ChloroquineV1, Main, Exploration, bibRecord, 003916

Chloroquine-induced lysosomal abnormalities in cultured foetal mouse hearts

Identifieur interne : 003916 ( Main/Exploration ); précédent : 003915; suivant : 003917

Chloroquine-induced lysosomal abnormalities in cultured foetal mouse hearts

Auteurs : Robert M. Ridout [États-Unis] ; Robert S. Decker [États-Unis] ; Kern Wildenthal [États-Unis]

Source :

Journal of Molecular and Cellular Cardiology [ 0022-2828 ] ; 1978.

RBID : ISTEX:3E313FF997E2BF4C00BD9FD49D8495483F6641FC

English descriptors

Teeft :
- Abnormality, Acid hydrolase reaction product, Acid phosphatase, Acid phosphatase activity, Acid phosphatase reaction product, Aryl sulfatase reaction product, Autophagic, Autophagic vacuoles, Biological chemistry, Cacodylate buffer, Cardiac, Cardiac lysosomal enzyme activities, Cardiac lysosomal function, Cardiac lysosomes, Cardiac myofilaments, Cardiac structure, Cathepsin, Cell biology, Cellular cardiology, Chloroquine, Chloroquine treatment, Circulation research, Control chloroquine difference, Creatine kinase, Cultured macrophages, Degradation, Electron microscopy, Enzyme, Enzyme activity, Extensive deposits, Fibroblast, Foetal, Foetal mouse heart, Foetal mouse hearts, Golgi, Heart tissue, Human fibroblasts, Immense vacuoles, Interstitial cells, Laboratory investigation, Lysosomal, Lysosomal abnormalities, Lysosomal activity, Lysosomal alterations, Lysosomal enzyme activities, Lysosomal enzymes, Lysosomal enzymes cathepsin, Lysosomal function, Lysosomal membranes, Lysosomal structure, Lysosome, Many tissues, Morphological changes, Myeloid, Myeloid bodies, Myocytes, Myofilamentous aggregates, Myofilaments, Nmol protein, Organ culture, Phosphatase, Polar lipids, Protein degradation, Recent advances, Ridout etal, Secondary lysosomes, Significant decrease, Total activities, University park press, Uranyl acetate, Vacuole, Wildenthal.

Abstract

Abstract: Chloroquine (100 μm) induces abnormalities of lysosomal structure in cultured mouse hearts. After 1 or 2 days' exposure to the drug, large autophagic vacuoles with myeloid figures and inclusion bodies develop within myocytes and interstitial cells. Secondary lysosomes in interstitial cells occasionally contain cardiac myofilaments. In addition, after 2 days, the amounts of cathepsin D and β-acetylglucosaminidase decrease significantly, along with a significant redistribution of enzyme activity between sedimentable and non-sedimentable fractions. The results suggest that chloroquine is a useful experimental agent for causing lysosomal derangements in cardiac tissues under controlled conditions.

Url:

https://api.istex.fr/ark:/67375/6H6-JT2GCL94-9/fulltext.pdf

DOI: 10.1016/0022-2828(78)90041-X

Affiliations:

États-Unis

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Le document en format XML

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<term>Acid hydrolase reaction product</term>
<term>Acid phosphatase</term>
<term>Acid phosphatase activity</term>
<term>Acid phosphatase reaction product</term>
<term>Aryl sulfatase reaction product</term>
<term>Autophagic</term>
<term>Autophagic vacuoles</term>
<term>Biological chemistry</term>
<term>Cacodylate buffer</term>
<term>Cardiac</term>
<term>Cardiac lysosomal enzyme activities</term>
<term>Cardiac lysosomal function</term>
<term>Cardiac lysosomes</term>
<term>Cardiac myofilaments</term>
<term>Cardiac structure</term>
<term>Cathepsin</term>
<term>Cell biology</term>
<term>Cellular cardiology</term>
<term>Chloroquine</term>
<term>Chloroquine treatment</term>
<term>Circulation research</term>
<term>Control chloroquine difference</term>
<term>Creatine kinase</term>
<term>Cultured macrophages</term>
<term>Degradation</term>
<term>Electron microscopy</term>
<term>Enzyme</term>
<term>Enzyme activity</term>
<term>Extensive deposits</term>
<term>Fibroblast</term>
<term>Foetal</term>
<term>Foetal mouse heart</term>
<term>Foetal mouse hearts</term>
<term>Golgi</term>
<term>Heart tissue</term>
<term>Human fibroblasts</term>
<term>Immense vacuoles</term>
<term>Interstitial cells</term>
<term>Laboratory investigation</term>
<term>Lysosomal</term>
<term>Lysosomal abnormalities</term>
<term>Lysosomal activity</term>
<term>Lysosomal alterations</term>
<term>Lysosomal enzyme activities</term>
<term>Lysosomal enzymes</term>
<term>Lysosomal enzymes cathepsin</term>
<term>Lysosomal function</term>
<term>Lysosomal membranes</term>
<term>Lysosomal structure</term>
<term>Lysosome</term>
<term>Many tissues</term>
<term>Morphological changes</term>
<term>Myeloid</term>
<term>Myeloid bodies</term>
<term>Myocytes</term>
<term>Myofilamentous aggregates</term>
<term>Myofilaments</term>
<term>Nmol protein</term>
<term>Organ culture</term>
<term>Phosphatase</term>
<term>Polar lipids</term>
<term>Protein degradation</term>
<term>Recent advances</term>
<term>Ridout etal</term>
<term>Secondary lysosomes</term>
<term>Significant decrease</term>
<term>Total activities</term>
<term>University park press</term>
<term>Uranyl acetate</term>
<term>Vacuole</term>
<term>Wildenthal</term>
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<front><div type="abstract" xml:lang="en">Abstract: Chloroquine (100 μm) induces abnormalities of lysosomal structure in cultured mouse hearts. After 1 or 2 days' exposure to the drug, large autophagic vacuoles with myeloid figures and inclusion bodies develop within myocytes and interstitial cells. Secondary lysosomes in interstitial cells occasionally contain cardiac myofilaments. In addition, after 2 days, the amounts of cathepsin D and β-acetylglucosaminidase decrease significantly, along with a significant redistribution of enzyme activity between sedimentable and non-sedimentable fractions. The results suggest that chloroquine is a useful experimental agent for causing lysosomal derangements in cardiac tissues under controlled conditions.</div>
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<name sortKey="Decker, Robert S" sort="Decker, Robert S" uniqKey="Decker R" first="Robert S." last="Decker">Robert S. Decker</name>
<name sortKey="Decker, Robert S" sort="Decker, Robert S" uniqKey="Decker R" first="Robert S." last="Decker">Robert S. Decker</name>
<name sortKey="Decker, Robert S" sort="Decker, Robert S" uniqKey="Decker R" first="Robert S." last="Decker">Robert S. Decker</name>
<name sortKey="Ridout, Robert M" sort="Ridout, Robert M" uniqKey="Ridout R" first="Robert M." last="Ridout">Robert M. Ridout</name>
<name sortKey="Ridout, Robert M" sort="Ridout, Robert M" uniqKey="Ridout R" first="Robert M." last="Ridout">Robert M. Ridout</name>
<name sortKey="Wildenthal, Kern" sort="Wildenthal, Kern" uniqKey="Wildenthal K" first="Kern" last="Wildenthal">Kern Wildenthal</name>
<name sortKey="Wildenthal, Kern" sort="Wildenthal, Kern" uniqKey="Wildenthal K" first="Kern" last="Wildenthal">Kern Wildenthal</name>
<name sortKey="Wildenthal, Kern" sort="Wildenthal, Kern" uniqKey="Wildenthal K" first="Kern" last="Wildenthal">Kern Wildenthal</name>
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Chloroquine-induced lysosomal abnormalities in cultured foetal mouse hearts

Chloroquine-induced lysosomal abnormalities in cultured foetal mouse hearts

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri