Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy
Identifieur interne : 000292 ( Main/Merge ); précédent : 000291; suivant : 000293Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy
Auteurs : Huanhuan Lv [République populaire de Chine] ; Chenxiao Zhen [République populaire de Chine] ; Junyu Liu [République populaire de Chine] ; Pengfei Yang [République populaire de Chine] ; Lijiang Hu [République populaire de Chine] ; Peng Shang [République populaire de Chine]Source :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2019.
Abstract
Glutathione is the principal intracellular antioxidant buffer against oxidative stress and mainly exists in the forms of reduced glutathione (GSH) and oxidized glutathione (GSSG). The processes of glutathione synthesis, transport, utilization, and metabolism are tightly controlled to maintain intracellular glutathione homeostasis and redox balance. As for cancer cells, they exhibit a greater ROS level than normal cells in order to meet the enhanced metabolism and vicious proliferation; meanwhile, they also have to develop an increased antioxidant defense system to cope with the higher oxidant state. Growing numbers of studies have implicated that altering the glutathione antioxidant system is associated with multiple forms of programmed cell death in cancer cells. In this review, we firstly focus on glutathione homeostasis from the perspectives of glutathione synthesis, distribution, transportation, and metabolism. Then, we discuss the function of glutathione in the antioxidant process. Afterwards, we also summarize the recent advance in the understanding of the mechanism by which glutathione plays a key role in multiple forms of programmed cell death, including apoptosis, necroptosis, ferroptosis, and autophagy. Finally, we highlight the glutathione-targeting therapeutic approaches toward cancers. A comprehensive review on the glutathione homeostasis and the role of glutathione depletion in programmed cell death provide insight into the redox-based research concerning cancer therapeutics.
Url:
DOI: 10.1155/2019/3150145
PubMed: 31281572
PubMed Central: 6590529
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A89
- to stream Pmc, to step Curation: 000A89
- to stream Pmc, to step Checkpoint: 000256
- to stream Ncbi, to step Merge: 000779
- to stream Ncbi, to step Curation: 000779
- to stream Ncbi, to step Checkpoint: 000779
Links to Exploration step
PMC:6590529Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy</title>
<author><name sortKey="Lv, Huanhuan" sort="Lv, Huanhuan" uniqKey="Lv H" first="Huanhuan" last="Lv">Huanhuan Lv</name>
<affiliation wicri:level="1"><nlm:aff id="I1">School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I3">Zhejiang Heye Health Technology Co. Ltd., Anji, Zhejiang 313300, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Zhejiang Heye Health Technology Co. Ltd., Anji, Zhejiang 313300</wicri:regionArea>
<wicri:noRegion>Zhejiang 313300</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I4">Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400</wicri:regionArea>
<wicri:noRegion>Jiangsu 215400</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I5">Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhen, Chenxiao" sort="Zhen, Chenxiao" uniqKey="Zhen C" first="Chenxiao" last="Zhen">Chenxiao Zhen</name>
<affiliation wicri:level="1"><nlm:aff id="I1">School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I5">Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Junyu" sort="Liu, Junyu" uniqKey="Liu J" first="Junyu" last="Liu">Junyu Liu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I5">Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Pengfei" sort="Yang, Pengfei" uniqKey="Yang P" first="Pengfei" last="Yang">Pengfei Yang</name>
<affiliation wicri:level="1"><nlm:aff id="I1">School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I4">Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400</wicri:regionArea>
<wicri:noRegion>Jiangsu 215400</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I5">Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hu, Lijiang" sort="Hu, Lijiang" uniqKey="Hu L" first="Lijiang" last="Hu">Lijiang Hu</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Zhejiang Heye Health Technology Co. Ltd., Anji, Zhejiang 313300, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Zhejiang Heye Health Technology Co. Ltd., Anji, Zhejiang 313300</wicri:regionArea>
<wicri:noRegion>Zhejiang 313300</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shang, Peng" sort="Shang, Peng" uniqKey="Shang P" first="Peng" last="Shang">Peng Shang</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I4">Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400</wicri:regionArea>
<wicri:noRegion>Jiangsu 215400</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I5">Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31281572</idno>
<idno type="pmc">6590529</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590529</idno>
<idno type="RBID">PMC:6590529</idno>
<idno type="doi">10.1155/2019/3150145</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000A89</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A89</idno>
<idno type="wicri:Area/Pmc/Curation">000A89</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A89</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000256</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000256</idno>
<idno type="wicri:Area/Ncbi/Merge">000779</idno>
<idno type="wicri:Area/Ncbi/Curation">000779</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000779</idno>
<idno type="wicri:doubleKey">1942-0900:2019:Lv H:unraveling:the:potential</idno>
<idno type="wicri:Area/Main/Merge">000292</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy</title>
<author><name sortKey="Lv, Huanhuan" sort="Lv, Huanhuan" uniqKey="Lv H" first="Huanhuan" last="Lv">Huanhuan Lv</name>
<affiliation wicri:level="1"><nlm:aff id="I1">School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I3">Zhejiang Heye Health Technology Co. Ltd., Anji, Zhejiang 313300, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Zhejiang Heye Health Technology Co. Ltd., Anji, Zhejiang 313300</wicri:regionArea>
<wicri:noRegion>Zhejiang 313300</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I4">Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400</wicri:regionArea>
<wicri:noRegion>Jiangsu 215400</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I5">Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhen, Chenxiao" sort="Zhen, Chenxiao" uniqKey="Zhen C" first="Chenxiao" last="Zhen">Chenxiao Zhen</name>
<affiliation wicri:level="1"><nlm:aff id="I1">School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I5">Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Junyu" sort="Liu, Junyu" uniqKey="Liu J" first="Junyu" last="Liu">Junyu Liu</name>
<affiliation wicri:level="1"><nlm:aff id="I1">School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I5">Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Pengfei" sort="Yang, Pengfei" uniqKey="Yang P" first="Pengfei" last="Yang">Pengfei Yang</name>
<affiliation wicri:level="1"><nlm:aff id="I1">School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I2">Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I4">Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400</wicri:regionArea>
<wicri:noRegion>Jiangsu 215400</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I5">Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hu, Lijiang" sort="Hu, Lijiang" uniqKey="Hu L" first="Lijiang" last="Hu">Lijiang Hu</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Zhejiang Heye Health Technology Co. Ltd., Anji, Zhejiang 313300, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Zhejiang Heye Health Technology Co. Ltd., Anji, Zhejiang 313300</wicri:regionArea>
<wicri:noRegion>Zhejiang 313300</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shang, Peng" sort="Shang, Peng" uniqKey="Shang P" first="Peng" last="Shang">Peng Shang</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I4">Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Research Centre of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University in Taicang, Suzhou, Jiangsu 215400</wicri:regionArea>
<wicri:noRegion>Jiangsu 215400</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I5">Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi 710072</wicri:regionArea>
<wicri:noRegion>Shaanxi 710072</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Oxidative Medicine and Cellular Longevity</title>
<idno type="ISSN">1942-0900</idno>
<idno type="eISSN">1942-0994</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Glutathione is the principal intracellular antioxidant buffer against oxidative stress and mainly exists in the forms of reduced glutathione (GSH) and oxidized glutathione (GSSG). The processes of glutathione synthesis, transport, utilization, and metabolism are tightly controlled to maintain intracellular glutathione homeostasis and redox balance. As for cancer cells, they exhibit a greater ROS level than normal cells in order to meet the enhanced metabolism and vicious proliferation; meanwhile, they also have to develop an increased antioxidant defense system to cope with the higher oxidant state. Growing numbers of studies have implicated that altering the glutathione antioxidant system is associated with multiple forms of programmed cell death in cancer cells. In this review, we firstly focus on glutathione homeostasis from the perspectives of glutathione synthesis, distribution, transportation, and metabolism. Then, we discuss the function of glutathione in the antioxidant process. Afterwards, we also summarize the recent advance in the understanding of the mechanism by which glutathione plays a key role in multiple forms of programmed cell death, including apoptosis, necroptosis, ferroptosis, and autophagy. Finally, we highlight the glutathione-targeting therapeutic approaches toward cancers. A comprehensive review on the glutathione homeostasis and the role of glutathione depletion in programmed cell death provide insight into the redox-based research concerning cancer therapeutics.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Meister, A" uniqKey="Meister A">A. Meister</name>
</author>
<author><name sortKey="Anderson, M E" uniqKey="Anderson M">M. E. Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, G" uniqKey="Wu G">G. Wu</name>
</author>
<author><name sortKey="Fang, Y Z" uniqKey="Fang Y">Y. Z. Fang</name>
</author>
<author><name sortKey="Yang, S" uniqKey="Yang S">S. Yang</name>
</author>
<author><name sortKey="Lupton, J R" uniqKey="Lupton J">J. R. Lupton</name>
</author>
<author><name sortKey="Turner, N D" uniqKey="Turner N">N. D. Turner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sies, H" uniqKey="Sies H">H. Sies</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moloney, J N" uniqKey="Moloney J">J. N. Moloney</name>
</author>
<author><name sortKey="Cotter, T G" uniqKey="Cotter T">T. G. Cotter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galadari, S" uniqKey="Galadari S">S. Galadari</name>
</author>
<author><name sortKey="Rahman, A" uniqKey="Rahman A">A. Rahman</name>
</author>
<author><name sortKey="Pallichankandy, S" uniqKey="Pallichankandy S">S. Pallichankandy</name>
</author>
<author><name sortKey="Thayyullathil, F" uniqKey="Thayyullathil F">F. Thayyullathil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Circu, M L" uniqKey="Circu M">M. L. Circu</name>
</author>
<author><name sortKey="Aw, T Y" uniqKey="Aw T">T. Y. Aw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Traverso, N" uniqKey="Traverso N">N. Traverso</name>
</author>
<author><name sortKey="Ricciarelli, R" uniqKey="Ricciarelli R">R. Ricciarelli</name>
</author>
<author><name sortKey="Nitti, M" uniqKey="Nitti M">M. Nitti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schumacker, P T" uniqKey="Schumacker P">P. T. Schumacker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hatem, E" uniqKey="Hatem E">E. Hatem</name>
</author>
<author><name sortKey="El Banna, N" uniqKey="El Banna N">N. el Banna</name>
</author>
<author><name sortKey="Huang, M E" uniqKey="Huang M">M. E. Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anderson, M E" uniqKey="Anderson M">M. E. Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dalton, T P" uniqKey="Dalton T">T. P. Dalton</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name>
</author>
<author><name sortKey="Schneider, S N" uniqKey="Schneider S">S. N. Schneider</name>
</author>
<author><name sortKey="Nebert, D W" uniqKey="Nebert D">D. W. Nebert</name>
</author>
<author><name sortKey="Shertzer, H G" uniqKey="Shertzer H">H. G. Shertzer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, S C" uniqKey="Lu S">S. C. Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diaz Vivancos, P" uniqKey="Diaz Vivancos P">P. Diaz Vivancos</name>
</author>
<author><name sortKey="Wolff, T" uniqKey="Wolff T">T. Wolff</name>
</author>
<author><name sortKey="Markovic, J" uniqKey="Markovic J">J. Markovic</name>
</author>
<author><name sortKey="Pallard, F V" uniqKey="Pallard F">F. V. Pallardó</name>
</author>
<author><name sortKey="Foyer, C H" uniqKey="Foyer C">C. H. Foyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Briviba, K" uniqKey="Briviba K">K. BRIVIBA</name>
</author>
<author><name sortKey="Fraser, G" uniqKey="Fraser G">G. Fraser</name>
</author>
<author><name sortKey="Sies, H" uniqKey="Sies H">H. Sies</name>
</author>
<author><name sortKey="Ketterer, B" uniqKey="Ketterer B">B. Ketterer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soderdahl, T" uniqKey="Soderdahl T">T. Söderdahl</name>
</author>
<author><name sortKey="Enoksson, M" uniqKey="Enoksson M">M. Enoksson</name>
</author>
<author><name sortKey="Lundberg, M" uniqKey="Lundberg M">M. Lundberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diaz Vivancos, P" uniqKey="Diaz Vivancos P">P. Diaz-Vivancos</name>
</author>
<author><name sortKey="De Simone, A" uniqKey="De Simone A">A. de Simone</name>
</author>
<author><name sortKey="Kiddle, G" uniqKey="Kiddle G">G. Kiddle</name>
</author>
<author><name sortKey="Foyer, C H" uniqKey="Foyer C">C. H. Foyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meredith, M J" uniqKey="Meredith M">M. J. Meredith</name>
</author>
<author><name sortKey="Reed, D J" uniqKey="Reed D">D. J. Reed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hwang, C" uniqKey="Hwang C">C. Hwang</name>
</author>
<author><name sortKey="Sinskey, A" uniqKey="Sinskey A">A. Sinskey</name>
</author>
<author><name sortKey="Lodish, H" uniqKey="Lodish H">H. Lodish</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morgan, B" uniqKey="Morgan B">B. Morgan</name>
</author>
<author><name sortKey="Ezeri A, D" uniqKey="Ezeri A D">D. Ezeriņa</name>
</author>
<author><name sortKey="Amoako, T N E" uniqKey="Amoako T">T. N. E. Amoako</name>
</author>
<author><name sortKey="Riemer, J" uniqKey="Riemer J">J. Riemer</name>
</author>
<author><name sortKey="Seedorf, M" uniqKey="Seedorf M">M. Seedorf</name>
</author>
<author><name sortKey="Dick, T P" uniqKey="Dick T">T. P. Dick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, S C" uniqKey="Lu S">S. C. Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morgan, B" uniqKey="Morgan B">B. Morgan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meyer, A J" uniqKey="Meyer A">A. J. Meyer</name>
</author>
<author><name sortKey="Brach, T" uniqKey="Brach T">T. Brach</name>
</author>
<author><name sortKey="Marty, L" uniqKey="Marty L">L. Marty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calabrese, G" uniqKey="Calabrese G">G. Calabrese</name>
</author>
<author><name sortKey="Morgan, B" uniqKey="Morgan B">B. Morgan</name>
</author>
<author><name sortKey="Riemer, J" uniqKey="Riemer J">J. Riemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mari, M" uniqKey="Mari M">M. Marí</name>
</author>
<author><name sortKey="Morales, A" uniqKey="Morales A">A. Morales</name>
</author>
<author><name sortKey="Colell, A" uniqKey="Colell A">A. Colell</name>
</author>
<author><name sortKey="Garcia Ruiz, C" uniqKey="Garcia Ruiz C">C. García-Ruiz</name>
</author>
<author><name sortKey="Fernandez Checa, J C" uniqKey="Fernandez Checa J">J. C. Fernández-Checa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lash, L H" uniqKey="Lash L">L. H. Lash</name>
</author>
<author><name sortKey="Visarius, T M" uniqKey="Visarius T">T. M. Visarius</name>
</author>
<author><name sortKey="Sall, J M" uniqKey="Sall J">J. M. Sall</name>
</author>
<author><name sortKey="Qian, W" uniqKey="Qian W">W. Qian</name>
</author>
<author><name sortKey="Tokarz, J J" uniqKey="Tokarz J">J. J. Tokarz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schnellmann, R G" uniqKey="Schnellmann R">R. G. Schnellmann</name>
</author>
<author><name sortKey="Gilchrist, S M" uniqKey="Gilchrist S">S. M. Gilchrist</name>
</author>
<author><name sortKey="Mandel, L J" uniqKey="Mandel L">L. J. Mandel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kojer, K" uniqKey="Kojer K">K. Kojer</name>
</author>
<author><name sortKey="Bien, M" uniqKey="Bien M">M. Bien</name>
</author>
<author><name sortKey="Gangel, H" uniqKey="Gangel H">H. Gangel</name>
</author>
<author><name sortKey="Morgan, B" uniqKey="Morgan B">B. Morgan</name>
</author>
<author><name sortKey="Dick, T P" uniqKey="Dick T">T. P. Dick</name>
</author>
<author><name sortKey="Riemer, J" uniqKey="Riemer J">J. Riemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Becker, T" uniqKey="Becker T">T. Becker</name>
</author>
<author><name sortKey="Gebert, M" uniqKey="Gebert M">M. Gebert</name>
</author>
<author><name sortKey="Pfanner, N" uniqKey="Pfanner N">N. Pfanner</name>
</author>
<author><name sortKey="Van Der Laan, M" uniqKey="Van Der Laan M">M. van der Laan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tatsuta, T" uniqKey="Tatsuta T">T. Tatsuta</name>
</author>
<author><name sortKey="Scharwey, M" uniqKey="Scharwey M">M. Scharwey</name>
</author>
<author><name sortKey="Langer, T" uniqKey="Langer T">T. Langer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cogliati, S" uniqKey="Cogliati S">S. Cogliati</name>
</author>
<author><name sortKey="Enriquez, J A" uniqKey="Enriquez J">J. A. Enriquez</name>
</author>
<author><name sortKey="Scorrano, L" uniqKey="Scorrano L">L. Scorrano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lash, L H" uniqKey="Lash L">L. H. Lash</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lash, L H" uniqKey="Lash L">L. H. Lash</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name>
</author>
<author><name sortKey="Putt, D A" uniqKey="Putt D">D. A. Putt</name>
</author>
<author><name sortKey="Lash, L H" uniqKey="Lash L">L. H. Lash</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Markovic, J" uniqKey="Markovic J">J. Markovic</name>
</author>
<author><name sortKey="Borras, C" uniqKey="Borras C">C. Borras</name>
</author>
<author><name sortKey="Ortega, A" uniqKey="Ortega A">A. Ortega</name>
</author>
<author><name sortKey="Sastre, J" uniqKey="Sastre J">J. Sastre</name>
</author>
<author><name sortKey="Vina, J" uniqKey="Vina J">J. Vina</name>
</author>
<author><name sortKey="Pallardo, F V" uniqKey="Pallardo F">F. V. Pallardo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vivancos, P D" uniqKey="Vivancos P">P. D. Vivancos</name>
</author>
<author><name sortKey="Dong, Y" uniqKey="Dong Y">Y. Dong</name>
</author>
<author><name sortKey="Ziegler, K" uniqKey="Ziegler K">K. Ziegler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmgren, A" uniqKey="Holmgren A">A. Holmgren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valko, M" uniqKey="Valko M">M. Valko</name>
</author>
<author><name sortKey="Leibfritz, D" uniqKey="Leibfritz D">D. Leibfritz</name>
</author>
<author><name sortKey="Moncol, J" uniqKey="Moncol J">J. Moncol</name>
</author>
<author><name sortKey="Cronin, M T D" uniqKey="Cronin M">M. T. D. Cronin</name>
</author>
<author><name sortKey="Mazur, M" uniqKey="Mazur M">M. Mazur</name>
</author>
<author><name sortKey="Telser, J" uniqKey="Telser J">J. Telser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmgren, A" uniqKey="Holmgren A">A. Holmgren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name>
</author>
<author><name sortKey="Kaufman, R J" uniqKey="Kaufman R">R. J. Kaufman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Montero, D" uniqKey="Montero D">D. Montero</name>
</author>
<author><name sortKey="Tachibana, C" uniqKey="Tachibana C">C. Tachibana</name>
</author>
<author><name sortKey="Rahr Winther, J" uniqKey="Rahr Winther J">J. Rahr Winther</name>
</author>
<author><name sortKey="Appenzeller Herzog, C" uniqKey="Appenzeller Herzog C">C. Appenzeller-Herzog</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, S S" uniqKey="Cao S">S. S. Cao</name>
</author>
<author><name sortKey="Kaufman, R J" uniqKey="Kaufman R">R. J. Kaufman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anderson, M E" uniqKey="Anderson M">M. E. Anderson</name>
</author>
<author><name sortKey="Bridges, R J" uniqKey="Bridges R">R. J. Bridges</name>
</author>
<author><name sortKey="Meister, A" uniqKey="Meister A">A. Meister</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="H Berle, D" uniqKey="H Berle D">D. Häberle</name>
</author>
<author><name sortKey="Wahll Nder, A" uniqKey="Wahll Nder A">A. Wahlländer</name>
</author>
<author><name sortKey="Sies, H" uniqKey="Sies H">H. Sies</name>
</author>
<author><name sortKey="Linke, I" uniqKey="Linke I">I. Linke</name>
</author>
<author><name sortKey="Lachenmaier, C" uniqKey="Lachenmaier C">C. Lachenmaier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hahn, R" uniqKey="Hahn R">R. Hahn</name>
</author>
<author><name sortKey="Wendel, A" uniqKey="Wendel A">A. Wendel</name>
</author>
<author><name sortKey="Flohe, L" uniqKey="Flohe L">L. Flohé</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lash, L H" uniqKey="Lash L">L. H. Lash</name>
</author>
<author><name sortKey="Putt, D A" uniqKey="Putt D">D. A. Putt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name>
</author>
<author><name sortKey="Tsukaguchi, H" uniqKey="Tsukaguchi H">H. Tsukaguchi</name>
</author>
<author><name sortKey="Chen, X Z" uniqKey="Chen X">X. Z. Chen</name>
</author>
<author><name sortKey="Berger, U V" uniqKey="Berger U">U. V. Berger</name>
</author>
<author><name sortKey="Hediger, M A" uniqKey="Hediger M">M. A. Hediger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Inoue, M" uniqKey="Inoue M">M. Inoue</name>
</author>
<author><name sortKey="Morino, Y" uniqKey="Morino Y">Y. Morino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ballatori, N" uniqKey="Ballatori N">N. Ballatori</name>
</author>
<author><name sortKey="Hammond, C L" uniqKey="Hammond C">C. L. Hammond</name>
</author>
<author><name sortKey="Cunningham, J B" uniqKey="Cunningham J">J. B. Cunningham</name>
</author>
<author><name sortKey="Krance, S M" uniqKey="Krance S">S. M. Krance</name>
</author>
<author><name sortKey="Marchan, R" uniqKey="Marchan R">R. Marchan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L. Li</name>
</author>
<author><name sortKey="Lee, T K" uniqKey="Lee T">T. K. Lee</name>
</author>
<author><name sortKey="Meier, P J" uniqKey="Meier P">P. J. Meier</name>
</author>
<author><name sortKey="Ballatori, N" uniqKey="Ballatori N">N. Ballatori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bachhawat, A K" uniqKey="Bachhawat A">A. K. Bachhawat</name>
</author>
<author><name sortKey="Thakur, A" uniqKey="Thakur A">A. Thakur</name>
</author>
<author><name sortKey="Kaur, J" uniqKey="Kaur J">J. Kaur</name>
</author>
<author><name sortKey="Zulkifli, M" uniqKey="Zulkifli M">M. Zulkifli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanigan, M H" uniqKey="Hanigan M">M. H. Hanigan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, S" uniqKey="Kumar S">S. Kumar</name>
</author>
<author><name sortKey="Kaur, A" uniqKey="Kaur A">A. Kaur</name>
</author>
<author><name sortKey="Chattopadhyay, B" uniqKey="Chattopadhyay B">B. Chattopadhyay</name>
</author>
<author><name sortKey="Bachhawat, A K" uniqKey="Bachhawat A">A. K. Bachhawat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name>
</author>
<author><name sortKey="Tikoo, S" uniqKey="Tikoo S">S. Tikoo</name>
</author>
<author><name sortKey="Maity, S" uniqKey="Maity S">S. Maity</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oakley, A J" uniqKey="Oakley A">A. J. Oakley</name>
</author>
<author><name sortKey="Yamada, T" uniqKey="Yamada T">T. Yamada</name>
</author>
<author><name sortKey="Liu, D" uniqKey="Liu D">D. Liu</name>
</author>
<author><name sortKey="Coggan, M" uniqKey="Coggan M">M. Coggan</name>
</author>
<author><name sortKey="Clark, A G" uniqKey="Clark A">A. G. Clark</name>
</author>
<author><name sortKey="Board, P G" uniqKey="Board P">P. G. Board</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaur, A" uniqKey="Kaur A">A. Kaur</name>
</author>
<author><name sortKey="Gautam, R" uniqKey="Gautam R">R. Gautam</name>
</author>
<author><name sortKey="Srivastava, R" uniqKey="Srivastava R">R. Srivastava</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gorrini, C" uniqKey="Gorrini C">C. Gorrini</name>
</author>
<author><name sortKey="Harris, I S" uniqKey="Harris I">I. S. Harris</name>
</author>
<author><name sortKey="Mak, T W" uniqKey="Mak T">T. W. Mak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ortega, A L" uniqKey="Ortega A">A. L. Ortega</name>
</author>
<author><name sortKey="Mena, S" uniqKey="Mena S">S. Mena</name>
</author>
<author><name sortKey="Estrela, J M" uniqKey="Estrela J">J. M. Estrela</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murphy, M P" uniqKey="Murphy M">M. P. Murphy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouyang, L" uniqKey="Ouyang L">L. Ouyang</name>
</author>
<author><name sortKey="Shi, Z" uniqKey="Shi Z">Z. Shi</name>
</author>
<author><name sortKey="Zhao, S" uniqKey="Zhao S">S. Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Su, Z" uniqKey="Su Z">Z. Su</name>
</author>
<author><name sortKey="Yang, Z" uniqKey="Yang Z">Z. Yang</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y. Xu</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name>
</author>
<author><name sortKey="Yu, Q" uniqKey="Yu Q">Q. Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elmore, S" uniqKey="Elmore S">S. Elmore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Y F" uniqKey="Zhao Y">Y. F. Zhao</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name>
</author>
<author><name sortKey="Suo, Y R" uniqKey="Suo Y">Y. R. Suo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Franco, R" uniqKey="Franco R">R. Franco</name>
</author>
<author><name sortKey="Panayiotidis, M I" uniqKey="Panayiotidis M">M. I. Panayiotidis</name>
</author>
<author><name sortKey="Cidlowski, J A" uniqKey="Cidlowski J">J. A. Cidlowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khan, M" uniqKey="Khan M">M. Khan</name>
</author>
<author><name sortKey="Yi, F" uniqKey="Yi F">F. Yi</name>
</author>
<author><name sortKey="Rasul, A" uniqKey="Rasul A">A. Rasul</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Armstrong, J S" uniqKey="Armstrong J">J. S. Armstrong</name>
</author>
<author><name sortKey="Steinauer, K K" uniqKey="Steinauer K">K. K. Steinauer</name>
</author>
<author><name sortKey="Hornung, B" uniqKey="Hornung B">B. Hornung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ghibelli, L" uniqKey="Ghibelli L">L. Ghibelli</name>
</author>
<author><name sortKey="Fanelli, C" uniqKey="Fanelli C">C. Fanelli</name>
</author>
<author><name sortKey="Rotilio, G" uniqKey="Rotilio G">G. Rotilio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hammond, C L" uniqKey="Hammond C">C. L. Hammond</name>
</author>
<author><name sortKey="Marchan, R" uniqKey="Marchan R">R. Marchan</name>
</author>
<author><name sortKey="Krance, S M" uniqKey="Krance S">S. M. Krance</name>
</author>
<author><name sortKey="Ballatori, N" uniqKey="Ballatori N">N. Ballatori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zou, X" uniqKey="Zou X">X. Zou</name>
</author>
<author><name sortKey="Feng, Z" uniqKey="Feng Z">Z. Feng</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akhtar, M J" uniqKey="Akhtar M">M. J. Akhtar</name>
</author>
<author><name sortKey="Ahamed, M" uniqKey="Ahamed M">M. Ahamed</name>
</author>
<author><name sortKey="Alhadlaq, H A" uniqKey="Alhadlaq H">H. A. Alhadlaq</name>
</author>
<author><name sortKey="Alshamsan, A" uniqKey="Alshamsan A">A. Alshamsan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, G" uniqKey="Chen G">G. Chen</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name>
</author>
<author><name sortKey="Huang, P" uniqKey="Huang P">P. Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Circu, M L" uniqKey="Circu M">M. L. Circu</name>
</author>
<author><name sortKey="Yee Aw, T" uniqKey="Yee Aw T">T. Yee Aw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guha, P" uniqKey="Guha P">P. Guha</name>
</author>
<author><name sortKey="Dey, A" uniqKey="Dey A">A. Dey</name>
</author>
<author><name sortKey="Sen, R" uniqKey="Sen R">R. Sen</name>
</author>
<author><name sortKey="Chatterjee, M" uniqKey="Chatterjee M">M. Chatterjee</name>
</author>
<author><name sortKey="Chattopadhyay, S" uniqKey="Chattopadhyay S">S. Chattopadhyay</name>
</author>
<author><name sortKey="Bandyopadhyay, S K" uniqKey="Bandyopadhyay S">S. K. Bandyopadhyay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Honda, T" uniqKey="Honda T">T. Honda</name>
</author>
<author><name sortKey="Coppola, S" uniqKey="Coppola S">S. Coppola</name>
</author>
<author><name sortKey="Ghibelli, L" uniqKey="Ghibelli L">L. Ghibelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P. Vandenabeele</name>
</author>
<author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L. Galluzzi</name>
</author>
<author><name sortKey="Vanden Berghe, T" uniqKey="Vanden Berghe T">T. vanden Berghe</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berghe, T V" uniqKey="Berghe T">T. V. Berghe</name>
</author>
<author><name sortKey="Linkermann, A" uniqKey="Linkermann A">A. Linkermann</name>
</author>
<author><name sortKey="Jouan Lanhouet, S" uniqKey="Jouan Lanhouet S">S. Jouan-Lanhouet</name>
</author>
<author><name sortKey="Walczak, H" uniqKey="Walczak H">H. Walczak</name>
</author>
<author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P. Vandenabeele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Christofferson, D E" uniqKey="Christofferson D">D. E. Christofferson</name>
</author>
<author><name sortKey="Yuan, J" uniqKey="Yuan J">J. Yuan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L. Galluzzi</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagai, H" uniqKey="Nagai H">H. Nagai</name>
</author>
<author><name sortKey="Matsumaru, K" uniqKey="Matsumaru K">K. Matsumaru</name>
</author>
<author><name sortKey="Feng, G" uniqKey="Feng G">G. Feng</name>
</author>
<author><name sortKey="Kaplowitz, N" uniqKey="Kaplowitz N">N. Kaplowitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name>
</author>
<author><name sortKey="Chua, C C" uniqKey="Chua C">C. C. Chua</name>
</author>
<author><name sortKey="Kong, J" uniqKey="Kong J">J. Kong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chauhan, A K" uniqKey="Chauhan A">A. K. Chauhan</name>
</author>
<author><name sortKey="Min, K J" uniqKey="Min K">K. J. Min</name>
</author>
<author><name sortKey="Kwon, T K" uniqKey="Kwon T">T. K. Kwon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xie, X" uniqKey="Xie X">X. Xie</name>
</author>
<author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name>
</author>
<author><name sortKey="Ma, C Y" uniqKey="Ma C">C. Y. Ma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, M S" uniqKey="Chen M">M. S. Chen</name>
</author>
<author><name sortKey="Wang, S F" uniqKey="Wang S">S. F. Wang</name>
</author>
<author><name sortKey="Hsu, C Y" uniqKey="Hsu C">C. Y. Hsu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dixon, S J" uniqKey="Dixon S">S. J. Dixon</name>
</author>
<author><name sortKey="Lemberg, K M" uniqKey="Lemberg K">K. M. Lemberg</name>
</author>
<author><name sortKey="Lamprecht, M R" uniqKey="Lamprecht M">M. R. Lamprecht</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reed, J C" uniqKey="Reed J">J. C. Reed</name>
</author>
<author><name sortKey="Pellecchia, M" uniqKey="Pellecchia M">M. Pellecchia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, W S" uniqKey="Yang W">W. S. Yang</name>
</author>
<author><name sortKey="Stockwell, B R" uniqKey="Stockwell B">B. R. Stockwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, X" uniqKey="Yu X">X. Yu</name>
</author>
<author><name sortKey="Long, Y C" uniqKey="Long Y">Y. C. Long</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, M" uniqKey="Gao M">M. Gao</name>
</author>
<author><name sortKey="Monian, P" uniqKey="Monian P">P. Monian</name>
</author>
<author><name sortKey="Quadri, N" uniqKey="Quadri N">N. Quadri</name>
</author>
<author><name sortKey="Ramasamy, R" uniqKey="Ramasamy R">R. Ramasamy</name>
</author>
<author><name sortKey="Jiang, X" uniqKey="Jiang X">X. Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sui, X" uniqKey="Sui X">X. Sui</name>
</author>
<author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Friedmann Angeli, J P" uniqKey="Friedmann Angeli J">J. P. Friedmann Angeli</name>
</author>
<author><name sortKey="Schneider, M" uniqKey="Schneider M">M. Schneider</name>
</author>
<author><name sortKey="Proneth, B" uniqKey="Proneth B">B. Proneth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seibt, T M" uniqKey="Seibt T">T. M. Seibt</name>
</author>
<author><name sortKey="Proneth, B" uniqKey="Proneth B">B. Proneth</name>
</author>
<author><name sortKey="Conrad, M" uniqKey="Conrad M">M. Conrad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hirschhorn, T" uniqKey="Hirschhorn T">T. Hirschhorn</name>
</author>
<author><name sortKey="Stockwell, B R" uniqKey="Stockwell B">B. R. Stockwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, W S" uniqKey="Yang W">W. S. Yang</name>
</author>
<author><name sortKey="Stockwell, B R" uniqKey="Stockwell B">B. R. Stockwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, W S" uniqKey="Yang W">W. S. Yang</name>
</author>
<author><name sortKey="Sriramaratnam, R" uniqKey="Sriramaratnam R">R. SriRamaratnam</name>
</author>
<author><name sortKey="Welsch, M E" uniqKey="Welsch M">M. E. Welsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shimada, K" uniqKey="Shimada K">K. Shimada</name>
</author>
<author><name sortKey="Skouta, R" uniqKey="Skouta R">R. Skouta</name>
</author>
<author><name sortKey="Kaplan, A" uniqKey="Kaplan A">A. Kaplan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miess, H" uniqKey="Miess H">H. Miess</name>
</author>
<author><name sortKey="Dankworth, B" uniqKey="Dankworth B">B. Dankworth</name>
</author>
<author><name sortKey="Gouw, A M" uniqKey="Gouw A">A. M. Gouw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Herde, K" uniqKey="D Herde K">K. D'Herde</name>
</author>
<author><name sortKey="Krysko, D V" uniqKey="Krysko D">D. V. Krysko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stoyanovsky, D A" uniqKey="Stoyanovsky D">D. A. Stoyanovsky</name>
</author>
<author><name sortKey="Tyurina, Y Y" uniqKey="Tyurina Y">Y. Y. Tyurina</name>
</author>
<author><name sortKey="Shrivastava, I" uniqKey="Shrivastava I">I. Shrivastava</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kagan, V E" uniqKey="Kagan V">V. E. Kagan</name>
</author>
<author><name sortKey="Mao, G" uniqKey="Mao G">G. Mao</name>
</author>
<author><name sortKey="Qu, F" uniqKey="Qu F">F. Qu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Angeli, J P F" uniqKey="Angeli J">J. P. F. Angeli</name>
</author>
<author><name sortKey="Shah, R" uniqKey="Shah R">R. Shah</name>
</author>
<author><name sortKey="Pratt, D A" uniqKey="Pratt D">D. A. Pratt</name>
</author>
<author><name sortKey="Conrad, M" uniqKey="Conrad M">M. Conrad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Louandre, C" uniqKey="Louandre C">C. Louandre</name>
</author>
<author><name sortKey="Ezzoukhry, Z" uniqKey="Ezzoukhry Z">Z. Ezzoukhry</name>
</author>
<author><name sortKey="Godin, C" uniqKey="Godin C">C. Godin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Louandre, C" uniqKey="Louandre C">C. Louandre</name>
</author>
<author><name sortKey="Marcq, I" uniqKey="Marcq I">I. Marcq</name>
</author>
<author><name sortKey="Bouhlal, H" uniqKey="Bouhlal H">H. Bouhlal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dikic, I" uniqKey="Dikic I">I. Dikic</name>
</author>
<author><name sortKey="Johansen, T" uniqKey="Johansen T">T. Johansen</name>
</author>
<author><name sortKey="Kirkin, V" uniqKey="Kirkin V">V. Kirkin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Green, D R" uniqKey="Green D">D. R. Green</name>
</author>
<author><name sortKey="Levine, B" uniqKey="Levine B">B. Levine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Filomeni, G" uniqKey="Filomeni G">G. Filomeni</name>
</author>
<author><name sortKey="De Zio, D" uniqKey="De Zio D">D. De Zio</name>
</author>
<author><name sortKey="Cecconi, F" uniqKey="Cecconi F">F. Cecconi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Filomeni, G" uniqKey="Filomeni G">G. Filomeni</name>
</author>
<author><name sortKey="Desideri, E" uniqKey="Desideri E">E. Desideri</name>
</author>
<author><name sortKey="Cardaci, S" uniqKey="Cardaci S">S. Cardaci</name>
</author>
<author><name sortKey="Rotilio, G" uniqKey="Rotilio G">G. Rotilio</name>
</author>
<author><name sortKey="Ciriolo, M R" uniqKey="Ciriolo M">M. R. Ciriolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mancilla, H" uniqKey="Mancilla H">H. Mancilla</name>
</author>
<author><name sortKey="Maldonado, R" uniqKey="Maldonado R">R. Maldonado</name>
</author>
<author><name sortKey="Cereceda, K" uniqKey="Cereceda K">K. Cereceda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ogier Denis, E" uniqKey="Ogier Denis E">E. Ogier-Denis</name>
</author>
<author><name sortKey="Codogno, P" uniqKey="Codogno P">P. Codogno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, W" uniqKey="Guo W">W. Guo</name>
</author>
<author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name>
</author>
<author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Desideri, E" uniqKey="Desideri E">E. Desideri</name>
</author>
<author><name sortKey="Filomeni, G" uniqKey="Filomeni G">G. Filomeni</name>
</author>
<author><name sortKey="Ciriolo, M R" uniqKey="Ciriolo M">M. R. Ciriolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seo, G" uniqKey="Seo G">G. Seo</name>
</author>
<author><name sortKey="Kim, S K" uniqKey="Kim S">S. K. Kim</name>
</author>
<author><name sortKey="Byun, Y J" uniqKey="Byun Y">Y. J. Byun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kang, R" uniqKey="Kang R">R. Kang</name>
</author>
<author><name sortKey="Tang, D" uniqKey="Tang D">D. Tang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ott, C" uniqKey="Ott C">C. Ott</name>
</author>
<author><name sortKey="Konig, J" uniqKey="Konig J">J. Konig</name>
</author>
<author><name sortKey="Hohn, A" uniqKey="Hohn A">A. Hohn</name>
</author>
<author><name sortKey="Jung, T" uniqKey="Jung T">T. Jung</name>
</author>
<author><name sortKey="Grune, T" uniqKey="Grune T">T. Grune</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Torii, S" uniqKey="Torii S">S. Torii</name>
</author>
<author><name sortKey="Shintoku, R" uniqKey="Shintoku R">R. Shintoku</name>
</author>
<author><name sortKey="Kubota, C" uniqKey="Kubota C">C. Kubota</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z. Wu</name>
</author>
<author><name sortKey="Geng, Y" uniqKey="Geng Y">Y. Geng</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, M" uniqKey="Gao M">M. Gao</name>
</author>
<author><name sortKey="Monian, P" uniqKey="Monian P">P. Monian</name>
</author>
<author><name sortKey="Pan, Q" uniqKey="Pan Q">Q. Pan</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name>
</author>
<author><name sortKey="Xiang, J" uniqKey="Xiang J">J. Xiang</name>
</author>
<author><name sortKey="Jiang, X" uniqKey="Jiang X">X. Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hou, W" uniqKey="Hou W">W. Hou</name>
</author>
<author><name sortKey="Xie, Y" uniqKey="Xie Y">Y. Xie</name>
</author>
<author><name sortKey="Song, X" uniqKey="Song X">X. Song</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Santana Codina, N" uniqKey="Santana Codina N">N. Santana-Codina</name>
</author>
<author><name sortKey="Mancias, J D" uniqKey="Mancias J">J. D. Mancias</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mancias, J D" uniqKey="Mancias J">J. D. Mancias</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
<author><name sortKey="Gygi, S P" uniqKey="Gygi S">S. P. Gygi</name>
</author>
<author><name sortKey="Harper, J W" uniqKey="Harper J">J. W. Harper</name>
</author>
<author><name sortKey="Kimmelman, A C" uniqKey="Kimmelman A">A. C. Kimmelman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dowdle, W E" uniqKey="Dowdle W">W. E. Dowdle</name>
</author>
<author><name sortKey="Nyfeler, B" uniqKey="Nyfeler B">B. Nyfeler</name>
</author>
<author><name sortKey="Nagel, J" uniqKey="Nagel J">J. Nagel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Du, J" uniqKey="Du J">J. Du</name>
</author>
<author><name sortKey="Wang, T" uniqKey="Wang T">T. Wang</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, H H W" uniqKey="Chen H">H. H. W. Chen</name>
</author>
<author><name sortKey="Kuo, M T" uniqKey="Kuo M">M. T. Kuo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roh, J L" uniqKey="Roh J">J. L. Roh</name>
</author>
<author><name sortKey="Kim, E H" uniqKey="Kim E">E. H. Kim</name>
</author>
<author><name sortKey="Jang, H J" uniqKey="Jang H">H. J. Jang</name>
</author>
<author><name sortKey="Park, J Y" uniqKey="Park J">J. Y. Park</name>
</author>
<author><name sortKey="Shin, D" uniqKey="Shin D">D. Shin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Habermann, K J" uniqKey="Habermann K">K. J. Habermann</name>
</author>
<author><name sortKey="Grunewald, L" uniqKey="Grunewald L">L. Grunewald</name>
</author>
<author><name sortKey="Van Wijk, S" uniqKey="Van Wijk S">S. van Wijk</name>
</author>
<author><name sortKey="Fulda, S" uniqKey="Fulda S">S. Fulda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lo, M" uniqKey="Lo M">M. Lo</name>
</author>
<author><name sortKey="Wang, Y Z" uniqKey="Wang Y">Y. Z. Wang</name>
</author>
<author><name sortKey="Gout, P W" uniqKey="Gout P">P. W. Gout</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name>
</author>
<author><name sortKey="Luo, B" uniqKey="Luo B">B. Luo</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barattin, R" uniqKey="Barattin R">R. Barattin</name>
</author>
<author><name sortKey="Perrotton, T" uniqKey="Perrotton T">T. Perrotton</name>
</author>
<author><name sortKey="Trompier, D" uniqKey="Trompier D">D. Trompier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lewerenz, J" uniqKey="Lewerenz J">J. Lewerenz</name>
</author>
<author><name sortKey="Hewett, S J" uniqKey="Hewett S">S. J. Hewett</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wada, F" uniqKey="Wada F">F. Wada</name>
</author>
<author><name sortKey="Koga, H" uniqKey="Koga H">H. Koga</name>
</author>
<author><name sortKey="Akiba, J" uniqKey="Akiba J">J. Akiba</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toyoda, M" uniqKey="Toyoda M">M. Toyoda</name>
</author>
<author><name sortKey="Kaira, K" uniqKey="Kaira K">K. Kaira</name>
</author>
<author><name sortKey="Ohshima, Y" uniqKey="Ohshima Y">Y. Ohshima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Habib, E" uniqKey="Habib E">E. Habib</name>
</author>
<author><name sortKey="Linher Melville, K" uniqKey="Linher Melville K">K. Linher-Melville</name>
</author>
<author><name sortKey="Lin, H X" uniqKey="Lin H">H. X. Lin</name>
</author>
<author><name sortKey="Singh, G" uniqKey="Singh G">G. Singh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sugano, K" uniqKey="Sugano K">K. Sugano</name>
</author>
<author><name sortKey="Maeda, K" uniqKey="Maeda K">K. Maeda</name>
</author>
<author><name sortKey="Ohtani, H" uniqKey="Ohtani H">H. Ohtani</name>
</author>
<author><name sortKey="Nagahara, H" uniqKey="Nagahara H">H. Nagahara</name>
</author>
<author><name sortKey="Shibutani, M" uniqKey="Shibutani M">M. Shibutani</name>
</author>
<author><name sortKey="Hirakawa, K" uniqKey="Hirakawa K">K. Hirakawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lo, M" uniqKey="Lo M">M. Lo</name>
</author>
<author><name sortKey="Ling, V" uniqKey="Ling V">V. Ling</name>
</author>
<author><name sortKey="Wang, Y Z" uniqKey="Wang Y">Y. Z. Wang</name>
</author>
<author><name sortKey="Gout, P W" uniqKey="Gout P">P. W. Gout</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okuno, S" uniqKey="Okuno S">S. Okuno</name>
</author>
<author><name sortKey="Sato, H" uniqKey="Sato H">H. Sato</name>
</author>
<author><name sortKey="Kuriyama Matsumura, K" uniqKey="Kuriyama Matsumura K">K. Kuriyama-Matsumura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ishimoto, T" uniqKey="Ishimoto T">T. Ishimoto</name>
</author>
<author><name sortKey="Nagano, O" uniqKey="Nagano O">O. Nagano</name>
</author>
<author><name sortKey="Yae, T" uniqKey="Yae T">T. Yae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Savaskan, N E" uniqKey="Savaskan N">N. E. Savaskan</name>
</author>
<author><name sortKey="Hahnen, E" uniqKey="Hahnen E">E. Hahnen</name>
</author>
<author><name sortKey="Eyupoglu, I Y" uniqKey="Eyupoglu I">I. Y. Eyüpoglu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, R S" uniqKey="Chen R">R. S. Chen</name>
</author>
<author><name sortKey="Song, Y M" uniqKey="Song Y">Y. M. Song</name>
</author>
<author><name sortKey="Zhou, Z Y" uniqKey="Zhou Z">Z. Y. Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Larraufie, M H" uniqKey="Larraufie M">M. H. Larraufie</name>
</author>
<author><name sortKey="Yang, W S" uniqKey="Yang W">W. S. Yang</name>
</author>
<author><name sortKey="Jiang, E" uniqKey="Jiang E">E. Jiang</name>
</author>
<author><name sortKey="Thomas, A G" uniqKey="Thomas A">A. G. Thomas</name>
</author>
<author><name sortKey="Slusher, B S" uniqKey="Slusher B">B. S. Slusher</name>
</author>
<author><name sortKey="Stockwell, B R" uniqKey="Stockwell B">B. R. Stockwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roh, J L" uniqKey="Roh J">J. L. Roh</name>
</author>
<author><name sortKey="Kim, E H" uniqKey="Kim E">E. H. Kim</name>
</author>
<author><name sortKey="Jang, H" uniqKey="Jang H">H. Jang</name>
</author>
<author><name sortKey="Shin, D" uniqKey="Shin D">D. Shin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, M Z" uniqKey="Ma M">M. Z. Ma</name>
</author>
<author><name sortKey="Chen, G" uniqKey="Chen G">G. Chen</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sleire, L" uniqKey="Sleire L">L. Sleire</name>
</author>
<author><name sortKey="Skeie, B S" uniqKey="Skeie B">B. S. Skeie</name>
</author>
<author><name sortKey="Netland, I A" uniqKey="Netland I">I. A. Netland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Narang, V S" uniqKey="Narang V">V. S. Narang</name>
</author>
<author><name sortKey="Pauletti, G M" uniqKey="Pauletti G">G. M. Pauletti</name>
</author>
<author><name sortKey="Gout, P W" uniqKey="Gout P">P. W. Gout</name>
</author>
<author><name sortKey="Buckley, D J" uniqKey="Buckley D">D. J. Buckley</name>
</author>
<author><name sortKey="Buckley, A R" uniqKey="Buckley A">A. R. Buckley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name>
</author>
<author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, B N" uniqKey="Zhou B">B. N. Zhou</name>
</author>
<author><name sortKey="Ying, B P" uniqKey="Ying B">B. P. Ying</name>
</author>
<author><name sortKey="Song, G Q" uniqKey="Song G">G. Q. Song</name>
</author>
<author><name sortKey="Chen, Z X" uniqKey="Chen Z">Z. X. Chen</name>
</author>
<author><name sortKey="Han, J" uniqKey="Han J">J. Han</name>
</author>
<author><name sortKey="Yan, Y F" uniqKey="Yan Y">Y. F. Yan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name>
</author>
<author><name sortKey="Shertzer, H G" uniqKey="Shertzer H">H. G. Shertzer</name>
</author>
<author><name sortKey="Schneider, S N" uniqKey="Schneider S">S. N. Schneider</name>
</author>
<author><name sortKey="Nebert, D W" uniqKey="Nebert D">D. W. Nebert</name>
</author>
<author><name sortKey="Dalton, T P" uniqKey="Dalton T">T. P. Dalton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shi, S" uniqKey="Shi S">S. Shi</name>
</author>
<author><name sortKey="Hudson, F N" uniqKey="Hudson F">F. N. Hudson</name>
</author>
<author><name sortKey="Botta, D" uniqKey="Botta D">D. Botta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, J Y" uniqKey="Kim J">J. Y. Kim</name>
</author>
<author><name sortKey="Yim, J H" uniqKey="Yim J">J. H. Yim</name>
</author>
<author><name sortKey="Cho, J H" uniqKey="Cho J">J. H. Cho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, M" uniqKey="Liu M">M. Liu</name>
</author>
<author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoang, Y D" uniqKey="Hoang Y">Y. D. Hoang</name>
</author>
<author><name sortKey="Avakian, A P" uniqKey="Avakian A">A. P. Avakian</name>
</author>
<author><name sortKey="Luderer, U" uniqKey="Luderer U">U. Luderer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Debiton, E" uniqKey="Debiton E">E. Debiton</name>
</author>
<author><name sortKey="Madelmont, J C" uniqKey="Madelmont J">J. C. Madelmont</name>
</author>
<author><name sortKey="Legault, J" uniqKey="Legault J">J. Legault</name>
</author>
<author><name sortKey="Barthomeuf, C" uniqKey="Barthomeuf C">C. Barthomeuf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ehrke, E" uniqKey="Ehrke E">E. Ehrke</name>
</author>
<author><name sortKey="Arend, C" uniqKey="Arend C">C. Arend</name>
</author>
<author><name sortKey="Dringen, R" uniqKey="Dringen R">R. Dringen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Sayed, S M" uniqKey="El Sayed S">S. M. El Sayed</name>
</author>
<author><name sortKey="Baghdadi, H" uniqKey="Baghdadi H">H. Baghdadi</name>
</author>
<author><name sortKey="Zolaly, M" uniqKey="Zolaly M">M. Zolaly</name>
</author>
<author><name sortKey="Almaramhy, H H" uniqKey="Almaramhy H">H. H. Almaramhy</name>
</author>
<author><name sortKey="Ayat, M" uniqKey="Ayat M">M. Ayat</name>
</author>
<author><name sortKey="Donki, J G" uniqKey="Donki J">J. G. Donki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cardaci, S" uniqKey="Cardaci S">S. Cardaci</name>
</author>
<author><name sortKey="Desideri, E" uniqKey="Desideri E">E. Desideri</name>
</author>
<author><name sortKey="Ciriolo, M R" uniqKey="Ciriolo M">M. R. Ciriolo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ko, Y H" uniqKey="Ko Y">Y. H. Ko</name>
</author>
<author><name sortKey="Smith, B L" uniqKey="Smith B">B. L. Smith</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amjad, A I" uniqKey="Amjad A">A. I. Amjad</name>
</author>
<author><name sortKey="Parikh, R A" uniqKey="Parikh R">R. A. Parikh</name>
</author>
<author><name sortKey="Appleman, L J" uniqKey="Appleman L">L. J. Appleman</name>
</author>
<author><name sortKey="Hahm, E R" uniqKey="Hahm E">E. R. Hahm</name>
</author>
<author><name sortKey="Singh, K" uniqKey="Singh K">K. Singh</name>
</author>
<author><name sortKey="Singh, S V" uniqKey="Singh S">S. V. Singh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheung, K L" uniqKey="Cheung K">K. L. Cheung</name>
</author>
<author><name sortKey="Kong, A N" uniqKey="Kong A">A. N. Kong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, P" uniqKey="Gupta P">P. Gupta</name>
</author>
<author><name sortKey="Kim, B" uniqKey="Kim B">B. Kim</name>
</author>
<author><name sortKey="Kim, S H" uniqKey="Kim S">S. H. Kim</name>
</author>
<author><name sortKey="Srivastava, S K" uniqKey="Srivastava S">S. K. Srivastava</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, P" uniqKey="Gupta P">P. Gupta</name>
</author>
<author><name sortKey="Wright, S E" uniqKey="Wright S">S. E. Wright</name>
</author>
<author><name sortKey="Kim, S H" uniqKey="Kim S">S. H. Kim</name>
</author>
<author><name sortKey="Srivastava, S K" uniqKey="Srivastava S">S. K. Srivastava</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clarke, J D" uniqKey="Clarke J">J. D. Clarke</name>
</author>
<author><name sortKey="Dashwood, R H" uniqKey="Dashwood R">R. H. Dashwood</name>
</author>
<author><name sortKey="Ho, E" uniqKey="Ho E">E. Ho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, S H" uniqKey="Huang S">S. H. Huang</name>
</author>
<author><name sortKey="Hsu, M H" uniqKey="Hsu M">M. H. Hsu</name>
</author>
<author><name sortKey="Hsu, S C" uniqKey="Hsu S">S. C. Hsu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gordillo, G M" uniqKey="Gordillo G">G. M. Gordillo</name>
</author>
<author><name sortKey="Biswas, A" uniqKey="Biswas A">A. Biswas</name>
</author>
<author><name sortKey="Khanna, S" uniqKey="Khanna S">S. Khanna</name>
</author>
<author><name sortKey="Spieldenner, J M" uniqKey="Spieldenner J">J. M. Spieldenner</name>
</author>
<author><name sortKey="Pan, X" uniqKey="Pan X">X. Pan</name>
</author>
<author><name sortKey="Sen, C K" uniqKey="Sen C">C. K. Sen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Da Evi, M" uniqKey="Da Evi M">M. Dačević</name>
</author>
<author><name sortKey="Isakovi, A" uniqKey="Isakovi A">A. Isaković</name>
</author>
<author><name sortKey="Podolski Reni, A" uniqKey="Podolski Reni A">A. Podolski-Renić</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Circu, M L" uniqKey="Circu M">M. L. Circu</name>
</author>
<author><name sortKey="Stringer, S" uniqKey="Stringer S">S. Stringer</name>
</author>
<author><name sortKey="Rhoads, C A" uniqKey="Rhoads C">C. A. Rhoads</name>
</author>
<author><name sortKey="Moyer, M P" uniqKey="Moyer M">M. P. Moyer</name>
</author>
<author><name sortKey="Aw, T Y" uniqKey="Aw T">T. Y. Aw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benlloch, M" uniqKey="Benlloch M">M. Benlloch</name>
</author>
<author><name sortKey="Ortega, A" uniqKey="Ortega A">A. Ortega</name>
</author>
<author><name sortKey="Ferrer, P" uniqKey="Ferrer P">P. Ferrer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brechbuhl, H M" uniqKey="Brechbuhl H">H. M. Brechbuhl</name>
</author>
<author><name sortKey="Kachadourian, R" uniqKey="Kachadourian R">R. Kachadourian</name>
</author>
<author><name sortKey="Min, E" uniqKey="Min E">E. Min</name>
</author>
<author><name sortKey="Chan, D" uniqKey="Chan D">D. Chan</name>
</author>
<author><name sortKey="Day, B J" uniqKey="Day B">B. J. Day</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000292 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000292 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Merge |type= RBID |clé= PMC:6590529 |texte= Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:31281572" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |