Mutagenicity of some intercalating agents in Chinese hamster V79 cells.
Identifieur interne : 004096 ( Main/Merge ); précédent : 004095; suivant : 004097Mutagenicity of some intercalating agents in Chinese hamster V79 cells.
Auteurs : M R O'DonovanSource :
- Mutation research [ 0027-5107 ]
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Ouabaïne.
- toxicité : Intercalants.
- Animaux, Cricetinae, Cricetulus, Lignée cellulaire, Mutagènes, Mutation, Poumon, Relation structure-activité, Tests de mutagénicité.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Ouabain.
- chemical , toxicity : Intercalating Agents.
- Animals, Cell Line, Cricetinae, Cricetulus, Lung, Mutagenicity Tests, Mutagens, Mutation, Structure-Activity Relationship.
Abstract
ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-resistance in Chinese hamster V79 cells. These results indicate that covalent binding to DNA is necessary for intercalating agents to induce mutation in this cell line, and that this assay can distinguish potential carcinogens from non-carcinogenic analogues of this chemical type. The induction of ouabain-resistance by both ICR 170 and ICR 191 indicates that these frameshift mutagens induce base-pair substitution to some extent in V79 cells.
DOI: 10.1016/0165-1218(84)90100-9
PubMed: 6472323
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pubmed:6472323Le document en format XML
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