The PHLPP2 phosphatase is a druggable driver of prostate cancer progression
Identifieur interne : 000360 ( Main/Exploration ); précédent : 000359; suivant : 000361The PHLPP2 phosphatase is a druggable driver of prostate cancer progression
Auteurs : Dawid G. Nowak ; Ksenya Cohen Katsenelson ; Kaitlin E. Watrud ; Muhan Chen ; Grinu Mathew ; Vincent D. D Ndrea ; Matthew F. Lee ; Manojit Mosur Swamynathan ; Irene Casanova-Salas ; Megan C. Jibilian ; Caroline L. Buckholtz ; Alexandra J. Ambrico ; Chun-Hao Pan ; John E. Wilkinson ; Alexandra C. Newton ; Lloyd C. TrotmanSource :
- The Journal of Cell Biology [ 0021-9525 ] ; 2019.
Abstract
Nowak et al. show that loss of the AKT-inactivating phosphatase PHLPP2 paradoxically blocks prostate tumor growth and metastasis. PHLPP2, they find, is critical for MYC stability, suggesting that PHLPP2 inhibitors may present a therapeutic opportunity to target MYC.
Url:
DOI: 10.1083/jcb.201902048
PubMed: 31092557
PubMed Central: 6548123
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Nowak et al. show that loss of the AKT-inactivating phosphatase PHLPP2 paradoxically blocks prostate tumor growth and metastasis. PHLPP2, they find, is critical for MYC stability, suggesting that PHLPP2 inhibitors may present a therapeutic opportunity to target MYC.</p>
</div>
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