Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy
Identifieur interne : 000A69 ( Main/Exploration ); précédent : 000A68; suivant : 000A70Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy
Auteurs : Iris Uribesalgo ; David Hoffmann ; Yin Zhang ; Anoop Kavirayani ; Jelena Lazovic ; Judit Berta ; Maria Novatchkova ; Tsung-Pin Pai ; Reiner A. Wimmer ; Vikt Ria Lászl ; Daniel Schramek ; Rezaul Karim ; Luigi Tortola ; Sumit Deswal ; Lisa Haas ; Johannes Zuber ; Mikl S Sz Cs ; Keiji Kuba ; Balazs Dome ; Yihai Cao ; Bernhard J. Haubner ; Josef M. PenningerSource :
- EMBO Molecular Medicine [ 1757-4676 ] ; 2019.
Abstract
Angiogenesis is a hallmark of cancer, promoting growth and metastasis. Anti‐angiogenic treatment has limited efficacy due to therapy‐induced blood vessel alterations, often followed by local hypoxia, tumor adaptation, progression, and metastasis. It is therefore paramount to overcome therapy‐induced resistance. We show that Apelin inhibition potently remodels the tumor microenvironment, reducing angiogenesis, and effectively blunting tumor growth. Functionally, targeting Apelin improves vessel function and reduces polymorphonuclear myeloid‐derived suppressor cell infiltration. Importantly, in mammary and lung cancer, Apelin prevents resistance to anti‐angiogenic receptor tyrosine kinase (RTK) inhibitor therapy, reducing growth and angiogenesis in lung and breast cancer models without increased hypoxia in the tumor microenvironment. Apelin blockage also prevents RTK inhibitor‐induced metastases, and high Apelin levels correlate with poor prognosis of anti‐angiogenic therapy patients. These data identify a druggable anti‐angiogenic drug target that reduces tumor blood vessel densities and normalizes the tumor vasculature to decrease metastases.
Url:
DOI: 10.15252/emmm.201809266
PubMed: 31267692
PubMed Central: 6685079
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000508
- to stream Pmc, to step Curation: 000508
- to stream Pmc, to step Checkpoint: 000999
- to stream Ncbi, to step Merge: 000760
- to stream Ncbi, to step Curation: 000760
- to stream Ncbi, to step Checkpoint: 000760
- to stream Main, to step Merge: 000A69
- to stream Main, to step Curation: 000A69
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy</title><author><name sortKey="Uribesalgo, Iris" sort="Uribesalgo, Iris" uniqKey="Uribesalgo I" first="Iris" last="Uribesalgo">Iris Uribesalgo</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Hoffmann, David" sort="Hoffmann, David" uniqKey="Hoffmann D" first="David" last="Hoffmann">David Hoffmann</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Yin" sort="Zhang, Yin" uniqKey="Zhang Y" first="Yin" last="Zhang">Yin Zhang</name><affiliation><nlm:aff id="emmm201809266-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Kavirayani, Anoop" sort="Kavirayani, Anoop" uniqKey="Kavirayani A" first="Anoop" last="Kavirayani">Anoop Kavirayani</name><affiliation><nlm:aff id="emmm201809266-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Lazovic, Jelena" sort="Lazovic, Jelena" uniqKey="Lazovic J" first="Jelena" last="Lazovic">Jelena Lazovic</name><affiliation><nlm:aff id="emmm201809266-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Berta, Judit" sort="Berta, Judit" uniqKey="Berta J" first="Judit" last="Berta">Judit Berta</name><affiliation><nlm:aff id="emmm201809266-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Novatchkova, Maria" sort="Novatchkova, Maria" uniqKey="Novatchkova M" first="Maria" last="Novatchkova">Maria Novatchkova</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Pai, Tsung In" sort="Pai, Tsung In" uniqKey="Pai T" first="Tsung-Pin" last="Pai">Tsung-Pin Pai</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Wimmer, Reiner A" sort="Wimmer, Reiner A" uniqKey="Wimmer R" first="Reiner A" last="Wimmer">Reiner A. Wimmer</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Laszl, Vikt Ria" sort="Laszl, Vikt Ria" uniqKey="Laszl V" first="Vikt Ria" last="Lászl">Vikt Ria Lászl</name><affiliation><nlm:aff id="emmm201809266-aff-0007"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Schramek, Daniel" sort="Schramek, Daniel" uniqKey="Schramek D" first="Daniel" last="Schramek">Daniel Schramek</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Karim, Rezaul" sort="Karim, Rezaul" uniqKey="Karim R" first="Rezaul" last="Karim">Rezaul Karim</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Tortola, Luigi" sort="Tortola, Luigi" uniqKey="Tortola L" first="Luigi" last="Tortola">Luigi Tortola</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Deswal, Sumit" sort="Deswal, Sumit" uniqKey="Deswal S" first="Sumit" last="Deswal">Sumit Deswal</name><affiliation><nlm:aff id="emmm201809266-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Haas, Lisa" sort="Haas, Lisa" uniqKey="Haas L" first="Lisa" last="Haas">Lisa Haas</name><affiliation><nlm:aff id="emmm201809266-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Zuber, Johannes" sort="Zuber, Johannes" uniqKey="Zuber J" first="Johannes" last="Zuber">Johannes Zuber</name><affiliation><nlm:aff id="emmm201809266-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Sz Cs, Mikl S" sort="Sz Cs, Mikl S" uniqKey="Sz Cs M" first="Mikl S" last="Sz Cs">Mikl S Sz Cs</name><affiliation><nlm:aff id="emmm201809266-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Kuba, Keiji" sort="Kuba, Keiji" uniqKey="Kuba K" first="Keiji" last="Kuba">Keiji Kuba</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Dome, Balazs" sort="Dome, Balazs" uniqKey="Dome B" first="Balazs" last="Dome">Balazs Dome</name><affiliation><nlm:aff id="emmm201809266-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0007"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0013"></nlm:aff></affiliation></author><author><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name><affiliation><nlm:aff id="emmm201809266-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Haubner, Bernhard J" sort="Haubner, Bernhard J" uniqKey="Haubner B" first="Bernhard J" last="Haubner">Bernhard J. Haubner</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M" last="Penninger">Josef M. Penninger</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0015"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31267692</idno><idno type="pmc">6685079</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685079</idno><idno type="RBID">PMC:6685079</idno><idno type="doi">10.15252/emmm.201809266</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000508</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000508</idno><idno type="wicri:Area/Pmc/Curation">000508</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000508</idno><idno type="wicri:Area/Pmc/Checkpoint">000999</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000999</idno><idno type="wicri:Area/Ncbi/Merge">000760</idno><idno type="wicri:Area/Ncbi/Curation">000760</idno><idno type="wicri:Area/Ncbi/Checkpoint">000760</idno><idno type="wicri:doubleKey">1757-4676:2019:Uribesalgo I:apelin:inhibition:prevents</idno><idno type="wicri:Area/Main/Merge">000A69</idno><idno type="wicri:Area/Main/Curation">000A69</idno><idno type="wicri:Area/Main/Exploration">000A69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy</title><author><name sortKey="Uribesalgo, Iris" sort="Uribesalgo, Iris" uniqKey="Uribesalgo I" first="Iris" last="Uribesalgo">Iris Uribesalgo</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Hoffmann, David" sort="Hoffmann, David" uniqKey="Hoffmann D" first="David" last="Hoffmann">David Hoffmann</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Yin" sort="Zhang, Yin" uniqKey="Zhang Y" first="Yin" last="Zhang">Yin Zhang</name><affiliation><nlm:aff id="emmm201809266-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Kavirayani, Anoop" sort="Kavirayani, Anoop" uniqKey="Kavirayani A" first="Anoop" last="Kavirayani">Anoop Kavirayani</name><affiliation><nlm:aff id="emmm201809266-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Lazovic, Jelena" sort="Lazovic, Jelena" uniqKey="Lazovic J" first="Jelena" last="Lazovic">Jelena Lazovic</name><affiliation><nlm:aff id="emmm201809266-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Berta, Judit" sort="Berta, Judit" uniqKey="Berta J" first="Judit" last="Berta">Judit Berta</name><affiliation><nlm:aff id="emmm201809266-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Novatchkova, Maria" sort="Novatchkova, Maria" uniqKey="Novatchkova M" first="Maria" last="Novatchkova">Maria Novatchkova</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Pai, Tsung In" sort="Pai, Tsung In" uniqKey="Pai T" first="Tsung-Pin" last="Pai">Tsung-Pin Pai</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Wimmer, Reiner A" sort="Wimmer, Reiner A" uniqKey="Wimmer R" first="Reiner A" last="Wimmer">Reiner A. Wimmer</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Laszl, Vikt Ria" sort="Laszl, Vikt Ria" uniqKey="Laszl V" first="Vikt Ria" last="Lászl">Vikt Ria Lászl</name><affiliation><nlm:aff id="emmm201809266-aff-0007"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Schramek, Daniel" sort="Schramek, Daniel" uniqKey="Schramek D" first="Daniel" last="Schramek">Daniel Schramek</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Karim, Rezaul" sort="Karim, Rezaul" uniqKey="Karim R" first="Rezaul" last="Karim">Rezaul Karim</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Tortola, Luigi" sort="Tortola, Luigi" uniqKey="Tortola L" first="Luigi" last="Tortola">Luigi Tortola</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Deswal, Sumit" sort="Deswal, Sumit" uniqKey="Deswal S" first="Sumit" last="Deswal">Sumit Deswal</name><affiliation><nlm:aff id="emmm201809266-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Haas, Lisa" sort="Haas, Lisa" uniqKey="Haas L" first="Lisa" last="Haas">Lisa Haas</name><affiliation><nlm:aff id="emmm201809266-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Zuber, Johannes" sort="Zuber, Johannes" uniqKey="Zuber J" first="Johannes" last="Zuber">Johannes Zuber</name><affiliation><nlm:aff id="emmm201809266-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Sz Cs, Mikl S" sort="Sz Cs, Mikl S" uniqKey="Sz Cs M" first="Mikl S" last="Sz Cs">Mikl S Sz Cs</name><affiliation><nlm:aff id="emmm201809266-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Kuba, Keiji" sort="Kuba, Keiji" uniqKey="Kuba K" first="Keiji" last="Kuba">Keiji Kuba</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Dome, Balazs" sort="Dome, Balazs" uniqKey="Dome B" first="Balazs" last="Dome">Balazs Dome</name><affiliation><nlm:aff id="emmm201809266-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0007"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0013"></nlm:aff></affiliation></author><author><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name><affiliation><nlm:aff id="emmm201809266-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Haubner, Bernhard J" sort="Haubner, Bernhard J" uniqKey="Haubner B" first="Bernhard J" last="Haubner">Bernhard J. Haubner</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M" last="Penninger">Josef M. Penninger</name><affiliation><nlm:aff id="emmm201809266-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201809266-aff-0015"></nlm:aff></affiliation></author></analytic><series><title level="j">EMBO Molecular Medicine</title><idno type="ISSN">1757-4676</idno><idno type="eISSN">1757-4684</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Angiogenesis is a hallmark of cancer, promoting growth and metastasis. Anti‐angiogenic treatment has limited efficacy due to therapy‐induced blood vessel alterations, often followed by local hypoxia, tumor adaptation, progression, and metastasis. It is therefore paramount to overcome therapy‐induced resistance. We show that Apelin inhibition potently remodels the tumor microenvironment, reducing angiogenesis, and effectively blunting tumor growth. Functionally, targeting Apelin improves vessel function and reduces polymorphonuclear myeloid‐derived suppressor cell infiltration. Importantly, in mammary and lung cancer, Apelin prevents resistance to anti‐angiogenic receptor tyrosine kinase (RTK) inhibitor therapy, reducing growth and angiogenesis in lung and breast cancer models without increased hypoxia in the tumor microenvironment. Apelin blockage also prevents RTK inhibitor‐induced metastases, and high Apelin levels correlate with poor prognosis of anti‐angiogenic therapy patients. These data identify a druggable anti‐angiogenic drug target that reduces tumor blood vessel densities and normalizes the tumor vasculature to decrease metastases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Berta, Judit" sort="Berta, Judit" uniqKey="Berta J" first="Judit" last="Berta">Judit Berta</name><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name><name sortKey="Deswal, Sumit" sort="Deswal, Sumit" uniqKey="Deswal S" first="Sumit" last="Deswal">Sumit Deswal</name><name sortKey="Dome, Balazs" sort="Dome, Balazs" uniqKey="Dome B" first="Balazs" last="Dome">Balazs Dome</name><name sortKey="Haas, Lisa" sort="Haas, Lisa" uniqKey="Haas L" first="Lisa" last="Haas">Lisa Haas</name><name sortKey="Haubner, Bernhard J" sort="Haubner, Bernhard J" uniqKey="Haubner B" first="Bernhard J" last="Haubner">Bernhard J. Haubner</name><name sortKey="Hoffmann, David" sort="Hoffmann, David" uniqKey="Hoffmann D" first="David" last="Hoffmann">David Hoffmann</name><name sortKey="Karim, Rezaul" sort="Karim, Rezaul" uniqKey="Karim R" first="Rezaul" last="Karim">Rezaul Karim</name><name sortKey="Kavirayani, Anoop" sort="Kavirayani, Anoop" uniqKey="Kavirayani A" first="Anoop" last="Kavirayani">Anoop Kavirayani</name><name sortKey="Kuba, Keiji" sort="Kuba, Keiji" uniqKey="Kuba K" first="Keiji" last="Kuba">Keiji Kuba</name><name sortKey="Laszl, Vikt Ria" sort="Laszl, Vikt Ria" uniqKey="Laszl V" first="Vikt Ria" last="Lászl">Vikt Ria Lászl</name><name sortKey="Lazovic, Jelena" sort="Lazovic, Jelena" uniqKey="Lazovic J" first="Jelena" last="Lazovic">Jelena Lazovic</name><name sortKey="Novatchkova, Maria" sort="Novatchkova, Maria" uniqKey="Novatchkova M" first="Maria" last="Novatchkova">Maria Novatchkova</name><name sortKey="Pai, Tsung In" sort="Pai, Tsung In" uniqKey="Pai T" first="Tsung-Pin" last="Pai">Tsung-Pin Pai</name><name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M" last="Penninger">Josef M. Penninger</name><name sortKey="Schramek, Daniel" sort="Schramek, Daniel" uniqKey="Schramek D" first="Daniel" last="Schramek">Daniel Schramek</name><name sortKey="Sz Cs, Mikl S" sort="Sz Cs, Mikl S" uniqKey="Sz Cs M" first="Mikl S" last="Sz Cs">Mikl S Sz Cs</name><name sortKey="Tortola, Luigi" sort="Tortola, Luigi" uniqKey="Tortola L" first="Luigi" last="Tortola">Luigi Tortola</name><name sortKey="Uribesalgo, Iris" sort="Uribesalgo, Iris" uniqKey="Uribesalgo I" first="Iris" last="Uribesalgo">Iris Uribesalgo</name><name sortKey="Wimmer, Reiner A" sort="Wimmer, Reiner A" uniqKey="Wimmer R" first="Reiner A" last="Wimmer">Reiner A. Wimmer</name><name sortKey="Zhang, Yin" sort="Zhang, Yin" uniqKey="Zhang Y" first="Yin" last="Zhang">Yin Zhang</name><name sortKey="Zuber, Johannes" sort="Zuber, Johannes" uniqKey="Zuber J" first="Johannes" last="Zuber">Johannes Zuber</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A69 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A69 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6685079
|texte= Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31267692" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |