Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells
Identifieur interne : 000B52 ( Main/Merge ); précédent : 000B51; suivant : 000B53Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells
Auteurs : Hsueh-Wei Chang [Taïwan] ; Pei-Feng Liu ; Wei-Lun Tsai ; Wan-Hsiang Hu ; Yu-Chang Hu ; Hsiu-Chen Yang ; Wei-Yu Lin ; Jing-Ru Weng [Taïwan] ; Chih-Wen Shu [Taïwan]Source :
- Toxins [ 2072-6651 ] ; 2019.
Abstract
Autophagy is an evolutionarily conserved pathway to degrade damaged proteins and organelles for subsequent recycling in cells during times of nutrient deprivation. This process plays an important role in tumor development and progression, allowing cancer cells to survive in nutrient-poor environments. The plant kingdom provides a powerful source for new drug development to treat cancer. Several plant extracts induce autophagy in cancer cells. However, little is known about the role of plant extracts in autophagy inhibition, particularly autophagy-related (ATG) proteins. In this study, we employed S-tagged gamma-aminobutyric acid receptor associated protein like 2 (GABARAPL2) as a reporter to screen 48 plant extracts for their effects on the activity of autophagy protease ATG4B.
Url:
DOI: 10.3390/toxins11060313
PubMed: 31159487
PubMed Central: 6628400
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PMC:6628400Le document en format XML
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Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Xanthium strumarium</italic>
Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells</title>
<author><name sortKey="Chang, Hsueh Wei" sort="Chang, Hsueh Wei" uniqKey="Chang H" first="Hsueh-Wei" last="Chang">Hsueh-Wei Chang</name>
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(H.-C.Y.)</nlm:aff>
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<author><name sortKey="Tsai, Wei Lun" sort="Tsai, Wei Lun" uniqKey="Tsai W" first="Wei-Lun" last="Tsai">Wei-Lun Tsai</name>
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<author><name sortKey="Hu, Wan Hsiang" sort="Hu, Wan Hsiang" uniqKey="Hu W" first="Wan-Hsiang" last="Hu">Wan-Hsiang Hu</name>
<affiliation><nlm:aff id="af6-toxins-11-00313">Department of Colorectal Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83341, Taiwan;<email>gary.hu0805@msa.hinet.net</email>
</nlm:aff>
</affiliation>
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<author><name sortKey="Hu, Yu Chang" sort="Hu, Yu Chang" uniqKey="Hu Y" first="Yu-Chang" last="Hu">Yu-Chang Hu</name>
<affiliation><nlm:aff id="af7-toxins-11-00313">Department of Radiation Oncology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan;<email>ychu81@gmail.com</email>
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<author><name sortKey="Yang, Hsiu Chen" sort="Yang, Hsiu Chen" uniqKey="Yang H" first="Hsiu-Chen" last="Yang">Hsiu-Chen Yang</name>
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(H.-C.Y.)</nlm:aff>
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<affiliation><nlm:aff id="af8-toxins-11-00313">Department of Pharmacy, Kinmen Hospital, Kinmen 89142, Taiwan;<email>u8557006@gmail.com</email>
</nlm:aff>
</affiliation>
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<series><title level="j">Toxins</title>
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<front><div type="abstract" xml:lang="en"><p>Autophagy is an evolutionarily conserved pathway to degrade damaged proteins and organelles for subsequent recycling in cells during times of nutrient deprivation. This process plays an important role in tumor development and progression, allowing cancer cells to survive in nutrient-poor environments. The plant kingdom provides a powerful source for new drug development to treat cancer. Several plant extracts induce autophagy in cancer cells. However, little is known about the role of plant extracts in autophagy inhibition, particularly autophagy-related (ATG) proteins. In this study, we employed S-tagged gamma-aminobutyric acid receptor associated protein like 2 (GABARAPL2) as a reporter to screen 48 plant extracts for their effects on the activity of autophagy protease ATG4B. <italic>Xanthium strumarium</italic>
and <italic>Tribulus terrestris</italic>
fruit extracts were validated as potential ATG4B inhibitors by another reporter substrate MAP1LC3B-PLA<sub>2</sub>
. The inhibitory effects of the extracts on cellular ATG4B and autophagic flux were further confirmed. Moreover, the plant extracts significantly reduced colorectal cancer cell viability and sensitized cancer cells to starvation conditions. The fruit extract of <italic>X. strumarium</italic>
consistently diminished cancer cell migration and invasion. Taken together, the results showed that the fruit of <italic>X. strumarium</italic>
may have an active ingredient to inhibit ATG4B and suppress the proliferation and metastatic characteristics of colorectal cancer cells. </p>
</div>
</front>
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