The skin as an immunologic organ
Identifieur interne : 003505 ( Main/Exploration ); précédent : 003504; suivant : 003506The skin as an immunologic organ
Auteurs : Stephen I. Katz [États-Unis]Source :
- Journal of the American Academy of Dermatology [ 0190-9622 ] ; 1985.
English descriptors
- Teeft :
- Acad dermatol, Allergic contact dermatitis, American academy, Arsphenamine hypersensitiveness, Bone marrow, Cell activation, Cell interactions, Contact sensitivity, Dendritic, Dendritic cells, Dermatitis herpetiformis, Dermatol, Dermatology katz, Different routes, Epidermal, Epidermal cell suspensions, Epidermal cells, Epidermal immunologic functions, Epidermal langerhans cells, Epidermal sheet, Epidermis, Etaf, Exogenous antigen, Georg stingl, Guinea pigs, Haptenated spleen cells, Hypersensitivity, Immune responses, Immunodeficiency syndrome, Immunofluorescent staining, Immunologic, Immunologic organ, Immunologic process, Interleukin, Katz, Keratinocyte, Keratinocyte cell line, Keratinocytes, Kunihiko tamaki, Langerhans, Langerhans cell, Langerhans cells, Lobulated nucleus, Masafumi iijima, Medical student, Murine epidermis, Neutrophil chemotaxis, Normal epidermis, Other organs, Paul langerhans, Recent years, Receptor, Sauder, Second signal, Stephen breathnach, Tamaki, Type hypersensitivity, Ultraviolet radiation, Various types, Vimentin receptors.
Abstract
The early experiments of Marion B. Sulzberger suggested that the skin played a vital role in the generation of allergic contact dermatitis and other delayed type hypersensitivity reactions. This lecture is presented in the historical context of Dr. Sulzberger's lifework and interest in mechanisms involved in delayed type hypersensitivity. I review recent studies indicating (1) that epidermal Langerhans cells are critical for many immune responses involving the skin and (2) that keratinocytes may also play a role in epidermal immunologic functions in that they secrete factors that may modulate various types of skin reactions. The interaction between these cells and factors and lymphoid cells indicates, as Dr. Sulzberger implied, that the skin should be viewed as an organ of immunity.
Url:
DOI: 10.1016/S0190-9622(85)70195-8
Affiliations:
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Le document en format XML
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Katz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Dermatology Branch, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the American Academy of Dermatology</title><title level="j" type="abbrev">YMJD</title><idno type="ISSN">0190-9622</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="530">530</biblScope><biblScope unit="page" to="536">536</biblScope></imprint><idno type="ISSN">0190-9622</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0190-9622</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acad dermatol</term><term>Allergic contact dermatitis</term><term>American academy</term><term>Arsphenamine hypersensitiveness</term><term>Bone marrow</term><term>Cell activation</term><term>Cell interactions</term><term>Contact sensitivity</term><term>Dendritic</term><term>Dendritic cells</term><term>Dermatitis herpetiformis</term><term>Dermatol</term><term>Dermatology katz</term><term>Different routes</term><term>Epidermal</term><term>Epidermal cell suspensions</term><term>Epidermal cells</term><term>Epidermal immunologic functions</term><term>Epidermal langerhans cells</term><term>Epidermal sheet</term><term>Epidermis</term><term>Etaf</term><term>Exogenous antigen</term><term>Georg stingl</term><term>Guinea pigs</term><term>Haptenated spleen cells</term><term>Hypersensitivity</term><term>Immune responses</term><term>Immunodeficiency syndrome</term><term>Immunofluorescent staining</term><term>Immunologic</term><term>Immunologic organ</term><term>Immunologic process</term><term>Interleukin</term><term>Katz</term><term>Keratinocyte</term><term>Keratinocyte cell line</term><term>Keratinocytes</term><term>Kunihiko tamaki</term><term>Langerhans</term><term>Langerhans cell</term><term>Langerhans cells</term><term>Lobulated nucleus</term><term>Masafumi iijima</term><term>Medical student</term><term>Murine epidermis</term><term>Neutrophil chemotaxis</term><term>Normal epidermis</term><term>Other organs</term><term>Paul langerhans</term><term>Recent years</term><term>Receptor</term><term>Sauder</term><term>Second signal</term><term>Stephen breathnach</term><term>Tamaki</term><term>Type hypersensitivity</term><term>Ultraviolet radiation</term><term>Various types</term><term>Vimentin receptors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The early experiments of Marion B. Sulzberger suggested that the skin played a vital role in the generation of allergic contact dermatitis and other delayed type hypersensitivity reactions. This lecture is presented in the historical context of Dr. Sulzberger's lifework and interest in mechanisms involved in delayed type hypersensitivity. I review recent studies indicating (1) that epidermal Langerhans cells are critical for many immune responses involving the skin and (2) that keratinocytes may also play a role in epidermal immunologic functions in that they secrete factors that may modulate various types of skin reactions. The interaction between these cells and factors and lymphoid cells indicates, as Dr. Sulzberger implied, that the skin should be viewed as an organ of immunity.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Katz, Stephen I" sort="Katz, Stephen I" uniqKey="Katz S" first="Stephen I." last="Katz">Stephen I. Katz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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