TUMOR NECROSIS FACTOR: STATUS IN REACTIONS IN LEPROSY BEFORE AND AFTER TREATMENT
Identifieur interne : 002D68 ( Main/Exploration ); précédent : 002D67; suivant : 002D69TUMOR NECROSIS FACTOR: STATUS IN REACTIONS IN LEPROSY BEFORE AND AFTER TREATMENT
Auteurs : Virendra N. Sehgal [Inde] ; Sambit N. Bhattacharya [Inde] ; Debasish Chattopadhaya [Inde] ; Kunal Saha [Inde]Source :
- International Journal of Dermatology [ 0011-9059 ] ; 1993-06.
Abstract
Background. Tumor necrosis factor‐alpha (TNF) is an important mediator of immunologic responses to chronic infections. Method. Sera from 25 patients with acute reactions (6 with type 1 upgrading, 8 with type 1 downgrading, and 11 with type 2 reaction) were assayed for TNF before treatment and after clinical remission of the acute episode. The results were compared with serum TNF levels in healthy controls and fresh pauci‐and multibacillary leprosy patients. Results. TNF levels in acute reactions were higher than in the control groups (significant only in upgrading reaction). In type 1 reaction, serum TNF concentrations fell to approximately the levels of the control patients following treatment and clinical remission. In type 2 reaction, however, levels of TNF were seen to rise further (became statistically significant) as a result of therapy induced clinical remission. Conclusions. The rise in TNF‐A level in reactions in leprosy is significant and indicates its active role in immunopathogenesis. The corresponding decline in TNF‐a levels seen following regression of type 1 (lepra) reactions was not observed in the case of type 2 (ENL) reaction. This probably reflects the enhancement of cellular immunity in such cases and/or an attempt by the immunologic process to overcome specific inhibitors.
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DOI: 10.1111/j.1365-4362.1993.tb02816.x
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Bhattacharya</name></author><author><name sortKey="Chattopadhaya, Debasish" sort="Chattopadhaya, Debasish" uniqKey="Chattopadhaya D" first="Debasish" last="Chattopadhaya">Debasish Chattopadhaya</name></author><author><name sortKey="Saha, Kunal" sort="Saha, Kunal" uniqKey="Saha K" first="Kunal" last="Saha">Kunal Saha</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DAD0441CD018FD8FAD742BB77751238990A10AF7</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1111/j.1365-4362.1993.tb02816.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-R3GW9NTZ-K/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002A62</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002A62</idno><idno type="wicri:Area/Istex/Curation">002A62</idno><idno type="wicri:Area/Istex/Checkpoint">001B50</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001B50</idno><idno type="wicri:doubleKey">0011-9059:1993:Sehgal V:tumor:necrosis:factor</idno><idno type="wicri:Area/Main/Merge">002E33</idno><idno type="wicri:Area/Main/Curation">002D68</idno><idno type="wicri:Area/Main/Exploration">002D68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">TUMOR NECROSIS FACTOR: STATUS IN REACTIONS IN LEPROSY BEFORE AND AFTER TREATMENT</title><author><name sortKey="Sehgal, Virendra N" sort="Sehgal, Virendra N" uniqKey="Sehgal V" first="Virendra N." last="Sehgal">Virendra N. Sehgal</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>From the Department of Dermatology and Venereology, Lady Hardinge Medical College and associated SK and KSC Hospital, New Delhi; National Institute of Communicable Diseases, Delhi; and Department of Allergy and Applied Immunology, VP Chest Institute, Delhi</wicri:regionArea><wicri:noRegion>Delhi</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Correspondence address: Address for correspondence: V.N. Sehgal, M.D., A/6 Panchwati, Opp. Azadpur Subzi Mandi, Delhi 110 033</wicri:regionArea><wicri:noRegion>Delhi 110 033</wicri:noRegion></affiliation></author><author><name sortKey="Bhattacharya, Sambit N" sort="Bhattacharya, Sambit N" uniqKey="Bhattacharya S" first="Sambit N." last="Bhattacharya">Sambit N. Bhattacharya</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>From the Department of Dermatology and Venereology, Lady Hardinge Medical College and associated SK and KSC Hospital, New Delhi; National Institute of Communicable Diseases, Delhi; and Department of Allergy and Applied Immunology, VP Chest Institute, Delhi</wicri:regionArea><wicri:noRegion>Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Chattopadhaya, Debasish" sort="Chattopadhaya, Debasish" uniqKey="Chattopadhaya D" first="Debasish" last="Chattopadhaya">Debasish Chattopadhaya</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>From the Department of Dermatology and Venereology, Lady Hardinge Medical College and associated SK and KSC Hospital, New Delhi; National Institute of Communicable Diseases, Delhi; and Department of Allergy and Applied Immunology, VP Chest Institute, Delhi</wicri:regionArea><wicri:noRegion>Delhi</wicri:noRegion></affiliation></author><author><name sortKey="Saha, Kunal" sort="Saha, Kunal" uniqKey="Saha K" first="Kunal" last="Saha">Kunal Saha</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>From the Department of Dermatology and Venereology, Lady Hardinge Medical College and associated SK and KSC Hospital, New Delhi; National Institute of Communicable Diseases, Delhi; and Department of Allergy and Applied Immunology, VP Chest Institute, Delhi</wicri:regionArea><wicri:noRegion>Delhi</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Dermatology</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF DERMATOLOGY</title><idno type="ISSN">0011-9059</idno><idno type="eISSN">1365-4632</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="436">436</biblScope><biblScope unit="page" to="439">439</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1993-06">1993-06</date></imprint><idno type="ISSN">0011-9059</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0011-9059</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Tumor necrosis factor‐alpha (TNF) is an important mediator of immunologic responses to chronic infections. Method. Sera from 25 patients with acute reactions (6 with type 1 upgrading, 8 with type 1 downgrading, and 11 with type 2 reaction) were assayed for TNF before treatment and after clinical remission of the acute episode. The results were compared with serum TNF levels in healthy controls and fresh pauci‐and multibacillary leprosy patients. Results. TNF levels in acute reactions were higher than in the control groups (significant only in upgrading reaction). In type 1 reaction, serum TNF concentrations fell to approximately the levels of the control patients following treatment and clinical remission. In type 2 reaction, however, levels of TNF were seen to rise further (became statistically significant) as a result of therapy induced clinical remission. Conclusions. The rise in TNF‐A level in reactions in leprosy is significant and indicates its active role in immunopathogenesis. The corresponding decline in TNF‐a levels seen following regression of type 1 (lepra) reactions was not observed in the case of type 2 (ENL) reaction. This probably reflects the enhancement of cellular immunity in such cases and/or an attempt by the immunologic process to overcome specific inhibitors.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Sehgal, Virendra N" sort="Sehgal, Virendra N" uniqKey="Sehgal V" first="Virendra N." last="Sehgal">Virendra N. Sehgal</name></noRegion><name sortKey="Bhattacharya, Sambit N" sort="Bhattacharya, Sambit N" uniqKey="Bhattacharya S" first="Sambit N." last="Bhattacharya">Sambit N. Bhattacharya</name><name sortKey="Chattopadhaya, Debasish" sort="Chattopadhaya, Debasish" uniqKey="Chattopadhaya D" first="Debasish" last="Chattopadhaya">Debasish Chattopadhaya</name><name sortKey="Saha, Kunal" sort="Saha, Kunal" uniqKey="Saha K" first="Kunal" last="Saha">Kunal Saha</name><name sortKey="Sehgal, Virendra N" sort="Sehgal, Virendra N" uniqKey="Sehgal V" first="Virendra N." last="Sehgal">Virendra N. Sehgal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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