Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome
Identifieur interne : 000481 ( Main/Merge ); précédent : 000480; suivant : 000482Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome
Auteurs : David L. Leverenz [États-Unis] ; E. William St. Clair [États-Unis]Source :
- F1000Research [ 2046-1402 ] ; 2019.
Abstract
Primary Sjögren’s syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren’s syndrome also have extraglandular systemic complications, some of which can be organ- or life-threatening. Over the last decade, numerous targeted immunomodulatory therapies for primary Sjögren’s syndrome have failed to show a benefit in clinical trials, and as yet no disease-modifying therapy has been approved for this disease. Herein, we provide an updated review of the clinical trial landscape for primary Sjögren’s syndrome and the numerous efforts to move the field forward, including the development of new classification criteria and outcome measures, the results of recent clinical trials in this field, the challenges faced in the search for effective therapies, and the expanding pipeline of novel therapies under development.
Url:
DOI: 10.12688/f1000research.19842.1
PubMed: 31508200
PubMed Central: 6719673
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome</title><author><name sortKey="Leverenz, David L" sort="Leverenz, David L" uniqKey="Leverenz D" first="David L." last="Leverenz">David L. Leverenz</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110</wicri:regionArea><wicri:noRegion>27110</wicri:noRegion></affiliation></author><author><name sortKey="St Clair, E William" sort="St Clair, E William" uniqKey="St Clair E" first="E. William" last="St. Clair">E. William St. Clair</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110</wicri:regionArea><wicri:noRegion>27110</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31508200</idno><idno type="pmc">6719673</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719673</idno><idno type="RBID">PMC:6719673</idno><idno type="doi">10.12688/f1000research.19842.1</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000948</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000948</idno><idno type="wicri:Area/Pmc/Curation">000948</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000948</idno><idno type="wicri:Area/Pmc/Checkpoint">000437</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000437</idno><idno type="wicri:Area/Ncbi/Merge">000A16</idno><idno type="wicri:Area/Ncbi/Curation">000A16</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A16</idno><idno type="wicri:Area/Main/Merge">000481</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome</title><author><name sortKey="Leverenz, David L" sort="Leverenz, David L" uniqKey="Leverenz D" first="David L." last="Leverenz">David L. Leverenz</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110</wicri:regionArea><wicri:noRegion>27110</wicri:noRegion></affiliation></author><author><name sortKey="St Clair, E William" sort="St Clair, E William" uniqKey="St Clair E" first="E. William" last="St. Clair">E. William St. Clair</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110</wicri:regionArea><wicri:noRegion>27110</wicri:noRegion></affiliation></author></analytic><series><title level="j">F1000Research</title><idno type="eISSN">2046-1402</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Primary Sjögren’s syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren’s syndrome also have extraglandular systemic complications, some of which can be organ- or life-threatening. Over the last decade, numerous targeted immunomodulatory therapies for primary Sjögren’s syndrome have failed to show a benefit in clinical trials, and as yet no disease-modifying therapy has been approved for this disease. Herein, we provide an updated review of the clinical trial landscape for primary Sjögren’s syndrome and the numerous efforts to move the field forward, including the development of new classification criteria and outcome measures, the results of recent clinical trials in this field, the challenges faced in the search for effective therapies, and the expanding pipeline of novel therapies under development.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sjogren, H" uniqKey="Sjogren H">H Sjögren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gottenberg, Je" uniqKey="Gottenberg J">JE Gottenberg</name></author><author><name sortKey="Ravaud, P" uniqKey="Ravaud P">P Ravaud</name></author><author><name sortKey="Puechal, X" uniqKey="Puechal X">X Puéchal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, Ri" uniqKey="Fox R">RI Fox</name></author><author><name sortKey="Chan, E" uniqKey="Chan E">E Chan</name></author><author><name sortKey="Benton, L" uniqKey="Benton L">L Benton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, Ri" uniqKey="Fox R">RI Fox</name></author><author><name sortKey="Dixon, R" uniqKey="Dixon R">R Dixon</name></author><author><name sortKey="Guarrasi, V" uniqKey="Guarrasi V">V Guarrasi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tishler, M" uniqKey="Tishler M">M Tishler</name></author><author><name sortKey="Yaron, I" uniqKey="Yaron I">I Yaron</name></author><author><name sortKey="Shirazi, I" uniqKey="Shirazi I">I Shirazi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kruize, Aa" uniqKey="Kruize A">AA Kruize</name></author><author><name sortKey="Hene, Rj" uniqKey="Hene R">RJ Hené</name></author><author><name sortKey="Kallenberg, Cg" uniqKey="Kallenberg C">CG Kallenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nocturne, G" uniqKey="Nocturne G">G Nocturne</name></author><author><name sortKey="Mariette, X" uniqKey="Mariette X">X Mariette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mielle, J" uniqKey="Mielle J">J Mielle</name></author><author><name sortKey="Tison, A" uniqKey="Tison A">A Tison</name></author><author><name sortKey="Cornec, D" uniqKey="Cornec D">D Cornec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dass, S" uniqKey="Dass S">S Dass</name></author><author><name sortKey="Bowman, Sj" uniqKey="Bowman S">SJ Bowman</name></author><author><name sortKey="Vital, Em" uniqKey="Vital E">EM Vital</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devauchelle Pensec, V" uniqKey="Devauchelle Pensec V">V Devauchelle-Pensec</name></author><author><name sortKey="Pennec, Y" uniqKey="Pennec Y">Y Pennec</name></author><author><name sortKey="Morvan, J" uniqKey="Morvan J">J Morvan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pijpe, J" uniqKey="Pijpe J">J Pijpe</name></author><author><name sortKey="Van Imhoff, Gw" uniqKey="Van Imhoff G">GW van Imhoff</name></author><author><name sortKey="Spijkervet, Fk" uniqKey="Spijkervet F">FK Spijkervet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devauchelle Pensec, V" uniqKey="Devauchelle Pensec V">V Devauchelle-Pensec</name></author><author><name sortKey="Mariette, X" uniqKey="Mariette X">X Mariette</name></author><author><name sortKey="Jousse Joulin, S" uniqKey="Jousse Joulin S">S Jousse-Joulin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bowman, Sj" uniqKey="Bowman S">SJ Bowman</name></author><author><name sortKey="Everett, Cc" uniqKey="Everett C">CC Everett</name></author><author><name sortKey="O Wyer, Jl" uniqKey="O Wyer J">JL O’Dwyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, L" uniqKey="Shen L">L Shen</name></author><author><name sortKey="Suresh, L" uniqKey="Suresh L">L Suresh</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gatumu, Mk" uniqKey="Gatumu M">MK Gatumu</name></author><author><name sortKey="Skarstein, K" uniqKey="Skarstein K">K Skarstein</name></author><author><name sortKey="Papandile, A" uniqKey="Papandile A">A Papandile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hjelmervik, To" uniqKey="Hjelmervik T">TO Hjelmervik</name></author><author><name sortKey="Petersen, K" uniqKey="Petersen K">K Petersen</name></author><author><name sortKey="Jonassen, I" uniqKey="Jonassen I">I Jonassen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="St Clair, Ew" uniqKey="St Clair E">EW St Clair</name></author><author><name sortKey="Baer, An" uniqKey="Baer A">AN Baer</name></author><author><name sortKey="Wei, C" uniqKey="Wei C">C Wei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meiners, Pm" uniqKey="Meiners P">PM Meiners</name></author><author><name sortKey="Vissink, A" uniqKey="Vissink A">A Vissink</name></author><author><name sortKey="Kroese, Fg" uniqKey="Kroese F">FG Kroese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adler, S" uniqKey="Adler S">S Adler</name></author><author><name sortKey="Korner, M" uniqKey="Korner M">M Körner</name></author><author><name sortKey="Forger, F" uniqKey="Forger F">F Förger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baer, A" uniqKey="Baer A">A Baer</name></author><author><name sortKey="Gottenberg, Je" uniqKey="Gottenberg J">JE Gottenberg</name></author><author><name sortKey="St Clair, Ew" uniqKey="St Clair E">EW St. Clair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shiboski, Ch" uniqKey="Shiboski C">CH Shiboski</name></author><author><name sortKey="Shiboski, Sc" uniqKey="Shiboski S">SC Shiboski</name></author><author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shiboski, Ch" uniqKey="Shiboski C">CH Shiboski</name></author><author><name sortKey="Shiboski, Sc" uniqKey="Shiboski S">SC Shiboski</name></author><author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vitali, C" uniqKey="Vitali C">C Vitali</name></author><author><name sortKey="Bombardieri, S" uniqKey="Bombardieri S">S Bombardieri</name></author><author><name sortKey="Jonsson, R" uniqKey="Jonsson R">R Jonsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shiboski, Sc" uniqKey="Shiboski S">SC Shiboski</name></author><author><name sortKey="Shiboski, Ch" uniqKey="Shiboski C">CH Shiboski</name></author><author><name sortKey="Criswell, L" uniqKey="Criswell L">L Criswell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rasmussen, A" uniqKey="Rasmussen A">A Rasmussen</name></author><author><name sortKey="Ice, Ja" uniqKey="Ice J">JA Ice</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cornec, D" uniqKey="Cornec D">D Cornec</name></author><author><name sortKey="Saraux, A" uniqKey="Saraux A">A Saraux</name></author><author><name sortKey="Cochener, B" uniqKey="Cochener B">B Cochener</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baer, An" uniqKey="Baer A">AN Baer</name></author><author><name sortKey="Mcadams Demarco, M" uniqKey="Mcadams Demarco M">M McAdams DeMarco</name></author><author><name sortKey="Shiboski, Sc" uniqKey="Shiboski S">SC Shiboski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Billings, M" uniqKey="Billings M">M Billings</name></author><author><name sortKey="Amin Hadavand, M" uniqKey="Amin Hadavand M">M Amin Hadavand</name></author><author><name sortKey="Alevizos, I" uniqKey="Alevizos I">I Alevizos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Goff, M" uniqKey="Le Goff M">M Le Goff</name></author><author><name sortKey="Cornec, D" uniqKey="Cornec D">D Cornec</name></author><author><name sortKey="Jousse Joulin, S" uniqKey="Jousse Joulin S">S Jousse-Joulin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsuboi, H" uniqKey="Tsuboi H">H Tsuboi</name></author><author><name sortKey="Hagiwara, S" uniqKey="Hagiwara S">S Hagiwara</name></author><author><name sortKey="Asashima, H" uniqKey="Asashima H">H Asashima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, L" uniqKey="Shen L">L Shen</name></author><author><name sortKey="Kapsogeorgou, Ek" uniqKey="Kapsogeorgou E">EK Kapsogeorgou</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, L" uniqKey="Shen L">L Shen</name></author><author><name sortKey="Suresh, L" uniqKey="Suresh L">L Suresh</name></author><author><name sortKey="Lindemann, M" uniqKey="Lindemann M">M Lindemann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karakus, S" uniqKey="Karakus S">S Karakus</name></author><author><name sortKey="Baer, An" uniqKey="Baer A">AN Baer</name></author><author><name sortKey="Agrawal, D" uniqKey="Agrawal D">D Agrawal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jousse Joulin, S" uniqKey="Jousse Joulin S">S Jousse-Joulin</name></author><author><name sortKey="Milic, V" uniqKey="Milic V">V Milic</name></author><author><name sortKey="Jonsson, Mv" uniqKey="Jonsson M">MV Jonsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chisholm, Dm" uniqKey="Chisholm D">DM Chisholm</name></author><author><name sortKey="Mason, Dk" uniqKey="Mason D">DK Mason</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tarpley, Tm" uniqKey="Tarpley T">TM Tarpley</name></author><author><name sortKey="Anderson, Lg" uniqKey="Anderson L">LG Anderson</name></author><author><name sortKey="White, Cl" uniqKey="White C">CL White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenspan, Js" uniqKey="Greenspan J">JS Greenspan</name></author><author><name sortKey="Daniels, Te" uniqKey="Daniels T">TE Daniels</name></author><author><name sortKey="Talal, N" uniqKey="Talal N">N Talal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daniels, Te" uniqKey="Daniels T">TE Daniels</name></author><author><name sortKey="Whitcher, Jp" uniqKey="Whitcher J">JP Whitcher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costa, S" uniqKey="Costa S">S Costa</name></author><author><name sortKey="Quintin Roue, I" uniqKey="Quintin Roue I">I Quintin-Roué</name></author><author><name sortKey="Lesourd, A" uniqKey="Lesourd A">A Lesourd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fisher, Ba" uniqKey="Fisher B">BA Fisher</name></author><author><name sortKey="Jonsson, R" uniqKey="Jonsson R">R Jonsson</name></author><author><name sortKey="Daniels, T" uniqKey="Daniels T">T Daniels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name></author><author><name sortKey="Ravaud, P" uniqKey="Ravaud P">P Ravaud</name></author><author><name sortKey="Bowman, Sj" uniqKey="Bowman S">SJ Bowman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name></author><author><name sortKey="Theander, E" uniqKey="Theander E">E Theander</name></author><author><name sortKey="Brun, Jg" uniqKey="Brun J">JG Brun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishikawa, A" uniqKey="Nishikawa A">A Nishikawa</name></author><author><name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name></author><author><name sortKey="Kassai, Y" uniqKey="Kassai Y">Y Kassai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanne, Am" uniqKey="Kanne A">AM Kanne</name></author><author><name sortKey="Julich, M" uniqKey="Julich M">M Jülich</name></author><author><name sortKey="Mahmutovic, A" uniqKey="Mahmutovic A">A Mahmutovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="James, K" uniqKey="James K">K James</name></author><author><name sortKey="Chipeta, C" uniqKey="Chipeta C">C Chipeta</name></author><author><name sortKey="Parker, A" uniqKey="Parker A">A Parker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martire, Mv" uniqKey="Martire M">MV Martire</name></author><author><name sortKey="Santiago, Ml" uniqKey="Santiago M">ML Santiago</name></author><author><name sortKey="Cazenave, T" uniqKey="Cazenave T">T Cazenave</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niemel, Rk" uniqKey="Niemel R">RK Niemelä</name></author><author><name sortKey="Takalo, R" uniqKey="Takalo R">R Takalo</name></author><author><name sortKey="P Kko, E" uniqKey="P Kko E">E Pääkkö</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jousse Joulin, S" uniqKey="Jousse Joulin S">S Jousse-Joulin</name></author><author><name sortKey="Devauchelle Pensec, V" uniqKey="Devauchelle Pensec V">V Devauchelle-Pensec</name></author><author><name sortKey="Cornec, D" uniqKey="Cornec D">D Cornec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fisher, Ba" uniqKey="Fisher B">BA Fisher</name></author><author><name sortKey="Everett, Cc" uniqKey="Everett C">CC Everett</name></author><author><name sortKey="Rout, J" uniqKey="Rout J">J Rout</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holdgate, N" uniqKey="Holdgate N">N Holdgate</name></author><author><name sortKey="St Clair, Ew" uniqKey="St Clair E">EW St Clair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mariette, X" uniqKey="Mariette X">X Mariette</name></author><author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name></author><author><name sortKey="Quartuccio, L" uniqKey="Quartuccio L">L Quartuccio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Vita, S" uniqKey="De Vita S">S De Vita</name></author><author><name sortKey="Quartuccio, L" uniqKey="Quartuccio L">L Quartuccio</name></author><author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dorner, T" uniqKey="Dorner T">T Dörner</name></author><author><name sortKey="Posch, M" uniqKey="Posch M">M Posch</name></author><author><name sortKey="Wagner, F" uniqKey="Wagner F">F Wagner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felten, R" uniqKey="Felten R">R Felten</name></author><author><name sortKey="Scher, F" uniqKey="Scher F">F Scher</name></author><author><name sortKey="Sibilia, J" uniqKey="Sibilia J">J Sibilia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cornec, D" uniqKey="Cornec D">D Cornec</name></author><author><name sortKey="Costa, S" uniqKey="Costa S">S Costa</name></author><author><name sortKey="Devauchelle Pensec, V" uniqKey="Devauchelle Pensec V">V Devauchelle-Pensec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pers, Jo" uniqKey="Pers J">JO Pers</name></author><author><name sortKey="Devauchelle, V" uniqKey="Devauchelle V">V Devauchelle</name></author><author><name sortKey="Daridon, C" uniqKey="Daridon C">C Daridon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dorner, T" uniqKey="Dorner T">T Dörner</name></author><author><name sortKey="Posch, Mg" uniqKey="Posch M">MG Posch</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nayar, S" uniqKey="Nayar S">S Nayar</name></author><author><name sortKey="Campos, J" uniqKey="Campos J">J Campos</name></author><author><name sortKey="Smith, Cg" uniqKey="Smith C">CG Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dorner, T" uniqKey="Dorner T">T Dörner</name></author><author><name sortKey="Zeher, M" uniqKey="Zeher M">M Zeher</name></author><author><name sortKey="Laessing, U" uniqKey="Laessing U">U Laessing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodewes, Ila" uniqKey="Bodewes I">ILA Bodewes</name></author><author><name sortKey="Bjork, A" uniqKey="Bjork A">A Björk</name></author><author><name sortKey="Versnel, Ma" uniqKey="Versnel M">MA Versnel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name></author><author><name sortKey="Nocturne, G" uniqKey="Nocturne G">G Nocturne</name></author><author><name sortKey="Lazure, T" uniqKey="Lazure T">T Lazure</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="James, J" uniqKey="James J">J James</name></author><author><name sortKey="Guthridge, J" uniqKey="Guthridge J">J Guthridge</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Kwok, Sk" uniqKey="Kwok S">SK Kwok</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dimitriou, Id" uniqKey="Dimitriou I">ID Dimitriou</name></author><author><name sortKey="Kapsogeorgou, Ek" uniqKey="Kapsogeorgou E">EK Kapsogeorgou</name></author><author><name sortKey="Moutsopoulos, Hm" uniqKey="Moutsopoulos H">HM Moutsopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wieczorek, G" uniqKey="Wieczorek G">G Wieczorek</name></author><author><name sortKey="Bigaud, M" uniqKey="Bigaud M">M Bigaud</name></author><author><name sortKey="Pfister, S" uniqKey="Pfister S">S Pfister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, Ri" uniqKey="Fox R">RI Fox</name></author><author><name sortKey="Fox, Cm" uniqKey="Fox C">CM Fox</name></author><author><name sortKey="Gottenberg, Je" uniqKey="Gottenberg J">JE Gottenberg</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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