EUROPEAN LEAGUE AGAINST RHEUMATISM STUDY OF ADVERSE REACTIONS TO D-PENICILLAMINE
Identifieur interne : 003394 ( Main/Exploration ); précédent : 003393; suivant : 003395EUROPEAN LEAGUE AGAINST RHEUMATISM STUDY OF ADVERSE REACTIONS TO D-PENICILLAMINE
Auteurs : A. Kay [Royaume-Uni]Source :
- Rheumatology [ 1462-0324 ] ; 1986.
Abstract
An international multicentre study of adverse reactions to D-penicillamine was undertaken on 2879 patients exposed to the drug—1491 of them a prospective sample. The majority of patients were being treated for rheumatoid arthritis. Over a period of 18 months, 319 (21%) of patients in the prospective sample developed adverse reactions necessitating drug withdrawal; two thirds of these occurred during the first 3 months of treatment. The most frequently-occurring adverse reactions involved skin (6%), kidneys (4%), gastro-intestinal tract (4%) and haemopoiesis (3%). Adverse effects, considered to be serious by the reporting physician, included fever and leucopenia during the early weeks of treatment and, after some months of drug exposure, proteinuria, myasthenia gravis, dyspnoea and pemphigus. Two patients died, one of fulminating septicaemia and the other was found at autopsy to have had multiple lung abscesses following unexplained anaemia and hemiparesis.
Url:
DOI: 10.1093/rheumatology/25.2.193
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002611
- to stream Istex, to step Curation: 002611
- to stream Istex, to step Checkpoint: 002152
- to stream Main, to step Merge: 003467
- to stream Main, to step Curation: 003394
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>EUROPEAN LEAGUE AGAINST RHEUMATISM STUDY OF ADVERSE REACTIONS TO D-PENICILLAMINE</title><author wicri:is="90%"><name sortKey="Kay, A" sort="Kay, A" uniqKey="Kay A" first="A." last="Kay">A. Kay</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:59319085D72192AAD3DB2FB1596EB7BCCFE74348</idno><date when="1986" year="1986">1986</date><idno type="doi">10.1093/rheumatology/25.2.193</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-3JWWJCL3-L/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002611</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002611</idno><idno type="wicri:Area/Istex/Curation">002611</idno><idno type="wicri:Area/Istex/Checkpoint">002152</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002152</idno><idno type="wicri:doubleKey">1462-0324:1986:Kay A:european:league:against</idno><idno type="wicri:Area/Main/Merge">003467</idno><idno type="wicri:Area/Main/Curation">003394</idno><idno type="wicri:Area/Main/Exploration">003394</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">EUROPEAN LEAGUE AGAINST RHEUMATISM STUDY OF ADVERSE REACTIONS TO D-PENICILLAMINE</title><author wicri:is="90%"><name sortKey="Kay, A" sort="Kay, A" uniqKey="Kay A" first="A." last="Kay">A. Kay</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>ARC Epidemiology Unit and Department of Rheumatology, Guy's Hospital, London SE1 9RT</wicri:regionArea><wicri:noRegion>London SE1 9RT</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Rheumatology</title><idno type="eISSN">1462-0332</idno><idno type="ISSN">1462-0324</idno><imprint><publisher>Oxford University Press</publisher><date when="1986-05">1986</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="193">193</biblScope><biblScope unit="page" to="198">198</biblScope></imprint><idno type="ISSN">1462-0324</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1462-0324</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">An international multicentre study of adverse reactions to D-penicillamine was undertaken on 2879 patients exposed to the drug—1491 of them a prospective sample. The majority of patients were being treated for rheumatoid arthritis. Over a period of 18 months, 319 (21%) of patients in the prospective sample developed adverse reactions necessitating drug withdrawal; two thirds of these occurred during the first 3 months of treatment. The most frequently-occurring adverse reactions involved skin (6%), kidneys (4%), gastro-intestinal tract (4%) and haemopoiesis (3%). Adverse effects, considered to be serious by the reporting physician, included fever and leucopenia during the early weeks of treatment and, after some months of drug exposure, proteinuria, myasthenia gravis, dyspnoea and pemphigus. Two patients died, one of fulminating septicaemia and the other was found at autopsy to have had multiple lung abscesses following unexplained anaemia and hemiparesis.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Kay, A" sort="Kay, A" uniqKey="Kay A" first="A." last="Kay">A. Kay</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003394 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003394 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:59319085D72192AAD3DB2FB1596EB7BCCFE74348
|texte= EUROPEAN LEAGUE AGAINST RHEUMATISM STUDY OF ADVERSE REACTIONS TO D-PENICILLAMINE
}}
| This area was generated with Dilib version V0.6.33. |  |