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Idiopathic Inflammatory Myopathy with Diffuse Alveolar Damage

Identifieur interne : 002242 ( Main/Merge ); précédent : 002241; suivant : 002243

Idiopathic Inflammatory Myopathy with Diffuse Alveolar Damage

Auteurs : C.-S. Lee [Taïwan] ; T.-L. Chen [Taïwan] ; C.-Y. Tzen [Taïwan] ; F.-J. Lin [Taïwan] ; M.-J. Peng [Taïwan] ; C.-L. Wu [Taïwan] ; P.-J. Chen [Taïwan]

Source :

RBID : ISTEX:4E4BDC8D9CA4504962F983A0E11B25B1A10FA13F

English descriptors

Abstract

Abstract:: Interstitial lung disease (ILD) in patients with myositis is defined by the presence of interstitial changes on radiographic examination. The reported prevalence of ILD varies from 0% to nearly 50%. However, only rarely has the pathological pattern of diffuse alveolar damage (DAD) associated with idiopathic inflammatory myopathy (IIM) been reported. We report five patients with IIM (one with dermatomyositis, one with polymyositis, and three with amyopathic dermatomyositis) and respiratory failure. Four underwent open lung biopsy with pathological proof of diffuse alveolar damage (DAD). Despite intensive immunosuppressive therapy, all of them died. In addition to the case reports, we discuss DAD in patients with IIM.

Url:
DOI: 10.1007/s100670200104

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ISTEX:4E4BDC8D9CA4504962F983A0E11B25B1A10FA13F

Le document en format XML

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<div type="abstract" xml:lang="en">Abstract:: Interstitial lung disease (ILD) in patients with myositis is defined by the presence of interstitial changes on radiographic examination. The reported prevalence of ILD varies from 0% to nearly 50%. However, only rarely has the pathological pattern of diffuse alveolar damage (DAD) associated with idiopathic inflammatory myopathy (IIM) been reported. We report five patients with IIM (one with dermatomyositis, one with polymyositis, and three with amyopathic dermatomyositis) and respiratory failure. Four underwent open lung biopsy with pathological proof of diffuse alveolar damage (DAD). Despite intensive immunosuppressive therapy, all of them died. In addition to the case reports, we discuss DAD in patients with IIM.</div>
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