Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling
Identifieur interne : 000C27 ( Ncbi/Checkpoint ); précédent : 000C26; suivant : 000C28Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling
Auteurs : Bao-Ming Wu ; Jun-Da Liu [République populaire de Chine] ; Yuan-Hai Li [République populaire de Chine] ; Jun LiSource :
- International Journal of Molecular Medicine [ 1107-3756 ] ; 2019.
Abstract
A number of macrophage phenotypes have been previously identified as crucial regulators in the progression of hepatic fibrosis (HF). Cytokines from macrophages or Kupffer cells (KCs) have also been identified to be important regulators in HF. Blocking Kv1.3 in models of HF, regulating macrophage polarization and cytokine secretion have not yet been assessed as potential treatments options for this condition. In the current study, a model of carbon tetrachloride (CCl4)-induced HF was established and examined the effects of margatoxin (MgTX; an inhibitor of Kv1.3) on HF. Hematoxylin and eosin, Masson's trichrome and immunohistochemistry staining were performed to determine whether MgTX can alleviate liver fibrosis. To elucidate the mechanisms through which MgTX attenuates liver injury, reverse transcription-quantitative PCR and western blot analysis were used to detect polarized macrophage markers in RAW264.7 cells and cytokines were examined using ELISA. Furthermore, macrophage polarization signal transducer and activator of transcription (STAT) signaling, which is associated with macrophage polarization, was identified in RAW264.7 cells. The results revealed that MgTX protected the mice from CCl4-induced liver fibrosis. Furthermore, MgTX decreased the expression of M1 phenotype biomarkers, and increased the expression of M2 phenotype biomarkers in CCl4-induced HF. Additionally, the production of pro-inflammatory cytokines was decreased and interleukin-10 production was increased in the serum of mice with HF injected with MgTX. Furthermore, MgTX was found to regulate the expression of M1 markers by suppressing p-STAT1 activity and increasing the expression of M2 markers by promoting p-STAT6 activity. On the whole, the findings of this study demonstrate that MgTX is able to alleviate CCl4-induced HF in mice, possibly via macrophage polarization, cytokine secretion and STAT signaling.
Url:
DOI: 10.3892/ijmm.2019.4395
PubMed: 31746414
PubMed Central: 6889929
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000601
- to stream Pmc, to step Curation: 000601
- to stream Pmc, to step Checkpoint: 000602
- to stream Ncbi, to step Merge: 000C27
- to stream Ncbi, to step Curation: 000C27
Links to Exploration step
PMC:6889929Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling</title>
<author><name sortKey="Wu, Bao Ming" sort="Wu, Bao Ming" uniqKey="Wu B" first="Bao-Ming" last="Wu">Bao-Ming Wu</name>
<affiliation><nlm:aff id="af1-ijmm-45-01-0103">School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-ijmm-45-01-0103">The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education</nlm:aff>
<wicri:noCountry code="subfield">Ministry of Education</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-ijmm-45-01-0103">Institute for Liver Diseases of Anhui Medical University</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4-ijmm-45-01-0103">Anhui Institute of Innovative Drugs, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Liu, Jun Da" sort="Liu, Jun Da" uniqKey="Liu J" first="Jun-Da" last="Liu">Jun-Da Liu</name>
<affiliation><nlm:aff id="af1-ijmm-45-01-0103">School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-ijmm-45-01-0103">The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education</nlm:aff>
<wicri:noCountry code="subfield">Ministry of Education</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-ijmm-45-01-0103">Institute for Liver Diseases of Anhui Medical University</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4-ijmm-45-01-0103">Anhui Institute of Innovative Drugs, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af5-ijmm-45-01-0103">The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032</wicri:regionArea>
<wicri:noRegion>Anhui 230032</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Yuan Hai" sort="Li, Yuan Hai" uniqKey="Li Y" first="Yuan-Hai" last="Li">Yuan-Hai Li</name>
<affiliation><nlm:aff id="af1-ijmm-45-01-0103">School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-ijmm-45-01-0103">The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education</nlm:aff>
<wicri:noCountry code="subfield">Ministry of Education</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-ijmm-45-01-0103">Institute for Liver Diseases of Anhui Medical University</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4-ijmm-45-01-0103">Anhui Institute of Innovative Drugs, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af5-ijmm-45-01-0103">The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032</wicri:regionArea>
<wicri:noRegion>Anhui 230032</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<affiliation><nlm:aff id="af1-ijmm-45-01-0103">School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-ijmm-45-01-0103">The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education</nlm:aff>
<wicri:noCountry code="subfield">Ministry of Education</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-ijmm-45-01-0103">Institute for Liver Diseases of Anhui Medical University</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4-ijmm-45-01-0103">Anhui Institute of Innovative Drugs, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31746414</idno>
<idno type="pmc">6889929</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889929</idno>
<idno type="RBID">PMC:6889929</idno>
<idno type="doi">10.3892/ijmm.2019.4395</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000601</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000601</idno>
<idno type="wicri:Area/Pmc/Curation">000601</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000601</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000602</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000602</idno>
<idno type="wicri:Area/Ncbi/Merge">000C27</idno>
<idno type="wicri:Area/Ncbi/Curation">000C27</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000C27</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling</title>
<author><name sortKey="Wu, Bao Ming" sort="Wu, Bao Ming" uniqKey="Wu B" first="Bao-Ming" last="Wu">Bao-Ming Wu</name>
<affiliation><nlm:aff id="af1-ijmm-45-01-0103">School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-ijmm-45-01-0103">The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education</nlm:aff>
<wicri:noCountry code="subfield">Ministry of Education</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-ijmm-45-01-0103">Institute for Liver Diseases of Anhui Medical University</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4-ijmm-45-01-0103">Anhui Institute of Innovative Drugs, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Liu, Jun Da" sort="Liu, Jun Da" uniqKey="Liu J" first="Jun-Da" last="Liu">Jun-Da Liu</name>
<affiliation><nlm:aff id="af1-ijmm-45-01-0103">School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-ijmm-45-01-0103">The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education</nlm:aff>
<wicri:noCountry code="subfield">Ministry of Education</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-ijmm-45-01-0103">Institute for Liver Diseases of Anhui Medical University</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4-ijmm-45-01-0103">Anhui Institute of Innovative Drugs, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af5-ijmm-45-01-0103">The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032</wicri:regionArea>
<wicri:noRegion>Anhui 230032</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Yuan Hai" sort="Li, Yuan Hai" uniqKey="Li Y" first="Yuan-Hai" last="Li">Yuan-Hai Li</name>
<affiliation><nlm:aff id="af1-ijmm-45-01-0103">School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-ijmm-45-01-0103">The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education</nlm:aff>
<wicri:noCountry code="subfield">Ministry of Education</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-ijmm-45-01-0103">Institute for Liver Diseases of Anhui Medical University</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4-ijmm-45-01-0103">Anhui Institute of Innovative Drugs, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af5-ijmm-45-01-0103">The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032</wicri:regionArea>
<wicri:noRegion>Anhui 230032</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<affiliation><nlm:aff id="af1-ijmm-45-01-0103">School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-ijmm-45-01-0103">The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education</nlm:aff>
<wicri:noCountry code="subfield">Ministry of Education</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-ijmm-45-01-0103">Institute for Liver Diseases of Anhui Medical University</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4-ijmm-45-01-0103">Anhui Institute of Innovative Drugs, Anhui Medical University</nlm:aff>
<wicri:noCountry code="subfield">Anhui Medical University</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">International Journal of Molecular Medicine</title>
<idno type="ISSN">1107-3756</idno>
<idno type="eISSN">1791-244X</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>A number of macrophage phenotypes have been previously identified as crucial regulators in the progression of hepatic fibrosis (HF). Cytokines from macrophages or Kupffer cells (KCs) have also been identified to be important regulators in HF. Blocking Kv1.3 in models of HF, regulating macrophage polarization and cytokine secretion have not yet been assessed as potential treatments options for this condition. In the current study, a model of carbon tetrachloride (CCl4)-induced HF was established and examined the effects of margatoxin (MgTX; an inhibitor of Kv1.3) on HF. Hematoxylin and eosin, Masson's trichrome and immunohistochemistry staining were performed to determine whether MgTX can alleviate liver fibrosis. To elucidate the mechanisms through which MgTX attenuates liver injury, reverse transcription-quantitative PCR and western blot analysis were used to detect polarized macrophage markers in RAW264.7 cells and cytokines were examined using ELISA. Furthermore, macrophage polarization signal transducer and activator of transcription (STAT) signaling, which is associated with macrophage polarization, was identified in RAW264.7 cells. The results revealed that MgTX protected the mice from CCl4-induced liver fibrosis. Furthermore, MgTX decreased the expression of M1 phenotype biomarkers, and increased the expression of M2 phenotype biomarkers in CCl4-induced HF. Additionally, the production of pro-inflammatory cytokines was decreased and interleukin-10 production was increased in the serum of mice with HF injected with MgTX. Furthermore, MgTX was found to regulate the expression of M1 markers by suppressing p-STAT1 activity and increasing the expression of M2 markers by promoting p-STAT6 activity. On the whole, the findings of this study demonstrate that MgTX is able to alleviate CCl4-induced HF in mice, possibly via macrophage polarization, cytokine secretion and STAT signaling.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mederacke, I" uniqKey="Mederacke I">I Mederacke</name>
</author>
<author><name sortKey="Hsu, Cc" uniqKey="Hsu C">CC Hsu</name>
</author>
<author><name sortKey="Troeger, Js" uniqKey="Troeger J">JS Troeger</name>
</author>
<author><name sortKey="Huebener, P" uniqKey="Huebener P">P Huebener</name>
</author>
<author><name sortKey="Mu, X" uniqKey="Mu X">X Mu</name>
</author>
<author><name sortKey="Dapito, Dh" uniqKey="Dapito D">DH Dapito</name>
</author>
<author><name sortKey="Pradere, Jp" uniqKey="Pradere J">JP Pradere</name>
</author>
<author><name sortKey="Schwabe, Rf" uniqKey="Schwabe R">RF Schwabe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zheng, Z" uniqKey="Zheng Z">Z Zheng</name>
</author>
<author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Wang, A" uniqKey="Wang A">A Wang</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name>
</author>
<author><name sortKey="Huttemann, M" uniqKey="Huttemann M">M Hüttemann</name>
</author>
<author><name sortKey="Grossman, Li" uniqKey="Grossman L">LI Grossman</name>
</author>
<author><name sortKey="Chen, Lc" uniqKey="Chen L">LC Chen</name>
</author>
<author><name sortKey="Rajagopalan, S" uniqKey="Rajagopalan S">S Rajagopalan</name>
</author>
<author><name sortKey="Sun, Q" uniqKey="Sun Q">Q Sun</name>
</author>
<author><name sortKey="Zhang, K" uniqKey="Zhang K">K Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Czaja, Aj" uniqKey="Czaja A">AJ Czaja</name>
</author>
<author><name sortKey="Carpenter, Ha" uniqKey="Carpenter H">HA Carpenter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schuppan, D" uniqKey="Schuppan D">D Schuppan</name>
</author>
<author><name sortKey="Kim, Yo" uniqKey="Kim Y">YO Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duffield, Js" uniqKey="Duffield J">JS Duffield</name>
</author>
<author><name sortKey="Forbes, Sj" uniqKey="Forbes S">SJ Forbes</name>
</author>
<author><name sortKey="Constandinou, Cm" uniqKey="Constandinou C">CM Constandinou</name>
</author>
<author><name sortKey="Clay, S" uniqKey="Clay S">S Clay</name>
</author>
<author><name sortKey="Partolina, M" uniqKey="Partolina M">M Partolina</name>
</author>
<author><name sortKey="Vuthoori, S" uniqKey="Vuthoori S">S Vuthoori</name>
</author>
<author><name sortKey="Wu, S" uniqKey="Wu S">S Wu</name>
</author>
<author><name sortKey="Lang, R" uniqKey="Lang R">R Lang</name>
</author>
<author><name sortKey="Iredale, Jp" uniqKey="Iredale J">JP Iredale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramachandran, P" uniqKey="Ramachandran P">P Ramachandran</name>
</author>
<author><name sortKey="Iredale, Jp" uniqKey="Iredale J">JP Iredale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chawla, A" uniqKey="Chawla A">A Chawla</name>
</author>
<author><name sortKey="Nguyen, Kd" uniqKey="Nguyen K">KD Nguyen</name>
</author>
<author><name sortKey="Goh, Yp" uniqKey="Goh Y">YP Goh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mosser, Dm" uniqKey="Mosser D">DM Mosser</name>
</author>
<author><name sortKey="Edwards, Jp" uniqKey="Edwards J">JP Edwards</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gundra, Um" uniqKey="Gundra U">UM Gundra</name>
</author>
<author><name sortKey="Girgis, Nm" uniqKey="Girgis N">NM Girgis</name>
</author>
<author><name sortKey="Gonzalez, Ma" uniqKey="Gonzalez M">MA Gonzalez</name>
</author>
<author><name sortKey="San Tang, M" uniqKey="San Tang M">M San Tang</name>
</author>
<author><name sortKey="Van Der Zande, Hjp" uniqKey="Van Der Zande H">HJP Van Der Zande</name>
</author>
<author><name sortKey="Lin, Jd" uniqKey="Lin J">JD Lin</name>
</author>
<author><name sortKey="Ouimet, M" uniqKey="Ouimet M">M Ouimet</name>
</author>
<author><name sortKey="Ma, Lj" uniqKey="Ma L">LJ Ma</name>
</author>
<author><name sortKey="Poles, J" uniqKey="Poles J">J Poles</name>
</author>
<author><name sortKey="Vozhilla, N" uniqKey="Vozhilla N">N Vozhilla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Borthwick, La" uniqKey="Borthwick L">LA Borthwick</name>
</author>
<author><name sortKey="Suwara, Mi" uniqKey="Suwara M">MI Suwara</name>
</author>
<author><name sortKey="Carnell, Sc" uniqKey="Carnell S">SC Carnell</name>
</author>
<author><name sortKey="Green, Nj" uniqKey="Green N">NJ Green</name>
</author>
<author><name sortKey="Mahida, R" uniqKey="Mahida R">R Mahida</name>
</author>
<author><name sortKey="Dixon, D" uniqKey="Dixon D">D Dixon</name>
</author>
<author><name sortKey="Gillespie, Cs" uniqKey="Gillespie C">CS Gillespie</name>
</author>
<author><name sortKey="Cartwright, Tn" uniqKey="Cartwright T">TN Cartwright</name>
</author>
<author><name sortKey="Horabin, J" uniqKey="Horabin J">J Horabin</name>
</author>
<author><name sortKey="Walker, A" uniqKey="Walker A">A Walker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gordon, S" uniqKey="Gordon S">S Gordon</name>
</author>
<author><name sortKey="Martinez, Fo" uniqKey="Martinez F">FO Martinez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murray, Pj" uniqKey="Murray P">PJ Murray</name>
</author>
<author><name sortKey="Allen, Je" uniqKey="Allen J">JE Allen</name>
</author>
<author><name sortKey="Biswas, Sk" uniqKey="Biswas S">SK Biswas</name>
</author>
<author><name sortKey="Fisher, Ea" uniqKey="Fisher E">EA Fisher</name>
</author>
<author><name sortKey="Gilroy, Dw" uniqKey="Gilroy D">DW Gilroy</name>
</author>
<author><name sortKey="Goerdt, S" uniqKey="Goerdt S">S Goerdt</name>
</author>
<author><name sortKey="Gordon, S" uniqKey="Gordon S">S Gordon</name>
</author>
<author><name sortKey="Hamilton, Ja" uniqKey="Hamilton J">JA Hamilton</name>
</author>
<author><name sortKey="Ivashkiv, Lb" uniqKey="Ivashkiv L">LB Ivashkiv</name>
</author>
<author><name sortKey="Lawrence, T" uniqKey="Lawrence T">T Lawrence</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sica, A" uniqKey="Sica A">A Sica</name>
</author>
<author><name sortKey="Invernizzi, P" uniqKey="Invernizzi P">P Invernizzi</name>
</author>
<author><name sortKey="Mantovani, A" uniqKey="Mantovani A">A Mantovani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heymann, F" uniqKey="Heymann F">F Heymann</name>
</author>
<author><name sortKey="Trautwein, C" uniqKey="Trautwein C">C Trautwein</name>
</author>
<author><name sortKey="Tacke, F" uniqKey="Tacke F">F Tacke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murray, Pj" uniqKey="Murray P">PJ Murray</name>
</author>
<author><name sortKey="Wynn, Ta" uniqKey="Wynn T">TA Wynn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chiaramonte, Mg" uniqKey="Chiaramonte M">MG Chiaramonte</name>
</author>
<author><name sortKey="Donaldson, Dd" uniqKey="Donaldson D">DD Donaldson</name>
</author>
<author><name sortKey="Cheever, Aw" uniqKey="Cheever A">AW Cheever</name>
</author>
<author><name sortKey="Wynn, Ta" uniqKey="Wynn T">TA Wynn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaviratne, M" uniqKey="Kaviratne M">M Kaviratne</name>
</author>
<author><name sortKey="Hesse, M" uniqKey="Hesse M">M Hesse</name>
</author>
<author><name sortKey="Leusink, M" uniqKey="Leusink M">M Leusink</name>
</author>
<author><name sortKey="Cheever, Aw" uniqKey="Cheever A">AW Cheever</name>
</author>
<author><name sortKey="Davies, Sj" uniqKey="Davies S">SJ Davies</name>
</author>
<author><name sortKey="Mckerrow, Jh" uniqKey="Mckerrow J">JH McKerrow</name>
</author>
<author><name sortKey="Wakefield, Lm" uniqKey="Wakefield L">LM Wakefield</name>
</author>
<author><name sortKey="Letterio, Jj" uniqKey="Letterio J">JJ Letterio</name>
</author>
<author><name sortKey="Wynn, Ta" uniqKey="Wynn T">TA Wynn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mckenzie, Gj" uniqKey="Mckenzie G">GJ McKenzie</name>
</author>
<author><name sortKey="Bancroft, A" uniqKey="Bancroft A">A Bancroft</name>
</author>
<author><name sortKey="Grencis, Rk" uniqKey="Grencis R">RK Grencis</name>
</author>
<author><name sortKey="Mckenzie, An" uniqKey="Mckenzie A">AN McKenzie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mckenzie, Gj" uniqKey="Mckenzie G">GJ McKenzie</name>
</author>
<author><name sortKey="Fallon, Pg" uniqKey="Fallon P">PG Fallon</name>
</author>
<author><name sortKey="Emson, Cl" uniqKey="Emson C">CL Emson</name>
</author>
<author><name sortKey="Grencis, Rk" uniqKey="Grencis R">RK Grencis</name>
</author>
<author><name sortKey="Mckenzie, An" uniqKey="Mckenzie A">AN McKenzie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mackenzie, Ab" uniqKey="Mackenzie A">AB Mackenzie</name>
</author>
<author><name sortKey="Chirakkal, H" uniqKey="Chirakkal H">H Chirakkal</name>
</author>
<author><name sortKey="North, Ra" uniqKey="North R">RA North</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kazama, I" uniqKey="Kazama I">I Kazama</name>
</author>
<author><name sortKey="Maruyama, Y" uniqKey="Maruyama Y">Y Maruyama</name>
</author>
<author><name sortKey="Murata, Y" uniqKey="Murata Y">Y Murata</name>
</author>
<author><name sortKey="Sano, M" uniqKey="Sano M">M Sano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toldi, G" uniqKey="Toldi G">G Toldi</name>
</author>
<author><name sortKey="Bajnok, A" uniqKey="Bajnok A">A Bajnok</name>
</author>
<author><name sortKey="Dobi, D" uniqKey="Dobi D">D Dobi</name>
</author>
<author><name sortKey="Kaposi, A" uniqKey="Kaposi A">A Kaposi</name>
</author>
<author><name sortKey="Kovacs, L" uniqKey="Kovacs L">L Kovács</name>
</author>
<author><name sortKey="Vasarhelyi, B" uniqKey="Vasarhelyi B">B Vásárhelyi</name>
</author>
<author><name sortKey="Balog, A" uniqKey="Balog A">A Balog</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beeton, C" uniqKey="Beeton C">C Beeton</name>
</author>
<author><name sortKey="Wulff, H" uniqKey="Wulff H">H Wulff</name>
</author>
<author><name sortKey="Standifer, Ne" uniqKey="Standifer N">NE Standifer</name>
</author>
<author><name sortKey="Azam, P" uniqKey="Azam P">P Azam</name>
</author>
<author><name sortKey="Mullen, Km" uniqKey="Mullen K">KM Mullen</name>
</author>
<author><name sortKey="Pennington, Mw" uniqKey="Pennington M">MW Pennington</name>
</author>
<author><name sortKey="Kolski Andreaco, A" uniqKey="Kolski Andreaco A">A Kolski-Andreaco</name>
</author>
<author><name sortKey="Wei, E" uniqKey="Wei E">E Wei</name>
</author>
<author><name sortKey="Grino, A" uniqKey="Grino A">A Grino</name>
</author>
<author><name sortKey="Counts, Dr" uniqKey="Counts D">DR Counts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chi, V" uniqKey="Chi V">V Chi</name>
</author>
<author><name sortKey="Pennington, Mw" uniqKey="Pennington M">MW Pennington</name>
</author>
<author><name sortKey="Norton, Rs" uniqKey="Norton R">RS Norton</name>
</author>
<author><name sortKey="Tarcha, Ej" uniqKey="Tarcha E">EJ Tarcha</name>
</author>
<author><name sortKey="Londono, Lm" uniqKey="Londono L">LM Londono</name>
</author>
<author><name sortKey="Sims Fahey, B" uniqKey="Sims Fahey B">B Sims-Fahey</name>
</author>
<author><name sortKey="Upadhyay, Sk" uniqKey="Upadhyay S">SK Upadhyay</name>
</author>
<author><name sortKey="Lakey, Jt" uniqKey="Lakey J">JT Lakey</name>
</author>
<author><name sortKey="Iadonato, S" uniqKey="Iadonato S">S Iadonato</name>
</author>
<author><name sortKey="Wulff, H" uniqKey="Wulff H">H Wulff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kazama, I" uniqKey="Kazama I">I Kazama</name>
</author>
<author><name sortKey="Maruyama, Y" uniqKey="Maruyama Y">Y Maruyama</name>
</author>
<author><name sortKey="Endo, Y" uniqKey="Endo Y">Y Endo</name>
</author>
<author><name sortKey="Toyama, H" uniqKey="Toyama H">H Toyama</name>
</author>
<author><name sortKey="Ejima, Y" uniqKey="Ejima Y">Y Ejima</name>
</author>
<author><name sortKey="Matsubara, M" uniqKey="Matsubara M">M Matsubara</name>
</author>
<author><name sortKey="Kurosawa, S" uniqKey="Kurosawa S">S Kurosawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shao, Pp" uniqKey="Shao P">PP Shao</name>
</author>
<author><name sortKey="Liu, Cj" uniqKey="Liu C">CJ Liu</name>
</author>
<author><name sortKey="Xu, Q" uniqKey="Xu Q">Q Xu</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name>
</author>
<author><name sortKey="Li, Sh" uniqKey="Li S">SH Li</name>
</author>
<author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name>
</author>
<author><name sortKey="Sun, Z" uniqKey="Sun Z">Z Sun</name>
</author>
<author><name sortKey="Cheng, Lf" uniqKey="Cheng L">LF Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moreno, C" uniqKey="Moreno C">C Moreno</name>
</author>
<author><name sortKey="Prieto, P" uniqKey="Prieto P">P Prieto</name>
</author>
<author><name sortKey="Macias, A" uniqKey="Macias A">Á Macías</name>
</author>
<author><name sortKey="Pimentel Santillana, M" uniqKey="Pimentel Santillana M">M Pimentel-Santillana</name>
</author>
<author><name sortKey="De La Cruz, A" uniqKey="De La Cruz A">A de la Cruz</name>
</author>
<author><name sortKey="Traves, Pg" uniqKey="Traves P">PG Través</name>
</author>
<author><name sortKey="Bosca, L" uniqKey="Bosca L">L Boscá</name>
</author>
<author><name sortKey="Valenzuela, C" uniqKey="Valenzuela C">C Valenzuela</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name>
</author>
<author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Wu, Xq" uniqKey="Wu X">XQ Wu</name>
</author>
<author><name sortKey="Li, Wx" uniqKey="Li W">WX Li</name>
</author>
<author><name sortKey="Huang, Hm" uniqKey="Huang H">HM Huang</name>
</author>
<author><name sortKey="Li, Hd" uniqKey="Li H">HD Li</name>
</author>
<author><name sortKey="Pan, Xy" uniqKey="Pan X">XY Pan</name>
</author>
<author><name sortKey="Li, Xf" uniqKey="Li X">XF Li</name>
</author>
<author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name>
</author>
<author><name sortKey="Meng, Xm" uniqKey="Meng X">XM Meng</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bitto, N" uniqKey="Bitto N">N Bitto</name>
</author>
<author><name sortKey="Liguori, E" uniqKey="Liguori E">E Liguori</name>
</author>
<author><name sortKey="La Mura, V" uniqKey="La Mura V">V La Mura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Kk" uniqKey="Wang K">KK Wang</name>
</author>
<author><name sortKey="Czaja, Aj" uniqKey="Czaja A">AJ Czaja</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nishiguchi, S" uniqKey="Nishiguchi S">S Nishiguchi</name>
</author>
<author><name sortKey="Kuroki, T" uniqKey="Kuroki T">T Kuroki</name>
</author>
<author><name sortKey="Nakatani, S" uniqKey="Nakatani S">S Nakatani</name>
</author>
<author><name sortKey="Morimoto, H" uniqKey="Morimoto H">H Morimoto</name>
</author>
<author><name sortKey="Takeda, T" uniqKey="Takeda T">T Takeda</name>
</author>
<author><name sortKey="Nakajima, S" uniqKey="Nakajima S">S Nakajima</name>
</author>
<author><name sortKey="Shiomi, S" uniqKey="Shiomi S">S Shiomi</name>
</author>
<author><name sortKey="Seki, S" uniqKey="Seki S">S Seki</name>
</author>
<author><name sortKey="Kobayashi, K" uniqKey="Kobayashi K">K Kobayashi</name>
</author>
<author><name sortKey="Otani, S" uniqKey="Otani S">S Otani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roberts, Sk" uniqKey="Roberts S">SK Roberts</name>
</author>
<author><name sortKey="Therneau, Tm" uniqKey="Therneau T">TM Therneau</name>
</author>
<author><name sortKey="Czaja, Aj" uniqKey="Czaja A">AJ Czaja</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singal, Ag" uniqKey="Singal A">AG Singal</name>
</author>
<author><name sortKey="Volk, Ml" uniqKey="Volk M">ML Volk</name>
</author>
<author><name sortKey="Jensen, D" uniqKey="Jensen D">D Jensen</name>
</author>
<author><name sortKey="Di Bisceglie, Am" uniqKey="Di Bisceglie A">AM Di Bisceglie</name>
</author>
<author><name sortKey="Schoenfeld, Ps" uniqKey="Schoenfeld P">PS Schoenfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lok, As" uniqKey="Lok A">AS Lok</name>
</author>
<author><name sortKey="Everhart, Je" uniqKey="Everhart J">JE Everhart</name>
</author>
<author><name sortKey="Wright, Ec" uniqKey="Wright E">EC Wright</name>
</author>
<author><name sortKey="Di Bisceglie, Am" uniqKey="Di Bisceglie A">AM Di Bisceglie</name>
</author>
<author><name sortKey="Kim, Hy" uniqKey="Kim H">HY Kim</name>
</author>
<author><name sortKey="Sterling, Rk" uniqKey="Sterling R">RK Sterling</name>
</author>
<author><name sortKey="Everson, Gt" uniqKey="Everson G">GT Everson</name>
</author>
<author><name sortKey="Lindsay, Kl" uniqKey="Lindsay K">KL Lindsay</name>
</author>
<author><name sortKey="Lee, Wm" uniqKey="Lee W">WM Lee</name>
</author>
<author><name sortKey="Bonkovsky, Hl" uniqKey="Bonkovsky H">HL Bonkovsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bruix, J" uniqKey="Bruix J">J Bruix</name>
</author>
<author><name sortKey="Poynard, T" uniqKey="Poynard T">T Poynard</name>
</author>
<author><name sortKey="Colombo, M" uniqKey="Colombo M">M Colombo</name>
</author>
<author><name sortKey="Schiff, E" uniqKey="Schiff E">E Schiff</name>
</author>
<author><name sortKey="Burak, K" uniqKey="Burak K">K Burak</name>
</author>
<author><name sortKey="Heathcote, Ej" uniqKey="Heathcote E">EJ Heathcote</name>
</author>
<author><name sortKey="Berg, T" uniqKey="Berg T">T Berg</name>
</author>
<author><name sortKey="Poo, Jl" uniqKey="Poo J">JL Poo</name>
</author>
<author><name sortKey="Mello, Cb" uniqKey="Mello C">CB Mello</name>
</author>
<author><name sortKey="Guenther, R" uniqKey="Guenther R">R Guenther</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krenkel, O" uniqKey="Krenkel O">O Krenkel</name>
</author>
<author><name sortKey="Tacke, F" uniqKey="Tacke F">F Tacke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seki, E" uniqKey="Seki E">E Seki</name>
</author>
<author><name sortKey="Schwabe, Rf" uniqKey="Schwabe R">RF Schwabe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baeck, C" uniqKey="Baeck C">C Baeck</name>
</author>
<author><name sortKey="Wei, X" uniqKey="Wei X">X Wei</name>
</author>
<author><name sortKey="Bartneck, M" uniqKey="Bartneck M">M Bartneck</name>
</author>
<author><name sortKey="Fech, V" uniqKey="Fech V">V Fech</name>
</author>
<author><name sortKey="Heymann, F" uniqKey="Heymann F">F Heymann</name>
</author>
<author><name sortKey="Gassler, N" uniqKey="Gassler N">N Gassler</name>
</author>
<author><name sortKey="Hittatiya, K" uniqKey="Hittatiya K">K Hittatiya</name>
</author>
<author><name sortKey="Eulberg, D" uniqKey="Eulberg D">D Eulberg</name>
</author>
<author><name sortKey="Luedde, T" uniqKey="Luedde T">T Luedde</name>
</author>
<author><name sortKey="Trautwein, C" uniqKey="Trautwein C">C Trautwein</name>
</author>
<author><name sortKey="Tacke, F" uniqKey="Tacke F">F Tacke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramachandran, P" uniqKey="Ramachandran P">P Ramachandran</name>
</author>
<author><name sortKey="Pellicoro, A" uniqKey="Pellicoro A">A Pellicoro</name>
</author>
<author><name sortKey="Vernon, Ma" uniqKey="Vernon M">MA Vernon</name>
</author>
<author><name sortKey="Boulter, L" uniqKey="Boulter L">L Boulter</name>
</author>
<author><name sortKey="Aucott, Rl" uniqKey="Aucott R">RL Aucott</name>
</author>
<author><name sortKey="Ali, A" uniqKey="Ali A">A Ali</name>
</author>
<author><name sortKey="Hartland, Sn" uniqKey="Hartland S">SN Hartland</name>
</author>
<author><name sortKey="Snowdon, Vk" uniqKey="Snowdon V">VK Snowdon</name>
</author>
<author><name sortKey="Cappon, A" uniqKey="Cappon A">A Cappon</name>
</author>
<author><name sortKey="Gordon Walker, Tt" uniqKey="Gordon Walker T">TT Gordon-Walker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Madala, Sk" uniqKey="Madala S">SK Madala</name>
</author>
<author><name sortKey="Pesce, Jt" uniqKey="Pesce J">JT Pesce</name>
</author>
<author><name sortKey="Ramalingam, Tr" uniqKey="Ramalingam T">TR Ramalingam</name>
</author>
<author><name sortKey="Wilson, Ms" uniqKey="Wilson M">MS Wilson</name>
</author>
<author><name sortKey="Minnicozzi, S" uniqKey="Minnicozzi S">S Minnicozzi</name>
</author>
<author><name sortKey="Cheever, Aw" uniqKey="Cheever A">AW Cheever</name>
</author>
<author><name sortKey="Thompson, Rw" uniqKey="Thompson R">RW Thompson</name>
</author>
<author><name sortKey="Mentink Kane, Mm" uniqKey="Mentink Kane M">MM Mentink-Kane</name>
</author>
<author><name sortKey="Wynn, Ta" uniqKey="Wynn T">TA Wynn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Conway, Sj" uniqKey="Conway S">SJ Conway</name>
</author>
<author><name sortKey="Izuhara, K" uniqKey="Izuhara K">K Izuhara</name>
</author>
<author><name sortKey="Kudo, Y" uniqKey="Kudo Y">Y Kudo</name>
</author>
<author><name sortKey="Litvin, J" uniqKey="Litvin J">J Litvin</name>
</author>
<author><name sortKey="Markwald, R" uniqKey="Markwald R">R Markwald</name>
</author>
<author><name sortKey="Ouyang, G" uniqKey="Ouyang G">G Ouyang</name>
</author>
<author><name sortKey="Arron, Jr" uniqKey="Arron J">JR Arron</name>
</author>
<author><name sortKey="Holweg, Ct" uniqKey="Holweg C">CT Holweg</name>
</author>
<author><name sortKey="Kudo, A" uniqKey="Kudo A">A Kudo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mosher, Df" uniqKey="Mosher D">DF Mosher</name>
</author>
<author><name sortKey="Johansson, Mw" uniqKey="Johansson M">MW Johansson</name>
</author>
<author><name sortKey="Gillis, Me" uniqKey="Gillis M">ME Gillis</name>
</author>
<author><name sortKey="Annis, Ds" uniqKey="Annis D">DS Annis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Xa" uniqKey="Zhao X">XA Zhao</name>
</author>
<author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name>
</author>
<author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name>
</author>
<author><name sortKey="Xiong, Y" uniqKey="Xiong Y">Y Xiong</name>
</author>
<author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
<author><name sortKey="Jia, B" uniqKey="Jia B">B Jia</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Xia, J" uniqKey="Xia J">J Xia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eder, C" uniqKey="Eder C">C Eder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rutar, M" uniqKey="Rutar M">M Rutar</name>
</author>
<author><name sortKey="Natoli, R" uniqKey="Natoli R">R Natoli</name>
</author>
<author><name sortKey="Provis, Jm" uniqKey="Provis J">JM Provis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pellicoro, A" uniqKey="Pellicoro A">A Pellicoro</name>
</author>
<author><name sortKey="Ramachandran, P" uniqKey="Ramachandran P">P Ramachandran</name>
</author>
<author><name sortKey="Iredale, Jp" uniqKey="Iredale J">JP Iredale</name>
</author>
<author><name sortKey="Fallowfield, Ja" uniqKey="Fallowfield J">JA Fallowfield</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kruglov, Ea" uniqKey="Kruglov E">EA Kruglov</name>
</author>
<author><name sortKey="Nathanson, Ra" uniqKey="Nathanson R">RA Nathanson</name>
</author>
<author><name sortKey="Nguyen, T" uniqKey="Nguyen T">T Nguyen</name>
</author>
<author><name sortKey="Dranoff, Ja" uniqKey="Dranoff J">JA Dranoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rockey, Dc" uniqKey="Rockey D">DC Rockey</name>
</author>
<author><name sortKey="Bell, Pd" uniqKey="Bell P">PD Bell</name>
</author>
<author><name sortKey="Hill, Ja" uniqKey="Hill J">JA Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chiu, Ys" uniqKey="Chiu Y">YS Chiu</name>
</author>
<author><name sortKey="Wei, Cc" uniqKey="Wei C">CC Wei</name>
</author>
<author><name sortKey="Lin, Yj" uniqKey="Lin Y">YJ Lin</name>
</author>
<author><name sortKey="Hsu, Yh" uniqKey="Hsu Y">YH Hsu</name>
</author>
<author><name sortKey="Chang, Ms" uniqKey="Chang M">MS Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sziksz, E" uniqKey="Sziksz E">E Sziksz</name>
</author>
<author><name sortKey="Pap, D" uniqKey="Pap D">D Pap</name>
</author>
<author><name sortKey="Lippai, R" uniqKey="Lippai R">R Lippai</name>
</author>
<author><name sortKey="Beres, Nj" uniqKey="Beres N">NJ Béres</name>
</author>
<author><name sortKey="Fekete, A" uniqKey="Fekete A">A Fekete</name>
</author>
<author><name sortKey="Szab, Aj" uniqKey="Szab A">AJ Szabó</name>
</author>
<author><name sortKey="Vannay, A" uniqKey="Vannay A">Á Vannay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galastri, S" uniqKey="Galastri S">S Galastri</name>
</author>
<author><name sortKey="Zamara, E" uniqKey="Zamara E">E Zamara</name>
</author>
<author><name sortKey="Milani, S" uniqKey="Milani S">S Milani</name>
</author>
<author><name sortKey="Novo, E" uniqKey="Novo E">E Novo</name>
</author>
<author><name sortKey="Provenzano, A" uniqKey="Provenzano A">A Provenzano</name>
</author>
<author><name sortKey="Delogu, W" uniqKey="Delogu W">W Delogu</name>
</author>
<author><name sortKey="Vizzutti, F" uniqKey="Vizzutti F">F Vizzutti</name>
</author>
<author><name sortKey="Sutti, S" uniqKey="Sutti S">S Sutti</name>
</author>
<author><name sortKey="Locatelli, I" uniqKey="Locatelli I">I Locatelli</name>
</author>
<author><name sortKey="Navari, N" uniqKey="Navari N">N Navari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khan, Z" uniqKey="Khan Z">Z Khan</name>
</author>
<author><name sortKey="Cao, Dy" uniqKey="Cao D">DY Cao</name>
</author>
<author><name sortKey="Giani, Jf" uniqKey="Giani J">JF Giani</name>
</author>
<author><name sortKey="Bernstein, Ea" uniqKey="Bernstein E">EA Bernstein</name>
</author>
<author><name sortKey="Veiras, Lc" uniqKey="Veiras L">LC Veiras</name>
</author>
<author><name sortKey="Fuchs, S" uniqKey="Fuchs S">S Fuchs</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Peng, Z" uniqKey="Peng Z">Z Peng</name>
</author>
<author><name sortKey="Kalkum, M" uniqKey="Kalkum M">M Kalkum</name>
</author>
<author><name sortKey="Liu, Gy" uniqKey="Liu G">GY Liu</name>
</author>
<author><name sortKey="Bernstein, Ke" uniqKey="Bernstein K">KE Bernstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, N" uniqKey="Ding N">N Ding</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Dou, C" uniqKey="Dou C">C Dou</name>
</author>
<author><name sortKey="Liu, F" uniqKey="Liu F">F Liu</name>
</author>
<author><name sortKey="Guan, G" uniqKey="Guan G">G Guan</name>
</author>
<author><name sortKey="Wei, K" uniqKey="Wei K">K Wei</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name>
</author>
<author><name sortKey="Yang, M" uniqKey="Yang M">M Yang</name>
</author>
<author><name sortKey="Tan, J" uniqKey="Tan J">J Tan</name>
</author>
<author><name sortKey="Zeng, W" uniqKey="Zeng W">W Zeng</name>
</author>
<author><name sortKey="Zhu, C" uniqKey="Zhu C">C Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Darnell, Je" uniqKey="Darnell J">JE Darnell</name>
</author>
<author><name sortKey="Kerr, Im" uniqKey="Kerr I">IM Kerr</name>
</author>
<author><name sortKey="Stark, Gr" uniqKey="Stark G">GR Stark</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herbert, Dr" uniqKey="Herbert D">DR Herbert</name>
</author>
<author><name sortKey="Holscher, C" uniqKey="Holscher C">C Hölscher</name>
</author>
<author><name sortKey="Mohrs, M" uniqKey="Mohrs M">M Mohrs</name>
</author>
<author><name sortKey="Arendse, B" uniqKey="Arendse B">B Arendse</name>
</author>
<author><name sortKey="Schwegmann, A" uniqKey="Schwegmann A">A Schwegmann</name>
</author>
<author><name sortKey="Radwanska, M" uniqKey="Radwanska M">M Radwanska</name>
</author>
<author><name sortKey="Leeto, M" uniqKey="Leeto M">M Leeto</name>
</author>
<author><name sortKey="Kirsch, R" uniqKey="Kirsch R">R Kirsch</name>
</author>
<author><name sortKey="Hall, P" uniqKey="Hall P">P Hall</name>
</author>
<author><name sortKey="Mossmann, H" uniqKey="Mossmann H">H Mossmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brombacher, F" uniqKey="Brombacher F">F Brombacher</name>
</author>
<author><name sortKey="Arendse, B" uniqKey="Arendse B">B Arendse</name>
</author>
<author><name sortKey="Peterson, R" uniqKey="Peterson R">R Peterson</name>
</author>
<author><name sortKey="Holscher, A" uniqKey="Holscher A">A Hölscher</name>
</author>
<author><name sortKey="Holscher, C" uniqKey="Holscher C">C Hölscher</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><noCountry><name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<name sortKey="Wu, Bao Ming" sort="Wu, Bao Ming" uniqKey="Wu B" first="Bao-Ming" last="Wu">Bao-Ming Wu</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Liu, Jun Da" sort="Liu, Jun Da" uniqKey="Liu J" first="Jun-Da" last="Liu">Jun-Da Liu</name>
</noRegion>
<name sortKey="Li, Yuan Hai" sort="Li, Yuan Hai" uniqKey="Li Y" first="Yuan-Hai" last="Li">Yuan-Hai Li</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C27 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000C27 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:6889929 |texte= Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:31746414" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |