Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells
Identifieur interne : 000668 ( Ncbi/Checkpoint ); précédent : 000667; suivant : 000669Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells
Auteurs : Hsueh-Wei Chang [Taïwan] ; Pei-Feng Liu ; Wei-Lun Tsai ; Wan-Hsiang Hu ; Yu-Chang Hu ; Hsiu-Chen Yang ; Wei-Yu Lin ; Jing-Ru Weng [Taïwan] ; Chih-Wen Shu [Taïwan]Source :
- Toxins [ 2072-6651 ] ; 2019.
Abstract
Autophagy is an evolutionarily conserved pathway to degrade damaged proteins and organelles for subsequent recycling in cells during times of nutrient deprivation. This process plays an important role in tumor development and progression, allowing cancer cells to survive in nutrient-poor environments. The plant kingdom provides a powerful source for new drug development to treat cancer. Several plant extracts induce autophagy in cancer cells. However, little is known about the role of plant extracts in autophagy inhibition, particularly autophagy-related (ATG) proteins. In this study, we employed S-tagged gamma-aminobutyric acid receptor associated protein like 2 (GABARAPL2) as a reporter to screen 48 plant extracts for their effects on the activity of autophagy protease ATG4B.
Url:
DOI: 10.3390/toxins11060313
PubMed: 31159487
PubMed Central: 6628400
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Xanthium strumarium</italic> Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells</title><author><name sortKey="Chang, Hsueh Wei" sort="Chang, Hsueh Wei" uniqKey="Chang H" first="Hsueh-Wei" last="Chang">Hsueh-Wei Chang</name><affiliation><nlm:aff id="af1-toxins-11-00313">Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;<email>changhw@kmu.edu.tw</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-toxins-11-00313">Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708</wicri:regionArea><wicri:noRegion>Kaohsiung 80708</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-toxins-11-00313">Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708</wicri:regionArea><wicri:noRegion>Kaohsiung 80708</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Pei Feng" sort="Liu, Pei Feng" uniqKey="Liu P" first="Pei-Feng" last="Liu">Pei-Feng Liu</name><affiliation><nlm:aff id="af4-toxins-11-00313">Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan;<email>pfliu@vghks.gov.tw</email> (P.-F.L.);<email>mini16610@gmail.com</email> (H.-C.Y.)</nlm:aff></affiliation></author><author><name sortKey="Tsai, Wei Lun" sort="Tsai, Wei Lun" uniqKey="Tsai W" first="Wei-Lun" last="Tsai">Wei-Lun Tsai</name><affiliation><nlm:aff id="af5-toxins-11-00313">Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan;<email>tsaiwl@yahoo.com.tw</email></nlm:aff></affiliation></author><author><name sortKey="Hu, Wan Hsiang" sort="Hu, Wan Hsiang" uniqKey="Hu W" first="Wan-Hsiang" last="Hu">Wan-Hsiang Hu</name><affiliation><nlm:aff id="af6-toxins-11-00313">Department of Colorectal Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83341, Taiwan;<email>gary.hu0805@msa.hinet.net</email></nlm:aff></affiliation></author><author><name sortKey="Hu, Yu Chang" sort="Hu, Yu Chang" uniqKey="Hu Y" first="Yu-Chang" last="Hu">Yu-Chang Hu</name><affiliation><nlm:aff id="af7-toxins-11-00313">Department of Radiation Oncology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan;<email>ychu81@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Yang, Hsiu Chen" sort="Yang, Hsiu Chen" uniqKey="Yang H" first="Hsiu-Chen" last="Yang">Hsiu-Chen Yang</name><affiliation><nlm:aff id="af4-toxins-11-00313">Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan;<email>pfliu@vghks.gov.tw</email> (P.-F.L.);<email>mini16610@gmail.com</email> (H.-C.Y.)</nlm:aff></affiliation></author><author><name sortKey="Lin, Wei Yu" sort="Lin, Wei Yu" uniqKey="Lin W" first="Wei-Yu" last="Lin">Wei-Yu Lin</name><affiliation><nlm:aff id="af8-toxins-11-00313">Department of Pharmacy, Kinmen Hospital, Kinmen 89142, Taiwan;<email>u8557006@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Weng, Jing Ru" sort="Weng, Jing Ru" uniqKey="Weng J" first="Jing-Ru" last="Weng">Jing-Ru Weng</name><affiliation wicri:level="1"><nlm:aff id="af9-toxins-11-00313">Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424</wicri:regionArea><wicri:noRegion>Kaohsiung 80424</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Chih Wen" sort="Shu, Chih Wen" uniqKey="Shu C" first="Chih-Wen" last="Shu">Chih-Wen Shu</name><affiliation wicri:level="1"><nlm:aff id="af10-toxins-11-00313">School of Medicine for International Students, I-Shou University, Kaohsiung 82445, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine for International Students, I-Shou University, Kaohsiung 82445</wicri:regionArea><wicri:noRegion>Kaohsiung 82445</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31159487</idno><idno type="pmc">6628400</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628400</idno><idno type="RBID">PMC:6628400</idno><idno type="doi">10.3390/toxins11060313</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000833</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000833</idno><idno type="wicri:Area/Pmc/Curation">000833</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000833</idno><idno type="wicri:Area/Pmc/Checkpoint">000A75</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A75</idno><idno type="wicri:Area/Ncbi/Merge">000668</idno><idno type="wicri:Area/Ncbi/Curation">000668</idno><idno type="wicri:Area/Ncbi/Checkpoint">000668</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Xanthium strumarium</italic> Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells</title><author><name sortKey="Chang, Hsueh Wei" sort="Chang, Hsueh Wei" uniqKey="Chang H" first="Hsueh-Wei" last="Chang">Hsueh-Wei Chang</name><affiliation><nlm:aff id="af1-toxins-11-00313">Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;<email>changhw@kmu.edu.tw</email></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-toxins-11-00313">Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708</wicri:regionArea><wicri:noRegion>Kaohsiung 80708</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-toxins-11-00313">Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708</wicri:regionArea><wicri:noRegion>Kaohsiung 80708</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Pei Feng" sort="Liu, Pei Feng" uniqKey="Liu P" first="Pei-Feng" last="Liu">Pei-Feng Liu</name><affiliation><nlm:aff id="af4-toxins-11-00313">Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan;<email>pfliu@vghks.gov.tw</email> (P.-F.L.);<email>mini16610@gmail.com</email> (H.-C.Y.)</nlm:aff></affiliation></author><author><name sortKey="Tsai, Wei Lun" sort="Tsai, Wei Lun" uniqKey="Tsai W" first="Wei-Lun" last="Tsai">Wei-Lun Tsai</name><affiliation><nlm:aff id="af5-toxins-11-00313">Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan;<email>tsaiwl@yahoo.com.tw</email></nlm:aff></affiliation></author><author><name sortKey="Hu, Wan Hsiang" sort="Hu, Wan Hsiang" uniqKey="Hu W" first="Wan-Hsiang" last="Hu">Wan-Hsiang Hu</name><affiliation><nlm:aff id="af6-toxins-11-00313">Department of Colorectal Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83341, Taiwan;<email>gary.hu0805@msa.hinet.net</email></nlm:aff></affiliation></author><author><name sortKey="Hu, Yu Chang" sort="Hu, Yu Chang" uniqKey="Hu Y" first="Yu-Chang" last="Hu">Yu-Chang Hu</name><affiliation><nlm:aff id="af7-toxins-11-00313">Department of Radiation Oncology, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan;<email>ychu81@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Yang, Hsiu Chen" sort="Yang, Hsiu Chen" uniqKey="Yang H" first="Hsiu-Chen" last="Yang">Hsiu-Chen Yang</name><affiliation><nlm:aff id="af4-toxins-11-00313">Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan;<email>pfliu@vghks.gov.tw</email> (P.-F.L.);<email>mini16610@gmail.com</email> (H.-C.Y.)</nlm:aff></affiliation></author><author><name sortKey="Lin, Wei Yu" sort="Lin, Wei Yu" uniqKey="Lin W" first="Wei-Yu" last="Lin">Wei-Yu Lin</name><affiliation><nlm:aff id="af8-toxins-11-00313">Department of Pharmacy, Kinmen Hospital, Kinmen 89142, Taiwan;<email>u8557006@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Weng, Jing Ru" sort="Weng, Jing Ru" uniqKey="Weng J" first="Jing-Ru" last="Weng">Jing-Ru Weng</name><affiliation wicri:level="1"><nlm:aff id="af9-toxins-11-00313">Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424</wicri:regionArea><wicri:noRegion>Kaohsiung 80424</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Chih Wen" sort="Shu, Chih Wen" uniqKey="Shu C" first="Chih-Wen" last="Shu">Chih-Wen Shu</name><affiliation wicri:level="1"><nlm:aff id="af10-toxins-11-00313">School of Medicine for International Students, I-Shou University, Kaohsiung 82445, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine for International Students, I-Shou University, Kaohsiung 82445</wicri:regionArea><wicri:noRegion>Kaohsiung 82445</wicri:noRegion></affiliation></author></analytic><series><title level="j">Toxins</title><idno type="eISSN">2072-6651</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Autophagy is an evolutionarily conserved pathway to degrade damaged proteins and organelles for subsequent recycling in cells during times of nutrient deprivation. This process plays an important role in tumor development and progression, allowing cancer cells to survive in nutrient-poor environments. The plant kingdom provides a powerful source for new drug development to treat cancer. Several plant extracts induce autophagy in cancer cells. However, little is known about the role of plant extracts in autophagy inhibition, particularly autophagy-related (ATG) proteins. In this study, we employed S-tagged gamma-aminobutyric acid receptor associated protein like 2 (GABARAPL2) as a reporter to screen 48 plant extracts for their effects on the activity of autophagy protease ATG4B. <italic>Xanthium strumarium</italic> and <italic>Tribulus terrestris</italic> fruit extracts were validated as potential ATG4B inhibitors by another reporter substrate MAP1LC3B-PLA<sub>2</sub>. The inhibitory effects of the extracts on cellular ATG4B and autophagic flux were further confirmed. Moreover, the plant extracts significantly reduced colorectal cancer cell viability and sensitized cancer cells to starvation conditions. The fruit extract of <italic>X. strumarium</italic> consistently diminished cancer cell migration and invasion. Taken together, the results showed that the fruit of <italic>X. strumarium</italic> may have an active ingredient to inhibit ATG4B and suppress the proliferation and metastatic characteristics of colorectal cancer cells. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Amaravadi, R" uniqKey="Amaravadi R">R. Amaravadi</name></author><author><name sortKey="Kimmelman, A C" uniqKey="Kimmelman A">A.C. Kimmelman</name></author><author><name sortKey="White, E" uniqKey="White E">E. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takamura, A" uniqKey="Takamura A">A. Takamura</name></author><author><name sortKey="Komatsu, M" uniqKey="Komatsu M">M. 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Chang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Hu, Wan Hsiang" sort="Hu, Wan Hsiang" uniqKey="Hu W" first="Wan-Hsiang" last="Hu">Wan-Hsiang Hu</name><name sortKey="Hu, Yu Chang" sort="Hu, Yu Chang" uniqKey="Hu Y" first="Yu-Chang" last="Hu">Yu-Chang Hu</name><name sortKey="Lin, Wei Yu" sort="Lin, Wei Yu" uniqKey="Lin W" first="Wei-Yu" last="Lin">Wei-Yu Lin</name><name sortKey="Liu, Pei Feng" sort="Liu, Pei Feng" uniqKey="Liu P" first="Pei-Feng" last="Liu">Pei-Feng Liu</name><name sortKey="Tsai, Wei Lun" sort="Tsai, Wei Lun" uniqKey="Tsai W" first="Wei-Lun" last="Tsai">Wei-Lun Tsai</name><name sortKey="Yang, Hsiu Chen" sort="Yang, Hsiu Chen" uniqKey="Yang H" first="Hsiu-Chen" last="Yang">Hsiu-Chen Yang</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Chang, Hsueh Wei" sort="Chang, Hsueh Wei" uniqKey="Chang H" first="Hsueh-Wei" last="Chang">Hsueh-Wei Chang</name></noRegion><name sortKey="Chang, Hsueh Wei" sort="Chang, Hsueh Wei" uniqKey="Chang H" first="Hsueh-Wei" last="Chang">Hsueh-Wei Chang</name><name sortKey="Shu, Chih Wen" sort="Shu, Chih Wen" uniqKey="Shu C" first="Chih-Wen" last="Shu">Chih-Wen Shu</name><name sortKey="Weng, Jing Ru" sort="Weng, Jing Ru" uniqKey="Weng J" first="Jing-Ru" last="Weng">Jing-Ru Weng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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