Terminalia albida treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties
Identifieur interne : 000D42 ( Ncbi/Merge ); précédent : 000D41; suivant : 000D43Terminalia albida treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties
Auteurs : Aissata Camara [France, Guinée] ; Mohamed Haddad [France] ; Karine Reybier [France] ; Mohamed Sahar Traoré [Guinée] ; Mamadou Aliou Baldé [Guinée] ; Jade Royo [France] ; Alpha Omar Baldé [Guinée] ; Philippe Batigne [France] ; Mahamane Haidara [Mali] ; Elhadj Saidou Baldé [Guinée] ; Agnès Coste [France] ; Aliou Mamadou Baldé [Guinée] ; Agnès Aubouy [France]Source :
- Malaria Journal [ 1475-2875 ] ; 2019.
Abstract
The development of
In vitro antiplasmodial activity was evaluated on a chloroquine-resistant strain of
In vitro antiplasmodial activity of
The traditional use of
Url:
DOI: 10.1186/s12936-019-3071-9
PubMed: 31852507
PubMed Central: 6921526
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PMC:6921526Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Terminalia albida</italic>
treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties</title>
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<author><name sortKey="Haddad, Mohamed" sort="Haddad, Mohamed" uniqKey="Haddad M" first="Mohamed" last="Haddad">Mohamed Haddad</name>
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<author><name sortKey="Reybier, Karine" sort="Reybier, Karine" uniqKey="Reybier K" first="Karine" last="Reybier">Karine Reybier</name>
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<author><name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name>
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<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
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<author><name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name>
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<wicri:noRegion>Conakry</wicri:noRegion>
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</author>
<author><name sortKey="Royo, Jade" sort="Royo, Jade" uniqKey="Royo J" first="Jade" last="Royo">Jade Royo</name>
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<author><name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name>
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<country xml:lang="fr">Guinée</country>
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<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
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<author><name sortKey="Batigne, Philippe" sort="Batigne, Philippe" uniqKey="Batigne P" first="Philippe" last="Batigne">Philippe Batigne</name>
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<country xml:lang="fr">France</country>
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<settlement type="city">Toulouse</settlement>
</placeName>
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</author>
<author><name sortKey="Haidara, Mahamane" sort="Haidara, Mahamane" uniqKey="Haidara M" first="Mahamane" last="Haidara">Mahamane Haidara</name>
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<institution>Department of Pharmacy,</institution>
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Bamako, Mali</nlm:aff>
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<author><name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name>
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<author><name sortKey="Coste, Agnes" sort="Coste, Agnes" uniqKey="Coste A" first="Agnès" last="Coste">Agnès Coste</name>
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<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balde, Aliou Mamadou" sort="Balde, Aliou Mamadou" uniqKey="Balde A" first="Aliou Mamadou" last="Baldé">Aliou Mamadou Baldé</name>
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<country xml:lang="fr">Guinée</country>
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<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
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<author><name sortKey="Aubouy, Agnes" sort="Aubouy, Agnes" uniqKey="Aubouy A" first="Agnès" last="Aubouy">Agnès Aubouy</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Terminalia albida</italic>
treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties</title>
<author><name sortKey="Camara, Aissata" sort="Camara, Aissata" uniqKey="Camara A" first="Aissata" last="Camara">Aissata Camara</name>
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<affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
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<wicri:noRegion>Dubréka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haddad, Mohamed" sort="Haddad, Mohamed" uniqKey="Haddad M" first="Mohamed" last="Haddad">Mohamed Haddad</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
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</placeName>
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</author>
<author><name sortKey="Reybier, Karine" sort="Reybier, Karine" uniqKey="Reybier K" first="Karine" last="Reybier">Karine Reybier</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
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<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea>
<wicri:noRegion>Dubréka</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea>
<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
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<author><name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea>
<wicri:noRegion>Dubréka</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea>
<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Royo, Jade" sort="Royo, Jade" uniqKey="Royo J" first="Jade" last="Royo">Jade Royo</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea>
<wicri:noRegion>Dubréka</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea>
<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Batigne, Philippe" sort="Batigne, Philippe" uniqKey="Batigne P" first="Philippe" last="Batigne">Philippe Batigne</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haidara, Mahamane" sort="Haidara, Mahamane" uniqKey="Haidara M" first="Mahamane" last="Haidara">Mahamane Haidara</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0567 336X</institution-id>
<institution-id institution-id-type="GRID">grid.461088.3</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Sciences, Technics and Technologies (USTTB) of Bamako,</institution>
</institution-wrap>
Bamako, Mali</nlm:aff>
<country xml:lang="fr">Mali</country>
<wicri:regionArea>Bamako</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka</wicri:regionArea>
<wicri:noRegion>Dubréka</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea>
<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coste, Agnes" sort="Coste, Agnes" uniqKey="Coste A" first="Agnès" last="Coste">Agnès Coste</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balde, Aliou Mamadou" sort="Balde, Aliou Mamadou" uniqKey="Balde A" first="Aliou Mamadou" last="Baldé">Aliou Mamadou Baldé</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</nlm:aff>
<country xml:lang="fr">Guinée</country>
<wicri:regionArea>Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry</wicri:regionArea>
<wicri:noRegion>Conakry</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aubouy, Agnes" sort="Aubouy, Agnes" uniqKey="Aubouy A" first="Agnès" last="Aubouy">Agnès Aubouy</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Malaria Journal</title>
<idno type="eISSN">1475-2875</idno>
<imprint><date when="2019">2019</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">The development of <italic>Plasmodium</italic>
resistance to the last effective anti-malarial drugs necessitates the urgent development of new anti-malarial therapeutic strategies. To this end, plants are an important source of new molecules. The objective of this study was to evaluate the anti-malarial effects of <italic>Terminalia albida</italic>
, a plant used in Guinean traditional medicine, as well as its anti-inflammatory and antioxidant properties, which may be useful in treating cases of severe malaria.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">In vitro antiplasmodial activity was evaluated on a chloroquine-resistant strain of <italic>Plasmodium falciparum</italic>
(K-1). In vivo efficacy of the plant extract was measured in the experimental cerebral malaria model based on <italic>Plasmodium berghei</italic>
(strain ANKA) infection. Mice brains were harvested on Day 7–8 post-infection, and T cells recruitment to the brain, expression levels of pro- and anti-inflammatory markers were measured by flow cytometry, RT-qPCR and ELISA. Non-malarial in vitro models of inflammation and oxidative response were used to confirm <italic>Terminalia albida</italic>
effects. Constituents of <italic>Terminalia albida</italic>
extract were characterized by ultra‐high performance liquid chromatography coupled with high resolution mass spectrometry. Top ranked compounds were putatively identified using plant databases and in silico fragmentation patterns.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">In vitro antiplasmodial activity of <italic>Terminalia albida</italic>
was confirmed with an IC50 of 1.5 μg/mL. In vivo, <italic>Terminalia albida</italic>
treatment greatly increased survival rates in <italic>P. berghei</italic>
-infected mice. Treated mice were all alive until Day 12, and the survival rate was 50% on Day 20. <italic>Terminalia albida</italic>
treatment also significantly decreased parasitaemia by 100% on Day 4 and 89% on Day 7 post-infection. In vivo anti-malarial activity was related to anti-inflammatory properties, as <italic>Terminalia albida</italic>
treatment decreased T lymphocyte recruitment and expression of pro-inflammatory markers in brains of treated mice. These properties were confirmed in vitro in the non-malarial model. In vitro, <italic>Terminalia albida</italic>
also demonstrated a remarkable dose-dependent neutralization activity of reactive oxygen species. Twelve compounds were putatively identified in <italic>Terminalia albida</italic>
stem bark. Among them, several molecules already identified may be responsible for the different biological activities observed, especially tannins and triterpenoids.</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par4">The traditional use of <italic>Terminalia albida</italic>
in the treatment of malaria was validated through the combination of in vitro and in vivo studies.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Ashley, Ea" uniqKey="Ashley E">EA Ashley</name>
</author>
<author><name sortKey="Dhorda, M" uniqKey="Dhorda M">M Dhorda</name>
</author>
<author><name sortKey="Fairhurst, Rm" uniqKey="Fairhurst R">RM Fairhurst</name>
</author>
<author><name sortKey="Amaratunga, C" uniqKey="Amaratunga C">C Amaratunga</name>
</author>
<author><name sortKey="Lim, P" uniqKey="Lim P">P Lim</name>
</author>
<author><name sortKey="Suon, S" uniqKey="Suon S">S Suon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ikeda, M" uniqKey="Ikeda M">M Ikeda</name>
</author>
<author><name sortKey="Kaneko, M" uniqKey="Kaneko M">M Kaneko</name>
</author>
<author><name sortKey="Tachibana, S I" uniqKey="Tachibana S">S-I Tachibana</name>
</author>
<author><name sortKey="Balikagala, B" uniqKey="Balikagala B">B Balikagala</name>
</author>
<author><name sortKey="Sakurai Yatsushiro, M" uniqKey="Sakurai Yatsushiro M">M Sakurai-Yatsushiro</name>
</author>
<author><name sortKey="Yatsushiro, S" uniqKey="Yatsushiro S">S Yatsushiro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, F" uniqKey="Lu F">F Lu</name>
</author>
<author><name sortKey="Culleton, R" uniqKey="Culleton R">R Culleton</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name>
</author>
<author><name sortKey="Ramaprasad, A" uniqKey="Ramaprasad A">A Ramaprasad</name>
</author>
<author><name sortKey="Von Seidlein, L" uniqKey="Von Seidlein L">L von Seidlein</name>
</author>
<author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dondorp, Am" uniqKey="Dondorp A">AM Dondorp</name>
</author>
<author><name sortKey="Fanello, Ci" uniqKey="Fanello C">CI Fanello</name>
</author>
<author><name sortKey="Hendriksen, Ice" uniqKey="Hendriksen I">ICE Hendriksen</name>
</author>
<author><name sortKey="Gomes, E" uniqKey="Gomes E">E Gomes</name>
</author>
<author><name sortKey="Seni, A" uniqKey="Seni A">A Seni</name>
</author>
<author><name sortKey="Chhaganlal, Kd" uniqKey="Chhaganlal K">KD Chhaganlal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Storm, J" uniqKey="Storm J">J Storm</name>
</author>
<author><name sortKey="Craig, Ag" uniqKey="Craig A">AG Craig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="White, Nj" uniqKey="White N">NJ White</name>
</author>
<author><name sortKey="Turner, Gdh" uniqKey="Turner G">GDH Turner</name>
</author>
<author><name sortKey="Day, Npj" uniqKey="Day N">NPJ Day</name>
</author>
<author><name sortKey="Dondorp, Am" uniqKey="Dondorp A">AM Dondorp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Howland, Sw" uniqKey="Howland S">SW Howland</name>
</author>
<author><name sortKey="Poh, Cm" uniqKey="Poh C">CM Poh</name>
</author>
<author><name sortKey="Renia, L" uniqKey="Renia L">L Rénia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Becker, K" uniqKey="Becker K">K Becker</name>
</author>
<author><name sortKey="Tilley, L" uniqKey="Tilley L">L Tilley</name>
</author>
<author><name sortKey="Vennerstrom, Jl" uniqKey="Vennerstrom J">JL Vennerstrom</name>
</author>
<author><name sortKey="Roberts, D" uniqKey="Roberts D">D Roberts</name>
</author>
<author><name sortKey="Rogerson, S" uniqKey="Rogerson S">S Rogerson</name>
</author>
<author><name sortKey="Ginsburg, H" uniqKey="Ginsburg H">H Ginsburg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aguilar, R" uniqKey="Aguilar R">R Aguilar</name>
</author>
<author><name sortKey="Marrocco, T" uniqKey="Marrocco T">T Marrocco</name>
</author>
<author><name sortKey="Skorokhod, Oa" uniqKey="Skorokhod O">OA Skorokhod</name>
</author>
<author><name sortKey="Barbosa, A" uniqKey="Barbosa A">A Barbosa</name>
</author>
<author><name sortKey="Nhabomba, A" uniqKey="Nhabomba A">A Nhabomba</name>
</author>
<author><name sortKey="Manaca, Mn" uniqKey="Manaca M">MN Manaca</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouji, M" uniqKey="Ouji M">M Ouji</name>
</author>
<author><name sortKey="Augereau, J M" uniqKey="Augereau J">J-M Augereau</name>
</author>
<author><name sortKey="Paloque, L" uniqKey="Paloque L">L Paloque</name>
</author>
<author><name sortKey="Benoit Vical, F" uniqKey="Benoit Vical F">F Benoit-Vical</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Traore, Ms" uniqKey="Traore M">MS Traore</name>
</author>
<author><name sortKey="Diane, S" uniqKey="Diane S">S Diane</name>
</author>
<author><name sortKey="Diallo, Mst" uniqKey="Diallo M">MST Diallo</name>
</author>
<author><name sortKey="Balde, Es" uniqKey="Balde E">ES Balde</name>
</author>
<author><name sortKey="Balde, Ma" uniqKey="Balde M">MA Balde</name>
</author>
<author><name sortKey="Camara, A" uniqKey="Camara A">A Camara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haidara, M" uniqKey="Haidara M">M Haidara</name>
</author>
<author><name sortKey="Haddad, M" uniqKey="Haddad M">M Haddad</name>
</author>
<author><name sortKey="Denou, A" uniqKey="Denou A">A Denou</name>
</author>
<author><name sortKey="Marti, G" uniqKey="Marti G">G Marti</name>
</author>
<author><name sortKey="Bourgeade Delmas, S" uniqKey="Bourgeade Delmas S">S Bourgeade-Delmas</name>
</author>
<author><name sortKey="Sanogo, R" uniqKey="Sanogo R">R Sanogo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Traore, Ms" uniqKey="Traore M">MS Traore</name>
</author>
<author><name sortKey="Balde, Ma" uniqKey="Balde M">MA Baldé</name>
</author>
<author><name sortKey="Diallo, Mst" uniqKey="Diallo M">MST Diallo</name>
</author>
<author><name sortKey="Balde, Es" uniqKey="Balde E">ES Baldé</name>
</author>
<author><name sortKey="Diane, S" uniqKey="Diane S">S Diané</name>
</author>
<author><name sortKey="Camara, A" uniqKey="Camara A">A Camara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smilkstein, M" uniqKey="Smilkstein M">M Smilkstein</name>
</author>
<author><name sortKey="Sriwilaijaroen, N" uniqKey="Sriwilaijaroen N">N Sriwilaijaroen</name>
</author>
<author><name sortKey="Kelly, Jx" uniqKey="Kelly J">JX Kelly</name>
</author>
<author><name sortKey="Wilairat, P" uniqKey="Wilairat P">P Wilairat</name>
</author>
<author><name sortKey="Riscoe, M" uniqKey="Riscoe M">M Riscoe</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Carroll, Rw" uniqKey="Carroll R">RW Carroll</name>
</author>
<author><name sortKey="Wainwright, Ms" uniqKey="Wainwright M">MS Wainwright</name>
</author>
<author><name sortKey="Kim, K Y" uniqKey="Kim K">K-Y Kim</name>
</author>
<author><name sortKey="Kidambi, T" uniqKey="Kidambi T">T Kidambi</name>
</author>
<author><name sortKey="G Mez, Nd" uniqKey="G Mez N">ND Gómez</name>
</author>
<author><name sortKey="Taylor, T" uniqKey="Taylor T">T Taylor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Derick, S" uniqKey="Derick S">S Derick</name>
</author>
<author><name sortKey="Gironde, C" uniqKey="Gironde C">C Gironde</name>
</author>
<author><name sortKey="Perio, P" uniqKey="Perio P">P Perio</name>
</author>
<author><name sortKey="Reybier, K" uniqKey="Reybier K">K Reybier</name>
</author>
<author><name sortKey="Nepveu, F" uniqKey="Nepveu F">F Nepveu</name>
</author>
<author><name sortKey="Jauneau, A" uniqKey="Jauneau A">A Jauneau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chassagne, F" uniqKey="Chassagne F">F Chassagne</name>
</author>
<author><name sortKey="Haddad, M" uniqKey="Haddad M">M Haddad</name>
</author>
<author><name sortKey="Amiel, A" uniqKey="Amiel A">A Amiel</name>
</author>
<author><name sortKey="Phakeovilay, C" uniqKey="Phakeovilay C">C Phakeovilay</name>
</author>
<author><name sortKey="Manithip, C" uniqKey="Manithip C">C Manithip</name>
</author>
<author><name sortKey="Bourdy, G" uniqKey="Bourdy G">G Bourdy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Howland, Sw" uniqKey="Howland S">SW Howland</name>
</author>
<author><name sortKey="Claser, C" uniqKey="Claser C">C Claser</name>
</author>
<author><name sortKey="Poh, Cm" uniqKey="Poh C">CM Poh</name>
</author>
<author><name sortKey="Gun, Sy" uniqKey="Gun S">SY Gun</name>
</author>
<author><name sortKey="Renia, L" uniqKey="Renia L">L Rénia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hintsa, G" uniqKey="Hintsa G">G Hintsa</name>
</author>
<author><name sortKey="Sibhat, Gg" uniqKey="Sibhat G">GG Sibhat</name>
</author>
<author><name sortKey="Karim, A" uniqKey="Karim A">A Karim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mzena, T" uniqKey="Mzena T">T Mzena</name>
</author>
<author><name sortKey="Swai, H" uniqKey="Swai H">H Swai</name>
</author>
<author><name sortKey="Chacha, M" uniqKey="Chacha M">M Chacha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nureye, D" uniqKey="Nureye D">D Nureye</name>
</author>
<author><name sortKey="Assefa, S" uniqKey="Assefa S">S Assefa</name>
</author>
<author><name sortKey="Nedi, T" uniqKey="Nedi T">T Nedi</name>
</author>
<author><name sortKey="Engidawork, E" uniqKey="Engidawork E">E Engidawork</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Conforti, F" uniqKey="Conforti F">F Conforti</name>
</author>
<author><name sortKey="Marcotullio, Mc" uniqKey="Marcotullio M">MC Marcotullio</name>
</author>
<author><name sortKey="Menichini, F" uniqKey="Menichini F">F Menichini</name>
</author>
<author><name sortKey="Statti, Ga" uniqKey="Statti G">GA Statti</name>
</author>
<author><name sortKey="Vannutelli, L" uniqKey="Vannutelli L">L Vannutelli</name>
</author>
<author><name sortKey="Burini, G" uniqKey="Burini G">G Burini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dunst, J" uniqKey="Dunst J">J Dunst</name>
</author>
<author><name sortKey="Kamena, F" uniqKey="Kamena F">F Kamena</name>
</author>
<author><name sortKey="Matuschewski, K" uniqKey="Matuschewski K">K Matuschewski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amante, Fh" uniqKey="Amante F">FH Amante</name>
</author>
<author><name sortKey="Haque, A" uniqKey="Haque A">A Haque</name>
</author>
<author><name sortKey="Stanley, Ac" uniqKey="Stanley A">AC Stanley</name>
</author>
<author><name sortKey="De Rivera, F" uniqKey="De Rivera F">F de Rivera</name>
</author>
<author><name sortKey="Randall, Lm" uniqKey="Randall L">LM Randall</name>
</author>
<author><name sortKey="Wilson, Ya" uniqKey="Wilson Y">YA Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cahayani, Wa" uniqKey="Cahayani W">WA Cahayani</name>
</author>
<author><name sortKey="Norahmawati, E" uniqKey="Norahmawati E">E Norahmawati</name>
</author>
<author><name sortKey="Budiarti, N" uniqKey="Budiarti N">N Budiarti</name>
</author>
<author><name sortKey="Fitri, Le" uniqKey="Fitri L">LE Fitri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tripathi, Ak" uniqKey="Tripathi A">AK Tripathi</name>
</author>
<author><name sortKey="Sha, W" uniqKey="Sha W">W Sha</name>
</author>
<author><name sortKey="Shulaev, V" uniqKey="Shulaev V">V Shulaev</name>
</author>
<author><name sortKey="Stins, Mf" uniqKey="Stins M">MF Stins</name>
</author>
<author><name sortKey="Sullivan, Dj" uniqKey="Sullivan D">DJ Sullivan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcgilvray, Id" uniqKey="Mcgilvray I">ID McGilvray</name>
</author>
<author><name sortKey="Serghides, L" uniqKey="Serghides L">L Serghides</name>
</author>
<author><name sortKey="Kapus, A" uniqKey="Kapus A">A Kapus</name>
</author>
<author><name sortKey="Rotstein, Od" uniqKey="Rotstein O">OD Rotstein</name>
</author>
<author><name sortKey="Kain, Kc" uniqKey="Kain K">KC Kain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Percario, S" uniqKey="Percario S">S Percário</name>
</author>
<author><name sortKey="Moreira, Dr" uniqKey="Moreira D">DR Moreira</name>
</author>
<author><name sortKey="Gomes, Baq" uniqKey="Gomes B">BAQ Gomes</name>
</author>
<author><name sortKey="Ferreira, Mes" uniqKey="Ferreira M">MES Ferreira</name>
</author>
<author><name sortKey="Goncalves, Acm" uniqKey="Goncalves A">ACM Gonçalves</name>
</author>
<author><name sortKey="Laurindo, Psoc" uniqKey="Laurindo P">PSOC Laurindo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Serghides, L" uniqKey="Serghides L">L Serghides</name>
</author>
<author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name>
</author>
<author><name sortKey="Lu, Z" uniqKey="Lu Z">Z Lu</name>
</author>
<author><name sortKey="Kain, Dc" uniqKey="Kain D">DC Kain</name>
</author>
<author><name sortKey="Miller, C" uniqKey="Miller C">C Miller</name>
</author>
<author><name sortKey="Francis, Rc" uniqKey="Francis R">RC Francis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name>
</author>
<author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name>
</author>
<author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name>
</author>
<author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name>
</author>
<author><name sortKey="Pang, W" uniqKey="Pang W">W Pang</name>
</author>
<author><name sortKey="Du, Y" uniqKey="Du Y">Y Du</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pamplona, A" uniqKey="Pamplona A">A Pamplona</name>
</author>
<author><name sortKey="Ferreira, A" uniqKey="Ferreira A">A Ferreira</name>
</author>
<author><name sortKey="Balla, J" uniqKey="Balla J">J Balla</name>
</author>
<author><name sortKey="Jeney, V" uniqKey="Jeney V">V Jeney</name>
</author>
<author><name sortKey="Balla, G" uniqKey="Balla G">G Balla</name>
</author>
<author><name sortKey="Epiphanio, S" uniqKey="Epiphanio S">S Epiphanio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ohashi, M" uniqKey="Ohashi M">M Ohashi</name>
</author>
<author><name sortKey="Amoa Bosompem, M" uniqKey="Amoa Bosompem M">M Amoa-Bosompem</name>
</author>
<author><name sortKey="Kwofie, Kd" uniqKey="Kwofie K">KD Kwofie</name>
</author>
<author><name sortKey="Agyapong, J" uniqKey="Agyapong J">J Agyapong</name>
</author>
<author><name sortKey="Adegle, R" uniqKey="Adegle R">R Adegle</name>
</author>
<author><name sortKey="Sakyiamah, Mm" uniqKey="Sakyiamah M">MM Sakyiamah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mbouna, Cdj" uniqKey="Mbouna C">CDJ Mbouna</name>
</author>
<author><name sortKey="Kouipou, Rmt" uniqKey="Kouipou R">RMT Kouipou</name>
</author>
<author><name sortKey="Keumoe, R" uniqKey="Keumoe R">R Keumoe</name>
</author>
<author><name sortKey="Tchokouaha, Lry" uniqKey="Tchokouaha L">LRY Tchokouaha</name>
</author>
<author><name sortKey="Fokou, Pvt" uniqKey="Fokou P">PVT Fokou</name>
</author>
<author><name sortKey="Tali, Bmt" uniqKey="Tali B">BMT Tali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muganga, R" uniqKey="Muganga R">R Muganga</name>
</author>
<author><name sortKey="Angenot, L" uniqKey="Angenot L">L Angenot</name>
</author>
<author><name sortKey="Tits, M" uniqKey="Tits M">M Tits</name>
</author>
<author><name sortKey="Frederich, M" uniqKey="Frederich M">M Frédérich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Apel, C" uniqKey="Apel C">C Apel</name>
</author>
<author><name sortKey="Bignon, J" uniqKey="Bignon J">J Bignon</name>
</author>
<author><name sortKey="Garcia Alvarez, Mc" uniqKey="Garcia Alvarez M">MC Garcia-Alvarez</name>
</author>
<author><name sortKey="Ciccone, S" uniqKey="Ciccone S">S Ciccone</name>
</author>
<author><name sortKey="Clerc, P" uniqKey="Clerc P">P Clerc</name>
</author>
<author><name sortKey="Grondin, I" uniqKey="Grondin I">I Grondin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Razak, Mr" uniqKey="Razak M">MR Razak</name>
</author>
<author><name sortKey="Afzan, A" uniqKey="Afzan A">A Afzan</name>
</author>
<author><name sortKey="Ali, R" uniqKey="Ali R">R Ali</name>
</author>
<author><name sortKey="Jalaluddin, Nf" uniqKey="Jalaluddin N">NF Jalaluddin</name>
</author>
<author><name sortKey="Wasiman, Mi" uniqKey="Wasiman M">MI Wasiman</name>
</author>
<author><name sortKey="Zahari, Sh" uniqKey="Zahari S">SH Zahari</name>
</author>
<author><name sortKey="Abdullah, Nr" uniqKey="Abdullah N">NR Abdullah</name>
</author>
<author><name sortKey="Ismail, Z" uniqKey="Ismail Z">Z Ismail</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abiodun, O" uniqKey="Abiodun O">O Abiodun</name>
</author>
<author><name sortKey="Gbotosho, G" uniqKey="Gbotosho G">G Gbotosho</name>
</author>
<author><name sortKey="Ajaiyeoba, E" uniqKey="Ajaiyeoba E">E Ajaiyeoba</name>
</author>
<author><name sortKey="Happi, T" uniqKey="Happi T">T Happi</name>
</author>
<author><name sortKey="Falade, M" uniqKey="Falade M">M Falade</name>
</author>
<author><name sortKey="Wittlin, S" uniqKey="Wittlin S">S Wittlin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanon, S" uniqKey="Sanon S">S Sanon</name>
</author>
<author><name sortKey="Gansane, A" uniqKey="Gansane A">A Gansane</name>
</author>
<author><name sortKey="Ouattara, Lp" uniqKey="Ouattara L">LP Ouattara</name>
</author>
<author><name sortKey="Traore, A" uniqKey="Traore A">A Traore</name>
</author>
<author><name sortKey="Ouedraogo, In" uniqKey="Ouedraogo I">IN Ouedraogo</name>
</author>
<author><name sortKey="Tiono, A" uniqKey="Tiono A">A Tiono</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouattara, Lp" uniqKey="Ouattara L">LP Ouattara</name>
</author>
<author><name sortKey="Sanon, S" uniqKey="Sanon S">S Sanon</name>
</author>
<author><name sortKey="Mahiou Leddet, V" uniqKey="Mahiou Leddet V">V Mahiou-Leddet</name>
</author>
<author><name sortKey="Gansane, A" uniqKey="Gansane A">A Gansané</name>
</author>
<author><name sortKey="Baghdikian, B" uniqKey="Baghdikian B">B Baghdikian</name>
</author>
<author><name sortKey="Traore, A" uniqKey="Traore A">A Traoré</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bagavan, A" uniqKey="Bagavan A">A Bagavan</name>
</author>
<author><name sortKey="Rahuman, Aa" uniqKey="Rahuman A">AA Rahuman</name>
</author>
<author><name sortKey="Kamaraj, C" uniqKey="Kamaraj C">C Kamaraj</name>
</author>
<author><name sortKey="Kaushik, Nk" uniqKey="Kaushik N">NK Kaushik</name>
</author>
<author><name sortKey="Mohanakrishnan, D" uniqKey="Mohanakrishnan D">D Mohanakrishnan</name>
</author>
<author><name sortKey="Sahal, D" uniqKey="Sahal D">D Sahal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soh, Pn" uniqKey="Soh P">PN Soh</name>
</author>
<author><name sortKey="Witkowski, B" uniqKey="Witkowski B">B Witkowski</name>
</author>
<author><name sortKey="Olagnier, D" uniqKey="Olagnier D">D Olagnier</name>
</author>
<author><name sortKey="Nicolau, M L" uniqKey="Nicolau M">M-L Nicolau</name>
</author>
<author><name sortKey="Garcia Alvarez, M C" uniqKey="Garcia Alvarez M">M-C Garcia-Alvarez</name>
</author>
<author><name sortKey="Berry, A" uniqKey="Berry A">A Berry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akanbi, Om" uniqKey="Akanbi O">OM Akanbi</name>
</author>
<author><name sortKey="Elekofehinti, O" uniqKey="Elekofehinti O">O Elekofehinti</name>
</author>
<author><name sortKey="Olatokunbo, A" uniqKey="Olatokunbo A">A Olatokunbo</name>
</author>
<author><name sortKey="Adejuyigbe, A" uniqKey="Adejuyigbe A">A Adejuyigbe</name>
</author>
<author><name sortKey="Jegede, A" uniqKey="Jegede A">A Jegede</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haddad, M" uniqKey="Haddad M">M Haddad</name>
</author>
<author><name sortKey="Laurens, V" uniqKey="Laurens V">V Laurens</name>
</author>
<author><name sortKey="Lacaille Dubois, M A" uniqKey="Lacaille Dubois M">M-A Lacaille-Dubois</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Machumi, F" uniqKey="Machumi F">F Machumi</name>
</author>
<author><name sortKey="Midiwo, Jo" uniqKey="Midiwo J">JO Midiwo</name>
</author>
<author><name sortKey="Jacob, Mr" uniqKey="Jacob M">MR Jacob</name>
</author>
<author><name sortKey="Khan, Si" uniqKey="Khan S">SI Khan</name>
</author>
<author><name sortKey="Tekwani, Bl" uniqKey="Tekwani B">BL Tekwani</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abiodun, Oo" uniqKey="Abiodun O">OO Abiodun</name>
</author>
<author><name sortKey="Rodriguez Nogales, A" uniqKey="Rodriguez Nogales A">A Rodríguez-Nogales</name>
</author>
<author><name sortKey="Algieri, F" uniqKey="Algieri F">F Algieri</name>
</author>
<author><name sortKey="Gomez Caravaca, Am" uniqKey="Gomez Caravaca A">AM Gomez-Caravaca</name>
</author>
<author><name sortKey="Segura Carretero, A" uniqKey="Segura Carretero A">A Segura-Carretero</name>
</author>
<author><name sortKey="Utrilla, Mp" uniqKey="Utrilla M">MP Utrilla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Araujo, A" uniqKey="De Araujo A">A de Araújo</name>
</author>
<author><name sortKey="Iles, B" uniqKey="Iles B">B Iles</name>
</author>
<author><name sortKey="De Nogueira, K" uniqKey="De Nogueira K">K de Nogueira</name>
</author>
<author><name sortKey="Dias, J" uniqKey="Dias J">J Dias</name>
</author>
<author><name sortKey="Placido, A" uniqKey="Placido A">A Plácido</name>
</author>
<author><name sortKey="Rodrigues, A" uniqKey="Rodrigues A">A Rodrigues</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manosroi, A" uniqKey="Manosroi A">A Manosroi</name>
</author>
<author><name sortKey="Jantrawut, P" uniqKey="Jantrawut P">P Jantrawut</name>
</author>
<author><name sortKey="Ogihara, E" uniqKey="Ogihara E">E Ogihara</name>
</author>
<author><name sortKey="Yamamoto, A" uniqKey="Yamamoto A">A Yamamoto</name>
</author>
<author><name sortKey="Fukatsu, M" uniqKey="Fukatsu M">M Fukatsu</name>
</author>
<author><name sortKey="Yasukawa, K" uniqKey="Yasukawa K">K Yasukawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeb, A" uniqKey="Zeb A">A Zeb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Shitany, Na" uniqKey="El Shitany N">NA El-Shitany</name>
</author>
<author><name sortKey="El Bastawissy, Ea" uniqKey="El Bastawissy E">EA El-Bastawissy</name>
</author>
<author><name sortKey="El Desoky, K" uniqKey="El Desoky K">K El-desoky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name>
</author>
<author><name sortKey="Zhang, Sl" uniqKey="Zhang S">SL Zhang</name>
</author>
<author><name sortKey="Tao, Jy" uniqKey="Tao J">JY Tao</name>
</author>
<author><name sortKey="Pang, R" uniqKey="Pang R">R Pang</name>
</author>
<author><name sortKey="Jin, F" uniqKey="Jin F">F Jin</name>
</author>
<author><name sortKey="Guo, Yj" uniqKey="Guo Y">YJ Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dong, Xr" uniqKey="Dong X">XR Dong</name>
</author>
<author><name sortKey="Luo, M" uniqKey="Luo M">M Luo</name>
</author>
<author><name sortKey="Fan, L" uniqKey="Fan L">L Fan</name>
</author>
<author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name>
</author>
<author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name>
</author>
<author><name sortKey="Dong, Jh" uniqKey="Dong J">JH Dong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, H R" uniqKey="Li H">H-R Li</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name>
</author>
<author><name sortKey="Zhang, S L" uniqKey="Zhang S">S-L Zhang</name>
</author>
<author><name sortKey="Luo, T" uniqKey="Luo T">T Luo</name>
</author>
<author><name sortKey="Wu, F" uniqKey="Wu F">F Wu</name>
</author>
<author><name sortKey="Dong, J H" uniqKey="Dong J">J-H Dong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, M C" uniqKey="Kim M">M-C Kim</name>
</author>
<author><name sortKey="Kim, S J" uniqKey="Kim S">S-J Kim</name>
</author>
<author><name sortKey="Kim, D S" uniqKey="Kim D">D-S Kim</name>
</author>
<author><name sortKey="Jeon, Y D" uniqKey="Jeon Y">Y-D Jeon</name>
</author>
<author><name sortKey="Park, Sj" uniqKey="Park S">SJ Park</name>
</author>
<author><name sortKey="Lee, Hs" uniqKey="Lee H">HS Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calixto Campos, C" uniqKey="Calixto Campos C">C Calixto-Campos</name>
</author>
<author><name sortKey="Carvalho, Tt" uniqKey="Carvalho T">TT Carvalho</name>
</author>
<author><name sortKey="Hohmann, Msn" uniqKey="Hohmann M">MSN Hohmann</name>
</author>
<author><name sortKey="Pinho Ribeiro, Fa" uniqKey="Pinho Ribeiro F">FA Pinho-Ribeiro</name>
</author>
<author><name sortKey="Fattori, V" uniqKey="Fattori V">V Fattori</name>
</author>
<author><name sortKey="Manchope, Mf" uniqKey="Manchope M">MF Manchope</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yadav, Vr" uniqKey="Yadav V">VR Yadav</name>
</author>
<author><name sortKey="Prasad, S" uniqKey="Prasad S">S Prasad</name>
</author>
<author><name sortKey="Sung, B" uniqKey="Sung B">B Sung</name>
</author>
<author><name sortKey="Kannappan, R" uniqKey="Kannappan R">R Kannappan</name>
</author>
<author><name sortKey="Aggarwal, Bb" uniqKey="Aggarwal B">BB Aggarwal</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Malar J</journal-id>
<journal-id journal-id-type="iso-abbrev">Malar. J</journal-id>
<journal-title-group><journal-title>Malaria Journal</journal-title>
</journal-title-group>
<issn pub-type="epub">1475-2875</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31852507</article-id>
<article-id pub-id-type="pmc">6921526</article-id>
<article-id pub-id-type="publisher-id">3071</article-id>
<article-id pub-id-type="doi">10.1186/s12936-019-3071-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title><italic>Terminalia albida</italic>
treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-6840-7489</contrib-id>
<name><surname>Camara</surname>
<given-names>Aissata</given-names>
</name>
<address><email>aichali2004@yahoo.fr</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haddad</surname>
<given-names>Mohamed</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Reybier</surname>
<given-names>Karine</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Traoré</surname>
<given-names>Mohamed Sahar</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baldé</surname>
<given-names>Mamadou Aliou</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Royo</surname>
<given-names>Jade</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baldé</surname>
<given-names>Alpha Omar</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Batigne</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haidara</surname>
<given-names>Mahamane</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baldé</surname>
<given-names>Elhadj Saidou</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coste</surname>
<given-names>Agnès</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baldé</surname>
<given-names>Aliou Mamadou</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aubouy</surname>
<given-names>Agnès</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<aff id="Aff1"><label>1</label>
UMR152 PHARMADEV, IRD, UPS, Université de Toulouse, Toulouse, France</aff>
<aff id="Aff2"><label>2</label>
Institute for Research and Development of Medicinal and Food Plants of Guinea (IRDPMAG), Dubréka, Guinea</aff>
<aff id="Aff3"><label>3</label>
Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Conakry, Guinea</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0567 336X</institution-id>
<institution-id institution-id-type="GRID">grid.461088.3</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>University of Sciences, Technics and Technologies (USTTB) of Bamako,</institution>
</institution-wrap>
Bamako, Mali</aff>
</contrib-group>
<pub-date pub-type="epub"><day>18</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>18</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>18</volume>
<elocation-id>431</elocation-id>
<history><date date-type="received"><day>11</day>
<month>9</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>11</day>
<month>12</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2019</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated in a credit line to the data.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p id="Par1">The development of <italic>Plasmodium</italic>
resistance to the last effective anti-malarial drugs necessitates the urgent development of new anti-malarial therapeutic strategies. To this end, plants are an important source of new molecules. The objective of this study was to evaluate the anti-malarial effects of <italic>Terminalia albida</italic>
, a plant used in Guinean traditional medicine, as well as its anti-inflammatory and antioxidant properties, which may be useful in treating cases of severe malaria.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">In vitro antiplasmodial activity was evaluated on a chloroquine-resistant strain of <italic>Plasmodium falciparum</italic>
(K-1). In vivo efficacy of the plant extract was measured in the experimental cerebral malaria model based on <italic>Plasmodium berghei</italic>
(strain ANKA) infection. Mice brains were harvested on Day 7–8 post-infection, and T cells recruitment to the brain, expression levels of pro- and anti-inflammatory markers were measured by flow cytometry, RT-qPCR and ELISA. Non-malarial in vitro models of inflammation and oxidative response were used to confirm <italic>Terminalia albida</italic>
effects. Constituents of <italic>Terminalia albida</italic>
extract were characterized by ultra‐high performance liquid chromatography coupled with high resolution mass spectrometry. Top ranked compounds were putatively identified using plant databases and in silico fragmentation patterns.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">In vitro antiplasmodial activity of <italic>Terminalia albida</italic>
was confirmed with an IC50 of 1.5 μg/mL. In vivo, <italic>Terminalia albida</italic>
treatment greatly increased survival rates in <italic>P. berghei</italic>
-infected mice. Treated mice were all alive until Day 12, and the survival rate was 50% on Day 20. <italic>Terminalia albida</italic>
treatment also significantly decreased parasitaemia by 100% on Day 4 and 89% on Day 7 post-infection. In vivo anti-malarial activity was related to anti-inflammatory properties, as <italic>Terminalia albida</italic>
treatment decreased T lymphocyte recruitment and expression of pro-inflammatory markers in brains of treated mice. These properties were confirmed in vitro in the non-malarial model. In vitro, <italic>Terminalia albida</italic>
also demonstrated a remarkable dose-dependent neutralization activity of reactive oxygen species. Twelve compounds were putatively identified in <italic>Terminalia albida</italic>
stem bark. Among them, several molecules already identified may be responsible for the different biological activities observed, especially tannins and triterpenoids.</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par4">The traditional use of <italic>Terminalia albida</italic>
in the treatment of malaria was validated through the combination of in vitro and in vivo studies.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd><italic>Terminalia albida</italic>
</kwd>
<kwd>Malaria</kwd>
<kwd>Experimental cerebral malaria</kwd>
<kwd>Inflammatory response</kwd>
<kwd>Oxidative stress</kwd>
<kwd>UHPLC-HRMS</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution>Ambassade de France en Guinée</institution>
</funding-source>
<award-id>001</award-id>
<principal-award-recipient><name><surname>Camara</surname>
<given-names>Aissata</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<funding-group><award-group><funding-source><institution>Ministère de l’Enseignement Supérieur, de la Recherche Scientifique et des Technologies de l'Information et de la Communication (TN)</institution>
</funding-source>
<award-id>001</award-id>
<principal-award-recipient><name><surname>Camara</surname>
<given-names>Aissata</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2019</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
<li>Guinée</li>
<li>Mali</li>
</country>
<region><li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement><li>Toulouse</li>
</settlement>
</list>
<tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Camara, Aissata" sort="Camara, Aissata" uniqKey="Camara A" first="Aissata" last="Camara">Aissata Camara</name>
</region>
<name sortKey="Aubouy, Agnes" sort="Aubouy, Agnes" uniqKey="Aubouy A" first="Agnès" last="Aubouy">Agnès Aubouy</name>
<name sortKey="Batigne, Philippe" sort="Batigne, Philippe" uniqKey="Batigne P" first="Philippe" last="Batigne">Philippe Batigne</name>
<name sortKey="Coste, Agnes" sort="Coste, Agnes" uniqKey="Coste A" first="Agnès" last="Coste">Agnès Coste</name>
<name sortKey="Haddad, Mohamed" sort="Haddad, Mohamed" uniqKey="Haddad M" first="Mohamed" last="Haddad">Mohamed Haddad</name>
<name sortKey="Reybier, Karine" sort="Reybier, Karine" uniqKey="Reybier K" first="Karine" last="Reybier">Karine Reybier</name>
<name sortKey="Royo, Jade" sort="Royo, Jade" uniqKey="Royo J" first="Jade" last="Royo">Jade Royo</name>
</country>
<country name="Guinée"><noRegion><name sortKey="Camara, Aissata" sort="Camara, Aissata" uniqKey="Camara A" first="Aissata" last="Camara">Aissata Camara</name>
</noRegion>
<name sortKey="Balde, Aliou Mamadou" sort="Balde, Aliou Mamadou" uniqKey="Balde A" first="Aliou Mamadou" last="Baldé">Aliou Mamadou Baldé</name>
<name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name>
<name sortKey="Balde, Alpha Omar" sort="Balde, Alpha Omar" uniqKey="Balde A" first="Alpha Omar" last="Baldé">Alpha Omar Baldé</name>
<name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name>
<name sortKey="Balde, Elhadj Saidou" sort="Balde, Elhadj Saidou" uniqKey="Balde E" first="Elhadj Saidou" last="Baldé">Elhadj Saidou Baldé</name>
<name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name>
<name sortKey="Balde, Mamadou Aliou" sort="Balde, Mamadou Aliou" uniqKey="Balde M" first="Mamadou Aliou" last="Baldé">Mamadou Aliou Baldé</name>
<name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name>
<name sortKey="Traore, Mohamed Sahar" sort="Traore, Mohamed Sahar" uniqKey="Traore M" first="Mohamed Sahar" last="Traoré">Mohamed Sahar Traoré</name>
</country>
<country name="Mali"><noRegion><name sortKey="Haidara, Mahamane" sort="Haidara, Mahamane" uniqKey="Haidara M" first="Mahamane" last="Haidara">Mahamane Haidara</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D42 | SxmlIndent | more
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{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:6921526 |texte= Terminalia albida treatment improves survival in experimental cerebral malaria through reactive oxygen species scavenging and anti-inflammatory properties }}
Pour générer des pages wiki
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