Mutagenicity of some intercalating agents in Chinese hamster V79 cells.
Identifieur interne : 000595 ( PubMed/Corpus ); précédent : 000594; suivant : 000596Mutagenicity of some intercalating agents in Chinese hamster V79 cells.
Auteurs : M R O'DonovanSource :
- Mutation research [ 0027-5107 ]
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Ouabain.
- chemical , toxicity : Intercalating Agents.
- Animals, Cell Line, Cricetinae, Cricetulus, Lung, Mutagenicity Tests, Mutagens, Mutation, Structure-Activity Relationship.
Abstract
ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-resistance in Chinese hamster V79 cells. These results indicate that covalent binding to DNA is necessary for intercalating agents to induce mutation in this cell line, and that this assay can distinguish potential carcinogens from non-carcinogenic analogues of this chemical type. The induction of ouabain-resistance by both ICR 170 and ICR 191 indicates that these frameshift mutagens induce base-pair substitution to some extent in V79 cells.
DOI: 10.1016/0165-1218(84)90100-9
PubMed: 6472323
Links to Exploration step
pubmed:6472323Le document en format XML
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<author><name sortKey="O Donovan, M R" sort="O Donovan, M R" uniqKey="O Donovan M" first="M R" last="O'Donovan">M R O'Donovan</name>
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<date when="????"><PubDate><MedlineDate>1984 Aug-Sep</MedlineDate>
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<series><title level="j">Mutation research</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Cricetinae</term>
<term>Cricetulus</term>
<term>Intercalating Agents (toxicity)</term>
<term>Lung</term>
<term>Mutagenicity Tests</term>
<term>Mutagens</term>
<term>Mutation</term>
<term>Ouabain (pharmacology)</term>
<term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ouabain</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Intercalating Agents</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Cricetinae</term>
<term>Cricetulus</term>
<term>Lung</term>
<term>Mutagenicity Tests</term>
<term>Mutagens</term>
<term>Mutation</term>
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<front><div type="abstract" xml:lang="en">ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-resistance in Chinese hamster V79 cells. These results indicate that covalent binding to DNA is necessary for intercalating agents to induce mutation in this cell line, and that this assay can distinguish potential carcinogens from non-carcinogenic analogues of this chemical type. The induction of ouabain-resistance by both ICR 170 and ICR 191 indicates that these frameshift mutagens induce base-pair substitution to some extent in V79 cells.</div>
</front>
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<DateCompleted><Year>1984</Year>
<Month>10</Month>
<Day>24</Day>
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<DateRevised><Year>2019</Year>
<Month>07</Month>
<Day>02</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0027-5107</ISSN>
<JournalIssue CitedMedium="Print"><Volume>137</Volume>
<Issue>2-3</Issue>
<PubDate><MedlineDate>1984 Aug-Sep</MedlineDate>
</PubDate>
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<Title>Mutation research</Title>
<ISOAbbreviation>Mutat. Res.</ISOAbbreviation>
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<ArticleTitle>Mutagenicity of some intercalating agents in Chinese hamster V79 cells.</ArticleTitle>
<Pagination><MedlinePgn>117-22</MedlinePgn>
</Pagination>
<Abstract><AbstractText>ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-resistance in Chinese hamster V79 cells. These results indicate that covalent binding to DNA is necessary for intercalating agents to induce mutation in this cell line, and that this assay can distinguish potential carcinogens from non-carcinogenic analogues of this chemical type. The induction of ouabain-resistance by both ICR 170 and ICR 191 indicates that these frameshift mutagens induce base-pair substitution to some extent in V79 cells.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>O'Donovan</LastName>
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<Initials>MR</Initials>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
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<MedlineJournalInfo><Country>Netherlands</Country>
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<MeshHeading><DescriptorName UI="D010042" MajorTopicYN="N">Ouabain</DescriptorName>
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