Livin Regulates H2A.XY142 Phosphorylation and Promotes Autophagy in Colon Cancer Cells via a Novel Kinase Activity
Identifieur interne : 000686 ( Main/Exploration ); précédent : 000685; suivant : 000687Livin Regulates H2A.XY142 Phosphorylation and Promotes Autophagy in Colon Cancer Cells via a Novel Kinase Activity
Auteurs : Yang Ge ; Bao-Lin Liu ; Jun-Peng Cui ; Shu-Qiang LiSource :
- Frontiers in Oncology [ 2234-943X ] ; 2019.
Abstract
Url:
DOI: 10.3389/fonc.2019.01233
PubMed: 31799193
PubMed Central: 6868062
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Livin Regulates H2A.X<sup>Y142</sup>
Phosphorylation and Promotes Autophagy in Colon Cancer Cells via a Novel Kinase Activity</title>
<author><name sortKey="Ge, Yang" sort="Ge, Yang" uniqKey="Ge Y" first="Yang" last="Ge">Yang Ge</name>
</author>
<author><name sortKey="Liu, Bao Lin" sort="Liu, Bao Lin" uniqKey="Liu B" first="Bao-Lin" last="Liu">Bao-Lin Liu</name>
</author>
<author><name sortKey="Cui, Jun Peng" sort="Cui, Jun Peng" uniqKey="Cui J" first="Jun-Peng" last="Cui">Jun-Peng Cui</name>
</author>
<author><name sortKey="Li, Shu Qiang" sort="Li, Shu Qiang" uniqKey="Li S" first="Shu-Qiang" last="Li">Shu-Qiang Li</name>
</author>
</titleStmt>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Livin Regulates H2A.X<sup>Y142</sup>
Phosphorylation and Promotes Autophagy in Colon Cancer Cells via a Novel Kinase Activity</title>
<author><name sortKey="Ge, Yang" sort="Ge, Yang" uniqKey="Ge Y" first="Yang" last="Ge">Yang Ge</name>
</author>
<author><name sortKey="Liu, Bao Lin" sort="Liu, Bao Lin" uniqKey="Liu B" first="Bao-Lin" last="Liu">Bao-Lin Liu</name>
</author>
<author><name sortKey="Cui, Jun Peng" sort="Cui, Jun Peng" uniqKey="Cui J" first="Jun-Peng" last="Cui">Jun-Peng Cui</name>
</author>
<author><name sortKey="Li, Shu Qiang" sort="Li, Shu Qiang" uniqKey="Li S" first="Shu-Qiang" last="Li">Shu-Qiang Li</name>
</author>
</analytic>
<series><title level="j">Frontiers in Oncology</title>
<idno type="eISSN">2234-943X</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
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</sourceDesc>
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<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Objective:</bold>
To investigate Livin-mediated regulation of H2A.X<sup>Y142</sup>
phosphorylation via a novel kinase activity and its effect on autophagy in colon cancer cells.</p>
<p><bold>Methods:</bold>
The interaction between Livin and H2A.X was tested by immunoprecipitation. H2A.X–/– HCT116 cells were transfected with human influenza hemagglutinin (HA)-tagged WT or Y142F phospho-dead mutantH2A.X plasmids. GST-tagged recombinant Livin protein was used to perform <italic>in vitro</italic>
pull-down experiment and kinase assay. H2A.X–/–Livin+/+ SW480 cells were co-transfected with H2A.X<sup>WT</sup>
/H2A.X<sup>Y142F</sup>
plasmid and LC3 EGFP-tagged plasmid to explore whether H2A.X<sup>Y142F</sup>
was involved in Livin-mediated autophagy induced by starvation in colon cancer cells.</p>
<p><bold>Results:</bold>
Co-immunoprecipitation studies confirmed that Livin interacted with H2A.X and that it was phosphorylation dependent. <italic>In vitro</italic>
kinase assay confirmed that Livin could phosphorylate H2A.X. Knockdown of Livin (Livin–/–) in SW480 cells or HCT116 cells canceled the starvation-induced autophagy in colon cancer cells; H2A.X–/–Livin+/+ SW480 cells transfected with H2A.X<sup>WT</sup>
activated autophagy induced by starvation while cells transfected with H2A.X<sup>Y142F</sup>
had no significant difference; Livin-H2A.X<sup>Y142F</sup>
axis activated autophagy in colon cancer cells through transcriptionally regulating <italic>ATG5</italic>
and <italic>ATG7</italic>
.</p>
<p><bold>Conclusion:</bold>
Livin promotes autophagy in colon cancer cells via regulating the phosphorylation of H2A.X<sup>Y142</sup>
.</p>
</div>
</front>
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<tree><noCountry><name sortKey="Cui, Jun Peng" sort="Cui, Jun Peng" uniqKey="Cui J" first="Jun-Peng" last="Cui">Jun-Peng Cui</name>
<name sortKey="Ge, Yang" sort="Ge, Yang" uniqKey="Ge Y" first="Yang" last="Ge">Yang Ge</name>
<name sortKey="Li, Shu Qiang" sort="Li, Shu Qiang" uniqKey="Li S" first="Shu-Qiang" last="Li">Shu-Qiang Li</name>
<name sortKey="Liu, Bao Lin" sort="Liu, Bao Lin" uniqKey="Liu B" first="Bao-Lin" last="Liu">Bao-Lin Liu</name>
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