Biological Activities of Gedunin—A Limonoid from the Meliaceae Family
Identifieur interne : 000E69 ( Ncbi/Checkpoint ); précédent : 000E68; suivant : 000E70Biological Activities of Gedunin—A Limonoid from the Meliaceae Family
Auteurs : Teresa M. Braga ; Lídia Rocha ; Tsz Yan Chung ; Rita F. Oliveira ; Cláudia Pinho ; Ana I. Oliveira ; Joaquim Morgado [Inde] ; Agostinho CruzSource :
- Molecules [ 1420-3049 ] ; 2020.
Abstract
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.
Url:
DOI: 10.3390/molecules25030493
PubMed: 31979346
PubMed Central: 7037920
Affiliations:
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PMC:7037920Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Biological Activities of Gedunin—A Limonoid from the Meliaceae Family</title>
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<series><title level="j">Molecules</title>
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<front><div type="abstract" xml:lang="en"><p>Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Several biological activities have been attributed to gedunin, including antibacterial, insecticidal, antimalarial, antiallergic, anti-inflammatory, anticancer, and neuroprotective effects. The discovery of gedunin as a heat shock protein (Hsp) inhibitor represented a very important landmark for its application as a biological therapeutic agent. The current study is a critical literature review based on the several biological activities so far described for gedunin, its therapeutic effect on some human diseases, and future directions of research for this natural compound.</p>
</div>
</front>
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<author><name sortKey="Ninomiya, K" uniqKey="Ninomiya K">K. Ninomiya</name>
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<affiliations><list><country><li>Inde</li>
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<tree><noCountry><name sortKey="Braga, Teresa M" sort="Braga, Teresa M" uniqKey="Braga T" first="Teresa M." last="Braga">Teresa M. Braga</name>
<name sortKey="Chung, Tsz Yan" sort="Chung, Tsz Yan" uniqKey="Chung T" first="Tsz Yan" last="Chung">Tsz Yan Chung</name>
<name sortKey="Cruz, Agostinho" sort="Cruz, Agostinho" uniqKey="Cruz A" first="Agostinho" last="Cruz">Agostinho Cruz</name>
<name sortKey="Oliveira, Ana I" sort="Oliveira, Ana I" uniqKey="Oliveira A" first="Ana I." last="Oliveira">Ana I. Oliveira</name>
<name sortKey="Oliveira, Rita F" sort="Oliveira, Rita F" uniqKey="Oliveira R" first="Rita F." last="Oliveira">Rita F. Oliveira</name>
<name sortKey="Pinho, Claudia" sort="Pinho, Claudia" uniqKey="Pinho C" first="Cláudia" last="Pinho">Cláudia Pinho</name>
<name sortKey="Rocha, Lidia" sort="Rocha, Lidia" uniqKey="Rocha L" first="Lídia" last="Rocha">Lídia Rocha</name>
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<country name="Inde"><noRegion><name sortKey="Morgado, Joaquim" sort="Morgado, Joaquim" uniqKey="Morgado J" first="Joaquim" last="Morgado">Joaquim Morgado</name>
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