Three cases of malignant neoplasm, pneumonitis, and pancytopenia during treatment with low-dose methotrexate
Identifieur interne : 002F17 ( Main/Merge ); précédent : 002F16; suivant : 002F18Three cases of malignant neoplasm, pneumonitis, and pancytopenia during treatment with low-dose methotrexate
Auteurs : P. Trenkwalder [Allemagne] ; H. Eisenlohr [Allemagne] ; K. Prechtel [Allemagne] ; H. Lydtin [Allemagne]Source :
- The clinical investigator [ 0941-0198 ] ; 1992-10-01.
English descriptors
- KwdEn :
- Teeft :
- Alveolar infiltrates, Arthritis, Asthma, Asthmatic patients, Bladder, Bowel disease, Carcinogenicity, Causal relationship, Cell carcinoma, Drug interactions, Dyspnea, Lung disease, Malignant, Malignant neoplasm, Malignant neoplasms, Malignant teratoma, Mediastinal, Mediastinal mass, Methotrexate, Methotrexate pneumonitis, Methotrexate therapy, Neoplasm, Nsaid, Pancytopenia, Pneumonitis, Psoriasis, Psoriatic arthritis, Pulmonary disease, Renal, Renal function, Rheumatoid, Rheumatoid arthritis, Risk factors, Several months, Severe dyspnea, Severe side effects, Sodium fluoride, Starnberg, Steroid, Steroid aerosols, Teratoma, Thoracic skin.
Abstract
Summary: A 77-year-old man with chronic obstructive pulmonary disease was treated with low-dose methotrexate (7.5–15 mg per week). After 15 months a diagnosis of urothelial carcinoma of the bladder was made; after a further 6 months pneumonitis and pancytopenia developed. The patient died due to massive pulmonary hemorrhage. A malignant teratoma was diagnosed in a 65-year-old asthmatic man 16 months after initiation of methotrexate therapy (15 mg per week). The patient died 4 months later due to fulminant progression of the neoplasm. A third malignant neoplasm (dermal squamous cell carcinoma) was seen in a 64-year-old woman with rheumatoid arthritis after 13 months treatment with 7.5 mg methotrexate per week. These three cases, while obviously not proving a causal relationship between long-term treatment with low-dose methotrexate and development of malignant neoplasm, do call for stringent treatment criteria, close surveillance, and prospective studies.
Url:
DOI: 10.1007/BF00180446
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Trenkwalder</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Krankenhaus des Landkreises Starnberg, Starnberg</wicri:regionArea><wicri:noRegion>Starnberg</wicri:noRegion><wicri:noRegion>Starnberg</wicri:noRegion></affiliation></author><author><name sortKey="Eisenlohr, H" sort="Eisenlohr, H" uniqKey="Eisenlohr H" first="H." last="Eisenlohr">H. Eisenlohr</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Krankenhaus des Landkreises Starnberg, Starnberg</wicri:regionArea><wicri:noRegion>Starnberg</wicri:noRegion><wicri:noRegion>Starnberg</wicri:noRegion></affiliation></author><author><name sortKey="Prechtel, K" sort="Prechtel, K" uniqKey="Prechtel K" first="K." last="Prechtel">K. Prechtel</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gemeinschaftspraxis Pathologie, Starnberg</wicri:regionArea><wicri:noRegion>Starnberg</wicri:noRegion><wicri:noRegion>Starnberg</wicri:noRegion></affiliation></author><author><name sortKey="Lydtin, H" sort="Lydtin, H" uniqKey="Lydtin H" first="H." last="Lydtin">H. Lydtin</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik, Krankenhaus des Landkreises Starnberg, Starnberg</wicri:regionArea><wicri:noRegion>Starnberg</wicri:noRegion><wicri:noRegion>Starnberg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">The clinical investigator</title><title level="j" type="abbrev">Clin Investig</title><idno type="ISSN">0941-0198</idno><idno type="eISSN">1432-1440</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1992-10-01">1992-10-01</date><biblScope unit="volume">70</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="951">951</biblScope><biblScope unit="page" to="955">955</biblScope></imprint><idno type="ISSN">0941-0198</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0941-0198</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carcinogenicity</term><term>Chronic obstructive pulmonary disease</term><term>Malignant neoplasm</term><term>Methotrexate</term><term>Side effects</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alveolar infiltrates</term><term>Arthritis</term><term>Asthma</term><term>Asthmatic patients</term><term>Bladder</term><term>Bowel disease</term><term>Carcinogenicity</term><term>Causal relationship</term><term>Cell carcinoma</term><term>Drug interactions</term><term>Dyspnea</term><term>Lung disease</term><term>Malignant</term><term>Malignant neoplasm</term><term>Malignant neoplasms</term><term>Malignant teratoma</term><term>Mediastinal</term><term>Mediastinal mass</term><term>Methotrexate</term><term>Methotrexate pneumonitis</term><term>Methotrexate therapy</term><term>Neoplasm</term><term>Nsaid</term><term>Pancytopenia</term><term>Pneumonitis</term><term>Psoriasis</term><term>Psoriatic arthritis</term><term>Pulmonary disease</term><term>Renal</term><term>Renal function</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Risk factors</term><term>Several months</term><term>Severe dyspnea</term><term>Severe side effects</term><term>Sodium fluoride</term><term>Starnberg</term><term>Steroid</term><term>Steroid aerosols</term><term>Teratoma</term><term>Thoracic skin</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: A 77-year-old man with chronic obstructive pulmonary disease was treated with low-dose methotrexate (7.5–15 mg per week). After 15 months a diagnosis of urothelial carcinoma of the bladder was made; after a further 6 months pneumonitis and pancytopenia developed. The patient died due to massive pulmonary hemorrhage. A malignant teratoma was diagnosed in a 65-year-old asthmatic man 16 months after initiation of methotrexate therapy (15 mg per week). The patient died 4 months later due to fulminant progression of the neoplasm. A third malignant neoplasm (dermal squamous cell carcinoma) was seen in a 64-year-old woman with rheumatoid arthritis after 13 months treatment with 7.5 mg methotrexate per week. These three cases, while obviously not proving a causal relationship between long-term treatment with low-dose methotrexate and development of malignant neoplasm, do call for stringent treatment criteria, close surveillance, and prospective studies.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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