Quality of life as outcome measures in randomized clinical trials
Identifieur interne : 002F63 ( Main/Exploration ); précédent : 002F62; suivant : 002F64Quality of life as outcome measures in randomized clinical trials
Auteurs : Sander J. O. Veldhuyzen Van Zanten [Canada]Source :
- Controlled Clinical Trials [ 0197-2456 ] ; 1991.
English descriptors
- KwdEn :
- Teeft :
- Acute asthma, Acute leukemia, American journal, Cancer patients, Clinical importance, Clinical trials, Combination chemotherapy, Daily activities, Dalhousie university, Diseasespecific measure, Donor bone marrow, Early discharge, Engl, England journal, Functional status, Health profile, Health status, Heart failure, Intern, Internal medicine, Marrow transplantation, Measure quality, Nonulcer dyspepsia, Nova scotia, Optimal treatment decision, Orthostatic hypotension, Prospective trial, Randomized, Randomized trial, Randomized trials, Rheumatoid arthritis, Stable stroke, Study group, Therapeutic benefit, Treatment decisions, Treatment recommendations, Utility measurement, Veterans administration, Weighted kappa.
Abstract
Abstract: A survey of 75 randomized trials published in 1986 in the Annals of Internal Medicine, American Journal of Medicine, and New England Journal of Medicine was carried out by two observers using predetermined criteria about the importance of health status as an outcome measurement and the quality-of-health status measurement that was used. The kappa statistic was used to measure agreement among the two observers. Although a number of investigators used well-established quality-of-life measurements, in only 10 of 55 trials in which health status was judged crucial or important were measures with established validity and responsiveness used. Despite the fact that reliable measurement of quality of life is now feasible, it is underutilized in randomized clinical trials.
Url:
DOI: 10.1016/S0197-2456(05)80027-3
Affiliations:
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O." last="Veldhuyzen Van Zanten">Sander J. O. Veldhuyzen Van Zanten</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Dalhousie University, Halifax, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Controlled Clinical Trials</title><title level="j" type="abbrev">CCT</title><idno type="ISSN">0197-2456</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">12</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="supplement">S</biblScope><biblScope unit="page" from="S234">S234</biblScope><biblScope unit="page" to="S242">S242</biblScope></imprint><idno type="ISSN">0197-2456</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0197-2456</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Quality-of-life measures, literature survey, kappa, random allocation</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acute asthma</term><term>Acute leukemia</term><term>American journal</term><term>Cancer patients</term><term>Clinical importance</term><term>Clinical trials</term><term>Combination chemotherapy</term><term>Daily activities</term><term>Dalhousie university</term><term>Diseasespecific measure</term><term>Donor bone marrow</term><term>Early discharge</term><term>Engl</term><term>England journal</term><term>Functional status</term><term>Health profile</term><term>Health status</term><term>Heart failure</term><term>Intern</term><term>Internal medicine</term><term>Marrow transplantation</term><term>Measure quality</term><term>Nonulcer dyspepsia</term><term>Nova scotia</term><term>Optimal treatment decision</term><term>Orthostatic hypotension</term><term>Prospective trial</term><term>Randomized</term><term>Randomized trial</term><term>Randomized trials</term><term>Rheumatoid arthritis</term><term>Stable stroke</term><term>Study group</term><term>Therapeutic benefit</term><term>Treatment decisions</term><term>Treatment recommendations</term><term>Utility measurement</term><term>Veterans administration</term><term>Weighted kappa</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: A survey of 75 randomized trials published in 1986 in the Annals of Internal Medicine, American Journal of Medicine, and New England Journal of Medicine was carried out by two observers using predetermined criteria about the importance of health status as an outcome measurement and the quality-of-health status measurement that was used. The kappa statistic was used to measure agreement among the two observers. Although a number of investigators used well-established quality-of-life measurements, in only 10 of 55 trials in which health status was judged crucial or important were measures with established validity and responsiveness used. Despite the fact that reliable measurement of quality of life is now feasible, it is underutilized in randomized clinical trials.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Veldhuyzen Van Zanten, Sander J O" sort="Veldhuyzen Van Zanten, Sander J O" uniqKey="Veldhuyzen Van Zanten S" first="Sander J. O." last="Veldhuyzen Van Zanten">Sander J. O. Veldhuyzen Van Zanten</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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