Effect of chloroquine and phenobarbital on morphine glucuronidation and biliary excretion in the rat
Identifieur interne : 003A64 ( Main/Exploration ); précédent : 003A63; suivant : 003A65Effect of chloroquine and phenobarbital on morphine glucuronidation and biliary excretion in the rat
Auteurs : David L. Roerig [États-Unis] ; Andrew T. Hasegawa [États-Unis] ; Richard E. Peterson [États-Unis] ; Richard I. H. Wang [États-Unis]Source :
- Biochemical Pharmacology [ 0006-2952 ] ; 1974.
English descriptors
- Teeft :
- Bile, Bile flow, Bile samples, Biliary, Biliary excretion, Bottom panel, Control rats, Countercurrent, Countercurrent distribution, Excretion, First collection period, Glucuronidation, Glucuronide, Metabolism, Middle panel, Morphine, Morphine administration, Morphine glucuronidation, Plasma concentration, Plasma disappearance, Present study, Pretreatment, Rat, Relative amounts, Relative proportions, Sanchez.
Abstract
Abstract: The relationship between morphine glucuronidation and biliary excretion was studied in rats pretreated with saline (control), chloroquine (CQ) or phenobarbital (PB) by determining the conversion of morphine to morphine-3-glucuronide (MG) in vitro and the biliary excretion of intravenously administered morphine and MG in vivo. For the biliary excretion studies. 14C-morphine or 14C-MG was administered intravenously and excretion measured in anesthetized renal-ligated rats in which the common bile ducts were cannulated. The effect of PB treatment on the biliary excretion of morphine and MG was complex and it was found that: (1) PB pretretment did not alter the proportions of morphine and MG in bile; (2) the rate of biliary excretion of morphine (as MG) was decreased in PB-pretreated rats even though MG formation was increased in vitro; (3) the plasma disappearance of 14C after 14C-morphine administration was also decreased by PB pretreatment; (4) the biliary excretion of administered MG was significantly decreased by PB pretreatment; and (5) the 14C plasma disappearance after 14C-MG administration was not changed by PB pretreatment. Several interpretations can be derived from these results. One possibility is that MG formation is not a rate-limiting step in the biliary excretion of morphine. An alternate interpretation would be that PB pretreatment may have an inhibitory effect on the biliary excretion of morphine and MG that is unrelated to metabolism. Chloroquine pretreatment produced only a slight effect on the biliary excretion of morphine and no effect on the biliary excretion of administered MG. Using studies in vitro, we could not demonstrate that CQ induced an increase in MG formation.
Url:
DOI: 10.1016/0006-2952(74)90335-9
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of chloroquine and phenobarbital on morphine glucuronidation and biliary excretion in the rat</title><author><name sortKey="Roerig, David L" sort="Roerig, David L" uniqKey="Roerig D" first="David L." last="Roerig">David L. Roerig</name></author><author><name sortKey="Hasegawa, Andrew T" sort="Hasegawa, Andrew T" uniqKey="Hasegawa A" first="Andrew T." last="Hasegawa">Andrew T. Hasegawa</name></author><author><name sortKey="Peterson, Richard E" sort="Peterson, Richard E" uniqKey="Peterson R" first="Richard E." last="Peterson">Richard E. Peterson</name></author><author><name sortKey="Wang, Richard I H" sort="Wang, Richard I H" uniqKey="Wang R" first="Richard I. H." last="Wang">Richard I. H. Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:64087A67919C6E22C09A0BCEDAB8CCC417C6FE6F</idno><date when="1974" year="1974">1974</date><idno type="doi">10.1016/0006-2952(74)90335-9</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-DDK9H4LG-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000E71</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E71</idno><idno type="wicri:Area/Istex/Curation">000E71</idno><idno type="wicri:Area/Istex/Checkpoint">002809</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002809</idno><idno type="wicri:doubleKey">0006-2952:1974:Roerig D:effect:of:chloroquine</idno><idno type="wicri:Area/Main/Merge">003B44</idno><idno type="wicri:Area/Main/Curation">003A64</idno><idno type="wicri:Area/Main/Exploration">003A64</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effect of chloroquine and phenobarbital on morphine glucuronidation and biliary excretion in the rat</title><author><name sortKey="Roerig, David L" sort="Roerig, David L" uniqKey="Roerig D" first="David L." last="Roerig">David L. Roerig</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pharmacology Research Laboratory, Wood Veterans Administration Center and Department of Pharmacology, The Medical College of Wisconsin, Milwaukee, Wis.</wicri:regionArea><wicri:noRegion>Wis.</wicri:noRegion></affiliation></author><author><name sortKey="Hasegawa, Andrew T" sort="Hasegawa, Andrew T" uniqKey="Hasegawa A" first="Andrew T." last="Hasegawa">Andrew T. Hasegawa</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pharmacology Research Laboratory, Wood Veterans Administration Center and Department of Pharmacology, The Medical College of Wisconsin, Milwaukee, Wis.</wicri:regionArea><wicri:noRegion>Wis.</wicri:noRegion></affiliation></author><author><name sortKey="Peterson, Richard E" sort="Peterson, Richard E" uniqKey="Peterson R" first="Richard E." last="Peterson">Richard E. Peterson</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pharmacology Research Laboratory, Wood Veterans Administration Center and Department of Pharmacology, The Medical College of Wisconsin, Milwaukee, Wis.</wicri:regionArea><wicri:noRegion>Wis.</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Richard I H" sort="Wang, Richard I H" uniqKey="Wang R" first="Richard I. H." last="Wang">Richard I. H. Wang</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pharmacology Research Laboratory, Wood Veterans Administration Center and Department of Pharmacology, The Medical College of Wisconsin, Milwaukee, Wis.</wicri:regionArea><wicri:noRegion>Wis.</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Biochemical Pharmacology</title><title level="j" type="abbrev">BCP</title><idno type="ISSN">0006-2952</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1974">1974</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1331">1331</biblScope><biblScope unit="page" to="1339">1339</biblScope></imprint><idno type="ISSN">0006-2952</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-2952</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Bile</term><term>Bile flow</term><term>Bile samples</term><term>Biliary</term><term>Biliary excretion</term><term>Bottom panel</term><term>Control rats</term><term>Countercurrent</term><term>Countercurrent distribution</term><term>Excretion</term><term>First collection period</term><term>Glucuronidation</term><term>Glucuronide</term><term>Metabolism</term><term>Middle panel</term><term>Morphine</term><term>Morphine administration</term><term>Morphine glucuronidation</term><term>Plasma concentration</term><term>Plasma disappearance</term><term>Present study</term><term>Pretreatment</term><term>Rat</term><term>Relative amounts</term><term>Relative proportions</term><term>Sanchez</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The relationship between morphine glucuronidation and biliary excretion was studied in rats pretreated with saline (control), chloroquine (CQ) or phenobarbital (PB) by determining the conversion of morphine to morphine-3-glucuronide (MG) in vitro and the biliary excretion of intravenously administered morphine and MG in vivo. For the biliary excretion studies. 14C-morphine or 14C-MG was administered intravenously and excretion measured in anesthetized renal-ligated rats in which the common bile ducts were cannulated. The effect of PB treatment on the biliary excretion of morphine and MG was complex and it was found that: (1) PB pretretment did not alter the proportions of morphine and MG in bile; (2) the rate of biliary excretion of morphine (as MG) was decreased in PB-pretreated rats even though MG formation was increased in vitro; (3) the plasma disappearance of 14C after 14C-morphine administration was also decreased by PB pretreatment; (4) the biliary excretion of administered MG was significantly decreased by PB pretreatment; and (5) the 14C plasma disappearance after 14C-MG administration was not changed by PB pretreatment. Several interpretations can be derived from these results. One possibility is that MG formation is not a rate-limiting step in the biliary excretion of morphine. An alternate interpretation would be that PB pretreatment may have an inhibitory effect on the biliary excretion of morphine and MG that is unrelated to metabolism. Chloroquine pretreatment produced only a slight effect on the biliary excretion of morphine and no effect on the biliary excretion of administered MG. Using studies in vitro, we could not demonstrate that CQ induced an increase in MG formation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Roerig, David L" sort="Roerig, David L" uniqKey="Roerig D" first="David L." last="Roerig">David L. Roerig</name></noRegion><name sortKey="Hasegawa, Andrew T" sort="Hasegawa, Andrew T" uniqKey="Hasegawa A" first="Andrew T." last="Hasegawa">Andrew T. Hasegawa</name><name sortKey="Peterson, Richard E" sort="Peterson, Richard E" uniqKey="Peterson R" first="Richard E." last="Peterson">Richard E. Peterson</name><name sortKey="Wang, Richard I H" sort="Wang, Richard I H" uniqKey="Wang R" first="Richard I. H." last="Wang">Richard I. H. Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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