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Iron withholding: A defense against viral infections

Identifieur interne : 000244 ( Istex/Corpus ); précédent : 000243; suivant : 000245

Iron withholding: A defense against viral infections

Auteurs : E. D. Weinberg

Source :

RBID : ISTEX:2F174D564843C1391FB7C8F58390766C0551B069

English descriptors

Abstract

Abstract: A variety of laboratory and clinical investigations during the past 15 years have observed that one of the dangers of excessive iron is its ability to favor animal viral infections. The metal is essential for host cell synthesis of virions and can also impair defense cell function and increase oxidative stress. In both animal models and humans, viral infections cause upregulation of the iron withholding defense system. Factors that suppress the system enhance viral progression; factors that strengthen the system augment host defense. Procedures designed to reinforce the system are being developed and tested; some of these may become useful adjuncts in prevention and management of viral diseases.

Url:
DOI: 10.1007/BF00140609

Links to Exploration step

ISTEX:2F174D564843C1391FB7C8F58390766C0551B069

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<dateCreated encoding="w3cdtf">1996-02-06</dateCreated>
<dateIssued encoding="w3cdtf">1996-10-01</dateIssued>
<copyrightDate encoding="w3cdtf">1996</copyrightDate>
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<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<abstract lang="en">Abstract: A variety of laboratory and clinical investigations during the past 15 years have observed that one of the dangers of excessive iron is its ability to favor animal viral infections. The metal is essential for host cell synthesis of virions and can also impair defense cell function and increase oxidative stress. In both animal models and humans, viral infections cause upregulation of the iron withholding defense system. Factors that suppress the system enhance viral progression; factors that strengthen the system augment host defense. Procedures designed to reinforce the system are being developed and tested; some of these may become useful adjuncts in prevention and management of viral diseases.</abstract>
<note>Mini-Review</note>
<subject lang="en">
<genre>Keywords</genre>
<topic>iron</topic>
<topic>iron withholding defense</topic>
<topic>viral infections</topic>
</subject>
<relatedItem type="host">
<titleInfo>
<title>Biometals</title>
</titleInfo>
<titleInfo type="abbreviated">
<title>Biometals</title>
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<originInfo>
<publisher>Springer</publisher>
<dateIssued encoding="w3cdtf">1996-10-01</dateIssued>
<copyrightDate encoding="w3cdtf">1996</copyrightDate>
</originInfo>
<subject>
<genre>Life Sciences</genre>
<topic>Physical Chemistry</topic>
<topic>Biochemistry, general</topic>
</subject>
<identifier type="ISSN">0966-0844</identifier>
<identifier type="eISSN">1572-8773</identifier>
<identifier type="JournalID">10534</identifier>
<identifier type="IssueArticleCount">10</identifier>
<identifier type="VolumeIssueCount">4</identifier>
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<date>1996</date>
<detail type="volume">
<number>9</number>
<caption>vol.</caption>
</detail>
<detail type="issue">
<number>4</number>
<caption>no.</caption>
</detail>
<extent unit="pages">
<start>393</start>
<end>399</end>
</extent>
</part>
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<recordOrigin>Rapid Science Publishers, 1996</recordOrigin>
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<identifier type="istex">2F174D564843C1391FB7C8F58390766C0551B069</identifier>
<identifier type="ark">ark:/67375/1BB-8S66VTG9-N</identifier>
<identifier type="DOI">10.1007/BF00140609</identifier>
<identifier type="ArticleID">BF00140609</identifier>
<identifier type="ArticleID">Art10</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Rapid Science Publishers Ltd, 1996</accessCondition>
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<recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource>
<recordOrigin>Rapid Science Publishers Ltd, 1996</recordOrigin>
</recordInfo>
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