CAPTOPRIL: A NEW TREATMENT FOR RHEUMATOID ARTHRITIS?
Identifieur interne : 003581 ( Main/Exploration ); précédent : 003580; suivant : 003582CAPTOPRIL: A NEW TREATMENT FOR RHEUMATOID ARTHRITIS?
Auteurs : M. F. R. Martin [Royaume-Uni] ; F. Mckenna [Royaume-Uni] ; H. A. Bird [Royaume-Uni] ; K. E. Surrall [Royaume-Uni] ; J. S. Dixon [Royaume-Uni] ; V. Wright [Royaume-Uni]Source :
- The Lancet [ 0140-6736 ] ; 1984.
English descriptors
- Teeft :
- Angiotensin, Arthritis, Arthritis rheum, Arthritis symptoms, Articular index, Captopril, Captopril therapy, Cigarette smoke, Clinical improvement, Clinical response, Clinical studies, Clinical variables, Gastrointestinal tracts, Human cells, Human model screening system, Hydrogen peroxide, Hydroxyl, Hypertension, Hypertensive patients, Immunochemical quantitation, Laboratory variables, Lancet, Morning stiffness, Mucus, Mucus layers, Night sweats, Open study, Other saards, Oxygen radicals, Plasma viscosity, Potential toxicity, Prostaglandin, Prostaglandin production, Rank test, Reactive species, Rheumatoid, Rheumatoid arthritis, Significant changes, Sodium aurothiomalate, Such cells, Surface epithelium, Table matrix.
Abstract
Abstract: Captopril, an inhibitor of angiotensin converting enzyme, is prescribed for hypertension. Its molecular structure shares features with D-penicillamine, in that both agents contain a thiol group. In addition, captopril has immunosuppressant activity. Captopril was therefore considered a potential slow-acting drug for treating rheumatoid arthritis. In an open study 15 patients with active arthritis were treated with captopril and followed for 48 weeks. Two-thirds of the patients reported improved arthritis symptoms, and significant changes were seen in several clinical and biochemical measurements, notably Ritchie articular index, clinical score, plasma viscosity, and C-reactive protein. Side-effects were generally mild and included transient taste loss, rashes, and hypotension. Only 2 patients withdrew as a result of drug intolerance.
Url:
DOI: 10.1016/S0140-6736(84)91821-X
Affiliations:
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Bird</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, Yorkshire</wicri:regionArea><wicri:noRegion>Yorkshire</wicri:noRegion></affiliation></author><author><name sortKey="Surrall, K E" sort="Surrall, K E" uniqKey="Surrall K" first="K. E." last="Surrall">K. E. Surrall</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, Yorkshire</wicri:regionArea><wicri:noRegion>Yorkshire</wicri:noRegion></affiliation></author><author><name sortKey="Dixon, J S" sort="Dixon, J S" uniqKey="Dixon J" first="J. S." last="Dixon">J. S. 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Wright</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Department of Medicine, General Infirmary at Leeds, LS2 9PJ, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">The Lancet</title><title level="j" type="abbrev">LANCET</title><idno type="ISSN">0140-6736</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984">1984</date><biblScope unit="volume">323</biblScope><biblScope unit="issue">8390</biblScope><biblScope unit="page" from="1325">1325</biblScope><biblScope unit="page" to="1328">1328</biblScope></imprint><idno type="ISSN">0140-6736</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Angiotensin</term><term>Arthritis</term><term>Arthritis rheum</term><term>Arthritis symptoms</term><term>Articular index</term><term>Captopril</term><term>Captopril therapy</term><term>Cigarette smoke</term><term>Clinical improvement</term><term>Clinical response</term><term>Clinical studies</term><term>Clinical variables</term><term>Gastrointestinal tracts</term><term>Human cells</term><term>Human model screening system</term><term>Hydrogen peroxide</term><term>Hydroxyl</term><term>Hypertension</term><term>Hypertensive patients</term><term>Immunochemical quantitation</term><term>Laboratory variables</term><term>Lancet</term><term>Morning stiffness</term><term>Mucus</term><term>Mucus layers</term><term>Night sweats</term><term>Open study</term><term>Other saards</term><term>Oxygen radicals</term><term>Plasma viscosity</term><term>Potential toxicity</term><term>Prostaglandin</term><term>Prostaglandin production</term><term>Rank test</term><term>Reactive species</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Significant changes</term><term>Sodium aurothiomalate</term><term>Such cells</term><term>Surface epithelium</term><term>Table matrix</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Captopril, an inhibitor of angiotensin converting enzyme, is prescribed for hypertension. Its molecular structure shares features with D-penicillamine, in that both agents contain a thiol group. In addition, captopril has immunosuppressant activity. Captopril was therefore considered a potential slow-acting drug for treating rheumatoid arthritis. In an open study 15 patients with active arthritis were treated with captopril and followed for 48 weeks. Two-thirds of the patients reported improved arthritis symptoms, and significant changes were seen in several clinical and biochemical measurements, notably Ritchie articular index, clinical score, plasma viscosity, and C-reactive protein. Side-effects were generally mild and included transient taste loss, rashes, and hypotension. Only 2 patients withdrew as a result of drug intolerance.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Martin, M F R" sort="Martin, M F R" uniqKey="Martin M" first="M. F. R." last="Martin">M. F. R. Martin</name></noRegion><name sortKey="Bird, H A" sort="Bird, H A" uniqKey="Bird H" first="H. A." last="Bird">H. A. Bird</name><name sortKey="Dixon, J S" sort="Dixon, J S" uniqKey="Dixon J" first="J. S." last="Dixon">J. S. Dixon</name><name sortKey="Mckenna, F" sort="Mckenna, F" uniqKey="Mckenna F" first="F." last="Mckenna">F. Mckenna</name><name sortKey="Surrall, K E" sort="Surrall, K E" uniqKey="Surrall K" first="K. E." last="Surrall">K. E. Surrall</name><name sortKey="Wright, V" sort="Wright, V" uniqKey="Wright V" first="V." last="Wright">V. Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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