Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation
Identifieur interne : 000691 ( Main/Exploration ); précédent : 000690; suivant : 000692Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation
Auteurs : Tai-Shan Shen [Taïwan] ; Yung-Ken Hsu [Taïwan] ; Yi-Fu Huang [Taïwan] ; Hsuan-Ying Chen [Taïwan] ; Cheng-Pu Hsieh [Taïwan] ; Chiu-Liang Chen [Taïwan]Source :
- Molecules [ 1420-3049 ] ; 2019.
Abstract
Licochalcone A, a flavonoid extracted from licorice root, has been shown to exhibit broad anti-inflammatory, anti-bacterial, anticancer, and antioxidative bioactivity. In this study, we investigated the antitumor activity of Licochalcone A against human osteosarcoma cell lines. The data showed that Licochalcone A significantly suppressed cell viability in MTT assay and colony formation assay in osteosarcoma cell lines. Exposure to Licochalcone A blocked cell cycle progression at the G2/M transition and induced extrinsic apoptotic pathway in osteosarcoma cell lines. Furthermore, we found the Licochalcone A exposure resulted in rapid ATM and Chk2 activation, and high levels of nuclear foci of phosphorylated Chk2 at Thr 68 site in osteosarcoma cell lines. In addition, Licochalcone A exposure significantly induced autophagy in osteosarcoma cell lines. When Licochalcone A-induced autophagy was blocked by the autophagy inhibitor chloroquine, the expression of activated caspase-3 and Annexin V positive cells were reduced, and cell viability was rescued in Licochalcone A-treated osteosarcoma cell lines. These data indicate that the activation of ATM-Chk2 checkpoint pathway and autophagy may contribute to Licochalcone A-induced anti-proliferating effect in osteosarcoma cell lines. Our findings display the possibility that Licochalcone A may serve as a potential therapeutic agent against osteosarcoma.
Url:
DOI: 10.3390/molecules24132435
PubMed: 31269698
PubMed Central: 6651087
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000716
- to stream Pmc, to step Curation: 000716
- to stream Pmc, to step Checkpoint: 000638
- to stream Ncbi, to step Merge: 000763
- to stream Ncbi, to step Curation: 000763
- to stream Ncbi, to step Checkpoint: 000763
- to stream Main, to step Merge: 000691
- to stream Main, to step Curation: 000691
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation</title>
<author><name sortKey="Shen, Tai Shan" sort="Shen, Tai Shan" uniqKey="Shen T" first="Tai-Shan" last="Shen">Tai-Shan Shen</name>
<affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02435">Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsu, Yung Ken" sort="Hsu, Yung Ken" uniqKey="Hsu Y" first="Yung-Ken" last="Hsu">Yung-Ken Hsu</name>
<affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02435">Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Yi Fu" sort="Huang, Yi Fu" uniqKey="Huang Y" first="Yi-Fu" last="Huang">Yi-Fu Huang</name>
<affiliation wicri:level="1"><nlm:aff id="af2-molecules-24-02435">Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Hsuan Ying" sort="Chen, Hsuan Ying" uniqKey="Chen H" first="Hsuan-Ying" last="Chen">Hsuan-Ying Chen</name>
<affiliation wicri:level="1"><nlm:aff id="af2-molecules-24-02435">Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsieh, Cheng Pu" sort="Hsieh, Cheng Pu" uniqKey="Hsieh C" first="Cheng-Pu" last="Hsieh">Cheng-Pu Hsieh</name>
<affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02435">Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-molecules-24-02435">Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Chiu Liang" sort="Chen, Chiu Liang" uniqKey="Chen C" first="Chiu-Liang" last="Chen">Chiu-Liang Chen</name>
<affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02435">Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-molecules-24-02435">Department of Nursing, Da Yeh University, Changhua 51591, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nursing, Da Yeh University, Changhua 51591</wicri:regionArea>
<wicri:noRegion>Changhua 51591</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31269698</idno>
<idno type="pmc">6651087</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651087</idno>
<idno type="RBID">PMC:6651087</idno>
<idno type="doi">10.3390/molecules24132435</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000716</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000716</idno>
<idno type="wicri:Area/Pmc/Curation">000716</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000716</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000638</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000638</idno>
<idno type="wicri:Area/Ncbi/Merge">000763</idno>
<idno type="wicri:Area/Ncbi/Curation">000763</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000763</idno>
<idno type="wicri:Area/Main/Merge">000691</idno>
<idno type="wicri:Area/Main/Curation">000691</idno>
<idno type="wicri:Area/Main/Exploration">000691</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation</title>
<author><name sortKey="Shen, Tai Shan" sort="Shen, Tai Shan" uniqKey="Shen T" first="Tai-Shan" last="Shen">Tai-Shan Shen</name>
<affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02435">Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsu, Yung Ken" sort="Hsu, Yung Ken" uniqKey="Hsu Y" first="Yung-Ken" last="Hsu">Yung-Ken Hsu</name>
<affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02435">Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Yi Fu" sort="Huang, Yi Fu" uniqKey="Huang Y" first="Yi-Fu" last="Huang">Yi-Fu Huang</name>
<affiliation wicri:level="1"><nlm:aff id="af2-molecules-24-02435">Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Hsuan Ying" sort="Chen, Hsuan Ying" uniqKey="Chen H" first="Hsuan-Ying" last="Chen">Hsuan-Ying Chen</name>
<affiliation wicri:level="1"><nlm:aff id="af2-molecules-24-02435">Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsieh, Cheng Pu" sort="Hsieh, Cheng Pu" uniqKey="Hsieh C" first="Cheng-Pu" last="Hsieh">Cheng-Pu Hsieh</name>
<affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02435">Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-molecules-24-02435">Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Chiu Liang" sort="Chen, Chiu Liang" uniqKey="Chen C" first="Chiu-Liang" last="Chen">Chiu-Liang Chen</name>
<affiliation wicri:level="1"><nlm:aff id="af1-molecules-24-02435">Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua 50006</wicri:regionArea>
<wicri:noRegion>Changhua 50006</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-molecules-24-02435">Department of Nursing, Da Yeh University, Changhua 51591, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Nursing, Da Yeh University, Changhua 51591</wicri:regionArea>
<wicri:noRegion>Changhua 51591</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Molecules</title>
<idno type="eISSN">1420-3049</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Licochalcone A, a flavonoid extracted from licorice root, has been shown to exhibit broad anti-inflammatory, anti-bacterial, anticancer, and antioxidative bioactivity. In this study, we investigated the antitumor activity of Licochalcone A against human osteosarcoma cell lines. The data showed that Licochalcone A significantly suppressed cell viability in MTT assay and colony formation assay in osteosarcoma cell lines. Exposure to Licochalcone A blocked cell cycle progression at the G2/M transition and induced extrinsic apoptotic pathway in osteosarcoma cell lines. Furthermore, we found the Licochalcone A exposure resulted in rapid ATM and Chk2 activation, and high levels of nuclear foci of phosphorylated Chk2 at Thr 68 site in osteosarcoma cell lines. In addition, Licochalcone A exposure significantly induced autophagy in osteosarcoma cell lines. When Licochalcone A-induced autophagy was blocked by the autophagy inhibitor chloroquine, the expression of activated caspase-3 and Annexin V positive cells were reduced, and cell viability was rescued in Licochalcone A-treated osteosarcoma cell lines. These data indicate that the activation of ATM-Chk2 checkpoint pathway and autophagy may contribute to Licochalcone A-induced anti-proliferating effect in osteosarcoma cell lines. Our findings display the possibility that Licochalcone A may serve as a potential therapeutic agent against osteosarcoma.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mirabello, L" uniqKey="Mirabello L">L. Mirabello</name>
</author>
<author><name sortKey="Troisi, R J" uniqKey="Troisi R">R.J. Troisi</name>
</author>
<author><name sortKey="Savage, S A" uniqKey="Savage S">S.A. Savage</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Otoukesh, B" uniqKey="Otoukesh B">B. Otoukesh</name>
</author>
<author><name sortKey="Boddouhi, B" uniqKey="Boddouhi B">B. Boddouhi</name>
</author>
<author><name sortKey="Moghtadaei, M" uniqKey="Moghtadaei M">M. Moghtadaei</name>
</author>
<author><name sortKey="Kaghazian, P" uniqKey="Kaghazian P">P. Kaghazian</name>
</author>
<author><name sortKey="Kaghazian, M" uniqKey="Kaghazian M">M. Kaghazian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rickel, K" uniqKey="Rickel K">K. Rickel</name>
</author>
<author><name sortKey="Fang, F" uniqKey="Fang F">F. Fang</name>
</author>
<author><name sortKey="Tao, J" uniqKey="Tao J">J. Tao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bernthal, N M" uniqKey="Bernthal N">N.M. Bernthal</name>
</author>
<author><name sortKey="Federman, N" uniqKey="Federman N">N. Federman</name>
</author>
<author><name sortKey="Eilber, F R" uniqKey="Eilber F">F.R. Eilber</name>
</author>
<author><name sortKey="Nelson, S D" uniqKey="Nelson S">S.D. Nelson</name>
</author>
<author><name sortKey="Eckardt, J J" uniqKey="Eckardt J">J.J. Eckardt</name>
</author>
<author><name sortKey="Eilber, F C" uniqKey="Eilber F">F.C. Eilber</name>
</author>
<author><name sortKey="Tap, W D" uniqKey="Tap W">W.D. Tap</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kempf Bielack, B" uniqKey="Kempf Bielack B">B. Kempf-Bielack</name>
</author>
<author><name sortKey="Bielack, S S" uniqKey="Bielack S">S.S. Bielack</name>
</author>
<author><name sortKey="Jurgens, H" uniqKey="Jurgens H">H. Jurgens</name>
</author>
<author><name sortKey="Branscheid, D" uniqKey="Branscheid D">D. Branscheid</name>
</author>
<author><name sortKey="Berdel, W E" uniqKey="Berdel W">W.E. Berdel</name>
</author>
<author><name sortKey="Exner, G U" uniqKey="Exner G">G.U. Exner</name>
</author>
<author><name sortKey="Gobel, U" uniqKey="Gobel U">U. Gobel</name>
</author>
<author><name sortKey="Helmke, K" uniqKey="Helmke K">K. Helmke</name>
</author>
<author><name sortKey="Jundt, G" uniqKey="Jundt G">G. Jundt</name>
</author>
<author><name sortKey="Kabisch, H" uniqKey="Kabisch H">H. Kabisch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carrle, D" uniqKey="Carrle D">D. Carrle</name>
</author>
<author><name sortKey="Bielack, S" uniqKey="Bielack S">S. Bielack</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siveen, K S" uniqKey="Siveen K">K.S. Siveen</name>
</author>
<author><name sortKey="Uddin, S" uniqKey="Uddin S">S. Uddin</name>
</author>
<author><name sortKey="Mohammad, R M" uniqKey="Mohammad R">R.M. Mohammad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chinembiri, T N" uniqKey="Chinembiri T">T.N. Chinembiri</name>
</author>
<author><name sortKey="Du Plessis, L H" uniqKey="Du Plessis L">L.H. du Plessis</name>
</author>
<author><name sortKey="Gerber, M" uniqKey="Gerber M">M. Gerber</name>
</author>
<author><name sortKey="Hamman, J H" uniqKey="Hamman J">J.H. Hamman</name>
</author>
<author><name sortKey="Du Plessis, J" uniqKey="Du Plessis J">J. du Plessis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name>
</author>
<author><name sortKey="Yang, R" uniqKey="Yang R">R. Yang</name>
</author>
<author><name sortKey="Yuan, B" uniqKey="Yuan B">B. Yuan</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Liu, C" uniqKey="Liu C">C. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sidhu, P" uniqKey="Sidhu P">P. Sidhu</name>
</author>
<author><name sortKey="Shankargouda, S" uniqKey="Shankargouda S">S. Shankargouda</name>
</author>
<author><name sortKey="Rath, A" uniqKey="Rath A">A. Rath</name>
</author>
<author><name sortKey="Ramamurthy, P H" uniqKey="Ramamurthy P">P.H. Ramamurthy</name>
</author>
<author><name sortKey="Fernandes, B" uniqKey="Fernandes B">B. Fernandes</name>
</author>
<author><name sortKey="Singh, A K" uniqKey="Singh A">A.K. Singh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adianti, M" uniqKey="Adianti M">M. Adianti</name>
</author>
<author><name sortKey="Aoki, C" uniqKey="Aoki C">C. Aoki</name>
</author>
<author><name sortKey="Komoto, M" uniqKey="Komoto M">M. Komoto</name>
</author>
<author><name sortKey="Deng, L" uniqKey="Deng L">L. Deng</name>
</author>
<author><name sortKey="Shoji, I" uniqKey="Shoji I">I. Shoji</name>
</author>
<author><name sortKey="Wahyuni, T S" uniqKey="Wahyuni T">T.S. Wahyuni</name>
</author>
<author><name sortKey="Lusida, M I" uniqKey="Lusida M">M.I. Lusida</name>
</author>
<author><name sortKey="Soetjipto" uniqKey="Soetjipto">Soetjipto</name>
</author>
<author><name sortKey="Fuchino, H" uniqKey="Fuchino H">H. Fuchino</name>
</author>
<author><name sortKey="Kawahara, N" uniqKey="Kawahara N">N. Kawahara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Si, H" uniqKey="Si H">H. Si</name>
</author>
<author><name sortKey="Xu, C" uniqKey="Xu C">C. Xu</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name>
</author>
<author><name sortKey="Li, B" uniqKey="Li B">B. Li</name>
</author>
<author><name sortKey="Zhou, X" uniqKey="Zhou X">X. Zhou</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liang, M" uniqKey="Liang M">M. Liang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Ouyang, X" uniqKey="Ouyang X">X. Ouyang</name>
</author>
<author><name sortKey="Xie, H" uniqKey="Xie H">H. Xie</name>
</author>
<author><name sortKey="Chen, D" uniqKey="Chen D">D. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Y H" uniqKey="Kim Y">Y.H. Kim</name>
</author>
<author><name sortKey="Shin, E K" uniqKey="Shin E">E.K. Shin</name>
</author>
<author><name sortKey="Kim, D H" uniqKey="Kim D">D.H. Kim</name>
</author>
<author><name sortKey="Lee, H H" uniqKey="Lee H">H.H. Lee</name>
</author>
<author><name sortKey="Park, J H" uniqKey="Park J">J.H. Park</name>
</author>
<author><name sortKey="Kim, J K" uniqKey="Kim J">J.K. Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jia, T" uniqKey="Jia T">T. Jia</name>
</author>
<author><name sortKey="Qiao, J" uniqKey="Qiao J">J. Qiao</name>
</author>
<author><name sortKey="Guan, D" uniqKey="Guan D">D. Guan</name>
</author>
<author><name sortKey="Chen, T" uniqKey="Chen T">T. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuramoto, K" uniqKey="Kuramoto K">K. Kuramoto</name>
</author>
<author><name sortKey="Suzuki, S" uniqKey="Suzuki S">S. Suzuki</name>
</author>
<author><name sortKey="Sakaki, H" uniqKey="Sakaki H">H. Sakaki</name>
</author>
<author><name sortKey="Takeda, H" uniqKey="Takeda H">H. Takeda</name>
</author>
<author><name sortKey="Sanomachi, T" uniqKey="Sanomachi T">T. Sanomachi</name>
</author>
<author><name sortKey="Seino, S" uniqKey="Seino S">S. Seino</name>
</author>
<author><name sortKey="Narita, Y" uniqKey="Narita Y">Y. Narita</name>
</author>
<author><name sortKey="Kayama, T" uniqKey="Kayama T">T. Kayama</name>
</author>
<author><name sortKey="Kitanaka, C" uniqKey="Kitanaka C">C. Kitanaka</name>
</author>
<author><name sortKey="Okada, M" uniqKey="Okada M">M. Okada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeng, G" uniqKey="Zeng G">G. Zeng</name>
</author>
<author><name sortKey="Shen, H" uniqKey="Shen H">H. Shen</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name>
</author>
<author><name sortKey="Cai, X" uniqKey="Cai X">X. Cai</name>
</author>
<author><name sortKey="Xun, W" uniqKey="Xun W">W. Xun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qiu, C" uniqKey="Qiu C">C. Qiu</name>
</author>
<author><name sortKey="Zhang, T" uniqKey="Zhang T">T. Zhang</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name>
</author>
<author><name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name>
</author>
<author><name sortKey="Yu, B" uniqKey="Yu B">B. Yu</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name>
</author>
<author><name sortKey="Yang, Z" uniqKey="Yang Z">Z. Yang</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name>
</author>
<author><name sortKey="Zou, P" uniqKey="Zou P">P. Zou</name>
</author>
<author><name sortKey="Liang, G" uniqKey="Liang G">G. Liang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xue, L" uniqKey="Xue L">L. Xue</name>
</author>
<author><name sortKey="Zhang, W J" uniqKey="Zhang W">W.J. Zhang</name>
</author>
<author><name sortKey="Fan, Q X" uniqKey="Fan Q">Q.X. Fan</name>
</author>
<author><name sortKey="Wang, L X" uniqKey="Wang L">L.X. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsai, J P" uniqKey="Tsai J">J.P. Tsai</name>
</author>
<author><name sortKey="Lee, C H" uniqKey="Lee C">C.H. Lee</name>
</author>
<author><name sortKey="Ying, T H" uniqKey="Ying T">T.H. Ying</name>
</author>
<author><name sortKey="Lin, C L" uniqKey="Lin C">C.L. Lin</name>
</author>
<author><name sortKey="Lin, C L" uniqKey="Lin C">C.L. Lin</name>
</author>
<author><name sortKey="Hsueh, J T" uniqKey="Hsueh J">J.T. Hsueh</name>
</author>
<author><name sortKey="Hsieh, Y H" uniqKey="Hsieh Y">Y.H. Hsieh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chuang, C Y" uniqKey="Chuang C">C.Y. Chuang</name>
</author>
<author><name sortKey="Tang, C M" uniqKey="Tang C">C.M. Tang</name>
</author>
<author><name sortKey="Ho, H Y" uniqKey="Ho H">H.Y. Ho</name>
</author>
<author><name sortKey="Hsin, C H" uniqKey="Hsin C">C.H. Hsin</name>
</author>
<author><name sortKey="Weng, C J" uniqKey="Weng C">C.J. Weng</name>
</author>
<author><name sortKey="Yang, S F" uniqKey="Yang S">S.F. Yang</name>
</author>
<author><name sortKey="Chen, P N" uniqKey="Chen P">P.N. Chen</name>
</author>
<author><name sortKey="Lin, C W" uniqKey="Lin C">C.W. Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, M R" uniqKey="Park M">M.R. Park</name>
</author>
<author><name sortKey="Kim, S G" uniqKey="Kim S">S.G. Kim</name>
</author>
<author><name sortKey="Cho, I A" uniqKey="Cho I">I.A. Cho</name>
</author>
<author><name sortKey="Oh, D" uniqKey="Oh D">D. Oh</name>
</author>
<author><name sortKey="Kang, K R" uniqKey="Kang K">K.R. Kang</name>
</author>
<author><name sortKey="Lee, S Y" uniqKey="Lee S">S.Y. Lee</name>
</author>
<author><name sortKey="Moon, S M" uniqKey="Moon S">S.M. Moon</name>
</author>
<author><name sortKey="Cho, S S" uniqKey="Cho S">S.S. Cho</name>
</author>
<author><name sortKey="Yoon, G" uniqKey="Yoon G">G. Yoon</name>
</author>
<author><name sortKey="Kim, C S" uniqKey="Kim C">C.S. Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ottaviano, L" uniqKey="Ottaviano L">L. Ottaviano</name>
</author>
<author><name sortKey="Schaefer, K L" uniqKey="Schaefer K">K.L. Schaefer</name>
</author>
<author><name sortKey="Gajewski, M" uniqKey="Gajewski M">M. Gajewski</name>
</author>
<author><name sortKey="Huckenbeck, W" uniqKey="Huckenbeck W">W. Huckenbeck</name>
</author>
<author><name sortKey="Baldus, S" uniqKey="Baldus S">S. Baldus</name>
</author>
<author><name sortKey="Rogel, U" uniqKey="Rogel U">U. Rogel</name>
</author>
<author><name sortKey="Mackintosh, C" uniqKey="Mackintosh C">C. Mackintosh</name>
</author>
<author><name sortKey="De Alava, E" uniqKey="De Alava E">E. de Alava</name>
</author>
<author><name sortKey="Myklebost, O" uniqKey="Myklebost O">O. Myklebost</name>
</author>
<author><name sortKey="Kresse, S H" uniqKey="Kresse S">S.H. Kresse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chandar, N" uniqKey="Chandar N">N. Chandar</name>
</author>
<author><name sortKey="Billig, B" uniqKey="Billig B">B. Billig</name>
</author>
<author><name sortKey="Mcmaster, J" uniqKey="Mcmaster J">J. McMaster</name>
</author>
<author><name sortKey="Novak, J" uniqKey="Novak J">J. Novak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Novello, C" uniqKey="Novello C">C. Novello</name>
</author>
<author><name sortKey="Pazzaglia, L" uniqKey="Pazzaglia L">L. Pazzaglia</name>
</author>
<author><name sortKey="Conti, A" uniqKey="Conti A">A. Conti</name>
</author>
<author><name sortKey="Quattrini, I" uniqKey="Quattrini I">I. Quattrini</name>
</author>
<author><name sortKey="Pollino, S" uniqKey="Pollino S">S. Pollino</name>
</author>
<author><name sortKey="Perego, P" uniqKey="Perego P">P. Perego</name>
</author>
<author><name sortKey="Picci, P" uniqKey="Picci P">P. Picci</name>
</author>
<author><name sortKey="Benassi, M S" uniqKey="Benassi M">M.S. Benassi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, Z" uniqKey="Guo Z">Z. Guo</name>
</author>
<author><name sortKey="Deshpande, R" uniqKey="Deshpande R">R. Deshpande</name>
</author>
<author><name sortKey="Paull, T T" uniqKey="Paull T">T.T. Paull</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name>
</author>
<author><name sortKey="Zhu, L" uniqKey="Zhu L">L. Zhu</name>
</author>
<author><name sortKey="Sun, D" uniqKey="Sun D">D. Sun</name>
</author>
<author><name sortKey="Gan, F" uniqKey="Gan F">F. Gan</name>
</author>
<author><name sortKey="Gao, S" uniqKey="Gao S">S. Gao</name>
</author>
<author><name sortKey="Yin, Y" uniqKey="Yin Y">Y. Yin</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elmore, S" uniqKey="Elmore S">S. Elmore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ouyang, L" uniqKey="Ouyang L">L. Ouyang</name>
</author>
<author><name sortKey="Shi, Z" uniqKey="Shi Z">Z. Shi</name>
</author>
<author><name sortKey="Zhao, S" uniqKey="Zhao S">S. Zhao</name>
</author>
<author><name sortKey="Wang, F T" uniqKey="Wang F">F.T. Wang</name>
</author>
<author><name sortKey="Zhou, T T" uniqKey="Zhou T">T.T. Zhou</name>
</author>
<author><name sortKey="Liu, B" uniqKey="Liu B">B. Liu</name>
</author>
<author><name sortKey="Bao, J K" uniqKey="Bao J">J.K. Bao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Awasthi, P" uniqKey="Awasthi P">P. Awasthi</name>
</author>
<author><name sortKey="Foiani, M" uniqKey="Foiani M">M. Foiani</name>
</author>
<author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, Z" uniqKey="Guo Z">Z. Guo</name>
</author>
<author><name sortKey="Kozlov, S" uniqKey="Kozlov S">S. Kozlov</name>
</author>
<author><name sortKey="Lavin, M F" uniqKey="Lavin M">M.F. Lavin</name>
</author>
<author><name sortKey="Person, M D" uniqKey="Person M">M.D. Person</name>
</author>
<author><name sortKey="Paull, T T" uniqKey="Paull T">T.T. Paull</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, L" uniqKey="Lin L">L. Lin</name>
</author>
<author><name sortKey="Baehrecke, E H" uniqKey="Baehrecke E">E.H. Baehrecke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lo, Y C" uniqKey="Lo Y">Y.C. Lo</name>
</author>
<author><name sortKey="Lin, Y C" uniqKey="Lin Y">Y.C. Lin</name>
</author>
<author><name sortKey="Huang, Y F" uniqKey="Huang Y">Y.F. Huang</name>
</author>
<author><name sortKey="Hsieh, C P" uniqKey="Hsieh C">C.P. Hsieh</name>
</author>
<author><name sortKey="Wu, C C" uniqKey="Wu C">C.C. Wu</name>
</author>
<author><name sortKey="Chang, I L" uniqKey="Chang I">I.L. Chang</name>
</author>
<author><name sortKey="Chen, C L" uniqKey="Chen C">C.L. Chen</name>
</author>
<author><name sortKey="Cheng, C H" uniqKey="Cheng C">C.H. Cheng</name>
</author>
<author><name sortKey="Chen, H Y" uniqKey="Chen H">H.Y. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ge, X Y" uniqKey="Ge X">X.Y. Ge</name>
</author>
<author><name sortKey="Yang, L Q" uniqKey="Yang L">L.Q. Yang</name>
</author>
<author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y. Jiang</name>
</author>
<author><name sortKey="Yang, W W" uniqKey="Yang W">W.W. Yang</name>
</author>
<author><name sortKey="Fu, J" uniqKey="Fu J">J. Fu</name>
</author>
<author><name sortKey="Li, S L" uniqKey="Li S">S.L. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mrakovcic, M" uniqKey="Mrakovcic M">M. Mrakovcic</name>
</author>
<author><name sortKey="Bohner, L" uniqKey="Bohner L">L. Bohner</name>
</author>
<author><name sortKey="Hanisch, M" uniqKey="Hanisch M">M. Hanisch</name>
</author>
<author><name sortKey="Frohlich, L F" uniqKey="Frohlich L">L.F. Frohlich</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Shen, Tai Shan" sort="Shen, Tai Shan" uniqKey="Shen T" first="Tai-Shan" last="Shen">Tai-Shan Shen</name>
</noRegion>
<name sortKey="Chen, Chiu Liang" sort="Chen, Chiu Liang" uniqKey="Chen C" first="Chiu-Liang" last="Chen">Chiu-Liang Chen</name>
<name sortKey="Chen, Chiu Liang" sort="Chen, Chiu Liang" uniqKey="Chen C" first="Chiu-Liang" last="Chen">Chiu-Liang Chen</name>
<name sortKey="Chen, Hsuan Ying" sort="Chen, Hsuan Ying" uniqKey="Chen H" first="Hsuan-Ying" last="Chen">Hsuan-Ying Chen</name>
<name sortKey="Hsieh, Cheng Pu" sort="Hsieh, Cheng Pu" uniqKey="Hsieh C" first="Cheng-Pu" last="Hsieh">Cheng-Pu Hsieh</name>
<name sortKey="Hsieh, Cheng Pu" sort="Hsieh, Cheng Pu" uniqKey="Hsieh C" first="Cheng-Pu" last="Hsieh">Cheng-Pu Hsieh</name>
<name sortKey="Hsu, Yung Ken" sort="Hsu, Yung Ken" uniqKey="Hsu Y" first="Yung-Ken" last="Hsu">Yung-Ken Hsu</name>
<name sortKey="Huang, Yi Fu" sort="Huang, Yi Fu" uniqKey="Huang Y" first="Yi-Fu" last="Huang">Yi-Fu Huang</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000691 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000691 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:6651087 |texte= Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31269698" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |