Respiratory function in systemic lupus erythematosus: relation with activity and severity
Identifieur interne : 002A24 ( Main/Exploration ); précédent : 002A23; suivant : 002A25Respiratory function in systemic lupus erythematosus: relation with activity and severity
Auteurs : G. Rolla [Italie] ; L. Brussino [Italie] ; Mt Bertero [Italie] ; C. Bucca [Italie] ; M. Converso [Italie] ; F. Caligaris-Cappio [Italie]Source :
- Lupus [ 0961-2033 ] ; 1996-02.
English descriptors
- Teeft :
- Airway, Airway caliber, Airway dysfunction, Airway reactivity, Alveolar inflammation, Alveolar volume, Ambulatory patients, Arthritis rheum, Asymptomatic patients, Bronchial reactivity, Bronchial threshold, Carbon monoxide, Clinical features, Control subjects, Cumulative damage, Cumulative dose, Diffusion abnormalities, Disease activity, Disease index, Disease severity, Dysfunction, Dyspnea, Eclam, Eclam score, Erythematosus, European consensus lupus activity measurement, Expiratory, Expiratory volume, Inflammation, Lung diffusion, Lung disease, Lung function tests, Lung involvement, Lung volumes, Lupus, Lupus activity index, Lupus severity, Maximal expiratory flow, Methacholine, Oxygen gradient, Plusmn, Present study, Pulmonary disease, Pulmonary dysfunction, Pulmonary function, Pulmonary involvement, Pulmonary manifestations, Pulmonary symptoms, Respir, Respiratory function, Respiratory function tests, Respiratory symptoms, Rheum, Rheumatoid arthritis, Sensitive test, Severity, Severity index, Significant decrease, Significant increase, Small airway function, Small airways, Systemic, Systemic lupus, Systemic lupus erythematosus, Total lung capacity, Transfer factor, Treatment intensification, Vital capacity.
Abstract
The objective of this study was to examine the relation between respiratory function tests, disease activity and disease severity in ambulatory patients with systemic lupus erythematosus (SLE) who did not present with overt respiratory problems. Lung volumes, maximal expiratory flows at 50% and 25% of vital capacity (MEF50 and MEF25), bronchial threshold to methacholine (PD15FEV 1), transfer factor CO (KCO) were measured in 24 consecutive SLE outpatients (22 women, age 41 ± 14.8 years) and in 24 healthy controls matched for age and sex. In SLE patients alveolar-arterial oxygen gradient (AaO2) was also measured. Disease activity was assessed by European Consensus Lupus Activity Measurement (ECLAM) scoring system and disease severity by Lupus Severity of Disease Index. In comparison to controls SLE patients showed a significant decrease of total lung capacity (TLC) (91.7 ± 16.5 vs 102.7 ± 12.9% predicted, P < 0.01), MEF25 (58.4 ± 25.2 vs 73.5 ± 19.5% predicted, P < 0.005), PD15FEV1 (2164 ± 1122 vs 4230 ± 1014 μg methacholine, P < 0.0001) and KCO (77.1 ± 20.5 vs 96.3 ± 12.4% predicted, P < 0.001). AaO2 (mean value 13.2 ± 8.4) was abnormally high (>20 mm Hg) in 12 patients. The ECLAM score of activity was inversely related with KCO (r = 0.48, P < 0.02). The severity index was significantly related with FEV1/VC ratio (r = 0.43, P < 0.05), MEF50 (r = 0.51, P < 0.01), MEF25 (r = 0.40, P < 0.05) and PD15FEV1 (r = 0.51, P < 0.01). In eight patients, evaluated also after treatment intensification, there was a significant increase in KCO (from 71.8 ± 24.7 to 84.9 ± 22.3% predicted, P < 0.01) along with a decrease in ECLAM score (from 3.0 ± 1.34 to 0.69 ± 0.75, P < 0.01). The relation between disease activity and KCO suggests a relation between systemic and alveolar inflammation whereas the relation between severity index, airway patency and reactivity indices suggests a cumulative damage to the airways in SLE patients, even in the absence of overt respiratory manifestations.
Url:
DOI: 10.1177/096120339600500108
Affiliations:
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<term>Airway reactivity</term>
<term>Alveolar inflammation</term>
<term>Alveolar volume</term>
<term>Ambulatory patients</term>
<term>Arthritis rheum</term>
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<term>Control subjects</term>
<term>Cumulative damage</term>
<term>Cumulative dose</term>
<term>Diffusion abnormalities</term>
<term>Disease activity</term>
<term>Disease index</term>
<term>Disease severity</term>
<term>Dysfunction</term>
<term>Dyspnea</term>
<term>Eclam</term>
<term>Eclam score</term>
<term>Erythematosus</term>
<term>European consensus lupus activity measurement</term>
<term>Expiratory</term>
<term>Expiratory volume</term>
<term>Inflammation</term>
<term>Lung diffusion</term>
<term>Lung disease</term>
<term>Lung function tests</term>
<term>Lung involvement</term>
<term>Lung volumes</term>
<term>Lupus</term>
<term>Lupus activity index</term>
<term>Lupus severity</term>
<term>Maximal expiratory flow</term>
<term>Methacholine</term>
<term>Oxygen gradient</term>
<term>Plusmn</term>
<term>Present study</term>
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<term>Pulmonary dysfunction</term>
<term>Pulmonary function</term>
<term>Pulmonary involvement</term>
<term>Pulmonary manifestations</term>
<term>Pulmonary symptoms</term>
<term>Respir</term>
<term>Respiratory function</term>
<term>Respiratory function tests</term>
<term>Respiratory symptoms</term>
<term>Rheum</term>
<term>Rheumatoid arthritis</term>
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<term>Severity index</term>
<term>Significant decrease</term>
<term>Significant increase</term>
<term>Small airway function</term>
<term>Small airways</term>
<term>Systemic</term>
<term>Systemic lupus</term>
<term>Systemic lupus erythematosus</term>
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<front><div type="abstract" xml:lang="en">The objective of this study was to examine the relation between respiratory function tests, disease activity and disease severity in ambulatory patients with systemic lupus erythematosus (SLE) who did not present with overt respiratory problems. Lung volumes, maximal expiratory flows at 50% and 25% of vital capacity (MEF50 and MEF25), bronchial threshold to methacholine (PD15FEV 1), transfer factor CO (KCO) were measured in 24 consecutive SLE outpatients (22 women, age 41 ± 14.8 years) and in 24 healthy controls matched for age and sex. In SLE patients alveolar-arterial oxygen gradient (AaO2) was also measured. Disease activity was assessed by European Consensus Lupus Activity Measurement (ECLAM) scoring system and disease severity by Lupus Severity of Disease Index. In comparison to controls SLE patients showed a significant decrease of total lung capacity (TLC) (91.7 ± 16.5 vs 102.7 ± 12.9% predicted, P < 0.01), MEF25 (58.4 ± 25.2 vs 73.5 ± 19.5% predicted, P < 0.005), PD15FEV1 (2164 ± 1122 vs 4230 ± 1014 μg methacholine, P < 0.0001) and KCO (77.1 ± 20.5 vs 96.3 ± 12.4% predicted, P < 0.001). AaO2 (mean value 13.2 ± 8.4) was abnormally high (>20 mm Hg) in 12 patients. The ECLAM score of activity was inversely related with KCO (r = 0.48, P < 0.02). The severity index was significantly related with FEV1/VC ratio (r = 0.43, P < 0.05), MEF50 (r = 0.51, P < 0.01), MEF25 (r = 0.40, P < 0.05) and PD15FEV1 (r = 0.51, P < 0.01). In eight patients, evaluated also after treatment intensification, there was a significant increase in KCO (from 71.8 ± 24.7 to 84.9 ± 22.3% predicted, P < 0.01) along with a decrease in ECLAM score (from 3.0 ± 1.34 to 0.69 ± 0.75, P < 0.01). The relation between disease activity and KCO suggests a relation between systemic and alveolar inflammation whereas the relation between severity index, airway patency and reactivity indices suggests a cumulative damage to the airways in SLE patients, even in the absence of overt respiratory manifestations.</div>
</front>
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