Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens.
Identifieur interne : 000470 ( Ncbi/Curation ); précédent : 000469; suivant : 000471Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens.
Auteurs : Ana Gomes [Portugal] ; Ricardo Ferraz [Portugal] ; Lauren Ficker [États-Unis] ; Margaret S. Collins [États-Unis] ; Cristina Prudêncio [Portugal] ; Melanie T. Cushion [États-Unis] ; Cátia Teixeira [Portugal] ; Paula Gomes [Portugal]Source :
- Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antipaludiques, Chloroquine.
- traitement médicamenteux : Pneumonie à Pneumocystis.
- Cellules A549, Humains, Lignée cellulaire tumorale, Pneumocystis carinii, Sujet immunodéprimé.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antimalarials, Chloroquine.
- drug effects : Immunocompromised Host, Pneumocystis carinii.
- drug therapy : Pneumonia, Pneumocystis.
- A549 Cells, Cell Line, Tumor, Humans.
Abstract
The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii in vitro Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.
DOI: 10.1128/AAC.00983-18
PubMed: 30201816
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pubmed:30201816Le document en format XML
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<term>Antimalarials (pharmacology)</term>
<term>Cell Line, Tumor</term>
<term>Chloroquine (pharmacology)</term>
<term>Humans</term>
<term>Immunocompromised Host (drug effects)</term>
<term>Pneumocystis carinii (drug effects)</term>
<term>Pneumonia, Pneumocystis (drug therapy)</term>
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<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
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<term>Pneumonie à Pneumocystis (traitement médicamenteux)</term>
<term>Sujet immunodéprimé ()</term>
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<term>Chloroquine</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunocompromised Host</term>
<term>Pneumocystis carinii</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pneumonia, Pneumocystis</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antipaludiques</term>
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<front><div type="abstract" xml:lang="en">The impact of <i>Pneumocystis</i>
pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both <i>in vitro</i>
and <i>in vivo</i>
, we now report the potent action of these compounds on <i>Pneumocystis carinii in vitro</i>
Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.</div>
</front>
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