Three cases of malignant neoplasm, pneumonitis, and pancytopenia during treatment with low-dose methotrexate
Identifieur interne : 002818 ( Istex/Corpus ); précédent : 002817; suivant : 002819Three cases of malignant neoplasm, pneumonitis, and pancytopenia during treatment with low-dose methotrexate
Auteurs : P. Trenkwalder ; H. Eisenlohr ; K. Prechtel ; H. LydtinSource :
- The clinical investigator [ 0941-0198 ] ; 1992-10-01.
English descriptors
- KwdEn :
- Teeft :
- Alveolar infiltrates, Arthritis, Asthma, Asthmatic patients, Bladder, Bowel disease, Carcinogenicity, Causal relationship, Cell carcinoma, Drug interactions, Dyspnea, Lung disease, Malignant, Malignant neoplasm, Malignant neoplasms, Malignant teratoma, Mediastinal, Mediastinal mass, Methotrexate, Methotrexate pneumonitis, Methotrexate therapy, Neoplasm, Nsaid, Pancytopenia, Pneumonitis, Psoriasis, Psoriatic arthritis, Pulmonary disease, Renal, Renal function, Rheumatoid, Rheumatoid arthritis, Risk factors, Several months, Severe dyspnea, Severe side effects, Sodium fluoride, Starnberg, Steroid, Steroid aerosols, Teratoma, Thoracic skin.
Abstract
Summary: A 77-year-old man with chronic obstructive pulmonary disease was treated with low-dose methotrexate (7.5–15 mg per week). After 15 months a diagnosis of urothelial carcinoma of the bladder was made; after a further 6 months pneumonitis and pancytopenia developed. The patient died due to massive pulmonary hemorrhage. A malignant teratoma was diagnosed in a 65-year-old asthmatic man 16 months after initiation of methotrexate therapy (15 mg per week). The patient died 4 months later due to fulminant progression of the neoplasm. A third malignant neoplasm (dermal squamous cell carcinoma) was seen in a 64-year-old woman with rheumatoid arthritis after 13 months treatment with 7.5 mg methotrexate per week. These three cases, while obviously not proving a causal relationship between long-term treatment with low-dose methotrexate and development of malignant neoplasm, do call for stringent treatment criteria, close surveillance, and prospective studies.
Url:
DOI: 10.1007/BF00180446
Links to Exploration step
ISTEX:428369D17DC8E89CA3CEBE1B5D833279BAE6E1E8Le document en format XML
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After 15 months a diagnosis of urothelial carcinoma of the bladder was made; after a further 6 months pneumonitis and pancytopenia developed. The patient died due to massive pulmonary hemorrhage. A malignant teratoma was diagnosed in a 65-year-old asthmatic man 16 months after initiation of methotrexate therapy (15 mg per week). The patient died 4 months later due to fulminant progression of the neoplasm. A third malignant neoplasm (dermal squamous cell carcinoma) was seen in a 64-year-old woman with rheumatoid arthritis after 13 months treatment with 7.5 mg methotrexate per week. These three cases, while obviously not proving a causal relationship between long-term treatment with low-dose methotrexate and development of malignant neoplasm, do call for stringent treatment criteria, close surveillance, and prospective studies.</div></front></TEI><istex><corpusName>springer-journals</corpusName><keywords><teeft><json:string>methotrexate</json:string><json:string>neoplasm</json:string><json:string>malignant</json:string><json:string>pneumonitis</json:string><json:string>methotrexate therapy</json:string><json:string>rheumatoid arthritis</json:string><json:string>rheumatoid</json:string><json:string>psoriasis</json:string><json:string>pulmonary disease</json:string><json:string>teratoma</json:string><json:string>malignant neoplasms</json:string><json:string>renal function</json:string><json:string>pancytopenia</json:string><json:string>malignant neoplasm</json:string><json:string>nsaid</json:string><json:string>starnberg</json:string><json:string>mediastinal</json:string><json:string>bladder</json:string><json:string>carcinogenicity</json:string><json:string>dyspnea</json:string><json:string>asthma</json:string><json:string>renal</json:string><json:string>severe side effects</json:string><json:string>lung disease</json:string><json:string>mediastinal mass</json:string><json:string>psoriatic arthritis</json:string><json:string>steroid aerosols</json:string><json:string>steroid</json:string><json:string>arthritis</json:string><json:string>methotrexate pneumonitis</json:string><json:string>alveolar infiltrates</json:string><json:string>malignant teratoma</json:string><json:string>several months</json:string><json:string>cell carcinoma</json:string><json:string>thoracic skin</json:string><json:string>bowel disease</json:string><json:string>risk factors</json:string><json:string>causal relationship</json:string><json:string>sodium fluoride</json:string><json:string>drug interactions</json:string><json:string>severe dyspnea</json:string><json:string>asthmatic patients</json:string></teeft></keywords><author><json:item><name>P. 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After 15 months a diagnosis of urothelial carcinoma of the bladder was made; after a further 6 months pneumonitis and pancytopenia developed. The patient died due to massive pulmonary hemorrhage. A malignant teratoma was diagnosed in a 65-year-old asthmatic man 16 months after initiation of methotrexate therapy (15 mg per week). The patient died 4 months later due to fulminant progression of the neoplasm. A third malignant neoplasm (dermal squamous cell carcinoma) was seen in a 64-year-old woman with rheumatoid arthritis after 13 months treatment with 7.5 mg methotrexate per week. These three cases, while obviously not proving a causal relationship between long-term treatment with low-dose methotrexate and development of malignant neoplasm, do call for stringent treatment criteria, close surveillance, and prospective studies.</abstract><qualityIndicators><refBibsNative>false</refBibsNative><abstractWordCount>141</abstractWordCount><abstractCharCount>968</abstractCharCount><keywordCount>6</keywordCount><score>5.803</score><pdfWordCount>2111</pdfWordCount><pdfCharCount>14640</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>598 x 785 pts</pdfPageSize></qualityIndicators><title>Three cases of malignant neoplasm, pneumonitis, and pancytopenia during treatment with low-dose methotrexate</title><pmid><json:string>1450620</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>The clinical investigator</title><language><json:string>unknown</json:string></language><publicationDate>1992</publicationDate><copyrightDate>1992</copyrightDate><issn><json:string>0941-0198</json:string></issn><eissn><json:string>1432-1440</json:string></eissn><journalId><json:string>109</json:string></journalId><volume>70</volume><issue>10</issue><pages><first>951</first><last>955</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Molecular Medicine</value></json:item><json:item><value>Internal Medicine</value></json:item></subject></host><namedEntities><unitex><date></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/1BB-1CJCJHST-F</json:string></ark><categories><wos></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - 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After 15 months a diagnosis of urothelial carcinoma of the bladder was made; after a further 6 months pneumonitis and pancytopenia developed. The patient died due to massive pulmonary hemorrhage. A malignant teratoma was diagnosed in a 65-year-old asthmatic man 16 months after initiation of methotrexate therapy (15 mg per week). The patient died 4 months later due to fulminant progression of the neoplasm. A third malignant neoplasm (dermal squamous cell carcinoma) was seen in a 64-year-old woman with rheumatoid arthritis after 13 months treatment with 7.5 mg methotrexate per week. These three cases, while obviously not proving a causal relationship between long-term treatment with low-dose methotrexate and development of malignant neoplasm, do call for stringent treatment criteria, close surveillance, and prospective studies.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Methotrexate</term></item><item><term>Malignant neoplasm</term></item><item><term>Carcinogenicity</term></item><item><term>Chronic obstructive pulmonary disease</term></item><item><term>Side effects</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Abbreviation:</head><item><term>NSAIDs=</term><term>nonsteroidal anti-inflammatory drugs</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Molecular Medicine</term></item><item><term>Internal Medicine</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1992-06-09">Created</change><change when="1992-10-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-1CJCJHST-F/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>109</JournalID><JournalPrintISSN>0941-0198</JournalPrintISSN><JournalElectronicISSN>1432-1440</JournalElectronicISSN><JournalTitle>The clinical investigator</JournalTitle><JournalAbbreviatedTitle>Clin Investig</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Molecular Medicine</JournalSubject><JournalSubject Type="Secondary">Internal Medicine</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>70</VolumeIDStart><VolumeIDEnd>70</VolumeIDEnd><VolumeIssueCount>12</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>10</IssueIDStart><IssueIDEnd>10</IssueIDEnd><IssueArticleCount>18</IssueArticleCount><IssueHistory><CoverDate><Year>1992</Year><Month>10</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1992</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art16"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00180446</ArticleID><ArticleDOI>10.1007/BF00180446</ArticleDOI><ArticleSequenceNumber>16</ArticleSequenceNumber><ArticleTitle Language="En">Three cases of malignant neoplasm, pneumonitis, and pancytopenia during treatment with low-dose methotrexate</ArticleTitle><ArticleCategory>Clinic Pharmacology</ArticleCategory><ArticleSubCategory>Case Report</ArticleSubCategory><ArticleFirstPage>951</ArticleFirstPage><ArticleLastPage>955</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>7</Month><Day>6</Day></RegistrationDate><Received><Year>1992</Year><Month>6</Month><Day>9</Day></Received><Accepted><Year>1992</Year><Month>7</Month><Day>14</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1992</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>109</JournalID><VolumeIDStart>70</VolumeIDStart><VolumeIDEnd>70</VolumeIDEnd><IssueIDStart>10</IssueIDStart><IssueIDEnd>10</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>P.</GivenName><FamilyName>Trenkwalder</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Eisenlohr</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>K.</GivenName><FamilyName>Prechtel</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Lydtin</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Medizinische Klinik</OrgDivision><OrgName>Krankenhaus des Landkreises Starnberg</OrgName><OrgAddress><City>Starnberg</City><Country>Germany</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Gemeinschaftspraxis Pathologie</OrgName><OrgAddress><City>Starnberg</City><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>A 77-year-old man with chronic obstructive pulmonary disease was treated with low-dose methotrexate (7.5–15 mg per week). After 15 months a diagnosis of urothelial carcinoma of the bladder was made; after a further 6 months pneumonitis and pancytopenia developed. The patient died due to massive pulmonary hemorrhage. A malignant teratoma was diagnosed in a 65-year-old asthmatic man 16 months after initiation of methotrexate therapy (15 mg per week). The patient died 4 months later due to fulminant progression of the neoplasm. A third malignant neoplasm (dermal squamous cell carcinoma) was seen in a 64-year-old woman with rheumatoid arthritis after 13 months treatment with 7.5 mg methotrexate per week. These three cases, while obviously not proving a causal relationship between long-term treatment with low-dose methotrexate and development of malignant neoplasm, do call for stringent treatment criteria, close surveillance, and prospective studies.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Methotrexate</Keyword><Keyword>Malignant neoplasm</Keyword><Keyword>Carcinogenicity</Keyword><Keyword>Chronic obstructive pulmonary disease</Keyword><Keyword>Side effects</Keyword></KeywordGroup><AbbreviationGroup><Heading>Abbreviation:</Heading><DefinitionList><DefinitionListEntry><Term>NSAIDs=</Term><Description><Para>nonsteroidal anti-inflammatory drugs</Para></Description></DefinitionListEntry></DefinitionList></AbbreviationGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Three cases of malignant neoplasm, pneumonitis, and pancytopenia during treatment with low-dose methotrexate</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Three cases of malignant neoplasm, pneumonitis, and pancytopenia during treatment with low-dose methotrexate</title></titleInfo><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Trenkwalder</namePart><affiliation>Medizinische Klinik, Krankenhaus des Landkreises Starnberg, Starnberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Eisenlohr</namePart><affiliation>Medizinische Klinik, Krankenhaus des Landkreises Starnberg, Starnberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Prechtel</namePart><affiliation>Gemeinschaftspraxis Pathologie, Starnberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Lydtin</namePart><affiliation>Medizinische Klinik, Krankenhaus des Landkreises Starnberg, Starnberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1992-06-09</dateCreated><dateIssued encoding="w3cdtf">1992-10-01</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: A 77-year-old man with chronic obstructive pulmonary disease was treated with low-dose methotrexate (7.5–15 mg per week). After 15 months a diagnosis of urothelial carcinoma of the bladder was made; after a further 6 months pneumonitis and pancytopenia developed. The patient died due to massive pulmonary hemorrhage. A malignant teratoma was diagnosed in a 65-year-old asthmatic man 16 months after initiation of methotrexate therapy (15 mg per week). The patient died 4 months later due to fulminant progression of the neoplasm. A third malignant neoplasm (dermal squamous cell carcinoma) was seen in a 64-year-old woman with rheumatoid arthritis after 13 months treatment with 7.5 mg methotrexate per week. These three cases, while obviously not proving a causal relationship between long-term treatment with low-dose methotrexate and development of malignant neoplasm, do call for stringent treatment criteria, close surveillance, and prospective studies.</abstract><note>Clinic Pharmacology/Case Report</note><subject lang="en"><genre>Key words</genre><topic>Methotrexate</topic><topic>Malignant neoplasm</topic><topic>Carcinogenicity</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Side effects</topic></subject><subject><genre>Abbreviation:</genre><topic>NSAIDs= : nonsteroidal anti-inflammatory drugs</topic></subject><relatedItem type="host"><titleInfo><title>The clinical investigator</title></titleInfo><titleInfo type="abbreviated"><title>Clin Investig</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1992-10-01</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Molecular Medicine</topic><topic>Internal Medicine</topic></subject><identifier type="ISSN">0941-0198</identifier><identifier type="eISSN">1432-1440</identifier><identifier type="JournalID">109</identifier><identifier type="IssueArticleCount">18</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>1992</date><detail type="volume"><number>70</number><caption>vol.</caption></detail><detail type="issue"><number>10</number><caption>no.</caption></detail><extent unit="pages"><start>951</start><end>955</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1992</recordOrigin></recordInfo></relatedItem><identifier type="istex">428369D17DC8E89CA3CEBE1B5D833279BAE6E1E8</identifier><identifier type="ark">ark:/67375/1BB-1CJCJHST-F</identifier><identifier type="DOI">10.1007/BF00180446</identifier><identifier type="ArticleID">BF00180446</identifier><identifier type="ArticleID">Art16</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1992</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1992</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-1CJCJHST-F/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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