Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer
Identifieur interne : 000743 ( Main/Exploration ); précédent : 000742; suivant : 000744Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer
Auteurs : Liyuan Zhu [République populaire de Chine] ; Yiran Zhu [République populaire de Chine] ; Shuting Han [République populaire de Chine] ; Miaoqin Chen [République populaire de Chine] ; Ping Song [République populaire de Chine] ; Dongjun Dai [République populaire de Chine] ; Wenxia Xu [République populaire de Chine] ; Tingting Jiang [République populaire de Chine] ; Lifeng Feng [République populaire de Chine] ; Vivian Y. Shin [République populaire de Chine] ; Xian Wang [République populaire de Chine] ; Hongchuan Jin [République populaire de Chine]Source :
- Cell Death & Disease [ 2041-4889 ] ; 2019.
Abstract
Chemoresistance remains the uppermost disincentive for cancer treatment on account of many genetic and epigenetic alterations. Long non-coding RNAs (lncRNAs) are emerging players in promoting cancer initiation and progression. However, the regulation and function in chemoresistance are largely unknown. Herein, we identified ARHGAP5-AS1 as a lncRNA upregulated in chemoresistant gastric cancer cells and its knockdown reversed chemoresistance. Meanwhile, high ARHGAP5-AS1 expression was associated with poor prognosis of gastric cancer patients. Intriguingly, its abundance is affected by autophagy and SQSTM1 is responsible for transporting ARHGAP5-AS1 to autophagosomes. Inhibition of autophagy in chemoresistant cells, thus, resulted in the upregulation of ARHGAP5-AS1. In turn, it activated the transcription of ARHGAP5 in the nucleus by directly interacting with ARHGAP5 promoter. Interestingly, ARHGAP5-AS1 also stabilized ARHGAP5 mRNA in the cytoplasm by recruiting METTL3 to stimulate m6A modification of ARHGAP5 mRNA. As a result, ARHGAP5 was upregulated to promote chemoresistance and its upregulation was also associated with poor prognosis in gastric cancer. In summary, impaired autophagic degradation of lncRNA ARHGAP5-AS1 in chemoresistant cancer cells promoted chemoresistance. It can activate the transcription of ARHGAP5 in the nucleus and stimulate m6A modification of ARHGAP5 mRNA to stabilize ARHGAP5 mRNA in the cytoplasm by recruiting METTL3. Therefore, targeting ARHGAP5-AS1/ARHGAP5 axis might be a promising strategy to overcome chemoresistance in gastric cancer.
Url:
DOI: 10.1038/s41419-019-1585-2
PubMed: 31097692
PubMed Central: 6522595
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer</title>
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<author><name sortKey="Chen, Miaoqin" sort="Chen, Miaoqin" uniqKey="Chen M" first="Miaoqin" last="Chen">Miaoqin Chen</name>
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<author><name sortKey="Song, Ping" sort="Song, Ping" uniqKey="Song P" first="Ping" last="Song">Ping Song</name>
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<author><name sortKey="Dai, Dongjun" sort="Dai, Dongjun" uniqKey="Dai D" first="Dongjun" last="Dai">Dongjun Dai</name>
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<author><name sortKey="Xu, Wenxia" sort="Xu, Wenxia" uniqKey="Xu W" first="Wenxia" last="Xu">Wenxia Xu</name>
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<author><name sortKey="Jin, Hongchuan" sort="Jin, Hongchuan" uniqKey="Jin H" first="Hongchuan" last="Jin">Hongchuan Jin</name>
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<front><div type="abstract" xml:lang="en"><p id="Par1">Chemoresistance remains the uppermost disincentive for cancer treatment on account of many genetic and epigenetic alterations. Long non-coding RNAs (lncRNAs) are emerging players in promoting cancer initiation and progression. However, the regulation and function in chemoresistance are largely unknown. Herein, we identified ARHGAP5-AS1 as a lncRNA upregulated in chemoresistant gastric cancer cells and its knockdown reversed chemoresistance. Meanwhile, high ARHGAP5-AS1 expression was associated with poor prognosis of gastric cancer patients. Intriguingly, its abundance is affected by autophagy and SQSTM1 is responsible for transporting ARHGAP5-AS1 to autophagosomes. Inhibition of autophagy in chemoresistant cells, thus, resulted in the upregulation of ARHGAP5-AS1. In turn, it activated the transcription of ARHGAP5 in the nucleus by directly interacting with ARHGAP5 promoter. Interestingly, ARHGAP5-AS1 also stabilized ARHGAP5 mRNA in the cytoplasm by recruiting METTL3 to stimulate m<sup>6</sup>
A modification of ARHGAP5 mRNA. As a result, ARHGAP5 was upregulated to promote chemoresistance and its upregulation was also associated with poor prognosis in gastric cancer. In summary, impaired autophagic degradation of lncRNA ARHGAP5-AS1 in chemoresistant cancer cells promoted chemoresistance. It can activate the transcription of ARHGAP5 in the nucleus and stimulate m<sup>6</sup>
A modification of ARHGAP5 mRNA to stabilize ARHGAP5 mRNA in the cytoplasm by recruiting METTL3. Therefore, targeting ARHGAP5-AS1/ARHGAP5 axis might be a promising strategy to overcome chemoresistance in gastric cancer.</p>
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