The Role of Iron In Protozoan and Fungal Infectious Diseases
Identifieur interne : 002635 ( Main/Exploration ); précédent : 002634; suivant : 002636The Role of Iron In Protozoan and Fungal Infectious Diseases
Auteurs : Eugene D. Weinberg [États-Unis]Source :
- Journal of Eukaryotic Microbiology [ 1066-5234 ] ; 1999-05.
English descriptors
- Teeft :
- Albicans, Biemba, Brain tissue, Brittenham, Candida, Candida albicans, Candidu albicans, Carinii, Cellular iron metabolism, Cerebral malaria, Chelators, Clinical studies, Cruzi, Cryptococcus, Cryptococcus neoformans, Deferoxamine, Dimier bout, Endothelial cells, Eukaryotic, Eukaryotic pathogens, Exper, Falciparum, Femc reductase, Ferrated, Ferrated lactoferrin, Ferrated siderophilins, Ferrated transferrin, Ferric, Ferric reductase activity, Fungal, Fungal acquisition, Fungal infections, Fungal invaders, Gondii, Gordeuk, Heme, Histoplasma, Histoplasma capsulatum, Host cells, Host iron, Hydroxamate siderophores, Hydroxamic acid, Hyphal form, Immun, Immunol, Indiana university, Infec, Inhibitory action, Intracellular, Intracellular growth, Intracellular iron, Invader, Iron absorption, Iron acquisition, Iron burden, Iron chelation, Iron chelation therapy, Iron chelators, Iron deprivation, Iron loading, Iron metabolism, Iron overload, Iron withholding, Iron withholding defense system, Lactoferrin, Leishmania, Macrophage, Macrophage activation, Malaria, Microbial, Microbial invaders, Microbiol, Microorganism, More information, Murine, Murine macrophages, Neoformans, Neoplastic episodes, Nitric, Nitric mechanism, Nitric oxide, Nitric oxide formation, Nmma, Oxide, Past decade, Pathogen, Pathogenic, Pathogenic eukaryotic microorganisms, Plasmodium, Plasmodium falciparum, Pneumocystis, Pneumocystis carinii, Pneumocystis carinii pneumonia, Pollack, Primary enterocytes, Protozoan, Receptor, Risk factor, Siderophilin, Siderophore, Siderophores, Successful pathogens, Thuma, Toxoplasma gondii, Transferrin, Transferrin receptors, Tritrichomonas foetus, Trypanosoma, Trypanosoma brucei, Tumor necrosis, Vertebrate hosts, Viral infections, Weinberg, Yeast form.
Abstract
ABSTRACT. To survive and replicate in vertebrate hosts, protozoan and fungal invaders must be capable of securing host iron. Successful pathogens obtain the metal from either extraction of heme, binding of siderophilins. binding of siderophores, and/or iron pools within host cells. the actual strategy can vary with the availability of iron in the particular host milieu. As a corollary, hosts have developed an elaborate iron withholding defense system. Conditions that can compromise the system as well as procedures that can strengthen it are reviewed.
Url:
DOI: 10.1111/j.1550-7408.1999.tb05119.x
Affiliations:
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Le document en format XML
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<term>Biemba</term>
<term>Brain tissue</term>
<term>Brittenham</term>
<term>Candida</term>
<term>Candida albicans</term>
<term>Candidu albicans</term>
<term>Carinii</term>
<term>Cellular iron metabolism</term>
<term>Cerebral malaria</term>
<term>Chelators</term>
<term>Clinical studies</term>
<term>Cruzi</term>
<term>Cryptococcus</term>
<term>Cryptococcus neoformans</term>
<term>Deferoxamine</term>
<term>Dimier bout</term>
<term>Endothelial cells</term>
<term>Eukaryotic</term>
<term>Eukaryotic pathogens</term>
<term>Exper</term>
<term>Falciparum</term>
<term>Femc reductase</term>
<term>Ferrated</term>
<term>Ferrated lactoferrin</term>
<term>Ferrated siderophilins</term>
<term>Ferrated transferrin</term>
<term>Ferric</term>
<term>Ferric reductase activity</term>
<term>Fungal</term>
<term>Fungal acquisition</term>
<term>Fungal infections</term>
<term>Fungal invaders</term>
<term>Gondii</term>
<term>Gordeuk</term>
<term>Heme</term>
<term>Histoplasma</term>
<term>Histoplasma capsulatum</term>
<term>Host cells</term>
<term>Host iron</term>
<term>Hydroxamate siderophores</term>
<term>Hydroxamic acid</term>
<term>Hyphal form</term>
<term>Immun</term>
<term>Immunol</term>
<term>Indiana university</term>
<term>Infec</term>
<term>Inhibitory action</term>
<term>Intracellular</term>
<term>Intracellular growth</term>
<term>Intracellular iron</term>
<term>Invader</term>
<term>Iron absorption</term>
<term>Iron acquisition</term>
<term>Iron burden</term>
<term>Iron chelation</term>
<term>Iron chelation therapy</term>
<term>Iron chelators</term>
<term>Iron deprivation</term>
<term>Iron loading</term>
<term>Iron metabolism</term>
<term>Iron overload</term>
<term>Iron withholding</term>
<term>Iron withholding defense system</term>
<term>Lactoferrin</term>
<term>Leishmania</term>
<term>Macrophage</term>
<term>Macrophage activation</term>
<term>Malaria</term>
<term>Microbial</term>
<term>Microbial invaders</term>
<term>Microbiol</term>
<term>Microorganism</term>
<term>More information</term>
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<term>Murine macrophages</term>
<term>Neoformans</term>
<term>Neoplastic episodes</term>
<term>Nitric</term>
<term>Nitric mechanism</term>
<term>Nitric oxide</term>
<term>Nitric oxide formation</term>
<term>Nmma</term>
<term>Oxide</term>
<term>Past decade</term>
<term>Pathogen</term>
<term>Pathogenic</term>
<term>Pathogenic eukaryotic microorganisms</term>
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<term>Pneumocystis</term>
<term>Pneumocystis carinii</term>
<term>Pneumocystis carinii pneumonia</term>
<term>Pollack</term>
<term>Primary enterocytes</term>
<term>Protozoan</term>
<term>Receptor</term>
<term>Risk factor</term>
<term>Siderophilin</term>
<term>Siderophore</term>
<term>Siderophores</term>
<term>Successful pathogens</term>
<term>Thuma</term>
<term>Toxoplasma gondii</term>
<term>Transferrin</term>
<term>Transferrin receptors</term>
<term>Tritrichomonas foetus</term>
<term>Trypanosoma</term>
<term>Trypanosoma brucei</term>
<term>Tumor necrosis</term>
<term>Vertebrate hosts</term>
<term>Viral infections</term>
<term>Weinberg</term>
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<front><div type="abstract" xml:lang="en">ABSTRACT. To survive and replicate in vertebrate hosts, protozoan and fungal invaders must be capable of securing host iron. Successful pathogens obtain the metal from either extraction of heme, binding of siderophilins. binding of siderophores, and/or iron pools within host cells. the actual strategy can vary with the availability of iron in the particular host milieu. As a corollary, hosts have developed an elaborate iron withholding defense system. Conditions that can compromise the system as well as procedures that can strengthen it are reviewed.</div>
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