Dapsone intoxication: Two case reports
Identifieur interne : 002732 ( Istex/Corpus ); précédent : 002731; suivant : 002733Dapsone intoxication: Two case reports
Auteurs : Duane G. Hansen ; Kathryn R. Challoner ; Dallas E. SmithSource :
- Journal of Emergency Medicine [ 0736-4679 ] ; 1994.
English descriptors
- Teeft :
- Acute dapsone intoxication, Arterial blood, Arterial blood gases, Ascorbic acid, Blood pressure mmhg, Case report, Charcoal hemoperfusion, Clin toxicol, Dapsone, Dapsone intoxication, Dapsone overdose, Dapsone poisoning, Dehydrogenase deficiency, Dermatitis herpetiformis, Dos, Elimination half, Emergency medicine, Face mask, Gastric decontamination, Gastric lavage, Hemolytic anemia, Hours postingestion, Ingestion, Intensive care unit, Intoxication, Methemoglobin, Methemoglobin concentration, Methemoglobin concentrations, Methemoglobin levels, Methemoglobinemia, Methylene, Mmhg, Nasogastric tube, Overdose, Oxygen saturation, Plasma exchange, Pulse rate, Respiratory rate, Reticulocyte count, Serum methemoglobin level, Southern california, Symptomatic methemoglobinemia, Toxic metabolites, Vital signs.
Abstract
Abstract: Two patients with dapsone intoxication, an adult and a 16-month-old child, are reported. Both developed symptomatic methemoglobin concentrations, of 35% and 37%, respectively, and improved with intravenous methylene blue. Methemoglobin levels subsequently rose in both cases to 25% at 24 and 37 hours, respectively. The recurrence of elevated methemoglobin levels resulted from either continued absorption of dapsone or its toxic metabolite from the gastrointestinal tract. Both patients were begun on serial oral activated charcoal and the child received a second methylene blue treatment. During the intoxication, serum hemoglobin concentrations dropped 2 gm with an increase in the reticulocyte count. Review of 20 cases of dapsone overdose from the literature showed that the major toxic manifestations are methemoglobinemia and hemolysis. Delayed sulfhemoglobinemia, reported in only one case, resolved spontaneously. The treatment of dapsone intoxication is intravenous methylene blue for symptomatic methemoglobinemia, gastric decontamination, and early administration of serial oral activated charcoal. Hemolysis is mild but transfusions may be required for patients with a glucose-6-phosphate dehydrogenase deficiency.
Url:
DOI: 10.1016/0736-4679(94)90277-1
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ISTEX:C60C5416821BFA12F26CB357972D7D2AA68C0BCELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Dapsone intoxication: Two case reports</title><author><name sortKey="Hansen, Duane G" sort="Hansen, Duane G" uniqKey="Hansen D" first="Duane G." last="Hansen">Duane G. Hansen</name><affiliation><mods:affiliation>Physician, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Challoner, Kathryn R" sort="Challoner, Kathryn R" uniqKey="Challoner K" first="Kathryn R." last="Challoner">Kathryn R. Challoner</name><affiliation><mods:affiliation>Reprint Address: Kathryn R. Challoner, MD, LAC + USC Medical Center, Unit 1, Room 1102, 1200 N. State Street, Los Angeles, CA 90033</mods:affiliation></affiliation><affiliation><mods:affiliation>Assistant Professor of Clinical Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Smith, Dallas E" sort="Smith, Dallas E" uniqKey="Smith D" first="Dallas E." last="Smith">Dallas E. Smith</name><affiliation><mods:affiliation>Resident, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C60C5416821BFA12F26CB357972D7D2AA68C0BCE</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1016/0736-4679(94)90277-1</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-PXV0RF6H-7/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002732</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002732</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Dapsone intoxication: Two case reports</title><author><name sortKey="Hansen, Duane G" sort="Hansen, Duane G" uniqKey="Hansen D" first="Duane G." last="Hansen">Duane G. Hansen</name><affiliation><mods:affiliation>Physician, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Challoner, Kathryn R" sort="Challoner, Kathryn R" uniqKey="Challoner K" first="Kathryn R." last="Challoner">Kathryn R. Challoner</name><affiliation><mods:affiliation>Reprint Address: Kathryn R. Challoner, MD, LAC + USC Medical Center, Unit 1, Room 1102, 1200 N. State Street, Los Angeles, CA 90033</mods:affiliation></affiliation><affiliation><mods:affiliation>Assistant Professor of Clinical Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Smith, Dallas E" sort="Smith, Dallas E" uniqKey="Smith D" first="Dallas E." last="Smith">Dallas E. Smith</name><affiliation><mods:affiliation>Resident, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Emergency Medicine</title><title level="j" type="abbrev">JEM</title><idno type="ISSN">0736-4679</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">12</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="347">347</biblScope><biblScope unit="page" to="351">351</biblScope></imprint><idno type="ISSN">0736-4679</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0736-4679</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute dapsone intoxication</term><term>Arterial blood</term><term>Arterial blood gases</term><term>Ascorbic acid</term><term>Blood pressure mmhg</term><term>Case report</term><term>Charcoal hemoperfusion</term><term>Clin toxicol</term><term>Dapsone</term><term>Dapsone intoxication</term><term>Dapsone overdose</term><term>Dapsone poisoning</term><term>Dehydrogenase deficiency</term><term>Dermatitis herpetiformis</term><term>Dos</term><term>Elimination half</term><term>Emergency medicine</term><term>Face mask</term><term>Gastric decontamination</term><term>Gastric lavage</term><term>Hemolytic anemia</term><term>Hours postingestion</term><term>Ingestion</term><term>Intensive care unit</term><term>Intoxication</term><term>Methemoglobin</term><term>Methemoglobin concentration</term><term>Methemoglobin concentrations</term><term>Methemoglobin levels</term><term>Methemoglobinemia</term><term>Methylene</term><term>Mmhg</term><term>Nasogastric tube</term><term>Overdose</term><term>Oxygen saturation</term><term>Plasma exchange</term><term>Pulse rate</term><term>Respiratory rate</term><term>Reticulocyte count</term><term>Serum methemoglobin level</term><term>Southern california</term><term>Symptomatic methemoglobinemia</term><term>Toxic metabolites</term><term>Vital signs</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Two patients with dapsone intoxication, an adult and a 16-month-old child, are reported. Both developed symptomatic methemoglobin concentrations, of 35% and 37%, respectively, and improved with intravenous methylene blue. Methemoglobin levels subsequently rose in both cases to 25% at 24 and 37 hours, respectively. The recurrence of elevated methemoglobin levels resulted from either continued absorption of dapsone or its toxic metabolite from the gastrointestinal tract. Both patients were begun on serial oral activated charcoal and the child received a second methylene blue treatment. During the intoxication, serum hemoglobin concentrations dropped 2 gm with an increase in the reticulocyte count. Review of 20 cases of dapsone overdose from the literature showed that the major toxic manifestations are methemoglobinemia and hemolysis. Delayed sulfhemoglobinemia, reported in only one case, resolved spontaneously. The treatment of dapsone intoxication is intravenous methylene blue for symptomatic methemoglobinemia, gastric decontamination, and early administration of serial oral activated charcoal. 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Hansen MD</name><affiliations><json:string>Physician, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</json:string></affiliations></json:item><json:item><name>Kathryn R. Challoner MD</name><affiliations><json:string>Reprint Address: Kathryn R. Challoner, MD, LAC + USC Medical Center, Unit 1, Room 1102, 1200 N. State Street, Los Angeles, CA 90033</json:string><json:string>Assistant Professor of Clinical Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</json:string></affiliations></json:item><json:item><name>Dallas E. 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Both developed symptomatic methemoglobin concentrations, of 35% and 37%, respectively, and improved with intravenous methylene blue. Methemoglobin levels subsequently rose in both cases to 25% at 24 and 37 hours, respectively. The recurrence of elevated methemoglobin levels resulted from either continued absorption of dapsone or its toxic metabolite from the gastrointestinal tract. Both patients were begun on serial oral activated charcoal and the child received a second methylene blue treatment. During the intoxication, serum hemoglobin concentrations dropped 2 gm with an increase in the reticulocyte count. Review of 20 cases of dapsone overdose from the literature showed that the major toxic manifestations are methemoglobinemia and hemolysis. Delayed sulfhemoglobinemia, reported in only one case, resolved spontaneously. The treatment of dapsone intoxication is intravenous methylene blue for symptomatic methemoglobinemia, gastric decontamination, and early administration of serial oral activated charcoal. Hemolysis is mild but transfusions may be required for patients with a glucose-6-phosphate dehydrogenase deficiency.</abstract><qualityIndicators><score>6.773</score><pdfWordCount>2781</pdfWordCount><pdfCharCount>17746</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>576 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>166</abstractWordCount><abstractCharCount>1237</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Dapsone intoxication: Two case reports</title><pmid><json:string>8040592</json:string></pmid><pii><json:string>0736-4679(94)90277-1</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Journal of Emergency Medicine</title><language><json:string>unknown</json:string></language><publicationDate>1994</publicationDate><issn><json:string>0736-4679</json:string></issn><pii><json:string>S0736-4679(00)X0116-3</json:string></pii><volume>12</volume><issue>3</issue><pages><first>347</first><last>351</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1994</json:string></date><geogName></geogName><orgName><json:string>USC Medical Center</json:string><json:string>University of Southern California Medical Center, Los Angeles</json:string><json:string>University of Southern California Medical Center</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>D. 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Challoner, MD, LAC + USC Medical Center, Unit 1, Room 1102, 1200 N. State Street, Los Angeles, CA 90033</affiliation><affiliation>Assistant Professor of Clinical Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Dallas E.</forename><surname>Smith</surname></persName><roleName type="degree">MD</roleName><affiliation>Resident, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</affiliation></author><idno type="istex">C60C5416821BFA12F26CB357972D7D2AA68C0BCE</idno><idno type="ark">ark:/67375/6H6-PXV0RF6H-7</idno><idno type="DOI">10.1016/0736-4679(94)90277-1</idno><idno type="PII">0736-4679(94)90277-1</idno></analytic><monogr><title level="j">Journal of Emergency Medicine</title><title level="j" type="abbrev">JEM</title><idno type="pISSN">0736-4679</idno><idno type="PII">S0736-4679(00)X0116-3</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994"></date><biblScope unit="volume">12</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="347">347</biblScope><biblScope unit="page" to="351">351</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Two patients with dapsone intoxication, an adult and a 16-month-old child, are reported. Both developed symptomatic methemoglobin concentrations, of 35% and 37%, respectively, and improved with intravenous methylene blue. Methemoglobin levels subsequently rose in both cases to 25% at 24 and 37 hours, respectively. The recurrence of elevated methemoglobin levels resulted from either continued absorption of dapsone or its toxic metabolite from the gastrointestinal tract. Both patients were begun on serial oral activated charcoal and the child received a second methylene blue treatment. During the intoxication, serum hemoglobin concentrations dropped 2 gm with an increase in the reticulocyte count. Review of 20 cases of dapsone overdose from the literature showed that the major toxic manifestations are methemoglobinemia and hemolysis. Delayed sulfhemoglobinemia, reported in only one case, resolved spontaneously. The treatment of dapsone intoxication is intravenous methylene blue for symptomatic methemoglobinemia, gastric decontamination, and early administration of serial oral activated charcoal. Hemolysis is mild but transfusions may be required for patients with a glucose-6-phosphate dehydrogenase deficiency.</p></abstract><textClass><keywords scheme="keyword"><list><head>article-category</head><item><term>Selected topics toxicology</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>dapsone overdose</term></item><item><term>methylene blue</term></item><item><term>methemoglobinemia</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1993-11-01">Modified</change><change when="1994">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-PXV0RF6H-7/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JEM</jid><aid>94902771</aid><ce:pii>0736-4679(94)90277-1</ce:pii><ce:doi>10.1016/0736-4679(94)90277-1</ce:doi><ce:copyright type="unknown" year="1994"></ce:copyright><ce:doctopics><ce:doctopic><ce:text>Selected topics toxicology</ce:text></ce:doctopic></ce:doctopics></item-info><head><ce:title>Dapsone intoxication: Two case reports</ce:title><ce:author-group><ce:author><ce:given-name>Duane G.</ce:given-name><ce:surname>Hansen</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Kathryn R.</ce:given-name><ce:surname>Challoner</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Dallas E.</ce:given-name><ce:surname>Smith</ce:surname><ce:degrees>MD</ce:degrees><ce:cross-ref refid="AFF3"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Physician, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Assistant Professor of Clinical Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Resident, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Reprint Address: Kathryn R. Challoner, MD, LAC + USC Medical Center, Unit 1, Room 1102, 1200 N. State Street, Los Angeles, CA 90033</ce:text></ce:correspondence></ce:author-group><ce:date-received day="10" month="3" year="1993"></ce:date-received><ce:date-revised day="1" month="11" year="1993"></ce:date-revised><ce:date-accepted day="15" month="11" year="1993"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Two patients with dapsone intoxication, an adult and a 16-month-old child, are reported. Both developed symptomatic methemoglobin concentrations, of 35% and 37%, respectively, and improved with intravenous methylene blue. Methemoglobin levels subsequently rose in both cases to 25% at 24 and 37 hours, respectively. The recurrence of elevated methemoglobin levels resulted from either continued absorption of dapsone or its toxic metabolite from the gastrointestinal tract. Both patients were begun on serial oral activated charcoal and the child received a second methylene blue treatment. During the intoxication, serum hemoglobin concentrations dropped 2 gm with an increase in the reticulocyte count. Review of 20 cases of dapsone overdose from the literature showed that the major toxic manifestations are methemoglobinemia and hemolysis. Delayed sulfhemoglobinemia, reported in only one case, resolved spontaneously. The treatment of dapsone intoxication is intravenous methylene blue for symptomatic methemoglobinemia, gastric decontamination, and early administration of serial oral activated charcoal. Hemolysis is mild but transfusions may be required for patients with a glucose-6-phosphate dehydrogenase deficiency.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>dapsone overdose</ce:text></ce:keyword><ce:keyword><ce:text>methylene blue</ce:text></ce:keyword><ce:keyword><ce:text>methemoglobinemia</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Dapsone intoxication: Two case reports</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Dapsone intoxication: Two case reports</title></titleInfo><name type="personal"><namePart type="given">Duane G.</namePart><namePart type="family">Hansen</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Physician, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kathryn R.</namePart><namePart type="family">Challoner</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Reprint Address: Kathryn R. Challoner, MD, LAC + USC Medical Center, Unit 1, Room 1102, 1200 N. State Street, Los Angeles, CA 90033</affiliation><affiliation>Assistant Professor of Clinical Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dallas E.</namePart><namePart type="family">Smith</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Resident, Emergency Medicine, The Department of Emergency Medicine, University of Southern California School of Medicine and Los Angeles County/University of Southern California Medical Center, Los Angeles, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><dateModified encoding="w3cdtf">1993-11-01</dateModified><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Two patients with dapsone intoxication, an adult and a 16-month-old child, are reported. Both developed symptomatic methemoglobin concentrations, of 35% and 37%, respectively, and improved with intravenous methylene blue. Methemoglobin levels subsequently rose in both cases to 25% at 24 and 37 hours, respectively. The recurrence of elevated methemoglobin levels resulted from either continued absorption of dapsone or its toxic metabolite from the gastrointestinal tract. Both patients were begun on serial oral activated charcoal and the child received a second methylene blue treatment. During the intoxication, serum hemoglobin concentrations dropped 2 gm with an increase in the reticulocyte count. Review of 20 cases of dapsone overdose from the literature showed that the major toxic manifestations are methemoglobinemia and hemolysis. Delayed sulfhemoglobinemia, reported in only one case, resolved spontaneously. The treatment of dapsone intoxication is intravenous methylene blue for symptomatic methemoglobinemia, gastric decontamination, and early administration of serial oral activated charcoal. Hemolysis is mild but transfusions may be required for patients with a glucose-6-phosphate dehydrogenase deficiency.</abstract><subject><genre>article-category</genre><topic>Selected topics toxicology</topic></subject><subject><genre>Keywords</genre><topic>dapsone overdose</topic><topic>methylene blue</topic><topic>methemoglobinemia</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Emergency Medicine</title></titleInfo><titleInfo type="abbreviated"><title>JEM</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued></originInfo><identifier type="ISSN">0736-4679</identifier><identifier type="PII">S0736-4679(00)X0116-3</identifier><part><date>1994</date><detail type="volume"><number>12</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue-pages"><start>285</start><end>439</end></extent><extent unit="pages"><start>347</start><end>351</end></extent></part></relatedItem><identifier type="istex">C60C5416821BFA12F26CB357972D7D2AA68C0BCE</identifier><identifier type="ark">ark:/67375/6H6-PXV0RF6H-7</identifier><identifier type="DOI">10.1016/0736-4679(94)90277-1</identifier><identifier type="PII">0736-4679(94)90277-1</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-PXV0RF6H-7/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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