Erythrocyte glutathione and tumour response to chemotherapy
Identifieur interne : 002E38 ( Main/Exploration ); précédent : 002E37; suivant : 002E39Erythrocyte glutathione and tumour response to chemotherapy
Auteurs : A. Hercbergs [États-Unis] ; F. Brok-Simoni [Israël] ; F. Holtzman [Israël] ; J. Bar-Am [Israël] ; H. J. Brenner [Israël] ; J. T. Leith [États-Unis]Source :
- The Lancet [ 0140-6736 ] ; 1992.
English descriptors
- Teeft :
- Atrium, Bicarbonate buffer, Blood samples, Breast cancer, Buthionine sulfoximine, Cancer patients, Cardiac effects, Chemotherapy, Cleveland clinic foundation, Clin oncol, Confidence interval, Drug resistance, Erythrocyte, Glutathione, Glutathione depletion, Glutathione metabolism, Glutathione reductase activity, Increase heart rate, Inotropic effects, Invasive procedure, Mammalian cells, Other tumours, Porcine relaxin, Preliminary study, Radiat oncol biol phys, Radiation therapy, Regression lines, Relaxin, Responder, Right atria, Thyroid function, Tumour, Tumour cells, Tumour response.
Abstract
Abstract: There is much evidence that tumour glutathione (GSH) concentration is an important factor in resistance to cancer chemotherapy. Since measurement of tumour GSH would require an invasive procedure in every patient, we have tried to find out whether GSH concentrations in peripheral-blood erythrocytes are related to the response to chemotherapy and thus whether they reflect those in tumour cells. Erythrocyte GSH concentrations were measured by spectrophotometry in peripheral blood from 28 patients with advanced breast cancer and 40 patients with other tumours before and after treatment with various conventional chemotherapeutic regimens. The mean pretreatment GSH concentration was lower in patients who showed a complete or partial response to chemotherapy than in those with stable or progressive disease in both the breast-cancer group (8·69 [95% confidence interval 5·99-11·39] vs 2·32 [1 ·23-3·41] μmol/g haemoglobin; p <0·01) and the group with other tumours (5·94 [4·14-7·74] vs 2·83 [1·71-3·95] μmol/g; p<0·01). The correlation of erythrocyte GSH concentration with response rate suggests that this measurement may be helpful in prediction of response to therapy. Lancet 1992; 339: 1074-76.
Url:
DOI: 10.1016/0140-6736(92)90664-O
Affiliations:
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Leith</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Radiation Research Laboratories, Department of Radiation Medicine, Brown University, Providence, Rhode Island</wicri:regionArea><placeName><region type="state">Rhode Island</region><settlement type="city">Providence (Rhode Island)</settlement></placeName><orgName type="university">Université Brown</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">The Lancet</title><title level="j" type="abbrev">LANCET</title><idno type="ISSN">0140-6736</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">339</biblScope><biblScope unit="issue">8801</biblScope><biblScope unit="page" from="1074">1074</biblScope><biblScope unit="page" to="1076">1076</biblScope></imprint><idno type="ISSN">0140-6736</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Atrium</term><term>Bicarbonate buffer</term><term>Blood samples</term><term>Breast cancer</term><term>Buthionine sulfoximine</term><term>Cancer patients</term><term>Cardiac effects</term><term>Chemotherapy</term><term>Cleveland clinic foundation</term><term>Clin oncol</term><term>Confidence interval</term><term>Drug resistance</term><term>Erythrocyte</term><term>Glutathione</term><term>Glutathione depletion</term><term>Glutathione metabolism</term><term>Glutathione reductase activity</term><term>Increase heart rate</term><term>Inotropic effects</term><term>Invasive procedure</term><term>Mammalian cells</term><term>Other tumours</term><term>Porcine relaxin</term><term>Preliminary study</term><term>Radiat oncol biol phys</term><term>Radiation therapy</term><term>Regression lines</term><term>Relaxin</term><term>Responder</term><term>Right atria</term><term>Thyroid function</term><term>Tumour</term><term>Tumour cells</term><term>Tumour response</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: There is much evidence that tumour glutathione (GSH) concentration is an important factor in resistance to cancer chemotherapy. Since measurement of tumour GSH would require an invasive procedure in every patient, we have tried to find out whether GSH concentrations in peripheral-blood erythrocytes are related to the response to chemotherapy and thus whether they reflect those in tumour cells. Erythrocyte GSH concentrations were measured by spectrophotometry in peripheral blood from 28 patients with advanced breast cancer and 40 patients with other tumours before and after treatment with various conventional chemotherapeutic regimens. The mean pretreatment GSH concentration was lower in patients who showed a complete or partial response to chemotherapy than in those with stable or progressive disease in both the breast-cancer group (8·69 [95% confidence interval 5·99-11·39] vs 2·32 [1 ·23-3·41] μmol/g haemoglobin; p <0·01) and the group with other tumours (5·94 [4·14-7·74] vs 2·83 [1·71-3·95] μmol/g; p<0·01). The correlation of erythrocyte GSH concentration with response rate suggests that this measurement may be helpful in prediction of response to therapy. Lancet 1992; 339: 1074-76.</div></front></TEI><affiliations><list><country><li>Israël</li><li>États-Unis</li></country><region><li>Ohio</li><li>Rhode Island</li></region><settlement><li>Providence (Rhode Island)</li></settlement><orgName><li>Université Brown</li></orgName></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Hercbergs, A" sort="Hercbergs, A" uniqKey="Hercbergs A" first="A." last="Hercbergs">A. Hercbergs</name></region><name sortKey="Leith, J T" sort="Leith, J T" uniqKey="Leith J" first="J. T." last="Leith">J. T. Leith</name></country><country name="Israël"><noRegion><name sortKey="Brok Simoni, F" sort="Brok Simoni, F" uniqKey="Brok Simoni F" first="F." last="Brok-Simoni">F. Brok-Simoni</name></noRegion><name sortKey="Bar Am, J" sort="Bar Am, J" uniqKey="Bar Am J" first="J." last="Bar-Am">J. Bar-Am</name><name sortKey="Brenner, H J" sort="Brenner, H J" uniqKey="Brenner H" first="H. J." last="Brenner">H. J. Brenner</name><name sortKey="Holtzman, F" sort="Holtzman, F" uniqKey="Holtzman F" first="F." last="Holtzman">F. Holtzman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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