Dapsone intoxication: Two case reports
Identifieur interne : 002D04 ( Main/Merge ); précédent : 002D03; suivant : 002D05Dapsone intoxication: Two case reports
Auteurs : Duane G. Hansen [États-Unis] ; Kathryn R. Challoner [États-Unis] ; Dallas E. Smith [États-Unis]Source :
- Journal of Emergency Medicine [ 0736-4679 ] ; 1994.
English descriptors
- Teeft :
- Acute dapsone intoxication, Arterial blood, Arterial blood gases, Ascorbic acid, Blood pressure mmhg, Case report, Charcoal hemoperfusion, Clin toxicol, Dapsone, Dapsone intoxication, Dapsone overdose, Dapsone poisoning, Dehydrogenase deficiency, Dermatitis herpetiformis, Dos, Elimination half, Emergency medicine, Face mask, Gastric decontamination, Gastric lavage, Hemolytic anemia, Hours postingestion, Ingestion, Intensive care unit, Intoxication, Methemoglobin, Methemoglobin concentration, Methemoglobin concentrations, Methemoglobin levels, Methemoglobinemia, Methylene, Mmhg, Nasogastric tube, Overdose, Oxygen saturation, Plasma exchange, Pulse rate, Respiratory rate, Reticulocyte count, Serum methemoglobin level, Southern california, Symptomatic methemoglobinemia, Toxic metabolites, Vital signs.
Abstract
Abstract: Two patients with dapsone intoxication, an adult and a 16-month-old child, are reported. Both developed symptomatic methemoglobin concentrations, of 35% and 37%, respectively, and improved with intravenous methylene blue. Methemoglobin levels subsequently rose in both cases to 25% at 24 and 37 hours, respectively. The recurrence of elevated methemoglobin levels resulted from either continued absorption of dapsone or its toxic metabolite from the gastrointestinal tract. Both patients were begun on serial oral activated charcoal and the child received a second methylene blue treatment. During the intoxication, serum hemoglobin concentrations dropped 2 gm with an increase in the reticulocyte count. Review of 20 cases of dapsone overdose from the literature showed that the major toxic manifestations are methemoglobinemia and hemolysis. Delayed sulfhemoglobinemia, reported in only one case, resolved spontaneously. The treatment of dapsone intoxication is intravenous methylene blue for symptomatic methemoglobinemia, gastric decontamination, and early administration of serial oral activated charcoal. Hemolysis is mild but transfusions may be required for patients with a glucose-6-phosphate dehydrogenase deficiency.
Url:
DOI: 10.1016/0736-4679(94)90277-1
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002732
- to stream Istex, to step Curation: 002732
- to stream Istex, to step Checkpoint: 001A29
Links to Exploration step
ISTEX:C60C5416821BFA12F26CB357972D7D2AA68C0BCELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Dapsone intoxication: Two case reports</title><author><name sortKey="Hansen, Duane G" sort="Hansen, Duane G" uniqKey="Hansen D" first="Duane G." last="Hansen">Duane G. Hansen</name></author><author><name sortKey="Challoner, Kathryn R" sort="Challoner, Kathryn R" uniqKey="Challoner K" first="Kathryn R." last="Challoner">Kathryn R. Challoner</name></author><author><name sortKey="Smith, Dallas E" sort="Smith, Dallas E" uniqKey="Smith D" first="Dallas E." last="Smith">Dallas E. Smith</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C60C5416821BFA12F26CB357972D7D2AA68C0BCE</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1016/0736-4679(94)90277-1</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-PXV0RF6H-7/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002732</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002732</idno><idno type="wicri:Area/Istex/Curation">002732</idno><idno type="wicri:Area/Istex/Checkpoint">001A29</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001A29</idno><idno type="wicri:doubleKey">0736-4679:1994:Hansen D:dapsone:intoxication:two</idno><idno type="wicri:Area/Main/Merge">002D04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Dapsone intoxication: Two case reports</title><author><name sortKey="Hansen, Duane G" sort="Hansen, Duane G" uniqKey="Hansen D" first="Duane G." last="Hansen">Duane G. Hansen</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Physician, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Challoner, Kathryn R" sort="Challoner, Kathryn R" uniqKey="Challoner K" first="Kathryn R." last="Challoner">Kathryn R. Challoner</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Reprint Address: Kathryn R. Challoner, MD, LAC + USC Medical Center, Unit 1, Room 1102, 1200 N. State Street, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Assistant Professor of Clinical Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Smith, Dallas E" sort="Smith, Dallas E" uniqKey="Smith D" first="Dallas E." last="Smith">Dallas E. Smith</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Resident, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Emergency Medicine</title><title level="j" type="abbrev">JEM</title><idno type="ISSN">0736-4679</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">12</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="347">347</biblScope><biblScope unit="page" to="351">351</biblScope></imprint><idno type="ISSN">0736-4679</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0736-4679</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute dapsone intoxication</term><term>Arterial blood</term><term>Arterial blood gases</term><term>Ascorbic acid</term><term>Blood pressure mmhg</term><term>Case report</term><term>Charcoal hemoperfusion</term><term>Clin toxicol</term><term>Dapsone</term><term>Dapsone intoxication</term><term>Dapsone overdose</term><term>Dapsone poisoning</term><term>Dehydrogenase deficiency</term><term>Dermatitis herpetiformis</term><term>Dos</term><term>Elimination half</term><term>Emergency medicine</term><term>Face mask</term><term>Gastric decontamination</term><term>Gastric lavage</term><term>Hemolytic anemia</term><term>Hours postingestion</term><term>Ingestion</term><term>Intensive care unit</term><term>Intoxication</term><term>Methemoglobin</term><term>Methemoglobin concentration</term><term>Methemoglobin concentrations</term><term>Methemoglobin levels</term><term>Methemoglobinemia</term><term>Methylene</term><term>Mmhg</term><term>Nasogastric tube</term><term>Overdose</term><term>Oxygen saturation</term><term>Plasma exchange</term><term>Pulse rate</term><term>Respiratory rate</term><term>Reticulocyte count</term><term>Serum methemoglobin level</term><term>Southern california</term><term>Symptomatic methemoglobinemia</term><term>Toxic metabolites</term><term>Vital signs</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Two patients with dapsone intoxication, an adult and a 16-month-old child, are reported. Both developed symptomatic methemoglobin concentrations, of 35% and 37%, respectively, and improved with intravenous methylene blue. Methemoglobin levels subsequently rose in both cases to 25% at 24 and 37 hours, respectively. The recurrence of elevated methemoglobin levels resulted from either continued absorption of dapsone or its toxic metabolite from the gastrointestinal tract. Both patients were begun on serial oral activated charcoal and the child received a second methylene blue treatment. During the intoxication, serum hemoglobin concentrations dropped 2 gm with an increase in the reticulocyte count. Review of 20 cases of dapsone overdose from the literature showed that the major toxic manifestations are methemoglobinemia and hemolysis. Delayed sulfhemoglobinemia, reported in only one case, resolved spontaneously. The treatment of dapsone intoxication is intravenous methylene blue for symptomatic methemoglobinemia, gastric decontamination, and early administration of serial oral activated charcoal. Hemolysis is mild but transfusions may be required for patients with a glucose-6-phosphate dehydrogenase deficiency.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D04 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002D04 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Merge
|type= RBID
|clé= ISTEX:C60C5416821BFA12F26CB357972D7D2AA68C0BCE
|texte= Dapsone intoxication: Two case reports
}}
| This area was generated with Dilib version V0.6.33. |  |