Cutaneous sarcoidosis treated with methotrexate
Identifieur interne : 003962 ( Main/Exploration ); précédent : 003961; suivant : 003963Cutaneous sarcoidosis treated with methotrexate
Auteurs : N. K. Veien [Danemark] ; H. Brodthagen [Danemark]Source :
- British Journal of Dermatology [ 0007-0963 ] ; 1977-08.
Abstract
Sixteen patients with cutaneous sarcoidosis, 15 of whom also had involvement of other organs, were treated with methotrexate (MTX) orally once a week in an open study. The treatment period was from 1 to 72 months (mean 23 months). In 12 patients the skin lesions cleared, and in 3 of 4 patients who had sarcoid uveitis this cleared as well. The chest X‐ray of 6 patients showed no corresponding improvement in pulmonary changes or in hilar adenopathy. Ten patients suffered side effects, usually nausea on the day MTX was taken. Two had transiently increased transaminase levels. Treatment was discontinued in 2 patients due to nausea. It is concluded that MTX is a useful alternative to systemically administered glucocorticoids in the treatment of disfiguring cutaneous sarcoidosis and sarcoid uveitis. The effect of MTX on hilar adenopathy and pulmonary sarcoidosis is uncertain.
Url:
DOI: 10.1111/j.1365-2133.1977.tb15068.x
Affiliations:
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K." last="Veien">N. K. Veien</name><affiliation wicri:level="3"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Dermatology, Finsen Institute, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Correspondence address: Dr Niels K. Veien, Department of Dermatology, Finsen Institute, Strandboulevarden 49, DK 2100 Copenhagen Ø</wicri:regionArea><wicri:noRegion>DK 2100 Copenhagen Ø</wicri:noRegion></affiliation></author><author><name sortKey="Brodthagen, H" sort="Brodthagen, H" uniqKey="Brodthagen H" first="H." last="Brodthagen">H. Brodthagen</name><affiliation wicri:level="3"><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Dermatology, Finsen Institute, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">British Journal of Dermatology</title><title level="j" type="alt">BRITISH JOURNAL OF DERMATOLOGY</title><idno type="ISSN">0007-0963</idno><idno type="eISSN">1365-2133</idno><imprint><biblScope unit="vol">97</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="213">213</biblScope><biblScope unit="page" to="216">216</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1977-08">1977-08</date></imprint><idno type="ISSN">0007-0963</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-0963</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sixteen patients with cutaneous sarcoidosis, 15 of whom also had involvement of other organs, were treated with methotrexate (MTX) orally once a week in an open study. The treatment period was from 1 to 72 months (mean 23 months). In 12 patients the skin lesions cleared, and in 3 of 4 patients who had sarcoid uveitis this cleared as well. The chest X‐ray of 6 patients showed no corresponding improvement in pulmonary changes or in hilar adenopathy. Ten patients suffered side effects, usually nausea on the day MTX was taken. Two had transiently increased transaminase levels. Treatment was discontinued in 2 patients due to nausea. It is concluded that MTX is a useful alternative to systemically administered glucocorticoids in the treatment of disfiguring cutaneous sarcoidosis and sarcoid uveitis. The effect of MTX on hilar adenopathy and pulmonary sarcoidosis is uncertain.</div></front></TEI><affiliations><list><country><li>Danemark</li></country><region><li>Hovedstaden</li></region><settlement><li>Copenhague</li></settlement></list><tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Veien, N K" sort="Veien, N K" uniqKey="Veien N" first="N. K." last="Veien">N. K. Veien</name></region><name sortKey="Brodthagen, H" sort="Brodthagen, H" uniqKey="Brodthagen H" first="H." last="Brodthagen">H. Brodthagen</name><name sortKey="Veien, N K" sort="Veien, N K" uniqKey="Veien N" first="N. K." last="Veien">N. K. Veien</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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