DRUG‐INDUCED LYSOSOMAL CHANGES and NEPHROTOXICITY IN RATS
Identifieur interne : 003932 ( Main/Exploration ); précédent : 003931; suivant : 003933DRUG‐INDUCED LYSOSOMAL CHANGES and NEPHROTOXICITY IN RATS
Auteurs : Mitsutoshi Watanabe [Japon]Source :
- Pathology International [ 1320-5463 ] ; 1978-11.
English descriptors
- Teeft :
- Acid phosphatase, Acid phosphatase activity, Acta, Apical, Apical vacuoles, Basal, Basal infoldings, Basement membrane, Brush border, Cell lesions, Cell membrane, Cell necrosis, Cephacetrile, Cephaloridine, Cephalothin, Cytoplasmic, Cytosomes, Daily administration, Dense materials, Destructed, Destructed lysosomes, Endoplasmic reticulum, Epithelial, Epithelial cell necrosis, Epithelial cells, Epithelium, Experimental animals, Focal cytoplasmic degradation, Gentamicin, Glutaraldehyde fixatives, Golgi, Golgi apparatus, Granule, Heterolysosomes, High density, Homogenous, Hypertrophic, Hypertrophic proliferation, Infolding, Intercellular, Intercellular space, Invagination, Lamellar structure, Large heterolysosome, Large heterolysosomes, Large lysosomes, Lesion, Lesions acta path, Leup, Leupeptin, Lysosomal, Lysosomal destruction, Lysosomal enzymes, Lysosomal membrane, Lysosome, Lysosome9, Membrane, Mitochondria1 cristae, Mitochondrion, Necrosis, Nephrotoxicity, Normal range, Organelle, Other cell organelles, Other hand, Other rats, Phosphatase, Primary lysosomes, Proximal, Rat, Renal, Reticulum, Serum chemistry, Single administration, Single membrane, Single subcutaneous administration, Subcutaneous, Subcutaneous administration, Tubular epithelium, Tubular lumina, Vacuole, Various size, Vesicular invaginations, Watanabe, Week administration.
Abstract
Lysosomal involvement In renal tubular lesions was studied mainly by electronmicroscopy after single and repeated administrations of cephacetrile, cephalothin, cephaloridine, gentamicin or leupeptin and combine administrations of cephalothin and gentamicin or gentamicin and leupeptin in female Wistar rats. Large cytosomes of high density were increased due probably to either reabsorption and secretion of drugs or their metabolites. These cytosomes displaying acid phosphatase activity were demonstrated histo‐chemically and were identified as heterolysosomes. In rats treated with cephaloridine, gentamicin or leupeptin, disruption of lysosomal membrane was noted and regional cytoplasmic destruction‘was seen in the vicinity of the disrupted heterolysosomes. Necrotic epithelial cells and renal insufficiency were observed in these animals. On the other hand, neither destruction of lysosomes nor cell lesion was found in rats treated with cephacetrile or cephalothin. It was speculated that lysosomal destruction might be the cause of the cell lesions found in cephaloridine, gentamicin or leupeptin treated rats.
Url:
DOI: 10.1111/j.1440-1827.1978.tb01277.x
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">DRUG‐INDUCED LYSOSOMAL CHANGES and NEPHROTOXICITY IN RATS</title><author><name sortKey="Watanabe, Mitsutoshi" sort="Watanabe, Mitsutoshi" uniqKey="Watanabe M" first="Mitsutoshi" last="Watanabe">Mitsutoshi Watanabe</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:72C49C86E64AF1E25E4E2A141BE47108E5A6A40B</idno><date when="1978" year="1978">1978</date><idno type="doi">10.1111/j.1440-1827.1978.tb01277.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-JR29KVH0-B/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001460</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001460</idno><idno type="wicri:Area/Istex/Curation">001460</idno><idno type="wicri:Area/Istex/Checkpoint">002684</idno><idno type="wicri:explorRef" wicri:stream="Istex" 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level="j" type="main">Pathology International</title><title level="j" type="alt">PATHOLOGY INTERNATIONAL</title><idno type="ISSN">1320-5463</idno><idno type="eISSN">1440-1827</idno><imprint><biblScope unit="vol">28</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="867">867</biblScope><biblScope unit="page" to="889">889</biblScope><biblScope unit="page-count">23</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1978-11">1978-11</date></imprint><idno type="ISSN">1320-5463</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1320-5463</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acid phosphatase</term><term>Acid phosphatase activity</term><term>Acta</term><term>Apical</term><term>Apical vacuoles</term><term>Basal</term><term>Basal infoldings</term><term>Basement membrane</term><term>Brush border</term><term>Cell lesions</term><term>Cell membrane</term><term>Cell necrosis</term><term>Cephacetrile</term><term>Cephaloridine</term><term>Cephalothin</term><term>Cytoplasmic</term><term>Cytosomes</term><term>Daily administration</term><term>Dense materials</term><term>Destructed</term><term>Destructed lysosomes</term><term>Endoplasmic reticulum</term><term>Epithelial</term><term>Epithelial cell necrosis</term><term>Epithelial cells</term><term>Epithelium</term><term>Experimental animals</term><term>Focal cytoplasmic degradation</term><term>Gentamicin</term><term>Glutaraldehyde fixatives</term><term>Golgi</term><term>Golgi apparatus</term><term>Granule</term><term>Heterolysosomes</term><term>High density</term><term>Homogenous</term><term>Hypertrophic</term><term>Hypertrophic proliferation</term><term>Infolding</term><term>Intercellular</term><term>Intercellular space</term><term>Invagination</term><term>Lamellar structure</term><term>Large heterolysosome</term><term>Large heterolysosomes</term><term>Large lysosomes</term><term>Lesion</term><term>Lesions acta path</term><term>Leup</term><term>Leupeptin</term><term>Lysosomal</term><term>Lysosomal destruction</term><term>Lysosomal enzymes</term><term>Lysosomal membrane</term><term>Lysosome</term><term>Lysosome9</term><term>Membrane</term><term>Mitochondria1 cristae</term><term>Mitochondrion</term><term>Necrosis</term><term>Nephrotoxicity</term><term>Normal range</term><term>Organelle</term><term>Other cell organelles</term><term>Other hand</term><term>Other rats</term><term>Phosphatase</term><term>Primary lysosomes</term><term>Proximal</term><term>Rat</term><term>Renal</term><term>Reticulum</term><term>Serum chemistry</term><term>Single administration</term><term>Single membrane</term><term>Single subcutaneous administration</term><term>Subcutaneous</term><term>Subcutaneous administration</term><term>Tubular epithelium</term><term>Tubular lumina</term><term>Vacuole</term><term>Various size</term><term>Vesicular invaginations</term><term>Watanabe</term><term>Week administration</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lysosomal involvement In renal tubular lesions was studied mainly by electronmicroscopy after single and repeated administrations of cephacetrile, cephalothin, cephaloridine, gentamicin or leupeptin and combine administrations of cephalothin and gentamicin or gentamicin and leupeptin in female Wistar rats. Large cytosomes of high density were increased due probably to either reabsorption and secretion of drugs or their metabolites. These cytosomes displaying acid phosphatase activity were demonstrated histo‐chemically and were identified as heterolysosomes. In rats treated with cephaloridine, gentamicin or leupeptin, disruption of lysosomal membrane was noted and regional cytoplasmic destruction‘was seen in the vicinity of the disrupted heterolysosomes. Necrotic epithelial cells and renal insufficiency were observed in these animals. On the other hand, neither destruction of lysosomes nor cell lesion was found in rats treated with cephacetrile or cephalothin. It was speculated that lysosomal destruction might be the cause of the cell lesions found in cephaloridine, gentamicin or leupeptin treated rats.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Watanabe, Mitsutoshi" sort="Watanabe, Mitsutoshi" uniqKey="Watanabe M" first="Mitsutoshi" last="Watanabe">Mitsutoshi Watanabe</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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