Inhibiting effects of morphine, chloroquine, nonsteroidal and steroidal anti-inflammatory drugs on electrically-induced contractions of guinea-pig ileum and the reversing effect of prostaglandins
Identifieur interne : 003A42 ( Main/Exploration ); précédent : 003A41; suivant : 003A43Inhibiting effects of morphine, chloroquine, nonsteroidal and steroidal anti-inflammatory drugs on electrically-induced contractions of guinea-pig ileum and the reversing effect of prostaglandins
Auteurs : J. P. Famaey [Belgique] ; J. Fontaine [Belgique] ; J. Reuse [Belgique]Source :
- Agents and Actions [ 0065-4299 ] ; 1975-10-01.
English descriptors
- Teeft :
- Acetylcholine, Antiinflammatory, Antiinflammatory steroids, Chloroquine, Corticosteroid, Discrepient results, Drug concentrations, Electrical stimulation, Flufenamic acid, Guineapig ileum, High doses, Ileum, Ileum contractions, Indomethacin, Inhibition, Morphine, Muscular cells, Nicotine, Nsaid, Other mediators, Other nsaid, Partial inhibition, Pge1, Pharmac, Prostaglandin, Prostaglandin synthesis, Steroid, Steroidal antiinflammatory drugs, Total inhibition.
Abstract
Abstract: Twelve different non steroidal antiinflammatory drugs (NSAID), five steroidal antiinflammatory drugs, morphine and chloroquine have been added at various concentrations to in vitro electrically-stimulated preparations of guinea-pig ileum. They all inhibit the electrically-induced contractions. Prostaglandins E as well as nicotine reverse this inhibition. These reversing effects are less evident on totally inhibiting drug concentrations than on partially inhibiting drug concentrations. It is suggested that this inhibiting effect could be due mostly to nervous as well as muscular membrane permeability changes induced by these drugs and not to inhibition of prostaglandin synthesis which could be only proposed as partial explanation for NSAID effects. The reversing action of nicotine could be related to a release of acetylcholine while a sensitization of guinea-pig ileum smooth muscle to acetylcholine could explain the reversing properties of prostaglandins.
Url:
DOI: 10.1007/BF02205242
Affiliations:
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P." last="Famaey">J. P. Famaey</name><affiliation wicri:level="3"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Pharmacology, Rheumatology unit, School of Medicine and Institute of Pharmacy, University of Brussels, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Fontaine, J" sort="Fontaine, J" uniqKey="Fontaine J" first="J." last="Fontaine">J. 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They all inhibit the electrically-induced contractions. Prostaglandins E as well as nicotine reverse this inhibition. These reversing effects are less evident on totally inhibiting drug concentrations than on partially inhibiting drug concentrations. It is suggested that this inhibiting effect could be due mostly to nervous as well as muscular membrane permeability changes induced by these drugs and not to inhibition of prostaglandin synthesis which could be only proposed as partial explanation for NSAID effects. The reversing action of nicotine could be related to a release of acetylcholine while a sensitization of guinea-pig ileum smooth muscle to acetylcholine could explain the reversing properties of prostaglandins.</div></front></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li></settlement></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Famaey, J P" sort="Famaey, J P" uniqKey="Famaey J" first="J. P." last="Famaey">J. P. Famaey</name></region><name sortKey="Fontaine, J" sort="Fontaine, J" uniqKey="Fontaine J" first="J." last="Fontaine">J. Fontaine</name><name sortKey="Reuse, J" sort="Reuse, J" uniqKey="Reuse J" first="J." last="Reuse">J. Reuse</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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