Craft-versus-lost disease from leukocyte transfusions
Identifieur interne : 003670 ( Main/Exploration ); précédent : 003669; suivant : 003671Craft-versus-lost disease from leukocyte transfusions
Auteurs : Bernadine Tolbert [États-Unis] ; Christian E. Kaufman Jr. [États-Unis] ; Walter H. C. Burgdorf [États-Unis] ; Daniel Brubaker [États-Unis]Source :
- Journal of the American Academy of Dermatology [ 0190-9622 ] ; 1983.
English descriptors
- Teeft :
- Acad dermatol, Acute gvhd, Basal layer, Biopsy, Blood cells, Blood product transfusion, Blood products, Body weight, Bone marrow, Bone marrow biopsy, Bone marrow involvement, Bone marrow transplantation, Case report, Cause gvhd, Chronic gvhd, Complete marrow aplasia, Cutaneous, Dermatitis, Dermatology, Erythema, Erythema multiforme, Exanthem, Exchange transfusions, Family history, Fitzsimons army, Gastrointestinal, Gastrointestinal tract, Gvhd, Immunoblastic sarcoma, Immunodeficient patients, Lesion, Leukocyte, Light testing, Lymphocyte, Lymphocyte satellitosis, Marrow, Multiforme, Photosensitive, Photosensitive dermatitis, Several weeks, Skin biopsy, Sunlight exposure, Transfusion, Transplantation.
Abstract
Transfusion of blood products containing immunocompetent lymphocytes may cause graft-versus-host disease (GVHD) in immunosuppressed recipients. We describe fatal GVHD which occurred in a 30-year-old renal transplant patient 2 weeks after transfusion of 1.0 x 108 lymphocytes/kilogram. In addition to typical cutaneous and gastrointestinal manifestations, she developed irreversible bone marrow failure, Acute GVHD following blood product transfusion from normal donors has a mortality of 88%. Treatment is unsatisfactory, but irradiation of blood products prior to administration is preventive.
Url:
DOI: 10.1016/S0190-9622(83)70151-9
Affiliations:
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Le document en format XML
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<term>Case report</term>
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<term>Gvhd</term>
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<term>Photosensitive dermatitis</term>
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<front><div type="abstract">Transfusion of blood products containing immunocompetent lymphocytes may cause graft-versus-host disease (GVHD) in immunosuppressed recipients. We describe fatal GVHD which occurred in a 30-year-old renal transplant patient 2 weeks after transfusion of 1.0 x 108 lymphocytes/kilogram. In addition to typical cutaneous and gastrointestinal manifestations, she developed irreversible bone marrow failure, Acute GVHD following blood product transfusion from normal donors has a mortality of 88%. Treatment is unsatisfactory, but irradiation of blood products prior to administration is preventive.</div>
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