Transferrin-targeting redox hyperbranched poly(amido amine)-functionalized graphene oxide for sensitized chemotherapy combined with gene therapy to nasopharyngeal carcinoma
Identifieur interne : 000276 ( Pmc/Checkpoint ); précédent : 000275; suivant : 000277Transferrin-targeting redox hyperbranched poly(amido amine)-functionalized graphene oxide for sensitized chemotherapy combined with gene therapy to nasopharyngeal carcinoma
Auteurs : Tao Liu [République populaire de Chine] ; Jingzhen Li [République populaire de Chine] ; Xidong Wu [République populaire de Chine] ; Siyi Zhang [République populaire de Chine] ; Zhongming Lu [République populaire de Chine] ; Guanxue Li [République populaire de Chine] ; Junzheng Li [République populaire de Chine] ; Shaohua Chen [République populaire de Chine]Source :
- Drug Delivery [ 1071-7544 ] ; 2019.
Abstract
A drug and gene co-delivery system with chemotherapeutic sensibilization was prepared and used for nasopharyngeal carcinoma therapy. For this purpose, the graphene oxide (GO) was conjugated with the redox hyperbranched poly(amido amine) (HPAA) and then the targeting molecule, transferrin (Tf), was also conjugated. The obtained Tf-HPAA-GO could co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid (pMMP-9) effectively and showed the targeting effect to HNE-1 cells. The co-delivery system showed the effective drug and gene delivery ability with high cytotoxicity and gene transfection efficiency. Besides that, Tf-HPAA-GO/DOC also showed the chemotherapeutic sensibilization effect, the formulation containing HPAA segments showed much higher cytotoxicity than free DOC. Benefiting from the sensibilization effect and DOC/pMMP-9 co-delivery strategy, this Tf-HPAA-GO/DOC/pMMP-9 co-delivery system exhibited the significantly improved therapeutic efficacy to HNE-1 tumor in a combined manner which was confirmed by
Url:
DOI: 10.1080/10717544.2019.1642421
PubMed: 31340676
PubMed Central: 6711081
Affiliations:
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<author><name sortKey="Chen, Shaohua" sort="Chen, Shaohua" uniqKey="Chen S" first="Shaohua" last="Chen">Shaohua Chen</name>
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<author><name sortKey="Li, Jingzhen" sort="Li, Jingzhen" uniqKey="Li J" first="Jingzhen" last="Li">Jingzhen Li</name>
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<series><title level="j">Drug Delivery</title>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>A drug and gene co-delivery system with chemotherapeutic sensibilization was prepared and used for nasopharyngeal carcinoma therapy. For this purpose, the graphene oxide (GO) was conjugated with the redox hyperbranched poly(amido amine) (HPAA) and then the targeting molecule, transferrin (Tf), was also conjugated. The obtained Tf-HPAA-GO could co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid (pMMP-9) effectively and showed the targeting effect to HNE-1 cells. The co-delivery system showed the effective drug and gene delivery ability with high cytotoxicity and gene transfection efficiency. Besides that, Tf-HPAA-GO/DOC also showed the chemotherapeutic sensibilization effect, the formulation containing HPAA segments showed much higher cytotoxicity than free DOC. Benefiting from the sensibilization effect and DOC/pMMP-9 co-delivery strategy, this Tf-HPAA-GO/DOC/pMMP-9 co-delivery system exhibited the significantly improved therapeutic efficacy to HNE-1 tumor in a combined manner which was confirmed by <italic>in vitro</italic>
and <italic>in vivo</italic>
assays. This strategy provided an easily delivery system combining the drug/gene co-delivery, chemotherapeutic sensibilization, and targeting into one single platform, which showed a promising application in cancer therapy.</p>
</div>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Drug Deliv</journal-id>
<journal-id journal-id-type="iso-abbrev">Drug Deliv</journal-id>
<journal-id journal-id-type="publisher-id">IDRD</journal-id>
<journal-id journal-id-type="publisher-id">idrd20</journal-id>
<journal-title-group><journal-title>Drug Delivery</journal-title>
</journal-title-group>
<issn pub-type="ppub">1071-7544</issn>
<issn pub-type="epub">1521-0464</issn>
<publisher><publisher-name>Taylor & Francis</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31340676</article-id>
<article-id pub-id-type="pmc">6711081</article-id>
<article-id pub-id-type="doi">10.1080/10717544.2019.1642421</article-id>
<article-id pub-id-type="publisher-id">1642421</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Transferrin-targeting redox hyperbranched poly(amido amine)-functionalized graphene oxide for sensitized chemotherapy combined with gene therapy to nasopharyngeal carcinoma</article-title>
<alt-title alt-title-type="running-authors">T. Liu et al.</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Tao</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>a</sup>
</xref>
<xref ref-type="corresp" rid="AN0001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Jingzhen</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wu</surname>
<given-names>Xidong</given-names>
</name>
<xref ref-type="aff" rid="AF0003"><sup>c</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Siyi</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lu</surname>
<given-names>Zhongming</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Guanxue</given-names>
</name>
<xref ref-type="aff" rid="AF0004"><sup>d</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Junzheng</given-names>
</name>
<xref ref-type="aff" rid="AF0005"><sup>e</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Shaohua</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>a</sup>
</xref>
<xref ref-type="corresp" rid="AN0002"></xref>
</contrib>
<aff id="AF0001"><label>a</label>
<institution>Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences</institution>
, Guangzhou,<country>China</country>
;</aff>
<aff id="AF0002"><label>b</label>
<institution>Department of Nephrology, Ningbo Yinzhou Second Hospital</institution>
, Ningbo,<country>China</country>
;</aff>
<aff id="AF0003"><label>c</label>
<institution>Department of Pharmacology, Jiangxi Testing Center of Medical Instruments</institution>
, Nanchang,<country>China</country>
;</aff>
<aff id="AF0004"><label>d</label>
<institution>Department of Pediatric Center, Zhujiang Hospital of Southern Medical University</institution>
, Guangzhou,<country>China</country>
;</aff>
<aff id="AF0005"><label>e</label>
<institution>Department of Otolaryngology-Head and Neck Surgery, The Affiliated Dongguan Hospital of Jinan University</institution>
, Dongguan,<country>China</country>
</aff>
</contrib-group>
<author-notes><corresp id="AN0001"><bold>CONTACT</bold>
Tao Liu <email>taoliu18@126.com</email>
</corresp>
<corresp id="AN0002">Shaohua Chen <email>csh_rl@163.com</email>
<institution>Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital</institution>
, Guangzhou 510080, <country>China</country>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>25</day>
<month>7</month>
<year>2019</year>
</pub-date>
<volume>26</volume>
<issue>1</issue>
<fpage seq="75">744</fpage>
<lpage>755</lpage>
<history><date date-type="received"><day>20</day>
<month>6</month>
<year>2019</year>
</date>
<date date-type="rev-recd"><day>03</day>
<month>7</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>08</day>
<month>7</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>The Author(s)</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="IDRD_26_1642421.pdf"></self-uri>
<abstract><title>Abstract</title>
<p>A drug and gene co-delivery system with chemotherapeutic sensibilization was prepared and used for nasopharyngeal carcinoma therapy. For this purpose, the graphene oxide (GO) was conjugated with the redox hyperbranched poly(amido amine) (HPAA) and then the targeting molecule, transferrin (Tf), was also conjugated. The obtained Tf-HPAA-GO could co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid (pMMP-9) effectively and showed the targeting effect to HNE-1 cells. The co-delivery system showed the effective drug and gene delivery ability with high cytotoxicity and gene transfection efficiency. Besides that, Tf-HPAA-GO/DOC also showed the chemotherapeutic sensibilization effect, the formulation containing HPAA segments showed much higher cytotoxicity than free DOC. Benefiting from the sensibilization effect and DOC/pMMP-9 co-delivery strategy, this Tf-HPAA-GO/DOC/pMMP-9 co-delivery system exhibited the significantly improved therapeutic efficacy to HNE-1 tumor in a combined manner which was confirmed by <italic>in vitro</italic>
and <italic>in vivo</italic>
assays. This strategy provided an easily delivery system combining the drug/gene co-delivery, chemotherapeutic sensibilization, and targeting into one single platform, which showed a promising application in cancer therapy.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords</title>
<kwd>GSH-response</kwd>
<kwd>transferrin</kwd>
<kwd>graphene oxide</kwd>
<kwd>drug and gene co-delivery</kwd>
<kwd>sensibilization</kwd>
<kwd>nasopharyngeal carcinoma</kwd>
</kwd-group>
<funding-group><award-group><funding-source><named-content content-type="funder-name">National Natural Science Foundation of China</named-content>
<named-content content-type="funderidentifier">10.13039/501100001809</named-content>
</funding-source>
<award-id>81573000</award-id>
</award-group>
<award-group><funding-source><named-content content-type="funder-name">the talent introduction fund of Guangdong Provincial People's Hospital</named-content>
</funding-source>
<award-id>Y012018142</award-id>
</award-group>
<award-group><funding-source><named-content content-type="funder-name">the Social Development Project of Dongguan</named-content>
</funding-source>
<award-id>2016108101025</award-id>
</award-group>
<award-group><funding-source><named-content content-type="funder-name">the Science and Technology Program of Guangzhou</named-content>
<named-content content-type="funderidentifier">10.13039/501100004000</named-content>
</funding-source>
<award-id>201707010489</award-id>
</award-group>
<funding-statement>This work was financially supported by the National Natural Science Foundation of China (81573000), the talent introduction fund of Guangdong Provincial People's Hospital (Y012018142), the Social Development Project of Dongguan (No. 2016108101025), and the Science and Technology Program of Guangzhou (201707010489).</funding-statement>
</funding-group>
<counts><fig-count count="12"></fig-count>
<table-count count="0"></table-count>
<page-count count="12"></page-count>
<word-count count="7826"></word-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Tao" sort="Liu, Tao" uniqKey="Liu T" first="Tao" last="Liu">Tao Liu</name>
</noRegion>
<name sortKey="Chen, Shaohua" sort="Chen, Shaohua" uniqKey="Chen S" first="Shaohua" last="Chen">Shaohua Chen</name>
<name sortKey="Li, Guanxue" sort="Li, Guanxue" uniqKey="Li G" first="Guanxue" last="Li">Guanxue Li</name>
<name sortKey="Li, Jingzhen" sort="Li, Jingzhen" uniqKey="Li J" first="Jingzhen" last="Li">Jingzhen Li</name>
<name sortKey="Li, Junzheng" sort="Li, Junzheng" uniqKey="Li J" first="Junzheng" last="Li">Junzheng Li</name>
<name sortKey="Lu, Zhongming" sort="Lu, Zhongming" uniqKey="Lu Z" first="Zhongming" last="Lu">Zhongming Lu</name>
<name sortKey="Wu, Xidong" sort="Wu, Xidong" uniqKey="Wu X" first="Xidong" last="Wu">Xidong Wu</name>
<name sortKey="Zhang, Siyi" sort="Zhang, Siyi" uniqKey="Zhang S" first="Siyi" last="Zhang">Siyi Zhang</name>
</country>
</tree>
</affiliations>
</record>
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