Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling
Identifieur interne : 000939 ( Ncbi/Curation ); précédent : 000938; suivant : 000940Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling
Auteurs : Fei Zhang ; Yuan Zhang ; Ting Yang ; Ze-Qing Ye ; Jing Tian ; Hai-Rong Fang ; Juan-Juan Han ; Zhe-Zhi Wang ; Xing LiSource :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2019.
Abstract
Scopoletin, a phenolic coumarin derived from many medical or edible plants, is involved in various pharmacological functions. In the present study, we showed that Scopoletin effectively ameliorated experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through novel regulatory mechanisms involving inhibition of NF-κB activity in dendritic cells (DCs). Scopoletin treatment significantly improved the severity of the disease and prominently decreased inflammation and demyelination of central nervous system (CNS) in EAE mice. Disease alleviation correlated with the downregulation of major histocompatibility complex (MHC) class II, CD80 and CD86, expressed on DCs of CNS or spleens, and the infiltration and polarization of encephalitogenic Th1/Th17 cells. Consistent with the
Url:
DOI: 10.3389/fphar.2019.00863
PubMed: 31427972
PubMed Central: 6688631
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000571
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000571
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000396
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000939
Links to Exploration step
PMC:6688631Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling</title>
<author><name sortKey="Zhang, Fei" sort="Zhang, Fei" uniqKey="Zhang F" first="Fei" last="Zhang">Fei Zhang</name>
</author>
<author><name sortKey="Zhang, Yuan" sort="Zhang, Yuan" uniqKey="Zhang Y" first="Yuan" last="Zhang">Yuan Zhang</name>
</author>
<author><name sortKey="Yang, Ting" sort="Yang, Ting" uniqKey="Yang T" first="Ting" last="Yang">Ting Yang</name>
</author>
<author><name sortKey="Ye, Ze Qing" sort="Ye, Ze Qing" uniqKey="Ye Z" first="Ze-Qing" last="Ye">Ze-Qing Ye</name>
</author>
<author><name sortKey="Tian, Jing" sort="Tian, Jing" uniqKey="Tian J" first="Jing" last="Tian">Jing Tian</name>
</author>
<author><name sortKey="Fang, Hai Rong" sort="Fang, Hai Rong" uniqKey="Fang H" first="Hai-Rong" last="Fang">Hai-Rong Fang</name>
</author>
<author><name sortKey="Han, Juan Juan" sort="Han, Juan Juan" uniqKey="Han J" first="Juan-Juan" last="Han">Juan-Juan Han</name>
</author>
<author><name sortKey="Wang, Zhe Zhi" sort="Wang, Zhe Zhi" uniqKey="Wang Z" first="Zhe-Zhi" last="Wang">Zhe-Zhi Wang</name>
</author>
<author><name sortKey="Li, Xing" sort="Li, Xing" uniqKey="Li X" first="Xing" last="Li">Xing Li</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31427972</idno>
<idno type="pmc">6688631</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688631</idno>
<idno type="RBID">PMC:6688631</idno>
<idno type="doi">10.3389/fphar.2019.00863</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000571</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000571</idno>
<idno type="wicri:Area/Pmc/Curation">000571</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000571</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000396</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000396</idno>
<idno type="wicri:Area/Ncbi/Merge">000939</idno>
<idno type="wicri:Area/Ncbi/Curation">000939</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling</title>
<author><name sortKey="Zhang, Fei" sort="Zhang, Fei" uniqKey="Zhang F" first="Fei" last="Zhang">Fei Zhang</name>
</author>
<author><name sortKey="Zhang, Yuan" sort="Zhang, Yuan" uniqKey="Zhang Y" first="Yuan" last="Zhang">Yuan Zhang</name>
</author>
<author><name sortKey="Yang, Ting" sort="Yang, Ting" uniqKey="Yang T" first="Ting" last="Yang">Ting Yang</name>
</author>
<author><name sortKey="Ye, Ze Qing" sort="Ye, Ze Qing" uniqKey="Ye Z" first="Ze-Qing" last="Ye">Ze-Qing Ye</name>
</author>
<author><name sortKey="Tian, Jing" sort="Tian, Jing" uniqKey="Tian J" first="Jing" last="Tian">Jing Tian</name>
</author>
<author><name sortKey="Fang, Hai Rong" sort="Fang, Hai Rong" uniqKey="Fang H" first="Hai-Rong" last="Fang">Hai-Rong Fang</name>
</author>
<author><name sortKey="Han, Juan Juan" sort="Han, Juan Juan" uniqKey="Han J" first="Juan-Juan" last="Han">Juan-Juan Han</name>
</author>
<author><name sortKey="Wang, Zhe Zhi" sort="Wang, Zhe Zhi" uniqKey="Wang Z" first="Zhe-Zhi" last="Wang">Zhe-Zhi Wang</name>
</author>
<author><name sortKey="Li, Xing" sort="Li, Xing" uniqKey="Li X" first="Xing" last="Li">Xing Li</name>
</author>
</analytic>
<series><title level="j">Frontiers in Pharmacology</title>
<idno type="eISSN">1663-9812</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Scopoletin, a phenolic coumarin derived from many medical or edible plants, is involved in various pharmacological functions. In the present study, we showed that Scopoletin effectively ameliorated experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through novel regulatory mechanisms involving inhibition of NF-κB activity in dendritic cells (DCs). Scopoletin treatment significantly improved the severity of the disease and prominently decreased inflammation and demyelination of central nervous system (CNS) in EAE mice. Disease alleviation correlated with the downregulation of major histocompatibility complex (MHC) class II, CD80 and CD86, expressed on DCs of CNS or spleens, and the infiltration and polarization of encephalitogenic Th1/Th17 cells. Consistent with the <italic>in vivo</italic>
data, Scopoletin-treated, bone marrow-derived dendritic cells (BM-DCs) exhibited reduced expression of MHC class II and costimulatory molecules (e.g., CD80 and CD86) and reduced NF-κB phosphorylation. These findings, for the first time, demonstrated the ability of Scopoletin to impair DC activation, downregulating pathogenic Th1/Th17 inflammatory cell responses and, eventually, reducing EAE severity. Our study demonstrates new evidence that natural products derived from medical or edible plants, such as Scopoletin, will be valuable in developing a novel therapeutic agent for MS in the future.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Agalioti, T" uniqKey="Agalioti T">T. Agalioti</name>
</author>
<author><name sortKey="Villablanca, E J" uniqKey="Villablanca E">E. J. Villablanca</name>
</author>
<author><name sortKey="Huber, S" uniqKey="Huber S">S. Huber</name>
</author>
<author><name sortKey="Gagliani, N" uniqKey="Gagliani N">N. Gagliani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amodio, G" uniqKey="Amodio G">G. Amodio</name>
</author>
<author><name sortKey="Gregori, S" uniqKey="Gregori S">S. Gregori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arcos, M L B" uniqKey="Arcos M">M. L. B. Arcos</name>
</author>
<author><name sortKey="Cremaschi, G" uniqKey="Cremaschi G">G. Cremaschi</name>
</author>
<author><name sortKey="Werner, S" uniqKey="Werner S">S. Werner</name>
</author>
<author><name sortKey="Coussio, J" uniqKey="Coussio J">J. Coussio</name>
</author>
<author><name sortKey="Ferraro, G" uniqKey="Ferraro G">G. Ferraro</name>
</author>
<author><name sortKey="Anesini, C" uniqKey="Anesini C">C. Anesini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ardeshna, K M" uniqKey="Ardeshna K">K. M. Ardeshna</name>
</author>
<author><name sortKey="Pizzey, A R" uniqKey="Pizzey A">A. R. Pizzey</name>
</author>
<author><name sortKey="Devereux, S A K A" uniqKey="Devereux S">S. a. K. A. Devereux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arellano, G" uniqKey="Arellano G">G. Arellano</name>
</author>
<author><name sortKey="Acuna, E" uniqKey="Acuna E">E. Acuna</name>
</author>
<author><name sortKey="Reyes, L I" uniqKey="Reyes L">L. I. Reyes</name>
</author>
<author><name sortKey="Ottum, P A" uniqKey="Ottum P">P. A. Ottum</name>
</author>
<author><name sortKey="De Sarno, P" uniqKey="De Sarno P">P. De Sarno</name>
</author>
<author><name sortKey="Villarroel, L" uniqKey="Villarroel L">L. Villarroel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baratin, M" uniqKey="Baratin M">M. Baratin</name>
</author>
<author><name sortKey="Foray, C" uniqKey="Foray C">C. Foray</name>
</author>
<author><name sortKey="Demaria, O" uniqKey="Demaria O">O. Demaria</name>
</author>
<author><name sortKey="Habbeddine, M" uniqKey="Habbeddine M">M. Habbeddine</name>
</author>
<author><name sortKey="Pollet, E" uniqKey="Pollet E">E. Pollet</name>
</author>
<author><name sortKey="Maurizio, J" uniqKey="Maurizio J">J. Maurizio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Basu, M" uniqKey="Basu M">M. Basu</name>
</author>
<author><name sortKey="Mayana, K" uniqKey="Mayana K">K. Mayana</name>
</author>
<author><name sortKey="Xavier, S" uniqKey="Xavier S">S. Xavier</name>
</author>
<author><name sortKey="Balachandran, S" uniqKey="Balachandran S">S. Balachandran</name>
</author>
<author><name sortKey="Mishra, N" uniqKey="Mishra N">N. Mishra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Besusso, D" uniqKey="Besusso D">D. Besusso</name>
</author>
<author><name sortKey="Saul, L" uniqKey="Saul L">L. Saul</name>
</author>
<author><name sortKey="Leech, M D" uniqKey="Leech M">M. D. Leech</name>
</author>
<author><name sortKey="O Onnor, R A" uniqKey="O Onnor R">R. A. O’connor</name>
</author>
<author><name sortKey="Macdonald, A S" uniqKey="Macdonald A">A. S. Macdonald</name>
</author>
<author><name sortKey="Anderton, S M" uniqKey="Anderton S">S. M. Anderton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chesi, M" uniqKey="Chesi M">M. Chesi</name>
</author>
<author><name sortKey="Mirza, N N" uniqKey="Mirza N">N. N. Mirza</name>
</author>
<author><name sortKey="Garbitt, V M" uniqKey="Garbitt V">V. M. Garbitt</name>
</author>
<author><name sortKey="Sharik, M E" uniqKey="Sharik M">M. E. Sharik</name>
</author>
<author><name sortKey="Dueck, A C" uniqKey="Dueck A">A. C. Dueck</name>
</author>
<author><name sortKey="Asmann, Y W" uniqKey="Asmann Y">Y. W. Asmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chiang, K C" uniqKey="Chiang K">K. C. Chiang</name>
</author>
<author><name sortKey="Tsui, K H" uniqKey="Tsui K">K. H. Tsui</name>
</author>
<author><name sortKey="Chung, L C" uniqKey="Chung L">L. C. Chung</name>
</author>
<author><name sortKey="Yeh, C N" uniqKey="Yeh C">C. N. Yeh</name>
</author>
<author><name sortKey="Chen, W T" uniqKey="Chen W">W. T. Chen</name>
</author>
<author><name sortKey="Chang, P L" uniqKey="Chang P">P. L. Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Codarri, L" uniqKey="Codarri L">L. Codarri</name>
</author>
<author><name sortKey="Gyulveszi, G" uniqKey="Gyulveszi G">G. Gyulveszi</name>
</author>
<author><name sortKey="Tosevski, V" uniqKey="Tosevski V">V. Tosevski</name>
</author>
<author><name sortKey="Hesske, L" uniqKey="Hesske L">L. Hesske</name>
</author>
<author><name sortKey="Fontana, A" uniqKey="Fontana A">A. Fontana</name>
</author>
<author><name sortKey="Magnenat, L" uniqKey="Magnenat L">L. Magnenat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Connell, B J" uniqKey="Connell B">B. J. Connell</name>
</author>
<author><name sortKey="Saleh, M C" uniqKey="Saleh M">M. C. Saleh</name>
</author>
<author><name sortKey="Rajagopal, D" uniqKey="Rajagopal D">D. Rajagopal</name>
</author>
<author><name sortKey="Saleh, T M" uniqKey="Saleh T">T. M. Saleh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, Z" uniqKey="Ding Z">Z. Ding</name>
</author>
<author><name sortKey="Dai, Y" uniqKey="Dai Y">Y. Dai</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dou, Y" uniqKey="Dou Y">Y. Dou</name>
</author>
<author><name sortKey="Tong, B" uniqKey="Tong B">B. Tong</name>
</author>
<author><name sortKey="Wei, Z" uniqKey="Wei Z">Z. Wei</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Xia, Y" uniqKey="Xia Y">Y. Xia</name>
</author>
<author><name sortKey="Dai, Y" uniqKey="Dai Y">Y. Dai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Behi, M" uniqKey="El Behi M">M. El-Behi</name>
</author>
<author><name sortKey="Ciric, B" uniqKey="Ciric B">B. Ciric</name>
</author>
<author><name sortKey="Dai, H" uniqKey="Dai H">H. Dai</name>
</author>
<author><name sortKey="Yan, Y" uniqKey="Yan Y">Y. Yan</name>
</author>
<author><name sortKey="Cullimore, M" uniqKey="Cullimore M">M. Cullimore</name>
</author>
<author><name sortKey="Safavi, F" uniqKey="Safavi F">F. Safavi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Behi, M" uniqKey="El Behi M">M. El-Behi</name>
</author>
<author><name sortKey="Rostami, A" uniqKey="Rostami A">A. Rostami</name>
</author>
<author><name sortKey="Ciric, B" uniqKey="Ciric B">B. Ciric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forino, M" uniqKey="Forino M">M. Forino</name>
</author>
<author><name sortKey="Tartaglione, L" uniqKey="Tartaglione L">L. Tartaglione</name>
</author>
<author><name sortKey="Dell Versano, C" uniqKey="Dell Versano C">C. Dell’aversano</name>
</author>
<author><name sortKey="Ciminiello, P" uniqKey="Ciminiello P">P. Ciminiello</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gabriele, L" uniqKey="Gabriele L">L. Gabriele</name>
</author>
<author><name sortKey="Ozato, K" uniqKey="Ozato K">K. Ozato</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garcia Morales, G" uniqKey="Garcia Morales G">G. Garcia-Morales</name>
</author>
<author><name sortKey="Huerta Reyes, M" uniqKey="Huerta Reyes M">M. Huerta-Reyes</name>
</author>
<author><name sortKey="Gonzalez Cortazar, M" uniqKey="Gonzalez Cortazar M">M. Gonzalez-Cortazar</name>
</author>
<author><name sortKey="Zamilpa, A" uniqKey="Zamilpa A">A. Zamilpa</name>
</author>
<author><name sortKey="Jimenez Ferrer, E" uniqKey="Jimenez Ferrer E">E. Jimenez-Ferrer</name>
</author>
<author><name sortKey="Silva Garcia, R" uniqKey="Silva Garcia R">R. Silva-Garcia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ginwala, R" uniqKey="Ginwala R">R. Ginwala</name>
</author>
<author><name sortKey="Mctish, E" uniqKey="Mctish E">E. Mctish</name>
</author>
<author><name sortKey="Raman, C" uniqKey="Raman C">C. Raman</name>
</author>
<author><name sortKey="Singh, N" uniqKey="Singh N">N. Singh</name>
</author>
<author><name sortKey="Nagarkatti, M" uniqKey="Nagarkatti M">M. Nagarkatti</name>
</author>
<author><name sortKey="Nagarkatti, P" uniqKey="Nagarkatti P">P. Nagarkatti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giralt, M" uniqKey="Giralt M">M. Giralt</name>
</author>
<author><name sortKey="Ramos, R" uniqKey="Ramos R">R. Ramos</name>
</author>
<author><name sortKey="Quintana, A" uniqKey="Quintana A">A. Quintana</name>
</author>
<author><name sortKey="Ferrer, B" uniqKey="Ferrer B">B. Ferrer</name>
</author>
<author><name sortKey="Erta, M" uniqKey="Erta M">M. Erta</name>
</author>
<author><name sortKey="Castro Freire, M" uniqKey="Castro Freire M">M. Castro-Freire</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grigoriadis, N" uniqKey="Grigoriadis N">N. Grigoriadis</name>
</author>
<author><name sortKey="Van Pesch, V" uniqKey="Van Pesch V">V. Van Pesch</name>
</author>
<author><name sortKey="Paradig, M S G" uniqKey="Paradig M">M. S. G. Paradig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grimbert, P" uniqKey="Grimbert P">P. Grimbert</name>
</author>
<author><name sortKey="Audard, V" uniqKey="Audard V">V. Audard</name>
</author>
<author><name sortKey="Diet, C" uniqKey="Diet C">C. Diet</name>
</author>
<author><name sortKey="Matignon, M" uniqKey="Matignon M">M. Matignon</name>
</author>
<author><name sortKey="Plonquet, A" uniqKey="Plonquet A">A. Plonquet</name>
</author>
<author><name sortKey="Mansour, H" uniqKey="Mansour H">H. Mansour</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, Z" uniqKey="He Z">Z. He</name>
</author>
<author><name sortKey="Ma, J" uniqKey="Ma J">J. Ma</name>
</author>
<author><name sortKey="Wang, R" uniqKey="Wang R">R. Wang</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Huang, Z" uniqKey="Huang Z">Z. Huang</name>
</author>
<author><name sortKey="Wang, F" uniqKey="Wang F">F. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hemmer, B" uniqKey="Hemmer B">B. Hemmer</name>
</author>
<author><name sortKey="Kerschensteiner, M" uniqKey="Kerschensteiner M">M. Kerschensteiner</name>
</author>
<author><name sortKey="Korn, T" uniqKey="Korn T">T. Korn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Honda, K" uniqKey="Honda K">K. Honda</name>
</author>
<author><name sortKey="Yanai, H" uniqKey="Yanai H">H. Yanai</name>
</author>
<author><name sortKey="Negishi, H" uniqKey="Negishi H">H. Negishi</name>
</author>
<author><name sortKey="Asagiri, M" uniqKey="Asagiri M">M. Asagiri</name>
</author>
<author><name sortKey="Sato, M" uniqKey="Sato M">M. Sato</name>
</author>
<author><name sortKey="Mizutani, T" uniqKey="Mizutani T">T. Mizutani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jamuna, S" uniqKey="Jamuna S">S. Jamuna</name>
</author>
<author><name sortKey="Karthika, K" uniqKey="Karthika K">K. Karthika</name>
</author>
<author><name sortKey="Paulsamy, S" uniqKey="Paulsamy S">S. Paulsamy</name>
</author>
<author><name sortKey="Thenmozhi, K" uniqKey="Thenmozhi K">K. Thenmozhi</name>
</author>
<author><name sortKey="Kathiravan, S" uniqKey="Kathiravan S">S. Kathiravan</name>
</author>
<author><name sortKey="Venkatesh, R" uniqKey="Venkatesh R">R. Venkatesh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kornberg, M D" uniqKey="Kornberg M">M. D. Kornberg</name>
</author>
<author><name sortKey="Smith, M D" uniqKey="Smith M">M. D. Smith</name>
</author>
<author><name sortKey="Shirazi, H A" uniqKey="Shirazi H">H. A. Shirazi</name>
</author>
<author><name sortKey="Calabresi, P A" uniqKey="Calabresi P">P. A. Calabresi</name>
</author>
<author><name sortKey="Snyder, S H" uniqKey="Snyder S">S. H. Snyder</name>
</author>
<author><name sortKey="Kim, P M" uniqKey="Kim P">P. M. Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lassmann, H" uniqKey="Lassmann H">H. Lassmann</name>
</author>
<author><name sortKey="Bradl, M" uniqKey="Bradl M">M. Bradl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, H I" uniqKey="Lee H">H. I. Lee</name>
</author>
<author><name sortKey="Yun, K W" uniqKey="Yun K">K. W. Yun</name>
</author>
<author><name sortKey="Seo, K I" uniqKey="Seo K">K. I. Seo</name>
</author>
<author><name sortKey="Kim, M J" uniqKey="Kim M">M. J. Kim</name>
</author>
<author><name sortKey="Lee, M K" uniqKey="Lee M">M. K. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, G" uniqKey="Li G">G. Li</name>
</author>
<author><name sortKey="Yamasaki, R" uniqKey="Yamasaki R">R. Yamasaki</name>
</author>
<author><name sortKey="Fang, M" uniqKey="Fang M">M. Fang</name>
</author>
<author><name sortKey="Masaki, K" uniqKey="Masaki K">K. Masaki</name>
</author>
<author><name sortKey="Ochi, H" uniqKey="Ochi H">H. Ochi</name>
</author>
<author><name sortKey="Matsushita, T" uniqKey="Matsushita T">T. Matsushita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Yan, Y" uniqKey="Yan Y">Y. Yan</name>
</author>
<author><name sortKey="Ciric, B" uniqKey="Ciric B">B. Ciric</name>
</author>
<author><name sortKey="Ma, C G" uniqKey="Ma C">C. G. Ma</name>
</author>
<author><name sortKey="Chin, J" uniqKey="Chin J">J. Chin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Yan, Y" uniqKey="Yan Y">Y. Yan</name>
</author>
<author><name sortKey="Ciric, B" uniqKey="Ciric B">B. Ciric</name>
</author>
<author><name sortKey="Ma, C G" uniqKey="Ma C">C. G. Ma</name>
</author>
<author><name sortKey="Gran, B" uniqKey="Gran B">B. Gran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, Y Z" uniqKey="Lin Y">Y. Z. Lin</name>
</author>
<author><name sortKey="Yao, S Y" uniqKey="Yao S">S. Y. Yao</name>
</author>
<author><name sortKey="Veach, R A" uniqKey="Veach R">R. A. Veach</name>
</author>
<author><name sortKey="Torgerson, T R" uniqKey="Torgerson T">T. R. Torgerson</name>
</author>
<author><name sortKey="Hawiger, J" uniqKey="Hawiger J">J. Hawiger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y. Lu</name>
</author>
<author><name sortKey="Chen, B" uniqKey="Chen B">B. Chen</name>
</author>
<author><name sortKey="Song, J H" uniqKey="Song J">J. H. Song</name>
</author>
<author><name sortKey="Zhen, T" uniqKey="Zhen T">T. Zhen</name>
</author>
<author><name sortKey="Wang, B Y" uniqKey="Wang B">B. Y. Wang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y. Lu</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M. Zhang</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name>
</author>
<author><name sortKey="Hong, B" uniqKey="Hong B">B. Hong</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name>
</author>
<author><name sortKey="Li, H" uniqKey="Li H">H. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luckheeram, R V" uniqKey="Luckheeram R">R. V. Luckheeram</name>
</author>
<author><name sortKey="Zhou, R" uniqKey="Zhou R">R. Zhou</name>
</author>
<author><name sortKey="Verma, A D" uniqKey="Verma A">A. D. Verma</name>
</author>
<author><name sortKey="Xia, B" uniqKey="Xia B">B. Xia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Malik, S" uniqKey="Malik S">S. Malik</name>
</author>
<author><name sortKey="Sadhu, S" uniqKey="Sadhu S">S. Sadhu</name>
</author>
<author><name sortKey="Elesela, S" uniqKey="Elesela S">S. Elesela</name>
</author>
<author><name sortKey="Pandey, R P" uniqKey="Pandey R">R. P. Pandey</name>
</author>
<author><name sortKey="Chawla, A S" uniqKey="Chawla A">A. S. Chawla</name>
</author>
<author><name sortKey="Sharma, D" uniqKey="Sharma D">D. Sharma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moon, P D" uniqKey="Moon P">P. D. Moon</name>
</author>
<author><name sortKey="Lee, B H" uniqKey="Lee B">B. H. Lee</name>
</author>
<author><name sortKey="Jeong, H J" uniqKey="Jeong H">H. J. Jeong</name>
</author>
<author><name sortKey="An, H J" uniqKey="An H">H. J. An</name>
</author>
<author><name sortKey="Park, S J" uniqKey="Park S">S. J. Park</name>
</author>
<author><name sortKey="Kim, H R" uniqKey="Kim H">H. R. Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pan, R" uniqKey="Pan R">R. Pan</name>
</author>
<author><name sortKey="Gao, X H" uniqKey="Gao X">X. H. Gao</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Xia, Y F" uniqKey="Xia Y">Y. F. Xia</name>
</author>
<author><name sortKey="Dai, Y" uniqKey="Dai Y">Y. Dai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Procaccini, C" uniqKey="Procaccini C">C. Procaccini</name>
</author>
<author><name sortKey="De Rosa, V" uniqKey="De Rosa V">V. De Rosa</name>
</author>
<author><name sortKey="Pucino, V" uniqKey="Pucino V">V. Pucino</name>
</author>
<author><name sortKey="Formisano, L" uniqKey="Formisano L">L. Formisano</name>
</author>
<author><name sortKey="Matarese, G" uniqKey="Matarese G">G. Matarese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rasouli, J" uniqKey="Rasouli J">J. Rasouli</name>
</author>
<author><name sortKey="Ciric, B" uniqKey="Ciric B">B. Ciric</name>
</author>
<author><name sortKey="Imitola, J" uniqKey="Imitola J">J. Imitola</name>
</author>
<author><name sortKey="Gonnella, P" uniqKey="Gonnella P">P. Gonnella</name>
</author>
<author><name sortKey="Hwang, D" uniqKey="Hwang D">D. Hwang</name>
</author>
<author><name sortKey="Mahajan, K" uniqKey="Mahajan K">K. Mahajan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rescigno, M" uniqKey="Rescigno M">M. Rescigno</name>
</author>
<author><name sortKey="Martino, M" uniqKey="Martino M">M. Martino</name>
</author>
<author><name sortKey="Sutherland, C L" uniqKey="Sutherland C">C. L. Sutherland</name>
</author>
<author><name sortKey="Gold, M R" uniqKey="Gold M">M. R. Gold</name>
</author>
<author><name sortKey="Ricciardi, C P" uniqKey="Ricciardi C">C. P. Ricciardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shalan, N A M" uniqKey="Shalan N">N.a.M. Shalan</name>
</author>
<author><name sortKey="Mustapha, N M" uniqKey="Mustapha N">N. M. Mustapha</name>
</author>
<author><name sortKey="Mohamed, S" uniqKey="Mohamed S">S. Mohamed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, J A" uniqKey="Smith J">J. A. Smith</name>
</author>
<author><name sortKey="Colbert, R A" uniqKey="Colbert R">R. A. Colbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thome, R" uniqKey="Thome R">R. Thome</name>
</author>
<author><name sortKey="Bonfanti, A P" uniqKey="Bonfanti A">A. P. Bonfanti</name>
</author>
<author><name sortKey="Rasouli, J" uniqKey="Rasouli J">J. Rasouli</name>
</author>
<author><name sortKey="Mari, E R" uniqKey="Mari E">E. R. Mari</name>
</author>
<author><name sortKey="Zhang, G X" uniqKey="Zhang G">G. X. Zhang</name>
</author>
<author><name sortKey="Rostami, A" uniqKey="Rostami A">A. Rostami</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thome, R" uniqKey="Thome R">R. Thome</name>
</author>
<author><name sortKey="Issayama, L K" uniqKey="Issayama L">L. K. Issayama</name>
</author>
<author><name sortKey="Alves Da Costa, T" uniqKey="Alves Da Costa T">T. Alves Da Costa</name>
</author>
<author><name sortKey="Gangi, R D" uniqKey="Gangi R">R. D. Gangi</name>
</author>
<author><name sortKey="Ferreira, I T" uniqKey="Ferreira I">I. T. Ferreira</name>
</author>
<author><name sortKey="Raposo, C" uniqKey="Raposo C">C. Raposo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thome, R" uniqKey="Thome R">R. Thome</name>
</author>
<author><name sortKey="Issayama, L K" uniqKey="Issayama L">L. K. Issayama</name>
</author>
<author><name sortKey="Digangi, R" uniqKey="Digangi R">R. Digangi</name>
</author>
<author><name sortKey="Bombeiro, A L" uniqKey="Bombeiro A">A. L. Bombeiro</name>
</author>
<author><name sortKey="Da Costa, T A" uniqKey="Da Costa T">T. A. Da Costa</name>
</author>
<author><name sortKey="Ferreira, I T" uniqKey="Ferreira I">I. T. Ferreira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, A J" uniqKey="Thompson A">A. J. Thompson</name>
</author>
<author><name sortKey="Baranzini, S E" uniqKey="Baranzini S">S. E. Baranzini</name>
</author>
<author><name sortKey="Geurts, J" uniqKey="Geurts J">J. Geurts</name>
</author>
<author><name sortKey="Hemmer, B" uniqKey="Hemmer B">B. Hemmer</name>
</author>
<author><name sortKey="Ciccarelli, O" uniqKey="Ciccarelli O">O. Ciccarelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamamoto, S" uniqKey="Yamamoto S">S. Yamamoto</name>
</author>
<author><name sortKey="Nava, R G" uniqKey="Nava R">R. G. Nava</name>
</author>
<author><name sortKey="Zhu, J" uniqKey="Zhu J">J. Zhu</name>
</author>
<author><name sortKey="Huang, H J" uniqKey="Huang H">H. J. Huang</name>
</author>
<author><name sortKey="Ibrahim, M" uniqKey="Ibrahim M">M. Ibrahim</name>
</author>
<author><name sortKey="Mohanakumar, T" uniqKey="Mohanakumar T">T. Mohanakumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yao, X" uniqKey="Yao X">X. Yao</name>
</author>
<author><name sortKey="Huang, J" uniqKey="Huang J">J. Huang</name>
</author>
<author><name sortKey="Zhong, H" uniqKey="Zhong H">H. Zhong</name>
</author>
<author><name sortKey="Shen, N" uniqKey="Shen N">N. Shen</name>
</author>
<author><name sortKey="Faggioni, R" uniqKey="Faggioni R">R. Faggioni</name>
</author>
<author><name sortKey="Fung, M" uniqKey="Fung M">M. Fung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yasuda, K" uniqKey="Yasuda K">K. Yasuda</name>
</author>
<author><name sortKey="Richez, C" uniqKey="Richez C">C. Richez</name>
</author>
<author><name sortKey="Maciaszek, J W" uniqKey="Maciaszek J">J. W. Maciaszek</name>
</author>
<author><name sortKey="Agrawal, N" uniqKey="Agrawal N">N. Agrawal</name>
</author>
<author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name>
</author>
<author><name sortKey="Marshak Rothstein, A" uniqKey="Marshak Rothstein A">A. Marshak-Rothstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeng, Y C" uniqKey="Zeng Y">Y. C. Zeng</name>
</author>
<author><name sortKey="Li, S" uniqKey="Li S">S. Li</name>
</author>
<author><name sortKey="Liu, C" uniqKey="Liu C">C. Liu</name>
</author>
<author><name sortKey="Gong, T" uniqKey="Gong T">T. Gong</name>
</author>
<author><name sortKey="Sun, X" uniqKey="Sun X">X. Sun</name>
</author>
<author><name sortKey="Fu, Y" uniqKey="Fu Y">Y. Fu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Ciric, B" uniqKey="Ciric B">B. Ciric</name>
</author>
<author><name sortKey="Ma, C G" uniqKey="Ma C">C. G. Ma</name>
</author>
<author><name sortKey="Gran, B" uniqKey="Gran B">B. Gran</name>
</author>
<author><name sortKey="Rostami, A" uniqKey="Rostami A">A. Rostami</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L. Zhao</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Ye, Z Q" uniqKey="Ye Z">Z. Q. Ye</name>
</author>
<author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name>
</author>
<author><name sortKey="Han, J J" uniqKey="Han J">J. J. Han</name>
</author>
<author><name sortKey="Yang, T" uniqKey="Yang T">T. Yang</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000939 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000939 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:6688631 |texte= Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:31427972" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |