Iron withholding: A defense against viral infections
Identifieur interne : 002A89 ( Main/Merge ); précédent : 002A88; suivant : 002A90Iron withholding: A defense against viral infections
Auteurs : E. D. Weinberg [États-Unis]Source :
- Biometals [ 0966-0844 ] ; 1996-10-01.
English descriptors
- KwdEn :
- Teeft :
- Alveolar macrophages, Animal models, Cemeroglu ozsoylu, Chronic hepatitis, Clinical phase, Daily dose, Defense system, Different study, Excessive iron, Ferritin, Hepatic, Hepatic iron content, Hepatitis, Herpes virus, Host cells, Human immunodeficiency virus type, Indiana university, Infection, Iron content, Iron loading, Iron metabolism, Iron reduction therapy, Iron values, Iron withholding, Iron withholding defense system, Japanese encephalitis virus, Karupiah harris, Kupffer cells, Macrophage, Mild infections, Nitric, Nitric oxide, Oxidative stress, Oxide, Replication, Serum ferritin, Serum iron, Serum iron levels, Similar study, Smoker, Surface antigen, Thalassemic patients, Transcriptase activity, Transferrin, Transferrin iron saturation, Transfusion, Viral, Viral infections, Viral replication, Weinberg, Weinberg weinberg.
Abstract
Abstract: A variety of laboratory and clinical investigations during the past 15 years have observed that one of the dangers of excessive iron is its ability to favor animal viral infections. The metal is essential for host cell synthesis of virions and can also impair defense cell function and increase oxidative stress. In both animal models and humans, viral infections cause upregulation of the iron withholding defense system. Factors that suppress the system enhance viral progression; factors that strengthen the system augment host defense. Procedures designed to reinforce the system are being developed and tested; some of these may become useful adjuncts in prevention and management of viral diseases.
Url:
DOI: 10.1007/BF00140609
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<term>Daily dose</term>
<term>Defense system</term>
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<term>Excessive iron</term>
<term>Ferritin</term>
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<term>Herpes virus</term>
<term>Host cells</term>
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<term>Indiana university</term>
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<term>Iron content</term>
<term>Iron loading</term>
<term>Iron metabolism</term>
<term>Iron reduction therapy</term>
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<term>Iron withholding</term>
<term>Iron withholding defense system</term>
<term>Japanese encephalitis virus</term>
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<term>Mild infections</term>
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<term>Nitric oxide</term>
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<term>Replication</term>
<term>Serum ferritin</term>
<term>Serum iron</term>
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<term>Transcriptase activity</term>
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<term>Transferrin iron saturation</term>
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<front><div type="abstract" xml:lang="en">Abstract: A variety of laboratory and clinical investigations during the past 15 years have observed that one of the dangers of excessive iron is its ability to favor animal viral infections. The metal is essential for host cell synthesis of virions and can also impair defense cell function and increase oxidative stress. In both animal models and humans, viral infections cause upregulation of the iron withholding defense system. Factors that suppress the system enhance viral progression; factors that strengthen the system augment host defense. Procedures designed to reinforce the system are being developed and tested; some of these may become useful adjuncts in prevention and management of viral diseases.</div>
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