Transferrin-targeting redox hyperbranched poly(amido amine)-functionalized graphene oxide for sensitized chemotherapy combined with gene therapy to nasopharyngeal carcinoma
Identifieur interne : 000843 ( Ncbi/Checkpoint ); précédent : 000842; suivant : 000844Transferrin-targeting redox hyperbranched poly(amido amine)-functionalized graphene oxide for sensitized chemotherapy combined with gene therapy to nasopharyngeal carcinoma
Auteurs : Tao Liu [République populaire de Chine] ; Jingzhen Li [République populaire de Chine] ; Xidong Wu [République populaire de Chine] ; Siyi Zhang [République populaire de Chine] ; Zhongming Lu [République populaire de Chine] ; Guanxue Li [République populaire de Chine] ; Junzheng Li [République populaire de Chine] ; Shaohua Chen [République populaire de Chine]Source :
- Drug Delivery [ 1071-7544 ] ; 2019.
Abstract
A drug and gene co-delivery system with chemotherapeutic sensibilization was prepared and used for nasopharyngeal carcinoma therapy. For this purpose, the graphene oxide (GO) was conjugated with the redox hyperbranched poly(amido amine) (HPAA) and then the targeting molecule, transferrin (Tf), was also conjugated. The obtained Tf-HPAA-GO could co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid (pMMP-9) effectively and showed the targeting effect to HNE-1 cells. The co-delivery system showed the effective drug and gene delivery ability with high cytotoxicity and gene transfection efficiency. Besides that, Tf-HPAA-GO/DOC also showed the chemotherapeutic sensibilization effect, the formulation containing HPAA segments showed much higher cytotoxicity than free DOC. Benefiting from the sensibilization effect and DOC/pMMP-9 co-delivery strategy, this Tf-HPAA-GO/DOC/pMMP-9 co-delivery system exhibited the significantly improved therapeutic efficacy to HNE-1 tumor in a combined manner which was confirmed by
Url:
DOI: 10.1080/10717544.2019.1642421
PubMed: 31340676
PubMed Central: 6711081
Affiliations:
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<series><title level="j">Drug Delivery</title>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>A drug and gene co-delivery system with chemotherapeutic sensibilization was prepared and used for nasopharyngeal carcinoma therapy. For this purpose, the graphene oxide (GO) was conjugated with the redox hyperbranched poly(amido amine) (HPAA) and then the targeting molecule, transferrin (Tf), was also conjugated. The obtained Tf-HPAA-GO could co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid (pMMP-9) effectively and showed the targeting effect to HNE-1 cells. The co-delivery system showed the effective drug and gene delivery ability with high cytotoxicity and gene transfection efficiency. Besides that, Tf-HPAA-GO/DOC also showed the chemotherapeutic sensibilization effect, the formulation containing HPAA segments showed much higher cytotoxicity than free DOC. Benefiting from the sensibilization effect and DOC/pMMP-9 co-delivery strategy, this Tf-HPAA-GO/DOC/pMMP-9 co-delivery system exhibited the significantly improved therapeutic efficacy to HNE-1 tumor in a combined manner which was confirmed by <italic>in vitro</italic>
and <italic>in vivo</italic>
assays. This strategy provided an easily delivery system combining the drug/gene co-delivery, chemotherapeutic sensibilization, and targeting into one single platform, which showed a promising application in cancer therapy.</p>
</div>
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<author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name>
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<author><name sortKey="Liu, R" uniqKey="Liu R">R Liu</name>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Tao" sort="Liu, Tao" uniqKey="Liu T" first="Tao" last="Liu">Tao Liu</name>
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<name sortKey="Chen, Shaohua" sort="Chen, Shaohua" uniqKey="Chen S" first="Shaohua" last="Chen">Shaohua Chen</name>
<name sortKey="Li, Guanxue" sort="Li, Guanxue" uniqKey="Li G" first="Guanxue" last="Li">Guanxue Li</name>
<name sortKey="Li, Jingzhen" sort="Li, Jingzhen" uniqKey="Li J" first="Jingzhen" last="Li">Jingzhen Li</name>
<name sortKey="Li, Junzheng" sort="Li, Junzheng" uniqKey="Li J" first="Junzheng" last="Li">Junzheng Li</name>
<name sortKey="Lu, Zhongming" sort="Lu, Zhongming" uniqKey="Lu Z" first="Zhongming" last="Lu">Zhongming Lu</name>
<name sortKey="Wu, Xidong" sort="Wu, Xidong" uniqKey="Wu X" first="Xidong" last="Wu">Xidong Wu</name>
<name sortKey="Zhang, Siyi" sort="Zhang, Siyi" uniqKey="Zhang S" first="Siyi" last="Zhang">Siyi Zhang</name>
</country>
</tree>
</affiliations>
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