j">Virchows Archiv. B, Cell pathology including molecular pathology</title><idno type="ISSN">0340-6075</idno><imprint><date when="1982" type="published">1982</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Glands (ultrastructure)</term><term>Animals</term><term>Chloroquine</term><term>Chlorphentermine</term><term>Female</term><term>Guinea Pigs</term><term>Hypothalamus (ultrastructure)</term><term>Kidney (ultrastructure)</term><term>Lipidoses (chemically induced)</term><term>Liver (ultrastructure)</term><term>Lung (ultrastructure)</term><term>Maternal-Fetal Exchange</term><term>Microscopy, Electron</term><term>Phentermine (analogs & derivatives)</term><term>Piperazines</term><term>Pituitary Gland (ultrastructure)</term><term>Pregnancy</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Spinal Cord (ultrastructure)</term><term>Spleen (ultrastructure)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Phentermine</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Chloroquine</term><term>Chlorphentermine</term><term>Piperazines</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Lipidoses</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Adrenal Glands</term><term>Hypothalamus</term><term>Kidney</term><term>Liver</term><term>Lung</term><term>Pituitary Gland</term><term>Spinal Cord</term><term>Spleen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Guinea Pigs</term><term>Maternal-Fetal Exchange</term><term>Microscopy, Electron</term><term>Pregnancy</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way; the quantitative differences found may be related to pharmacokinetic and cellular factors.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">6123182</PMID><DateCompleted><Year>1982</Year><Month>07</Month><Day>08</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0340-6075</ISSN><JournalIssue CitedMedium="Print"><Volume>39</Volume><Issue>1</Issue><PubDate><Year>1982</Year></PubDate></JournalIssue><Title>Virchows Archiv. B, Cell pathology including molecular pathology</Title><ISOAbbreviation>Virchows Arch., B, Cell Pathol.</ISOAbbreviation></Journal><ArticleTitle>Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.</ArticleTitle><Pagination><MedlinePgn>59-73</MedlinePgn></Pagination><Abstract><AbstractText>Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way; the quantitative differences found may be related to pharmacokinetic and cellular factors.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lüllmann-Rauch</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Stoermer</LastName><ForeName>B</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Virchows Arch B Cell Pathol Incl Mol Pathol</MedlineTA><NlmUniqueID>9316922</NlmUniqueID><ISSNLinking>0340-6075</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010879">Piperazines</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>C045TQL4WP</RegistryNumber><NameOfSubstance UI="D010645">Phentermine</NameOfSubstance></Chemical><Chemical><RegistryNumber>NHW07912O7</RegistryNumber><NameOfSubstance UI="D002745">Chlorphentermine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000311" MajorTopicYN="N">Adrenal Glands</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="Y">Chloroquine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002745" MajorTopicYN="Y">Chlorphentermine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006168" MajorTopicYN="N">Guinea Pigs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007031" MajorTopicYN="N">Hypothalamus</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007668" MajorTopicYN="N">Kidney</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008064" MajorTopicYN="N">Lipidoses</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008431" MajorTopicYN="N">Maternal-Fetal Exchange</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008854" MajorTopicYN="N">Microscopy, Electron</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010645" MajorTopicYN="Y">Phentermine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010879" MajorTopicYN="Y">Piperazines</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010902" MajorTopicYN="N">Pituitary Gland</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011919" MajorTopicYN="N">Rats, Inbred Strains</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013116" MajorTopicYN="N">Spinal Cord</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013154" MajorTopicYN="N">Spleen</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1982</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1982</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1982</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">6123182</ArticleId><ArticleId IdType="doi">10.1007/bf02892837</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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