The distribution and metabolism in the rat of a short series of 4-amino-7-iodoquinolines labelled with radioiodine
Identifieur interne : 003809 ( Main/Exploration ); précédent : 003808; suivant : 003810The distribution and metabolism in the rat of a short series of 4-amino-7-iodoquinolines labelled with radioiodine
Auteurs : M. N. Eakins [Royaume-Uni] ; R. W. Goulding [Royaume-Uni] ; S. Somaia [Royaume-Uni]Source :
- The International Journal Of Applied Radiation And Isotopes [ 0020-708X ] ; 1980.
English descriptors
- Teeft :
- Amphoteric metabolites, Analogue, Aqueous phase, Benzene ring, Bile, Chloroquine, Degradation products, Exchange iodination, Gastrointestinal tract, High levels, Intravenous injection, Iodoquinolines, Lipid solubility, Lungs liver kidnevs spleen heart brain, Lungs liver kidneys spleen heart brain, Metabolism, Metabolite, Metabolites others, Parent compound, Phosphate buffer, Radioactivity, Side chain, Spleen, Time course, Tissue distribution, Urine.
Abstract
Abstract: 4-Amino-7-iodoquinoline and five N4-substituted [(CH2)nNR'R″] 4-amino-7-iodoquinolines were labelled with iodine-125 for distribution studies in the rat. Following intravenous injection the iodoquinolines clear rapidly from the blood and high levels of radioactivity are found in the lungs and the liver with a progressive increase in activity in the spleen. The excretion of the bile and urine varies between 7 and 63% in total, depending on the stucture of the amino side chain, and the activity represents a mixture of metabolites of which the major components are amphoteric.
Url:
DOI: 10.1016/0020-708X(80)90097-6
Affiliations:
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Le document en format XML
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Somaia</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Cyclotron Unit, Hammersmith Hospital, DuCane Road, London W12 OHS</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">The International Journal Of Applied Radiation And Isotopes</title><title level="j" type="abbrev">IJARA</title><idno type="ISSN">0020-708X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1980">1980</date><biblScope unit="volume">31</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="553">553</biblScope><biblScope unit="page" to="557">557</biblScope></imprint><idno type="ISSN">0020-708X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0020-708X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Amphoteric metabolites</term><term>Analogue</term><term>Aqueous phase</term><term>Benzene ring</term><term>Bile</term><term>Chloroquine</term><term>Degradation products</term><term>Exchange iodination</term><term>Gastrointestinal tract</term><term>High levels</term><term>Intravenous injection</term><term>Iodoquinolines</term><term>Lipid solubility</term><term>Lungs liver kidnevs spleen heart brain</term><term>Lungs liver kidneys spleen heart brain</term><term>Metabolism</term><term>Metabolite</term><term>Metabolites others</term><term>Parent compound</term><term>Phosphate buffer</term><term>Radioactivity</term><term>Side chain</term><term>Spleen</term><term>Time course</term><term>Tissue distribution</term><term>Urine</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: 4-Amino-7-iodoquinoline and five N4-substituted [(CH2)nNR'R″] 4-amino-7-iodoquinolines were labelled with iodine-125 for distribution studies in the rat. Following intravenous injection the iodoquinolines clear rapidly from the blood and high levels of radioactivity are found in the lungs and the liver with a progressive increase in activity in the spleen. The excretion of the bile and urine varies between 7 and 63% in total, depending on the stucture of the amino side chain, and the activity represents a mixture of metabolites of which the major components are amphoteric.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Eakins, M N" sort="Eakins, M N" uniqKey="Eakins M" first="M. N." last="Eakins">M. N. Eakins</name></region><name sortKey="Goulding, R W" sort="Goulding, R W" uniqKey="Goulding R" first="R. W." last="Goulding">R. W. Goulding</name><name sortKey="Somaia, S" sort="Somaia, S" uniqKey="Somaia S" first="S." last="Somaia">S. 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