ChloroquineV1, Main, Exploration, bibRecord, 003F92

The effects of chloroquine on pulmonary saccular growth near term.

Identifieur interne : 003F92 ( Main/Exploration ); précédent : 003F91; suivant : 003F93

The effects of chloroquine on pulmonary saccular growth near term.

Auteurs : A O Okanlawon [Nigeria] ; A B Ejiwunmi ; M O Dada ; O A Ashiru

Source :

West African journal of medicine [ 0189-160X ]

RBID : pubmed:1911486

Descripteurs français

KwdFr :
- Alvéoles pulmonaires (), Alvéoles pulmonaires (croissance et développement), Alvéoles pulmonaires (embryologie), Animaux, Chloroquine (effets indésirables), Femelle, Grossesse, Hydrocortisone (pharmacologie), Hydrocortisone (usage thérapeutique), Lignées consanguines de rats, Maturité foetale (), Mesure des volumes pulmonaires, Poids du corps, Rats, Taille d'organe, Évaluation préclinique de médicament.
MESH :
- croissance et développement : Alvéoles pulmonaires.
- effets indésirables : Chloroquine.
- embryologie : Alvéoles pulmonaires.
- pharmacologie : Hydrocortisone.
- usage thérapeutique : Hydrocortisone.
- Alvéoles pulmonaires, Animaux, Femelle, Grossesse, Lignées consanguines de rats, Maturité foetale, Mesure des volumes pulmonaires, Poids du corps, Rats, Taille d'organe, Évaluation préclinique de médicament.

English descriptors

KwdEn :
- Animals, Body Weight, Chloroquine (adverse effects), Drug Evaluation, Preclinical, Female, Fetal Organ Maturity (drug effects), Hydrocortisone (pharmacology), Hydrocortisone (therapeutic use), Lung Volume Measurements, Organ Size, Pregnancy, Pulmonary Alveoli (drug effects), Pulmonary Alveoli (embryology), Pulmonary Alveoli (growth & development), Rats, Rats, Inbred Strains.
MESH :
- chemical , adverse effects : Chloroquine.
- drug effects : Fetal Organ Maturity, Pulmonary Alveoli.
- embryology : Pulmonary Alveoli.
- growth & development : Pulmonary Alveoli.
- chemical , pharmacology : Hydrocortisone.
- chemical , therapeutic use : Hydrocortisone.
- Animals, Body Weight, Drug Evaluation, Preclinical, Female, Lung Volume Measurements, Organ Size, Pregnancy, Rats, Rats, Inbred Strains.

Abstract

The Antimalaria drug, chloroquine is an amphiphilic cationic compound and might therefore be suspected to interfere with foetal lung maturity as previously observed with other amphilphilic cationic drugs. Single doses of chloroquine phosphate (40mg/kg b. wt) was administered to pregnant rats on days 20 and 21 of gestation (term = 22 days). Morphometric analysis revealed a decrease in volume density (Vv) of parenchyma, saccular space and average saccular volume. Concurrent administration of single doses hydrocortisone on day 21 increased the Vv of the Parenchyma saccules and average saccular volume. This result suggests that the retardation of foetal lung maturity induced by chloroquine could be reversed by a concurrent administration of hydrocortisone. Questions concerning the mechanism by which these effects are produced must remain open.

PubMed: 1911486

Affiliations:

Nigeria

Le document en format XML

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<term>Chloroquine (effets indésirables)</term>
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<term>Drug Evaluation, Preclinical</term>
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<front><div type="abstract" xml:lang="en">The Antimalaria drug, chloroquine is an amphiphilic cationic compound and might therefore be suspected to interfere with foetal lung maturity as previously observed with other amphilphilic cationic drugs. Single doses of chloroquine phosphate (40mg/kg b. wt) was administered to pregnant rats on days 20 and 21 of gestation (term = 22 days). Morphometric analysis revealed a decrease in volume density (Vv) of parenchyma, saccular space and average saccular volume. Concurrent administration of single doses hydrocortisone on day 21 increased the Vv of the Parenchyma saccules and average saccular volume. This result suggests that the retardation of foetal lung maturity induced by chloroquine could be reversed by a concurrent administration of hydrocortisone. Questions concerning the mechanism by which these effects are produced must remain open.</div>
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Serveur d'exploration Chloroquine

The effects of chloroquine on pulmonary saccular growth near term.

The effects of chloroquine on pulmonary saccular growth near term.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Chloroquine
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