The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
Identifieur interne : 000333 ( Main/Exploration ); précédent : 000332; suivant : 000334The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
Auteurs : Navdeep Malik [États-Unis] ; Hualong Yan [États-Unis] ; Nellie Moshkovich [États-Unis] ; Murali Palangat [États-Unis] ; Howard Yang [États-Unis] ; Vanesa Sanchez [États-Unis] ; Zhuo Cai [États-Unis] ; Tyler J. Peat [États-Unis] ; Shunlin Jiang [États-Unis] ; Chengyu Liu [États-Unis] ; Maxwell Lee [États-Unis] ; Beverly A. Mock [États-Unis] ; Stuart H. Yuspa [États-Unis] ; Daniel Larson [États-Unis] ; Lalage M. Wakefield [États-Unis] ; Jing Huang [États-Unis]Source :
- Nature Communications [ 2041-1723 ] ; 2019.
Abstract
Translation and transcription are frequently dysregulated in cancer. These two processes are generally regulated by distinct sets of factors. The
Url:
DOI: 10.1038/s41467-019-10102-6
PubMed: 31061501
PubMed Central: 6502810
Affiliations:
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Bethesda</wicri:cityArea>
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<author><name sortKey="Lee, Maxwell" sort="Lee, Maxwell" uniqKey="Lee M" first="Maxwell" last="Lee">Maxwell Lee</name>
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<institution-id institution-id-type="GRID">grid.417768.b</institution-id>
<institution>High-Dimension Data Analysis Group, Laboratory of Cancer Biology and Genetics,</institution>
<institution>Center for Cancer Research, National Cancer Institute, National Institutes of Health,</institution>
</institution-wrap>
Bethesda, MD 20892 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mock, Beverly A" sort="Mock, Beverly A" uniqKey="Mock B" first="Beverly A." last="Mock">Beverly A. Mock</name>
<affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0483 9129</institution-id>
<institution-id institution-id-type="GRID">grid.417768.b</institution-id>
<institution>Cancer Genetics Section, Laboratory of Cancer Biology and Genetics,</institution>
<institution>Center for Cancer Research, National Cancer Institute, National Institutes of Health,</institution>
</institution-wrap>
Bethesda, MD 20892 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yuspa, Stuart H" sort="Yuspa, Stuart H" uniqKey="Yuspa S" first="Stuart H." last="Yuspa">Stuart H. Yuspa</name>
<affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0483 9129</institution-id>
<institution-id institution-id-type="GRID">grid.417768.b</institution-id>
<institution>In Vitro Pathogenesis Section, Laboratory of Cancer Biology and Genetics,</institution>
<institution>Center for Cancer Research, National Cancer Institute, National Institutes of Health,</institution>
</institution-wrap>
Bethesda, MD 20892 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Larson, Daniel" sort="Larson, Daniel" uniqKey="Larson D" first="Daniel" last="Larson">Daniel Larson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8075</institution-id>
<institution-id institution-id-type="GRID">grid.48336.3a</institution-id>
<institution>Laboratory of Receptor Biology & Gene Expression, Center for Cancer Research,</institution>
<institution>National Cancer Institute, National Institutes of Health,</institution>
</institution-wrap>
Bethesda, MD 20892 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wakefield, Lalage M" sort="Wakefield, Lalage M" uniqKey="Wakefield L" first="Lalage M." last="Wakefield">Lalage M. Wakefield</name>
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<institution-id institution-id-type="GRID">grid.417768.b</institution-id>
<institution>Cancer Biology of TGF-beta Section, Laboratory of Cancer Biology and Genetics,</institution>
<institution>Center for Cancer Research, National Cancer Institute, National Institutes of Health,</institution>
</institution-wrap>
Bethesda, MD 20892 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Huang, Jing" sort="Huang, Jing" uniqKey="Huang J" first="Jing" last="Huang">Jing Huang</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0483 9129</institution-id>
<institution-id institution-id-type="GRID">grid.417768.b</institution-id>
<institution>Cancer and Stem Cell Epigenetics Section, Laboratory of Cancer Biology and Genetics,</institution>
<institution>Center for Cancer Research, National Cancer Institute, National Institutes of Health,</institution>
</institution-wrap>
Bethesda, MD 20892 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Bethesda</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature Communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="Par1">Translation and transcription are frequently dysregulated in cancer. These two processes are generally regulated by distinct sets of factors. The <italic>CBFB</italic>
gene, which encodes a transcription factor, has recently emerged as a highly mutated driver in a variety of human cancers including breast cancer. Here we report a noncanonical role of CBFB in translation regulation. RNA immunoprecipitation followed by deep sequencing (RIP-seq) reveals that cytoplasmic CBFB binds to hundreds of transcripts and regulates their translation. CBFB binds to mRNAs via hnRNPK and enhances translation through eIF4B, a general translation initiation factor. Interestingly, the <italic>RUNX1</italic>
mRNA, which encodes the transcriptional partner of CBFB, is bound and translationally regulated by CBFB. Furthermore, nuclear CBFB/RUNX1 complex transcriptionally represses the oncogenic NOTCH signaling pathway in breast cancer. Thus, our data reveal an unexpected function of CBFB in translation regulation and propose that breast cancer cells evade translation and transcription surveillance simultaneously through downregulating CBFB.</p>
</div>
</front>
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</div1>
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</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Malik, Navdeep" sort="Malik, Navdeep" uniqKey="Malik N" first="Navdeep" last="Malik">Navdeep Malik</name>
</region>
<name sortKey="Cai, Zhuo" sort="Cai, Zhuo" uniqKey="Cai Z" first="Zhuo" last="Cai">Zhuo Cai</name>
<name sortKey="Huang, Jing" sort="Huang, Jing" uniqKey="Huang J" first="Jing" last="Huang">Jing Huang</name>
<name sortKey="Jiang, Shunlin" sort="Jiang, Shunlin" uniqKey="Jiang S" first="Shunlin" last="Jiang">Shunlin Jiang</name>
<name sortKey="Larson, Daniel" sort="Larson, Daniel" uniqKey="Larson D" first="Daniel" last="Larson">Daniel Larson</name>
<name sortKey="Lee, Maxwell" sort="Lee, Maxwell" uniqKey="Lee M" first="Maxwell" last="Lee">Maxwell Lee</name>
<name sortKey="Liu, Chengyu" sort="Liu, Chengyu" uniqKey="Liu C" first="Chengyu" last="Liu">Chengyu Liu</name>
<name sortKey="Mock, Beverly A" sort="Mock, Beverly A" uniqKey="Mock B" first="Beverly A." last="Mock">Beverly A. Mock</name>
<name sortKey="Moshkovich, Nellie" sort="Moshkovich, Nellie" uniqKey="Moshkovich N" first="Nellie" last="Moshkovich">Nellie Moshkovich</name>
<name sortKey="Palangat, Murali" sort="Palangat, Murali" uniqKey="Palangat M" first="Murali" last="Palangat">Murali Palangat</name>
<name sortKey="Peat, Tyler J" sort="Peat, Tyler J" uniqKey="Peat T" first="Tyler J." last="Peat">Tyler J. Peat</name>
<name sortKey="Sanchez, Vanesa" sort="Sanchez, Vanesa" uniqKey="Sanchez V" first="Vanesa" last="Sanchez">Vanesa Sanchez</name>
<name sortKey="Wakefield, Lalage M" sort="Wakefield, Lalage M" uniqKey="Wakefield L" first="Lalage M." last="Wakefield">Lalage M. Wakefield</name>
<name sortKey="Yan, Hualong" sort="Yan, Hualong" uniqKey="Yan H" first="Hualong" last="Yan">Hualong Yan</name>
<name sortKey="Yang, Howard" sort="Yang, Howard" uniqKey="Yang H" first="Howard" last="Yang">Howard Yang</name>
<name sortKey="Yuspa, Stuart H" sort="Yuspa, Stuart H" uniqKey="Yuspa S" first="Stuart H." last="Yuspa">Stuart H. Yuspa</name>
</country>
</tree>
</affiliations>
</record>
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