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Craft-versus-lost disease from leukocyte transfusions

Identifieur interne : 003670 ( Main/Exploration ); précédent : 003669; suivant : 003671

Craft-versus-lost disease from leukocyte transfusions

Auteurs : Bernadine Tolbert [États-Unis] ; Christian E. Kaufman Jr. [États-Unis] ; Walter H. C. Burgdorf [États-Unis] ; Daniel Brubaker [États-Unis]

Source :

RBID : ISTEX:A52FB6D832B17DE8B409118574EF414CD390E3C0

English descriptors

Abstract

Transfusion of blood products containing immunocompetent lymphocytes may cause graft-versus-host disease (GVHD) in immunosuppressed recipients. We describe fatal GVHD which occurred in a 30-year-old renal transplant patient 2 weeks after transfusion of 1.0 x 108 lymphocytes/kilogram. In addition to typical cutaneous and gastrointestinal manifestations, she developed irreversible bone marrow failure, Acute GVHD following blood product transfusion from normal donors has a mortality of 88%. Treatment is unsatisfactory, but irradiation of blood products prior to administration is preventive.

Url:
DOI: 10.1016/S0190-9622(83)70151-9


Affiliations:


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Le document en format XML

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