Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens.
Identifieur interne : 000118 ( PubMed/Checkpoint ); précédent : 000117; suivant : 000119Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens.
Auteurs : Ana Gomes [Portugal] ; Ricardo Ferraz [Portugal] ; Lauren Ficker [États-Unis] ; Margaret S. Collins [États-Unis] ; Cristina Prudêncio [Portugal] ; Melanie T. Cushion [États-Unis] ; Cátia Teixeira [Portugal] ; Paula Gomes [Portugal]Source :
- Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antipaludiques, Chloroquine.
- traitement médicamenteux : Pneumonie à Pneumocystis.
- Cellules A549, Humains, Lignée cellulaire tumorale, Pneumocystis carinii, Sujet immunodéprimé.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antimalarials, Chloroquine.
- drug effects : Immunocompromised Host, Pneumocystis carinii.
- drug therapy : Pneumonia, Pneumocystis.
- A549 Cells, Cell Line, Tumor, Humans.
Abstract
The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both in vitro and in vivo, we now report the potent action of these compounds on Pneumocystis carinii in vitro Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.
DOI: 10.1128/AAC.00983-18
PubMed: 30201816
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:30201816Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens.</title><author><name sortKey="Gomes, Ana" sort="Gomes, Ana" uniqKey="Gomes A" first="Ana" last="Gomes">Ana Gomes</name><affiliation wicri:level="1"><nlm:affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Ferraz, Ricardo" sort="Ferraz, Ricardo" uniqKey="Ferraz R" first="Ricardo" last="Ferraz">Ricardo Ferraz</name><affiliation wicri:level="1"><nlm:affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Ficker, Lauren" sort="Ficker, Lauren" uniqKey="Ficker L" first="Lauren" last="Ficker">Lauren Ficker</name><affiliation wicri:level="2"><nlm:affiliation>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Collins, Margaret S" sort="Collins, Margaret S" uniqKey="Collins M" first="Margaret S" last="Collins">Margaret S. Collins</name><affiliation wicri:level="2"><nlm:affiliation>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Prudencio, Cristina" sort="Prudencio, Cristina" uniqKey="Prudencio C" first="Cristina" last="Prudêncio">Cristina Prudêncio</name><affiliation wicri:level="1"><nlm:affiliation>Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Politécnico do Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Politécnico do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Cushion, Melanie T" sort="Cushion, Melanie T" uniqKey="Cushion M" first="Melanie T" last="Cushion">Melanie T. Cushion</name><affiliation wicri:level="2"><nlm:affiliation>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Teixeira, Catia" sort="Teixeira, Catia" uniqKey="Teixeira C" first="Cátia" last="Teixeira">Cátia Teixeira</name><affiliation wicri:level="1"><nlm:affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><affiliation wicri:level="1"><nlm:affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal pgomes@fc.up.pt.</nlm:affiliation><country wicri:rule="url">Portugal</country><wicri:regionArea>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30201816</idno><idno type="pmid">30201816</idno><idno type="doi">10.1128/AAC.00983-18</idno><idno type="wicri:Area/PubMed/Corpus">000085</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000085</idno><idno type="wicri:Area/PubMed/Curation">000085</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000085</idno><idno type="wicri:Area/PubMed/Checkpoint">000118</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000118</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens.</title><author><name sortKey="Gomes, Ana" sort="Gomes, Ana" uniqKey="Gomes A" first="Ana" last="Gomes">Ana Gomes</name><affiliation wicri:level="1"><nlm:affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Ferraz, Ricardo" sort="Ferraz, Ricardo" uniqKey="Ferraz R" first="Ricardo" last="Ferraz">Ricardo Ferraz</name><affiliation wicri:level="1"><nlm:affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Ficker, Lauren" sort="Ficker, Lauren" uniqKey="Ficker L" first="Lauren" last="Ficker">Lauren Ficker</name><affiliation wicri:level="2"><nlm:affiliation>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Collins, Margaret S" sort="Collins, Margaret S" uniqKey="Collins M" first="Margaret S" last="Collins">Margaret S. Collins</name><affiliation wicri:level="2"><nlm:affiliation>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Prudencio, Cristina" sort="Prudencio, Cristina" uniqKey="Prudencio C" first="Cristina" last="Prudêncio">Cristina Prudêncio</name><affiliation wicri:level="1"><nlm:affiliation>Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Politécnico do Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Politécnico do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Cushion, Melanie T" sort="Cushion, Melanie T" uniqKey="Cushion M" first="Melanie T" last="Cushion">Melanie T. Cushion</name><affiliation wicri:level="2"><nlm:affiliation>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Teixeira, Catia" sort="Teixeira, Catia" uniqKey="Teixeira C" first="Cátia" last="Teixeira">Cátia Teixeira</name><affiliation wicri:level="1"><nlm:affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><affiliation wicri:level="1"><nlm:affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal pgomes@fc.up.pt.</nlm:affiliation><country wicri:rule="url">Portugal</country><wicri:regionArea>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author></analytic><series><title level="j">Antimicrobial agents and chemotherapy</title><idno type="eISSN">1098-6596</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells</term><term>Antimalarials (pharmacology)</term><term>Cell Line, Tumor</term><term>Chloroquine (pharmacology)</term><term>Humans</term><term>Immunocompromised Host (drug effects)</term><term>Pneumocystis carinii (drug effects)</term><term>Pneumonia, Pneumocystis (drug therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antipaludiques (pharmacologie)</term><term>Cellules A549</term><term>Chloroquine (pharmacologie)</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Pneumocystis carinii ()</term><term>Pneumonie à Pneumocystis (traitement médicamenteux)</term><term>Sujet immunodéprimé ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunocompromised Host</term><term>Pneumocystis carinii</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pneumonia, Pneumocystis</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antipaludiques</term><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Pneumonie à Pneumocystis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term><term>Cell Line, Tumor</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules A549</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Pneumocystis carinii</term><term>Sujet immunodéprimé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The impact of <i>Pneumocystis</i> pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both <i>in vitro</i> and <i>in vivo</i>, we now report the potent action of these compounds on <i>Pneumocystis carinii in vitro</i> Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30201816</PMID><DateCompleted><Year>2019</Year><Month>10</Month><Day>10</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>10</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1098-6596</ISSN><JournalIssue CitedMedium="Internet"><Volume>62</Volume><Issue>11</Issue><PubDate><Year>2018</Year><Month>11</Month></PubDate></JournalIssue><Title>Antimicrobial agents and chemotherapy</Title><ISOAbbreviation>Antimicrob. Agents Chemother.</ISOAbbreviation></Journal><ArticleTitle>Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">e00983-18</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1128/AAC.00983-18</ELocationID><Abstract><AbstractText>The impact of <i>Pneumocystis</i> pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both <i>in vitro</i> and <i>in vivo</i>, we now report the potent action of these compounds on <i>Pneumocystis carinii in vitro</i> Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.</AbstractText><CopyrightInformation>Copyright © 2018 American Society for Microbiology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gomes</LastName><ForeName>Ana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferraz</LastName><ForeName>Ricardo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Politécnico do Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ficker</LastName><ForeName>Lauren</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Collins</LastName><ForeName>Margaret S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prudêncio</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Politécnico do Porto, Porto, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cushion</LastName><ForeName>Melanie T</ForeName><Initials>MT</Initials><Identifier Source="ORCID">0000-0001-6621-2784</Identifier><AffiliationInfo><Affiliation>Cincinnati Veterans Affairs Medical Center, Cincinnati Education and Research for Veterans Foundation, Cincinnati, Ohio, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teixeira</LastName><ForeName>Cátia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gomes</LastName><ForeName>Paula</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0002-6018-4724</Identifier><AffiliationInfo><Affiliation>LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal pgomes@fc.up.pt.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>10</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Antimicrob Agents Chemother</MedlineTA><NlmUniqueID>0315061</NlmUniqueID><ISSNLinking>0066-4804</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000072283" MajorTopicYN="N">A549 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016867" MajorTopicYN="N">Immunocompromised Host</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045363" MajorTopicYN="N">Pneumocystis carinii</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011020" MajorTopicYN="N">Pneumonia, Pneumocystis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Pneumocystis</Keyword><Keyword MajorTopicYN="Y">chloroquine</Keyword><Keyword MajorTopicYN="Y">cinnamic acids</Keyword><Keyword MajorTopicYN="Y">immunosuppressed</Keyword><Keyword MajorTopicYN="Y">lung infection</Keyword><Keyword MajorTopicYN="Y">malaria</Keyword><Keyword MajorTopicYN="Y">pneumonia</Keyword><Keyword MajorTopicYN="Y">primaquine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>08</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>10</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30201816</ArticleId><ArticleId IdType="pii">AAC.00983-18</ArticleId><ArticleId IdType="doi">10.1128/AAC.00983-18</ArticleId><ArticleId IdType="pmc">PMC6201078</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Med Chem. 2005 Feb 10;48(3):888-92</Citation><ArticleIdList><ArticleId IdType="pubmed">15689174</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Chem. 2010 Apr 8;53(7):2719-40</Citation><ArticleIdList><ArticleId IdType="pubmed">20131845</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 1999 Dec;180(6):1809-18</Citation><ArticleIdList><ArticleId IdType="pubmed">10558935</ArticleId></ArticleIdList></Reference><Reference><Citation>Korean J Parasitol. 2015 Jun;53(3):321-7</Citation><ArticleIdList><ArticleId IdType="pubmed">26174826</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioorg Med Chem Lett. 2008 Jan 15;18(2):485-8</Citation><ArticleIdList><ArticleId IdType="pubmed">18077165</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 2012 Nov;56(11):5774-81</Citation><ArticleIdList><ArticleId IdType="pubmed">22926569</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Chem. 2015 Sep 10;58(17):7076-87</Citation><ArticleIdList><ArticleId IdType="pubmed">26295373</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Pulm Med. 2016 Nov 11;16(1):144</Citation><ArticleIdList><ArticleId IdType="pubmed">27835947</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Med Chem. 2009 Mar;44(3):937-53</Citation><ArticleIdList><ArticleId IdType="pubmed">18930565</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Anti Infect Ther. 2017 May;15(5):435-447</Citation><ArticleIdList><ArticleId IdType="pubmed">28287010</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Med Chem. 2009;16(20):2514-30</Citation><ArticleIdList><ArticleId IdType="pubmed">19601796</ArticleId></ArticleIdList></Reference><Reference><Citation>ChemMedChem. 2015 Aug;10(8):1344-9</Citation><ArticleIdList><ArticleId IdType="pubmed">26038181</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 1988 Jun;32(6):896-905</Citation><ArticleIdList><ArticleId IdType="pubmed">3137861</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2015 Apr 24;10(4):e0122171</Citation><ArticleIdList><ArticleId IdType="pubmed">25909634</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2004 Oct;10(10):1721-8</Citation><ArticleIdList><ArticleId IdType="pubmed">15504256</ArticleId></ArticleIdList></Reference><Reference><Citation>ChemMedChem. 2012 Sep;7(9):1537-40</Citation><ArticleIdList><ArticleId IdType="pubmed">22753234</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Drug Targets. 2012 Nov;13(12):1575-85</Citation><ArticleIdList><ArticleId IdType="pubmed">22934582</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2017 Nov;145:178-191</Citation><ArticleIdList><ArticleId IdType="pubmed">28869864</ArticleId></ArticleIdList></Reference><Reference><Citation>ChemMedChem. 2014 Feb;9(2):305-10</Citation><ArticleIdList><ArticleId IdType="pubmed">24474655</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2001 Jun 1;32(11):1608-14</Citation><ArticleIdList><ArticleId IdType="pubmed">11340533</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2014 May 13;5(3):e01186-14</Citation><ArticleIdList><ArticleId IdType="pubmed">24825015</ArticleId></ArticleIdList></Reference><Reference><Citation>Parasitol Res. 2015 Oct;114(10):3577-85</Citation><ArticleIdList><ArticleId IdType="pubmed">26281787</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 2013 Oct;57(10):5112-5</Citation><ArticleIdList><ArticleId IdType="pubmed">23917315</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2014 Nov 04;5(6):e02020</Citation><ArticleIdList><ArticleId IdType="pubmed">25370496</ArticleId></ArticleIdList></Reference><Reference><Citation>Rheumatology (Oxford). 2012 Dec;51(12):2120-30</Citation><ArticleIdList><ArticleId IdType="pubmed">23001613</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2001 Nov 15;184(10):1355-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11679930</ArticleId></ArticleIdList></Reference><Reference><Citation>FEMS Yeast Res. 2011 Feb;11(1):2-17</Citation><ArticleIdList><ArticleId IdType="pubmed">21114625</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 2012 Mar;56(3):1564-70</Citation><ArticleIdList><ArticleId IdType="pubmed">22155838</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 2011 Oct;55(10):4513-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21788469</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 2006 Jul;50(7):2337-43</Citation><ArticleIdList><ArticleId IdType="pubmed">16801410</ArticleId></ArticleIdList></Reference><Reference><Citation>J Acquir Immune Defic Syndr. 2008 May 1;48(1):63-7</Citation><ArticleIdList><ArticleId IdType="pubmed">18360286</ArticleId></ArticleIdList></Reference><Reference><Citation>J Chem Inf Model. 2015 Nov 23;55(11):2324-37</Citation><ArticleIdList><ArticleId IdType="pubmed">26479676</ArticleId></ArticleIdList></Reference><Reference><Citation>Can Med Assoc J. 1957 Feb 15;76(4):299-302</Citation><ArticleIdList><ArticleId IdType="pubmed">13396693</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 1999 Dec;29(6):1489-93</Citation><ArticleIdList><ArticleId IdType="pubmed">10585801</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Rev. 2014 Nov 26;114(22):11164-220</Citation><ArticleIdList><ArticleId IdType="pubmed">25329927</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Med Chem. 2012 Feb;48:164-73</Citation><ArticleIdList><ArticleId IdType="pubmed">22200403</ArticleId></ArticleIdList></Reference><Reference><Citation>Antimicrob Agents Chemother. 2001 Nov;45(11):3234-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11600389</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Chem. 2013 Jan 24;56(2):556-67</Citation><ArticleIdList><ArticleId IdType="pubmed">23273038</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Chemother. 2009 Oct;15(5):343-6</Citation><ArticleIdList><ArticleId IdType="pubmed">19856077</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Anti Infect Ther. 2017 Sep;15(9):873-892</Citation><ArticleIdList><ArticleId IdType="pubmed">28782390</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Chem. 2017 Mar 23;60(6):2165-2168</Citation><ArticleIdList><ArticleId IdType="pubmed">28244745</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Chem. 2009 Dec 10;52(23):7800-7</Citation><ArticleIdList><ArticleId IdType="pubmed">19799426</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2017 Jul;50(1):55-62</Citation><ArticleIdList><ArticleId IdType="pubmed">28506804</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Microbiol. 2010;64:431-52</Citation><ArticleIdList><ArticleId IdType="pubmed">20528694</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Portugal</li><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="Portugal"><noRegion><name sortKey="Gomes, Ana" sort="Gomes, Ana" uniqKey="Gomes A" first="Ana" last="Gomes">Ana Gomes</name></noRegion><name sortKey="Ferraz, Ricardo" sort="Ferraz, Ricardo" uniqKey="Ferraz R" first="Ricardo" last="Ferraz">Ricardo Ferraz</name><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><name sortKey="Prudencio, Cristina" sort="Prudencio, Cristina" uniqKey="Prudencio C" first="Cristina" last="Prudêncio">Cristina Prudêncio</name><name sortKey="Teixeira, Catia" sort="Teixeira, Catia" uniqKey="Teixeira C" first="Cátia" last="Teixeira">Cátia Teixeira</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Ficker, Lauren" sort="Ficker, Lauren" uniqKey="Ficker L" first="Lauren" last="Ficker">Lauren Ficker</name></region><name sortKey="Collins, Margaret S" sort="Collins, Margaret S" uniqKey="Collins M" first="Margaret S" last="Collins">Margaret S. Collins</name><name sortKey="Cushion, Melanie T" sort="Cushion, Melanie T" uniqKey="Cushion M" first="Melanie T" last="Cushion">Melanie T. Cushion</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000118 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000118 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:30201816
|texte= Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:30201816" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |