Experimental lipidosis of the inner ear
Identifieur interne : 003837 ( Main/Exploration ); précédent : 003836; suivant : 003838Experimental lipidosis of the inner ear
Auteurs : E. Bichler [Autriche] ; H. Spoendlin [Autriche]Source :
- Archives of oto-rhino-laryngology [ 0302-9530 ] ; 1980-12-01.
English descriptors
- KwdEn :
- Teeft :
- Amorphous bodies, Amphiphilic, Amphiphilic drugs, Arch otorhinolaryngol, Basal, Block surface technique, Cell pathol, Chlorphentermine, Corti, Dark granules, Different types, Experimental lipidosis, Fibre, Inclusion, Inner hair cells, Inner pillar cells, Lateral crista, Lipidosis, Lysosomal, Lysosomal inclusions, Lysosome, Myelinoid bodies, Nerve fibres, Outer hair cells, Phospholipid, Secondary lysosomes, Sensory cells, Spoendlin, Supranuclear portions, Vestibular, Vestibular labyrinth, Virchows arch.
Abstract
Zusammenfassung: Die chronische Gabe von sogenannten amphiphilen Substanzen führt im Innenohr zu einer Anhäufung von Lysosomen verschiedenen Typs, welche Phospholipide enthalten. Regelmäßig sind die inneren Haarzellen des Cortischen Organs betroffen, manchmal die Stützzellen, während die äußeren Haarzellen fast unverändert bleiben. Einige Nervenfasern in der Gegend der inneren Pfeilerzellen und in geringerem Maß des Vestibularapparates sind aufgetrieben und mit osmiphilem Material und Vakuolen gefüllt. Gelegentlich sind sie degeneriert. Diese Bevorzugung der inneren Haarzellen könnte Ausdruck eines besonders regen Fettstoffwechsels in diesen Zellen sein.
Summary: Chronic administration of so-called amphiphilic drugs induces an accumulation of lysosomes of different types containing phospholipids in the inner ear. The inclusions are regularly found in the inner hair cells of the organ of Corti, sometimes in supporting cells, whereas the outer hair cells remain almost unchanged. Several nerve fibres in the area of the inner pillar cells and to a lesser degree in the vestibular labyrinth are swollen and filled with osmiphilic material and vacuoles; sometimes they are degenerated. The preference of the inner hair cells is probably the expression of a specially high turnover of lipids in these cells.
Url:
DOI: 10.1007/BF02565523
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001113
- to stream Istex, to step Curation: 001113
- to stream Istex, to step Checkpoint: 002594
- to stream Main, to step Merge: 003916
- to stream Main, to step Curation: 003837
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Experimental lipidosis of the inner ear</title><author><name sortKey="Bichler, E" sort="Bichler, E" uniqKey="Bichler E" first="E." last="Bichler">E. Bichler</name></author><author><name sortKey="Spoendlin, H" sort="Spoendlin, H" uniqKey="Spoendlin H" first="H." last="Spoendlin">H. Spoendlin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:814E1B6D3DB25C2CB43876D638A11B9A8C99B246</idno><date when="1980" year="1980">1980</date><idno type="doi">10.1007/BF02565523</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-SQ2ZKXBX-5/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001113</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001113</idno><idno type="wicri:Area/Istex/Curation">001113</idno><idno type="wicri:Area/Istex/Checkpoint">002594</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002594</idno><idno type="wicri:doubleKey">0302-9530:1980:Bichler E:experimental:lipidosis:of</idno><idno type="wicri:Area/Main/Merge">003916</idno><idno type="wicri:Area/Main/Curation">003837</idno><idno type="wicri:Area/Main/Exploration">003837</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Experimental lipidosis of the inner ear</title><author><name sortKey="Bichler, E" sort="Bichler, E" uniqKey="Bichler E" first="E." last="Bichler">E. Bichler</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Otorhinolaryngology, University of Innsbruck, Anichstraße 35, A-6020, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Spoendlin, H" sort="Spoendlin, H" uniqKey="Spoendlin H" first="H." last="Spoendlin">H. Spoendlin</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Otorhinolaryngology, University of Innsbruck, Anichstraße 35, A-6020, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of oto-rhino-laryngology</title><title level="j" type="abbrev">Arch Otorhinolaryngol</title><idno type="ISSN">0302-9530</idno><idno type="eISSN">1434-4726</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1980-12-01">1980-12-01</date><biblScope unit="volume">229</biblScope><biblScope unit="issue">3-4</biblScope><biblScope unit="page" from="201">201</biblScope><biblScope unit="page" to="207">207</biblScope></imprint><idno type="ISSN">0302-9530</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0302-9530</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amphiphilic substances</term><term>Inner ear</term><term>Lipidosis</term><term>Organ of Corti</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Amorphous bodies</term><term>Amphiphilic</term><term>Amphiphilic drugs</term><term>Arch otorhinolaryngol</term><term>Basal</term><term>Block surface technique</term><term>Cell pathol</term><term>Chlorphentermine</term><term>Corti</term><term>Dark granules</term><term>Different types</term><term>Experimental lipidosis</term><term>Fibre</term><term>Inclusion</term><term>Inner hair cells</term><term>Inner pillar cells</term><term>Lateral crista</term><term>Lipidosis</term><term>Lysosomal</term><term>Lysosomal inclusions</term><term>Lysosome</term><term>Myelinoid bodies</term><term>Nerve fibres</term><term>Outer hair cells</term><term>Phospholipid</term><term>Secondary lysosomes</term><term>Sensory cells</term><term>Spoendlin</term><term>Supranuclear portions</term><term>Vestibular</term><term>Vestibular labyrinth</term><term>Virchows arch</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="de">Zusammenfassung: Die chronische Gabe von sogenannten amphiphilen Substanzen führt im Innenohr zu einer Anhäufung von Lysosomen verschiedenen Typs, welche Phospholipide enthalten. Regelmäßig sind die inneren Haarzellen des Cortischen Organs betroffen, manchmal die Stützzellen, während die äußeren Haarzellen fast unverändert bleiben. Einige Nervenfasern in der Gegend der inneren Pfeilerzellen und in geringerem Maß des Vestibularapparates sind aufgetrieben und mit osmiphilem Material und Vakuolen gefüllt. Gelegentlich sind sie degeneriert. Diese Bevorzugung der inneren Haarzellen könnte Ausdruck eines besonders regen Fettstoffwechsels in diesen Zellen sein.</div><div type="abstract" xml:lang="en">Summary: Chronic administration of so-called amphiphilic drugs induces an accumulation of lysosomes of different types containing phospholipids in the inner ear. The inclusions are regularly found in the inner hair cells of the organ of Corti, sometimes in supporting cells, whereas the outer hair cells remain almost unchanged. Several nerve fibres in the area of the inner pillar cells and to a lesser degree in the vestibular labyrinth are swollen and filled with osmiphilic material and vacuoles; sometimes they are degenerated. The preference of the inner hair cells is probably the expression of a specially high turnover of lipids in these cells.</div></front></TEI><affiliations><list><country><li>Autriche</li></country></list><tree><country name="Autriche"><noRegion><name sortKey="Bichler, E" sort="Bichler, E" uniqKey="Bichler E" first="E." last="Bichler">E. Bichler</name></noRegion><name sortKey="Spoendlin, H" sort="Spoendlin, H" uniqKey="Spoendlin H" first="H." last="Spoendlin">H. Spoendlin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003837 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003837 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:814E1B6D3DB25C2CB43876D638A11B9A8C99B246
|texte= Experimental lipidosis of the inner ear
}}
| This area was generated with Dilib version V0.6.33. |  |