ChloroquineV1, PubMed, Corpus, bibRecord, 000595

Mutagenicity of some intercalating agents in Chinese hamster V79 cells.

Identifieur interne : 000595 ( PubMed/Corpus ); précédent : 000594; suivant : 000596

Mutagenicity of some intercalating agents in Chinese hamster V79 cells.

Auteurs : M R O'Donovan

Source :

Mutation research [ 0027-5107 ]

RBID : pubmed:6472323

English descriptors

KwdEn :
- Animals, Cell Line, Cricetinae, Cricetulus, Intercalating Agents (toxicity), Lung, Mutagenicity Tests, Mutagens, Mutation, Ouabain (pharmacology), Structure-Activity Relationship.
MESH :
- chemical , pharmacology : Ouabain.
- chemical , toxicity : Intercalating Agents.
- Animals, Cell Line, Cricetinae, Cricetulus, Lung, Mutagenicity Tests, Mutagens, Mutation, Structure-Activity Relationship.

Abstract

ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-resistance in Chinese hamster V79 cells. These results indicate that covalent binding to DNA is necessary for intercalating agents to induce mutation in this cell line, and that this assay can distinguish potential carcinogens from non-carcinogenic analogues of this chemical type. The induction of ouabain-resistance by both ICR 170 and ICR 191 indicates that these frameshift mutagens induce base-pair substitution to some extent in V79 cells.

DOI: 10.1016/0165-1218(84)90100-9
PubMed: 6472323

Links to Exploration step

pubmed:6472323

Le document en format XML

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<author><name sortKey="O Donovan, M R" sort="O Donovan, M R" uniqKey="O Donovan M" first="M R" last="O'Donovan">M R O'Donovan</name>
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<date when="????"><PubDate><MedlineDate>1984 Aug-Sep</MedlineDate>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Cricetinae</term>
<term>Cricetulus</term>
<term>Intercalating Agents (toxicity)</term>
<term>Lung</term>
<term>Mutagenicity Tests</term>
<term>Mutagens</term>
<term>Mutation</term>
<term>Ouabain (pharmacology)</term>
<term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ouabain</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Intercalating Agents</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Cricetinae</term>
<term>Cricetulus</term>
<term>Lung</term>
<term>Mutagenicity Tests</term>
<term>Mutagens</term>
<term>Mutation</term>
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<front><div type="abstract" xml:lang="en">ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-resistance in Chinese hamster V79 cells. These results indicate that covalent binding to DNA is necessary for intercalating agents to induce mutation in this cell line, and that this assay can distinguish potential carcinogens from non-carcinogenic analogues of this chemical type. The induction of ouabain-resistance by both ICR 170 and ICR 191 indicates that these frameshift mutagens induce base-pair substitution to some extent in V79 cells.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">6472323</PMID>
<DateCompleted><Year>1984</Year>
<Month>10</Month>
<Day>24</Day>
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<DateRevised><Year>2019</Year>
<Month>07</Month>
<Day>02</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0027-5107</ISSN>
<JournalIssue CitedMedium="Print"><Volume>137</Volume>
<Issue>2-3</Issue>
<PubDate><MedlineDate>1984 Aug-Sep</MedlineDate>
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<Title>Mutation research</Title>
<ISOAbbreviation>Mutat. Res.</ISOAbbreviation>
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<ArticleTitle>Mutagenicity of some intercalating agents in Chinese hamster V79 cells.</ArticleTitle>
<Pagination><MedlinePgn>117-22</MedlinePgn>
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<Abstract><AbstractText>ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-resistance in Chinese hamster V79 cells. These results indicate that covalent binding to DNA is necessary for intercalating agents to induce mutation in this cell line, and that this assay can distinguish potential carcinogens from non-carcinogenic analogues of this chemical type. The induction of ouabain-resistance by both ICR 170 and ICR 191 indicates that these frameshift mutagens induce base-pair substitution to some extent in V79 cells.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>O'Donovan</LastName>
<ForeName>M R</ForeName>
<Initials>MR</Initials>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
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<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Mutat Res</MedlineTA>
<NlmUniqueID>0400763</NlmUniqueID>
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<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
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<MeshHeading><DescriptorName UI="D009152" MajorTopicYN="N">Mutagenicity Tests</DescriptorName>
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<MeshHeading><DescriptorName UI="D009153" MajorTopicYN="Y">Mutagens</DescriptorName>
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<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName>
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<MeshHeading><DescriptorName UI="D010042" MajorTopicYN="N">Ouabain</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
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<MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName>
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Mutagenicity of some intercalating agents in Chinese hamster V79 cells.

Mutagenicity of some intercalating agents in Chinese hamster V79 cells.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki