Origanum majorana Ethanolic Extract Promotes Colorectal Cancer Cell Death by Triggering Abortive Autophagy and Activation of the Extrinsic Apoptotic Pathway
Identifieur interne : 000B56 ( Main/Exploration ); précédent : 000B55; suivant : 000B57Origanum majorana Ethanolic Extract Promotes Colorectal Cancer Cell Death by Triggering Abortive Autophagy and Activation of the Extrinsic Apoptotic Pathway
Auteurs : Nehla Benhalilou [Émirats arabes unis] ; Halima Alsamri [Émirats arabes unis] ; Aysha Alneyadi [Émirats arabes unis] ; Khawlah Athamneh [Émirats arabes unis] ; Asma Alrashedi [Émirats arabes unis] ; Nedaa Altamimi [Émirats arabes unis] ; Yusra Al Dhaheri [Émirats arabes unis] ; Ali H. Eid [Liban] ; Rabah Iratni [Émirats arabes unis]Source :
- Frontiers in Oncology [ 2234-943X ] ; 2019.
Abstract
Colorectal cancer is considered as the third leading cause of cancer death. In the present study, we investigated the potential anticancer effect and the molecular mechanism of
Url:
DOI: 10.3389/fonc.2019.00795
PubMed: 31497536
PubMed Central: 6712482
Affiliations:
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Le document en format XML
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Ethanolic Extract Promotes Colorectal Cancer Cell Death by Triggering Abortive Autophagy and Activation of the Extrinsic Apoptotic Pathway</title>
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<country xml:lang="fr">Liban</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Origanum majorana</italic>
Ethanolic Extract Promotes Colorectal Cancer Cell Death by Triggering Abortive Autophagy and Activation of the Extrinsic Apoptotic Pathway</title>
<author><name sortKey="Benhalilou, Nehla" sort="Benhalilou, Nehla" uniqKey="Benhalilou N" first="Nehla" last="Benhalilou">Nehla Benhalilou</name>
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,<country>United Arab Emirates</country>
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<country xml:lang="fr">Émirats arabes unis</country>
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<author><name sortKey="Athamneh, Khawlah" sort="Athamneh, Khawlah" uniqKey="Athamneh K" first="Khawlah" last="Athamneh">Khawlah Athamneh</name>
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<author><name sortKey="Alrashedi, Asma" sort="Alrashedi, Asma" uniqKey="Alrashedi A" first="Asma" last="Alrashedi">Asma Alrashedi</name>
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,<addr-line>Abu Dhabi</addr-line>
,<country>United Arab Emirates</country>
</nlm:aff>
<country xml:lang="fr">Émirats arabes unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Altamimi, Nedaa" sort="Altamimi, Nedaa" uniqKey="Altamimi N" first="Nedaa" last="Altamimi">Nedaa Altamimi</name>
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<author><name sortKey="Eid, Ali H" sort="Eid, Ali H" uniqKey="Eid A" first="Ali H." last="Eid">Ali H. Eid</name>
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<country xml:lang="fr">Liban</country>
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<series><title level="j">Frontiers in Oncology</title>
<idno type="eISSN">2234-943X</idno>
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<front><div type="abstract" xml:lang="en"><p>Colorectal cancer is considered as the third leading cause of cancer death. In the present study, we investigated the potential anticancer effect and the molecular mechanism of <italic>Origanum majorana</italic>
ethanolic extract (OME) against human colorectal cancer cells. We showed that OME exhibited strong anti-proliferative activity in a concentration- and time-dependent manner against two human colorectal cancer cell lines (HT-29 and Caco-2). OME inhibited cell viability, colony growth and induced mitotic arrest of HT-29 cells. Also, OME induced DNA damage, triggered abortive autophagy and activated a caspase 3 and 7-dependent extrinsic apoptotic pathway, most likely through activation of the TNFα pathway. Time-course analysis revealed that DNA damage occurred concomitantly with abortive autophagy after 4 h post-OME treatment while apoptosis was activated only 24 h later. Blockade of autophagy initiation, by 3-methyladenine, partially rescued OME-induced cell death. Cell viability arose from 37% in control group to 67% in group pre-treated with 3-MA before addition of OME. Inhibition of apoptosis, however, had a minimal effect on cell viability; it rose from 37% in control group to 43% in group pre-treated with Z-VAD-FMK. We also found that OME downregulated survivin in HT-29 cells. Our findings provide a strong evidence that <italic>O. majorana</italic>
extract possesses strong anti-colon cancer potential, at least, through induction of autophagy and apoptosis. These finding provide the basis for therapeutic potential of <italic>O. majorana</italic>
in the treatment of colon cancer.</p>
</div>
</front>
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