Terminalia albida treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties
Identifieur interne : 000D42 ( Ncbi/Checkpoint ); précédent : 000D41; suivant : 000D43Terminalia albida treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties
Auteurs : Aissata Camara [France, Guinée] ; Mohamed Haddad [France] ; Karine Reybier [France] ; Mohamed Sahar Traoré [Guinée] ; Mamadou Aliou Baldé [Guinée] ; Jade Royo [France] ; Alpha Omar Baldé [Guinée] ; Philippe Batigne [France] ; Mahamane Haidara [Mali] ; Elhadj Saidou Baldé [Guinée] ; Agnès Coste [France] ; Aliou Mamadou Baldé [Guinée] ; Agnès Aubouy [France]Source :
- Malaria Journal [ 1475-2875 ] ; 2019.
Abstract
The development of
In vitro antiplasmodial activity was evaluated on a chloroquine-resistant strain of
In vitro antiplasmodial activity of
The traditional use of
Url:
DOI: 10.1186/s12936-019-3071-9
PubMed: 31852507
PubMed Central: 6921526
Affiliations:
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PMC:6921526Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Terminalia albida</italic>
treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties</title>
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<author><name sortKey="Haddad, Mohamed" sort="Haddad, Mohamed" uniqKey="Haddad M" first="Mohamed" last="Haddad">Mohamed Haddad</name>
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<author><name sortKey="Reybier, Karine" sort="Reybier, Karine" uniqKey="Reybier K" first="Karine" last="Reybier">Karine Reybier</name>
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<author><name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name>
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<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
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<author><name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name>
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</author>
<author><name sortKey="Royo, Jade" sort="Royo, Jade" uniqKey="Royo J" first="Jade" last="Royo">Jade Royo</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name>
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<author><name sortKey="Batigne, Philippe" sort="Batigne, Philippe" uniqKey="Batigne P" first="Philippe" last="Batigne">Philippe Batigne</name>
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<country xml:lang="fr">France</country>
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<settlement type="city">Toulouse</settlement>
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<author><name sortKey="Haidara, Mahamane" sort="Haidara, Mahamane" uniqKey="Haidara M" first="Mahamane" last="Haidara">Mahamane Haidara</name>
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Bamako, Mali</nlm:aff>
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<author><name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name>
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<author><name sortKey="Coste, Agnes" sort="Coste, Agnes" uniqKey="Coste A" first="Agnès" last="Coste">Agnès Coste</name>
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</author>
<author><name sortKey="Balde, Aliou Mamadou" sort="Balde, Aliou Mamadou" uniqKey="Balde A" first="Aliou Mamadou" last="Baldé">Aliou Mamadou Baldé</name>
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</affiliation>
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<author><name sortKey="Aubouy, Agnes" sort="Aubouy, Agnes" uniqKey="Aubouy A" first="Agnès" last="Aubouy">Agnès Aubouy</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Terminalia albida</italic>
treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties</title>
<author><name sortKey="Camara, Aissata" sort="Camara, Aissata" uniqKey="Camara A" first="Aissata" last="Camara">Aissata Camara</name>
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</placeName>
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<affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
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<author><name sortKey="Haddad, Mohamed" sort="Haddad, Mohamed" uniqKey="Haddad M" first="Mohamed" last="Haddad">Mohamed Haddad</name>
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<author><name sortKey="Reybier, Karine" sort="Reybier, Karine" uniqKey="Reybier K" first="Karine" last="Reybier">Karine Reybier</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name>
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<country xml:lang="fr">Guinée</country>
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<wicri:noRegion>Dubréka</wicri:noRegion>
</affiliation>
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<country xml:lang="fr">Guinée</country>
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<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
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<author><name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name>
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<country xml:lang="fr">Guinée</country>
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<wicri:noRegion>Dubréka</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea>
<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Royo, Jade" sort="Royo, Jade" uniqKey="Royo J" first="Jade" last="Royo">Jade Royo</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
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<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
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<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Batigne, Philippe" sort="Batigne, Philippe" uniqKey="Batigne P" first="Philippe" last="Batigne">Philippe Batigne</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haidara, Mahamane" sort="Haidara, Mahamane" uniqKey="Haidara M" first="Mahamane" last="Haidara">Mahamane Haidara</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0567 336X</institution-id>
<institution-id institution-id-type="GRID">grid.461088.3</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Sciences, Technics and Technologies (USTTB) of Bamako,</institution>
</institution-wrap>
Bamako, Mali</nlm:aff>
<country xml:lang="fr">Mali</country>
<wicri:regionArea>Bamako</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea>
<wicri:noRegion>Dubréka</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea>
<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coste, Agnes" sort="Coste, Agnes" uniqKey="Coste A" first="Agnès" last="Coste">Agnès Coste</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balde, Aliou Mamadou" sort="Balde, Aliou Mamadou" uniqKey="Balde A" first="Aliou Mamadou" last="Baldé">Aliou Mamadou Baldé</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea>
<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aubouy, Agnes" sort="Aubouy, Agnes" uniqKey="Aubouy A" first="Agnès" last="Aubouy">Agnès Aubouy</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Malaria Journal</title>
<idno type="eISSN">1475-2875</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">The development of <italic>Plasmodium</italic>
resistance to the last effective anti-malarial drugs necessitates the urgent development of new anti-malarial therapeutic strategies. To this end, plants are an important source of new molecules. The objective of this study was to evaluate the anti-malarial effects of <italic>Terminalia albida</italic>
, a plant used in Guinean traditional medicine, as well as its anti-inflammatory and antioxidant properties, which may be useful in treating cases of severe malaria.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">In vitro antiplasmodial activity was evaluated on a chloroquine-resistant strain of <italic>Plasmodium falciparum</italic>
(K-1). In vivo efficacy of the plant extract was measured in the experimental cerebral malaria model based on <italic>Plasmodium berghei</italic>
(strain ANKA) infection. Mice brains were harvested on Day 7–8 post-infection, and T cells recruitment to the brain, expression levels of pro- and anti-inflammatory markers were measured by flow cytometry, RT-qPCR and ELISA. Non-malarial in vitro models of inflammation and oxidative response were used to confirm <italic>Terminalia albida</italic>
effects. Constituents of <italic>Terminalia albida</italic>
extract were characterized by ultra‐high performance liquid chromatography coupled with high resolution mass spectrometry. Top ranked compounds were putatively identified using plant databases and in silico fragmentation patterns.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">In vitro antiplasmodial activity of <italic>Terminalia albida</italic>
was confirmed with an IC50 of 1.5 μg/mL. In vivo, <italic>Terminalia albida</italic>
treatment greatly increased survival rates in <italic>P. berghei</italic>
-infected mice. Treated mice were all alive until Day 12, and the survival rate was 50% on Day 20. <italic>Terminalia albida</italic>
treatment also significantly decreased parasitaemia by 100% on Day 4 and 89% on Day 7 post-infection. In vivo anti-malarial activity was related to anti-inflammatory properties, as <italic>Terminalia albida</italic>
treatment decreased T lymphocyte recruitment and expression of pro-inflammatory markers in brains of treated mice. These properties were confirmed in vitro in the non-malarial model. In vitro, <italic>Terminalia albida</italic>
also demonstrated a remarkable dose-dependent neutralization activity of reactive oxygen species. Twelve compounds were putatively identified in <italic>Terminalia albida</italic>
stem bark. Among them, several molecules already identified may be responsible for the different biological activities observed, especially tannins and triterpenoids.</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par4">The traditional use of <italic>Terminalia albida</italic>
in the treatment of malaria was validated through the combination of in vitro and in vivo studies.</p>
</sec>
</div>
</front>
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<author><name sortKey="Wittlin, S" uniqKey="Wittlin S">S Wittlin</name>
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</analytic>
</biblStruct>
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</author>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouattara, Lp" uniqKey="Ouattara L">LP Ouattara</name>
</author>
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<author><name sortKey="Sahal, D" uniqKey="Sahal D">D Sahal</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soh, Pn" uniqKey="Soh P">PN Soh</name>
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</biblStruct>
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</biblStruct>
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</analytic>
</biblStruct>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Manosroi, A" uniqKey="Manosroi A">A Manosroi</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="El Shitany, Na" uniqKey="El Shitany N">NA El-Shitany</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name>
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</analytic>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>France</li>
<li>Guinée</li>
<li>Mali</li>
</country>
<region><li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement><li>Toulouse</li>
</settlement>
</list>
<tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Camara, Aissata" sort="Camara, Aissata" uniqKey="Camara A" first="Aissata" last="Camara">Aissata Camara</name>
</region>
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<name sortKey="Coste, Agnes" sort="Coste, Agnes" uniqKey="Coste A" first="Agnès" last="Coste">Agnès Coste</name>
<name sortKey="Haddad, Mohamed" sort="Haddad, Mohamed" uniqKey="Haddad M" first="Mohamed" last="Haddad">Mohamed Haddad</name>
<name sortKey="Reybier, Karine" sort="Reybier, Karine" uniqKey="Reybier K" first="Karine" last="Reybier">Karine Reybier</name>
<name sortKey="Royo, Jade" sort="Royo, Jade" uniqKey="Royo J" first="Jade" last="Royo">Jade Royo</name>
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<country name="Guinée"><noRegion><name sortKey="Camara, Aissata" sort="Camara, Aissata" uniqKey="Camara A" first="Aissata" last="Camara">Aissata Camara</name>
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<name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name>
<name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name>
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<name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name>
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<name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name>
<name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name>
</country>
<country name="Mali"><noRegion><name sortKey="Haidara, Mahamane" sort="Haidara, Mahamane" uniqKey="Haidara M" first="Mahamane" last="Haidara">Mahamane Haidara</name>
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</tree>
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</record>
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