Vitamin D, calcium, and sarcoidosis
Identifieur interne : 002A67 ( Main/Exploration ); précédent : 002A66; suivant : 002A68Vitamin D, calcium, and sarcoidosis
Auteurs : O. P. Sharma [États-Unis]Source :
- Chest [ 0012-3692 ] ; 1996.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
Hypercalcemia occurs in about 10% of the patients with sarcoidosis ; hypercalciuria is about three times more frequent. These abnormalities of calcium metabolism are due to dysregulated production of 1,25-(OH) 2-D3 (calcitriol) by activated macrophages trapped in pulmonary alveoli and granulomatous inflammation. Undetected hypercalcemia and hypercalciuria can cause nephrocalcinosis, renal stones, and renal failure. Corticosteroids cause prompt reversal of the metabolic defect. Chloroquine, hydroxychloroqune, and ketoconazole are the drugs that should be used if the patient fails to respond or develops dangerous side effects to corticosteroid therapy.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000088
- to stream PascalFrancis, to step Curation: 000082
- to stream PascalFrancis, to step Checkpoint: 000086
- to stream Main, to step Merge: 002B20
- to stream Main, to step Curation: 002A67
Le document en format XML
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<author><name sortKey="Sharma, O P" sort="Sharma, O P" uniqKey="Sharma O" first="O. P." last="Sharma">O. P. Sharma</name>
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<s2>Los Angeles CA</s2>
<s3>USA</s3>
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<country>États-Unis</country>
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<author><name sortKey="Sharma, O P" sort="Sharma, O P" uniqKey="Sharma O" first="O. P." last="Sharma">O. P. Sharma</name>
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<s3>USA</s3>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcium</term>
<term>Human</term>
<term>Hypercalcemia</term>
<term>Inorganic element</term>
<term>Macrophage</term>
<term>Metabolism</term>
<term>Pulmonary alveolus</term>
<term>Sarcoidosis</term>
<term>Vitamin D</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Sarcoïdose</term>
<term>Homme</term>
<term>Calcium</term>
<term>Vitamine D</term>
<term>Métabolisme</term>
<term>Macrophage</term>
<term>Hypercalcémie</term>
<term>Alvéole pulmonaire</term>
<term>Kétoconazole</term>
<term>Elément minéral</term>
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<front><div type="abstract" xml:lang="en">Hypercalcemia occurs in about 10% of the patients with sarcoidosis ; hypercalciuria is about three times more frequent. These abnormalities of calcium metabolism are due to dysregulated production of 1,25-(OH) <sub>2</sub>
-D<sub>3</sub>
(calcitriol) by activated macrophages trapped in pulmonary alveoli and granulomatous inflammation. Undetected hypercalcemia and hypercalciuria can cause nephrocalcinosis, renal stones, and renal failure. Corticosteroids cause prompt reversal of the metabolic defect. Chloroquine, hydroxychloroqune, and ketoconazole are the drugs that should be used if the patient fails to respond or develops dangerous side effects to corticosteroid therapy.</div>
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